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Journa. of Clinica. a.d Tra.sla.iona. Hepa.ology 2018年第1期6卷 97-104页

作者： amir a. rahnemai-azar Jorda. M. Cloyd Sha.on M. Weber Ma.y Dillhoff Ca.l Schmidt Emily R. Winslow Timothy M. Pa.lik Depa.tment of Surgery Division of Surgical OncologyUniversity of Wisconsin HospitalMadisonWIUSA Depa.tment of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA Depa.tment of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liver resection is increa.ingly used for a.va.iety of benign a.d ma.igna.t conditions.Despite a.va.ces in preopera.ive selection,surgica. technique a.d periopera.ive ma.a.ement,posthepa.ectomy liver fa.lure(PHLF)is still a.lea.ing ca.se of morbidity a.d morta.ity following liver resection.Given the deva.ta.ing physiologica. consequences of PHLF a.d the la.k of effective trea.ment options,identifying risk fa.tors a.d preventa.ive stra.egies for PHLF is pa.a.ount.In the pa.t,a.ma.or limita.ion to conducting high qua.ity resea.ch on risk fa.tors a.d prevention stra.egies for PHLF ha. been the a.sence of a.sta.da.dized definition.In this a.ticle,we describe releva.t definitions for PHLF,discuss risk fa.tors a.d prediction models,a.d review a.va.ces in liver a.sessment tools a.d PHLF prevention stra.egies.

关键词： Complica.ion Hepa.ectomy Liver fa.lure Liver resection Prevention Risk models

a.plitude modula.ion;high-frequency modula.ion;a.toresona.ce;ion a.oustic wa.e

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High Power La.er Science a.d Engineering 2024年第1期12卷 74-83页

作者： Micha.l Va.dma. amir Hen Gila. Ma.cus a.plied Physics Institute Hebrew University of JerusalemJerusalemIsrael

The genera.ion a.d control of la.ge a.plitude pla.ma.gra.ings a.d other pla.ma.structures is of pa.a.ount importa.ce for the rea.iza.ion of pla.ma.photonics. a.toresona.t excita.ion of such structures by mea.s of chirped a.plitude-modula.ed la.ers ha. been recently discussed a.d a.a.yzed theoretica.ly. Here we discuss the pa.a.eter spa.e for the rea.iza.ion of such a.scheme a.d describe the la.er system tha. wa. built towa.ds this goa.. We a.so expa.d our ea.lier theoretica. study to a.count for the more rea.istic ca.e of a.modera.ely focused la.er bea., instea. of the simplified pla.e wa.e a.proxima.ion.

关键词： a.plitude modula.ion high-frequency modula.ion a.toresona.ce ion a.oustic wa.e

Synergistic effect of a.sorption a.d photoca.a.ytic degra.a.ion of oilfield-produced wa.er by electrospun photoca.a.ytic fibers of Polystyrene/Na.orod-Gra.hitic ca.bon nitride

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Journa. of Environmenta. Sciences 2024年第7期141卷 287-303页

作者： Pa.isa.a.moon Mehrda. Fa.ha.ia. a.ireza.Penda.hteh amir H.Na.a.chia. Depa.tment of Chemica. Engineering Faculty of EngineeringUniversity of IsfahanIsfahanIran Depa.tment of Chemica. Engineering Faculty of EngineeringUniversity of GuilanRashtIran Depa.tment of Wa.er a.d Environmenta. Engineering Caspian Sea Basin Research CenterUniversity of GuilanRashtIran

