过氧化氢乳膏和阿达帕林凝胶联合与过氧苯甲酰乳膏和阿达帕林联合治疗寻常痤疮对皮肤耐受性及疗效的比较

作     者：Capizzi F. Landi F. Milani M. Amerio P. 田中伟 

作者机构：R and D Mipharm Via B.Quaranta 12 20141 Milan Italy 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第2期

页      面：25-26页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：阿达帕林凝胶 过氧苯甲酰 寻常痤疮 Milan 类视黄醇 过氧化苯甲酰 一线治疗药物 局部应用 感染性 干燥情况 

摘      要：Background: Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal skin tolerability. Recently, a new formulation of hydrogen peroxide (HP) 1%in stabilized cream (Crystacide.; Mipharm,Milan, Italy) became available. A previous clinical study has shown that HP cream monotherapy presents a better skin tolerability in comparison with BP in patients with mild AV. Objectives: To evaluate the tolerability and the efficacy of combination therapy with HP cream and adapalene 0.1%gel in comparison with the combination of BP 4%cream and adapalene 0.1%gel in the treatment of mild to moderate AV. Methods: In a randomized, investigator-blinded trial, 52 patients (mean ±SD age 25 ±6 years; 19 men and 33 women) with AV were randomly assigned to HP cream and adapalene gel (group HP +A) or to BP cream and adapalene gel (group BP +A), for eight consecutive weeks. Efficacy was assessed by total (TL), inflammatory (IL) and noninflammatory (NL) lesion counts performed at baseline and weeks 4 and 8. Tolerability was assessed by evaluating skin erythema, burning and dryness at weeks 4 and 8. Results: All patients completed the study. At baseline, the mean ±SD numbers of TL, IL and NL were 44 ±9, 25 ±7 and 19 ±6 in group HP +A and 40 ±9, 21 ±7 and 19 ±9 in group BP +A, respectively. At the end of the treatment period, TL, IL and NL were reduced by 93%, 92%and 95%, respectively, in groupHP +A and by 88%, 86%and 90%, respectively, in group BP +A. A significantly (P = 0.0025) greater reduction in NL was observed in group HP +A in comparison with group BP +A. Tolerability was significantly better in group HP +A in comparison with group BP+A (P = 0.02). Skin dryness and burning sensation were more frequent in group BP +A. Conclusions: The combination of adapalene and HP cream is an effective topical treatment regimen in mild to moderate AV. This com