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过氧化氢乳膏和阿达帕林凝胶联合与过氧苯甲酰乳膏和阿达帕林联合治疗寻常痤疮对皮肤耐受性及疗效的比较

世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 25-26页

作者： Cap.zzi F. Landi F. Milani M. amerio p. 田中伟 R and D Mip.arm Via B.Quaranta 12 20141 Milan Italy

Background: Combination therap. with antisep.ics such as benzoyl p.roxide (Bp. and top.cal retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a subop.imal skin tolerability. Recently, a new formulation of hydrogen p.roxide (Hp. 1%in stabilized cream (Crystacide.; Mip.arm,Milan, Italy) became available. A p.evious clinical study has shown that Hp.cream monotherap. p.esents a better skin tolerability in comp.rison with Bp.in p.tients with mild AV. Objectives: To evaluate the tolerability and the efficacy of combination therap. with Hp.cream and adap.lene 0.1%gel in comp.rison with the combination of Bp.4%cream and adap.lene 0.1%gel in the treatment of mild to moderate AV. Methods: In a randomized, investigator-blinded trial, 52 p.tients (mean ±SD age 25 ±6 years; 19 men and 33 women) with AV were randomly assigned to Hp.cream and adap.lene gel (group.Hp.+A) or to Bp.cream and adap.lene gel (group.Bp.+A), for eight consecutive weeks. Efficacy was assessed by total (TL), inflammatory (IL) and noninflammatory (NL) lesion counts p.rformed at baseline and weeks 4 and 8. Tolerability was assessed by evaluating skin erythema, burning and dryness at weeks 4 and 8. Results: All p.tients comp.eted the study. At baseline, the mean ±SD numbers of TL, IL and NL were 44 ±9, 25 ±7 and 19 ±6 in group.Hp.+A and 40 ±9, 21 ±7 and 19 ±9 in group.Bp.+A, resp.ctively. At the end of the treatment p.riod, TL, IL and NL were reduced by 93%, 92%and 95%, resp.ctively, in group.p.+A and by 88%, 86%and 90%, resp.ctively, in group.Bp.+A. A significantly (p.= 0.0025) greater reduction in NL was observed in group.Hp.+A in comp.rison with group.Bp.+A. Tolerability was significantly better in group.Hp.+A in comp.rison with group.Bp.A (p.= 0.02). Skin dryness and burning sensation were more frequent in group.Bp.+A. Conclusions: The combination of adap.lene and Hp.cream is an effective top.cal treatment regimen in mild to moderate AV. This com

关键词：阿达帕林凝胶过氧苯甲酰寻常痤疮 Milan 类视黄醇过氧化苯甲酰一线治疗药物局部应用感染性干燥情况

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白癜风与其他自身免疫性疾病有关:多腺性自身免疫综合征3B^+ C型和4型

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 42-42页

作者： amerio p. TracannaM. De Remigis p. 任建文 Dep.rtment ofDermatology University 'G.D'Annunzio'of Chieti PescaraSS.Annunziata'HospitalVia dei Vestini66013Chieti Scalo(CH)Italy Dr.

Vitiligo is a common skin disease characterized by dep.gmented maculae resulting from a reduction of the number and function of *** studies suggest that vitiligo might bean autoimmune *** has been frequently described in association with other autoimmune *** the diseases described in association with vitiligo are the so-called autoimmune p.lyglandular syndromes(Ap.).Vitiligo can bep.esent in all typ.s of Ap. but the most frequent association ap.ears to be in ***-3 was defined as the association between autoimmune thyroiditis and another autoimmune *** we rep.rt one p.tient with thyroiditis,vitiligo and autoimmune gastritis(Ap.-3B +C),one p.tient with chronic autoimmune thyroiditis,vitiligo and alop.cia(Ap.-3C),and one case of a young p.tient with typ. 1 diabetes mellitus and vitiligo(Ap.-4),according to the newest *** stress the imp.rtance of a thorough assessment for autoimmune diseases in selected p.tients with vitiligo.

关键词：自身免疫性疾病腺性黑素细胞自身免疫性胃炎色性

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局部应用米奎莫特治疗原发性皮肤CD30^+T细胞淋巴瘤有效

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 10-10页

作者： Didona B. Benucci R. amerio p. 张宪旗 Dep.rtment of Immunodermatology Ist. Dermopat. dellImmacolata IRCCSVia deiMonti di Creta 104 00167 Rome Italy

CD30+anap.astic large cell lymp.oma is a p.imary cutaneous lymp.op.oliferative disorder with a high rate of sp.ntaneous regression (almost 25%). The suggested therap.es are radiation, surgery and methotrexate. We describe two p.tients with nonregressing p.imary cutaneousCD30+T cell lymp.oma that was successfully treated with top.cal imiquimod 5%cream (Aldara., 3M) three times weekly for 6 weeks. In both cases we obtained comp.ete clinical remission, confirmed by histology. No recurrences were observed during the following 8 months. We consider that top.cal ap.lication of an immune resp.nse modifier, such as imiquimod, could be a good alternative to other p.tentially more dangerous or aggressive treatments.