Gra.hitic ca.bon nitride with na.orod structure(Nr-GCN)wa. synthesized using mela.ine a. a.precursor without a.y other rea.ents by hydrotherma. pretrea.ment method.XRD,FTIR,SEM,N_(2)a.sorption-desorption from BET,UV-Vis DRS spectroscopy,a.d photoluminescence were used to cha.a.terize the prepa.ed sa.ples.a.so,the photoelectrochemica. beha.ior of na.opa.ticles wa. studied by photocurrent tra.sient response a.d cyclic volta.metry a.a.ysis.Polystyrene(PS)fibrous ma. wa. fa.rica.ed by electrospinning technique a.d used a. a.support for the sta.iliza.ion of the na.opa.ticles.The performa.ce of the synthesized na.opa.ticles a.d photoca.a.ytic fibers(PS/Nr-GCN)wa. eva.ua.ed in oilfield-produced wa.er trea.ment under visible light irra.ia.ion.During this process,oil conta.ina.ts were a.sorbed by hydrophobic polystyrene fibers a.d simulta.eously degra.ed by Nr-GCN.The remova. efficiency of chemica. oxygen dema.d(COD)ha. been obta.ned 96.6%a.d 98.4%by Nr-GCN a.d PS/Nr-GCN,respectively,a. the optimum conditions of pH4,photoca.a.yst dosa.e 0.5 g/L,COD initia. concentra.ion 550 mg/L,a.d illumina.ion time 150 min.The ga. chroma.ogra.hy-ma.s spectroscopy a.a.ysis results showed 99.3%remova. of tota. petroleum hydroca.bons using photoca.a.ytic fibers of PS/Nr-GCN.The results demonstra.ed tha. the GCN ha. outsta.ding fea.ures like controlla.le morphology,visible-light-driven,a.d showing high potentia. in oily wa.tewa.er remedia.ion.Moreover,the synergistic effect of a.sorption a.d photoca.a.ytic degra.a.ion is a. effective technique in oilfield-produced wa.er trea.ment.

关键词： Gra.hitic ca.bon nitride(GCN) Na.orod structure Polystyrene fibrous ma. Photoca.a.ytic fibers Oilfield-produced wa.er(OPW)

CRISPR,Ca.-T,a.d NK:Current a.plica.ions a.d future perspectives

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Genes & Disea.es 2024年第4期11卷 246-257页

作者： Moha.eseh Khosha.da. Hossein Solta.ineja. amir a.i Ha.idieh Sa.a. Hosseinkha.i Depa.tment of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran Na.iona. Institute of Genetic Engineering a.d Biotechnology(NIGEB) Tehran 14965/161Iran Depa.tment of stem cells technology a.d Tissue Regenera.ion Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pedia.ric Cell Thera.y a.d Gene Thera.y Resea.ch Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Depa.tment of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric a.tigen receptor T(Ca.-T)cell thera.y represents a.brea.through in persona.ized ca.cer trea.ments.In this rega.d,synthetic receptors comprised of a.tigen recognition doma.ns,signa.ing,a.d stimula.ory doma.ns a.e used to reprogra. T-cells to ta.get tum or cells a.d destroy them.Despite the success of this a.proa.h in refra.tory B-cell ma.igna.cies,the optima. potency of Ca. T-cell thera.y for ma.y other ca.cers,pa.ticula.ly solid tumors,ha. not been va.ida.ed.Na.ura. killer cells a.e powerful cytotoxic lymphocytes specia.ized in recognizing a.d dispensing the tumor cells in coordina.ion with other a.ti-tumor immunity cells.Ba.ed on these studies,ma.y investiga.ions a.e focused on the a.cura.e designing of Ca. T-cells with clustered regula.ly interspa.ed short pa.indromic repea.s(CRISPR)/CRISPR-a.socia.ed protein 9(Ca.9)system or other novel gene editing tools tha. ca. induce heredita.y cha.ges with or without the presence of a.double-stra.ded brea. into the genome.These methodologies ca. be specifica.ly focused on nega.ive controllers of T-cells,induce modifica.ions to a.pa.ticula. gene,a.d produce reproducible,sa.e,a.d powerful a.logeneic Ca. T-cells for on-dema.d ca.cer immunothera.y.The improvement of the CRISPR/Ca.9 innova.ion offers a. a.a.ta.le a.d proficient gene-editing ca.a.ility in a.tiva.ing different pa.hwa.s to help na.ura. killer cells intera.t with novel Ca.s to pa.ticula.ly ta.get tumor cells.Novel a.hievements a.d future cha.lenges of combining next-genera.ion CRISPR-Ca.9 gene editing tools to optimize Ca. T-cell a.d na.ura. killer cell trea.ment for future clinica. tria.s towa.d the founda.ion of modern ca.cer trea.ments ha.e been a.sessed inthis review.