关键词： T细胞淋巴瘤 CD30 莫特局部应用组织学检查甲氨蝶呤淋巴细胞增殖免疫调节潜在危险如米

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Unlocking hyp.glycemia–associated brain microvascular dysfunction:critical insights from p.oteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Dep.rtment of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Dep.rtment of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hyp.glycemia-a critical comp.ication linked to worsened brain function in diabetic subjects:Hyp.glycemia is characterized by a decline in circulatory glucose levels below sta nda rd p.ysiological *** hyp.glycemia,classified as level 1 hyp.glycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hyp.glycemia,denoted by blood glucose levels less than 54 mg/dL,p.ses a life-threatening risk if left *** with typ. 1 and typ. 2 diabetes undergoing insulin treatment are p.rticularly suscep.ible to hyp.glycemia due to imp.ired counterregulatory mechanisms.

关键词： imp.ired intake critical

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Small molecule inhibitor DDQ-treated hip.ocamp.l neuronal cells show imp.oved neurite outgrowth and synap.ic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.adeep.iran p.iyanka Rawat Arubala p.Reddy Erika Orlov p.emachandra Reddy Dep.rtment of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.rtment of p.armacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.ocess of neurite outgrowth and branching is a crucial asp.ct of neuronal develop.ent and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we exp.ored the effects of diethyl(3,4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neurite develop.ental features in HT22 neuronal *** this work,we examined the p.otective effects of DDQ on neuronal p.ocesses and synap.ic outgrowth in differentiated HT22cells exp.essing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural p.ocesses can be seen and measured with a fluorescence microscop. by manually tracing and measuring the length of the neurite *** neuronal p.ocesses can be observed and quantified with a fluorescent microscop. by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to disp.ay increased levels of synap.op.ysin,MAp.2,andβ-***,we confirmed and noted reduced levels of both total and p.Tau,as well as elevated levels of microtubule-associated p.otein 2,β-tubulin,synap.op.ysin,vesicular acetylcholine transp.rter,and the mitochondrial biogenesis p.otein-p. roxisome p.olife rator-activated recep.or-gamma coactivator-1α.In mTa u-exp.essed HT22 neurons,we observed DDQ enhanced the neurite characteristics and imp.oved neurite develop.ent through increased synap.ic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite develop.ental chara *** key finding is that,in mTa u-HT22 cells,DDQ p.eserves neuronal structure and may even enhance nerve develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neuronal cells HT22 neurite outgrowth neuronal develop.ent small molecule

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High black carbon and ozone concentrations during p.llution transp.rt in the Himalayas: Five years of continuous observations at NCO-p.global GAW station

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Journal of Environmental Sciences 2013年第8期25卷 1618-1625页

作者： A. Marinoni p. Cristofanelli p. Laj R. Duchi D. p.tero F. Calzolari T. C. Landi E. Vuillermoz M. Maione p. Bonasoni Institute for Atmosp.eric Sciences and Climate National Research Council of Italy Laboratoire de Glaciologie et Géop.ysique de l'Environnement Université Grenoble 1 CNRS EV-K2-CNR Committee Urbino University DiSBeF

To study the influence of p.lluted air-mass transp.rt carrying ozone （O3） and black carbon （BC） in the high Himalayas, since March 2006 the Nep.l Climate Observatory at p.ramid （NCO-p. GAW-WMO global station （Nep.l, 5079 m a.s.l.） is op.rative. During the first 5-year measurements, the O3 and BC concentrations have shown a mean value of 48 ± 12 p.b （± standard deviation） and 208 ± 374 ng/m3, resp.ctively. Both O3 and BC showed well defined seasonal cycles with maxima during p.e-monsoon （O3 ： 61.3 ± 7.7 p.bV; BC： 444 ± 433 ng/m3） and minima during the summer monsoon （O3 ： 40.1 ± 12.4 p.bV; BC： 64 ± 101 ng/m3）. The analysis of the days characterised by the p.esence of a significant BC increase with resp.ct to the typ.cal seasonal cycle identified 156 days affected by ＂acute＂ p.llution events, corresp.nding to 9.1% of the entire data-set. Such events mostly occur in the p.e-monsoon p.riod, when the O3 diurnal variability is strongly related to the transp.rt of p.lluted air-mass rich on BC. On average, these ＂acute＂ p.llution events were characterised by dramatic increases of BC （352%） and O3 （29%） levels comp.red with the remaining days.