关键词： Ca.cer Ca. T-cell CRISPR Gene editing Immunothera.y NK cell

Clinica. a.plica.ions of the CRISPR/Ca.9 genome-editing system: Delivery options a.d cha.lenges in precision medicine

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Genes & Disea.es 2024年第1期11卷 268-282页

作者： Moha.eseh Khosha.da. Hossein Solta.ineja. Ma.ziyeh Mousa.a.eh amir a.i Ha.idieh Sa.a. Hosseinkha.i Depa.tment of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran Na.iona. Institute of Genetic Engineering a.d Biotechnology(NIGEB) Tehran 14155-6463Iran Fa.ulty of Interdisciplina.y Science a.d Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pedia.ric Cell a.d Gene Thera.y Resea.ch Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Depa.tment of Na.obiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Depa.tment of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Ca.9 is a. effective gene editing tool with broa. a.plica.ions for the pre-vention or trea.ment of numerous disea.es.It depends on CRiSPR(clustered regula.ly inter-spa.ed short pa.indromic repea.s)a. a.ba.teria. immune system a.d pla.s a. a.gene editing tool.Due to the higher specificity a.d efficiency of CRISPR/Ca.9 compa.ed to other editing a.-proa.hes,it ha. been broa.ly investiga.ed to trea. numerous heredita.y a.d a.quired ill-nesses,including ca.cers,hemolytic disea.es,immunodeficiency disorders,ca.diova.cula. disea.es,visua. ma.a.ies,neurodegenera.ive conditions,a.d a.few X-linked disorders.CRISPR/Ca.9 system ha. been used to trea. ca.cers through a.va.iety of a.proa.hes,with sta.ble gene editing techniques.Here,the a.plica.ions a.d clinica. tria.s of CRisPR/Ca.9 in va.ious illnesses a.e described.Due to its high precision a.d efficiency,CRISPR/Ca.9 stra.egies ma. trea. gene-rela.ed illnesses by deleting,inserting,modifying,or blocking the expression of specific genes.The most cha.lenging ba.rier to the in vivo use of CRISPR/Ca.9 like off-ta.get effects will be discussed.The use of tra.sfection vehicles for CRISPR/Ca.9,including vira. vectors(such a. a. a.eno-a.socia.ed virus(a.V),a.d the development of non-vira. vectors is a.so considered.

关键词： Clinica. tria.s CRISPR/Ca.9 Gene thera.y Non-vira. vectors Vira. vectors

Experimenta. investiga.ion into effects of the na.ura. polymer a.d na.ocla. pa.ticles on the EOR performa.ce of chemica. flooding in ca.bona.e reservoirs

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Petroleum Science 2024年第2期21卷 951-961页

作者： amir Moha.ma. Za.a.i a.hka. Moslemi Ka.ra. Ha.sa.i Depa.tment of Petroleum Engineering Islamic Azad University Science and Research BranchTehranIran Institute of Petroleum Engineering University of TehranTehranIran

This pa.er a.ms to investiga.e the tra.a.a.th gum potentia. a. a.na.ura. polymer combined with na.ura. cla. minera.(montmorillonite,ka.linite,a.d illite)na.opa.ticles(NPs)to form NP-polymer suspension for enha.ced oil recovery(EOR)in ca.bona.e reservoirs.Therma. gra.imetric a.a.ysis(TGa.tests were conducted initia.ly in order to eva.ua.e the properties of tra.a.a.th gum.Subsequently,sca.ning electron microscopy(SEM)a.d energy-dispersive X-ra.(EDX)tests were used to detect the structure of cla. pa.ticles.In va.ious scena.ios,the effects of na.ura. NPs a.d polymer on the wetta.ility a.tera.ion,interfa.ia. tension(IFT)reduction,viscosity improvement,a.d oil recovery were investiga.ed through conta.t a.gle system,ring method,a.ton Pa.r viscometer,a.d core flooding tests,respectively.The entire experiment wa. conducted a. 25,50,a.d 75℃,respectively.a.cording to the experimenta. results,the cla. minera.s a.one did not ha.e a.significa.t effect on viscosity,but the a.dition of minera.s to the polymer solution lea.s to the viscosity enha.cement rema.ka.ly,resulting mobility ra.io improvement.a.ong cla. NPs,the combina.ion of na.ura. polymer a.d ka.linite results in increa.ed viscosity a. a.l tempera.ures.Considera.le wetta.ility a.tera.ion wa. a.so observed in the ca.e of na.ura. polymer a.d illite NPs.Illite in combina.ion with na.ura. polymer showed a. a.ility in reducing IFT.Fina.ly,the results of displa.ement experiments revea.ed tha. the combina.ion of na.ura. polymer a.d ka.linite could be the best option for EOR due to its substa.tia. a.ility to improve the recovery fa.tor.

关键词： Chemica. flooding Tra.a.a.th gum Cla. na.opa.ticle Wetta.ility IFT

a.ra.e complica.ion of mea.les infection presented with suba.ute sclerosing pa.encepha.itis: Report of two ca.es in India

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a.ia. Pa.ific Journa. of Tropica. Medicine 2024年第4期17卷 184-187页

作者： Ra.een Fa.ima.amir Husa.n Ira. Ta.ish Depa.tment of Medicine JN Medical CollegeAMUAligarhIndia

Ra.iona.e:Suba.ute sclerosing pa.encepha.itis(SSPE)is a.progressive neurologica. disorder ca.sed by persistent mea.les virus infection.SSPE predomina.tly a.fects children a.d a.olescents.The symptoms usua.ly develop 6-15 yea.s a.ter mea.les infection a.d ultima.ely lea.ing to dea.h in ma.y ca.es.Pa.ient concerns:Pa.ient 1 presented with cognitive decline a.d myoclonus a.d the Pa.ient 2 presented with diminution of vision with myoclonic jerks.Dia.nosis:Ba.ed on the clinica. fea.ures with a.cha.a.teristic electroencepha.ogra. pa.tern a.d the presence of a.high titer of a.ti-mea.les IgG in serum a.d cerebrospina. fluid,these pa.ients were dia.nosed a. SSPE.Interventions:a.tiepileptics were sta.ted for controlling myoclonus a.ong with supportive trea.ment.Outcomes:Both pa.ients were discha.ged on a.tiepileptics a.d supportive ca.e.Lessons:Whenever there a.e unusua. clinica. ma.ifesta.ions with unknown va.cina.ion sta.us,SSPE ca. be suspected a.d the cerebrospina. fluid should be exa.ined for a.ti-mea.les a.tibodies.Our ca.e study a.so highlights the importa.ce of universa. covera.e of mea.les va.cina.ion.To reduce the incidence of mea.les a.d a.socia.ed dea.hs,it is importa.t to ma.nta.n a.high level of immuniza.ion covera.e for the mea.les va.cine a.d to strengthen a.l the integra. components of the na.iona. immuniza.ion progra..

关键词： Suba.ute sclerosing pa.encepha.itis Mea.les Myoclonus Electroencepha.ogra. Cerebrospina. fluid

Geyser Inspired a.gorithm:a.New Geologica.-inspired Meta.heuristic for Rea.-pa.a.eter a.d Constra.ned Engineering Optimiza.ion

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Journa. of Bionic Engineering 2024年第1期21卷 374-408页

作者： Mojta.a.Gha.emi Mohsen Za.e amir Za.edi Moha.ma.-a.in a.ba.i Seyeda.i Mirja.ili La.th a.ua.iga. Depa.tment of Electronics a.d Electrica. Engineering Shiraz University of TechnologyShirazIran Depa.tment of Electrica. Engineering Faculty of EngineeringJahrom UniversityJahromFrasIran Depa.tment of Electrica. a.d Computer Engineering Tarbiat Modares UniversityTehranIran Depa.tment of Electrica. a.d Computer Engineering University ofCyprusNicosiaCyprus Centre for a.tificia. Intelligence Resea.ch a.d Optimisa.ion Torrens University AustraliaBrisbaneQLD 4006Australia University Resea.ch a.d Innova.ion Center Obuda University1034 BudapestHungary Depa.tment of Electrica. a.d Computer Engineering Lebanese American UniversityByblos 13-5053Lebanon Houra.i Center for a.plied Scientific Resea.ch Al-Ahliyya Amman UniversityAmman 19328Jordan MEU Resea.ch Unit Middle East UniversityAmman 11831Jordan a.plied Science Resea.ch Center Applied Science Private UniversityAmman 11931Jordan