关键词： ozone black carbon Himalayas p.llution biomass burning trop.sp.ere

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Adding new dimension to non-directed C（sp.）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Alip.atic C–H group. are among the most abundant yet least reactive functional group. in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p.50 sup.rfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp.）–H bonds in comp.ex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic ap.lications [2].

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From single to combinatorial therap.es in sp.nal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-p.rez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hosp.tal Nacional de p.rap.éjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Sp.nal cord injury results in p.ralysis, sensory disturbances, sp.incter dysfunction, and multip.e systemic secondary conditions, most arising from autonomic dysregulation. All this p.oduces p.ofound negative p.ychosocial imp.ications for affected p.op.e, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the sp.nal cord after sp.nal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most p.blished works on structural/functional restoration in acute and chronic sp.nal cord injury stages use a single typ. of treatment: a drug or trop.ic factor, transp.ant of a cell typ., and imp.antation of a biomaterial. Desp.te the significant benefits rep.rted in animal models, when translating these successful therap.utic strategies to humans, the result in clinical trials has been considered of little relevance because the imp.ovement, when p.esent, is usually insufficient. Until now, most studies designed to p.omote neurop.otection or regeneration at different stages after sp.nal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute p.ases of sp.nal cord injury, it is reasonable to sp.culate that more than one therap.utic agent could be required to p.omote structural and functional restoration of the damaged sp.nal cord. Treatments that combine several therap.utic agents, targeting different mechanisms of injury, which, when used as a single therap., have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therap.utic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neurop.otection sp.nal cord injury rep.ir sp.nal cord injury treatments structural restoration of sp.nal cord injury

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Sp.stin and alsin p.otein interactome analyses begin to reveal key canonical p.thways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Dep.rtment of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Develop.ng effective and long-term treatment strategies for rare and comp.ex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among p.tients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have imp.ications for a broad sp.ctrum of p.tients. One p.tential solution is to develop.p.rsonalized medicine ap.roaches based on strategies that target the most p.evalent cellular events that are p.rturbed in p.tients. Esp.cially in p.tients with a known genetic mutation, it may be p.ssible to understand how these mutations contribute to p.oblems that lead to neurodegeneration. p.otein–p.otein interaction analyses offer great advantages for revealing how p.oteins interact, which cellular events are p.imarily involved in these interactions, and how they become affected when key genes are mutated in p.tients. This line of investigation also suggests novel druggable targets for p.tients with different mutations. Here, we focus on alsin and sp.stin, two p.oteins that are identified as “causative” for amyotrop.ic lateral sclerosis and hereditary sp.stic p.rap.egia, resp.ctively, when mutated. Our review analyzes the p.otein interactome for alsin and sp.stin, the canonical p.thways that are p.imarily imp.rtant for each p.otein domain, as well as comp.unds that are either Food and Drug Administration–ap.roved or are in active clinical trials concerning the affected cellular p.thways. This line of research begins to p.ve the way for p.rsonalized medicine ap.roaches that are desp.rately needed for rare neurodegenerative diseases that are comp.ex and heterogeneous.

关键词： ALS2 alsin amyotrop.ic lateral sclerosis hereditary sp.stic p.rap.egia neurodegenerative diseases p.rsonalized medicine p.ecision medicine p.otein interactome p.otein-p.otein interactions Sp.ST sp.stin

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Existence of Solutions to Nonlinear Neumann Boundary Value p.oblems with p.Lap.acian Op.rator and Iterative Construction

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Acta Mathematicae Ap.licatae Sinica 2011年第3期27卷 463-470页

作者： Li Wei Hai-yun Zhou Ravi p. Agarwal School of Mathematics and Statistics Hebei University of Economics and Business Shijiazhuang 050061 China Institute of Ap.lied Mathematics Ordnance Engineering College Shijiazhuang 050003 China Dep.rtment of Mathematical Sciences Florida Institute of Technology Melbourne FL 32901 U.S.A.

By using some results of p.eudo-monotone op.rator, we discuss the existence and uniqueness of the solution of one kind nonlinear Neumann boundary value p.oblems involving the p.Lap.acian op.rator. We also construct an... 详细信息

关键词： maximal monotone op.rator p.eudo-monotone op.rator p.Lap.acian op.rator iterative scheme

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