Over the pa.t yea.s,ma.y efforts ha.e been a.complished to a.hieve fa.t a.d a.cura.e meta.heuristic a.gorithms to optimize a.va.iety of rea.-world problems.This study presents a.new optimiza.ion method ba.ed on a. unusua. geologica. phenomenon in na.ure,na.ed Geyser inspired a.gorithm(GEa..The ma.hema.ica. modeling of this geologica. phenomenon is ca.ried out to ha.e a.better understa.ding of the optimiza.ion process.The efficiency a.d a.cura.y of GEa.a.e verified using sta.istica. exa.ina.ion a.d convergence ra.e compa.ison on numerous CEC 2005,CEC 2014,CEC 2017,a.d rea.-pa.a.eter benchma.k functions.Moreover,GEa.ha. been a.plied to severa. rea.-pa.a.eter engineering optimiza.ion problems to eva.ua.e its effectiveness.In a.dition,to demonstra.e the a.plica.ility a.d robustness of GEa.a.comprehensive investiga.ion is performed for a.fa.r compa.ison with other sta.da.d optimiza.ion methods.The results demonstra.e tha. GEa.is noticea.ly prosperous in rea.hing the optima. solutions with a.high convergence ra.e in compa.ison with other well-known na.ure-inspired a.gorithms,including a.C,BBO,PSO,a.d RCGa.Note tha. the source code of the GEa.is publicly a.a.la.le a. https://***/projects/gea.

关键词： Na.ure-inspired a.gorithms Rea.-world a.d engineering optimiza.ion Ma.hema.ica. modeling Geyser a.gorithm(GEa.

Prolonged a.ystole following a.enosine. Wa. it necessa.y?

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Journa. of Geria.ric Ca.diology 2024年第6期21卷 686-688页

作者： Yuva. a.ida. amir a.er Vsevolod Ta.a.hnikov Depa.tment of Ca.diology Lady Davis Carmel Medical CenterHaifaIsrael

a.7-yea.-old woma. presented with intercha.gea.le episodes of both fa.t a.d slow hea.t ra.e.Pa.t history wa. nota.le for pa.oxysma. a.ria. fibrilla.ion trea.ed with eliquis a.d ta.bocor a.d a.ria. septa. defect closure 35 yea.s a.o.Except for mild ta.hyca.dia.vita.s a.d physica. exa.ina.ion were unrema.ka.le.The 12-lea. electroca.diogra.(Figure 1)showed na.row complex ta.hyca.dia.a. 106 bea.s/min without obvious P-wa.es.

关键词： ta.hyca.dia septa. a.ria.

Signa.ing pa.hwa.s governing the beha.iors of leukemia.stem cells

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Genes & Disea.es 2024年第2期11卷 830-846页

作者： Shirin a.izidoost a.a.Na.rola.i Moha.eseh Sheykhi-Sa.zehpoush amir a.biya.ee Seyed Esma.il Khoshna. Ma.ya. Fa.za.eh Sha.a. Uddin a.herosclerosis Resea.ch Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Infectious Ophtha.mologic Resea.ch Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Depa.tment of La.ora.ory Imam Khomeini Hospital ComplexTehran University of Medical SciencesTehran ***Iran Depa.tment of Surgery School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Persia. Gulf Physiology Resea.ch Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Fertility Infertility and Perinatology Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Tra.sla.iona. Resea.ch Institute a.d Derma.ology Institute Academic Health SystemHamad Medical CorporationDoha 3050Qatar

Leukemia.is a.ma.igna.cy in the blood tha. develops from the lympha.ic system a.d bone ma.row.a.though va.ious trea.ment options ha.e been used for different types of leukemia.understa.ding the molecula. pa.hwa.s involved in the development a.d progression of leukemia.is necessa.y.Recent studies showed tha. leukemia.stem cells(LSCs)pla. essentia. roles in the pa.hogenesis of leukemia.by ta.geting severa. signa.ing pa.hwa.s,including Notch,Wnt,Hedgehog,a.d STa.3.LSCs a.e highly prolifera.ive cells tha. stimula.e tumor initia.ion,migra.ion,EMT,a.d drug resista.ce.This review summa.izes cellula. pa.hwa.s tha. stimula.e a.d prevent LSCs'self-renewa.,meta.ta.is,a.d tumorigenesis.

关键词： Leukemia Leukemia.stem cells Pa.hogenesis Signa.ing pa.hwa.s Stem cells