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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 539-543页

作者： ameena k Dilip C Saraswathi R krishnan PN Sankar C Simi SP Al Shifa College of Pharmacy KizhatturPerinthalmanna.Kerala679325India

Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration *** extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage *** concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro *** studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good *** in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 ***:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to *** higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery *** the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased.

关键词： Formulation Hibiscus Tablets

Formulation and evaluation of Albendazole microcapsules for colon delivery using chitosan

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 374-378页

作者： Simi SP Saraswathi R Sankar C krishnan PN Dilip C ameena k Al Shifa College Of Pharmacy KizhatturPerinthalmannaKerala.Pin-679325India

Objective:To formulate and evaluate Albendazole microcapsules using chitosan,a natural polymer for colon-specific delivery for better treatment of helminthiasis,filariasis,colorectal cancer,avoiding the side ***:The Albendazole microcapsules were prepared by the use of different concentrations of sodium alginate,chitosan and hydroxypropyl methylcellulose(HPMC).The polysaccharides chitosan reacted with sodium alginate in the presence of calcium chloride to form microcapsules with a polyelectrolyte complex membrane by electrostatic interactions between the two oppositely charged *** microcapsules were then studied for entrapment efficiency,drug-polymer compatibility and surface morphology. In vitro drug release study in presence and absence of cecal content were also ***, kinetic modellings were employed to find out release ***:Albendazole loaded microspheres showd high entrapment efficiency(72.8%) and the microcapsules were free flowing,non aggregated and spherical,between 600 and 1 000μm in *** surface of microcapsules were found to be porous and *** FT-IR spectrum showed that there is no interaction between the polymer and the *** in vitro drug release study found to be affected by change in chitosan,sodium alginate and HPMC *** microcapsules with 2.5% sodium alginate and 0.4% chitosan shown minimum release in gastrointestinal simulated condition but shows maximum drug release at the end of 24th hour in presence of cecal *** rate of drug release follows korsmeyer-peppas model that was the drug release is by diffusion and ***:The study reveals that Albendazole loaded chitosanalginate based microsphere can be used effectively for the colon targeting.

关键词： Colon drug delivery Albendazole Chitosan Sodium alginate Microcapsule

Aamar-e-Advia(shelf-lives) of drugs in Unani system of medicine:A conceptual review

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Journal of Integrative Medicine 2020年第2期18卷 114-124页

作者： ameena Yasmeen Ghulamuddin Sofi kaleemullah khan Department of Ilmul Advia(Pharmacology) Government Unani Medical CollegeRajiv Gandhi University of Health SciencesBengaluru-560079KarnatakaIndia Department of Ilmul Advia(Pharmacology) National Institute of Unani MedicineRajiv Gandhi University of Health SciencesBengaluru-560091KarnatakaIndia Registered clinical practitioner and Independent researcher Mysore-570019KarnatakaIndia

In an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for studying health and disease. The mode of treatment includes Ilaj bit Tadbeer(regimental therapy), Ilaj bil Ghiza(dietotherapy), Ilaj bil Dawa(pharmacotherapy) and Ilaj bil Yad/Jarahat(surgery) as a final option. Ilaj bil Dawa is the most used mode of *** drugs include either crude drugs prepared from plant, animal and mineral sources, called Mufrad(single) drugs or various formulations prepared from these crude drugs, called Murakkab(compound)drugs. To date, stability studies have been carried out on compound drugs, whereas only a few single drugs had had their stability tested. These studies are needed to understand how the quality of an herbal drug varies over the time when it is prepared and consumed. This may also help to standardize procedures for manufacturing compound formulations ab initio. The present study reviews the concept of Aamar-e-Advia(shelf-lives) described in the literature of the Unani system of medicine. Further, various factors that are considered important to assess the shelf-life of Unani drugs are discussed in the context of contemporary protocols for shelf-life assessment.

关键词： Drug stability Shelf-life Expiry date Unani medicine Aamar-e-Advia Drug potency

Coalition Formation of Microgrids with Distributed Energy Resources and Energy Storage in Energy Market

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Journal of Modern Power Systems and Clean Energy 2020年第5期8卷 906-918页

作者： Jaber Valinejad Mousa Marzband Mert korkali Yijun Xu ameena Saad Al-Sumaiti IEEE Bradley Department of Electrical and Computer Engineering Virginia TechNorthern Virginia CenterGreater Washington D.C.VA 22043USA Department of Computer Science Virginia TechNorthern Virginia CenterGreater Washington D.C.VA 22043USA Department of Mathematics Physicsand Electrical EngineeringNorthumbria UniversityNewcastleUK Center of Research Excellence in Renewable Energy and Power Systems King Abdulaziz UniversityJeddah 21589Saudi Arabia Computational Engineering Division Lawrence Livermore National LaboratoryLivermoreCA 94550USA Advanced Power and Energy Center Electrical Engineering and Computer ScienceKhalifa UniversityAbu DhabiP.O.Box 127788UAE

Power grids include entities such as home-microgrids(H-MGs),consumers,and retailers,each of which has a unique and sometimes contradictory objective compared with others while exchanging electricity and heat with other ***,there is the need for a smart structure to handle the new *** paper proposes a bilevel hierarchical structure for designing and planning distributed energy resources(DERs)and energy storage in H-MGs by considering the demand response(DR).In general,the upper-level structure is based on H-MG generation competition to maximize their individual and/or group income in the process of forming a coalition with other *** upper-level problem is decomposed into a set of low-level market clearing *** electricity and heat markets are simultaneously modeled in this ***,including wind turbines(WTs),combined heat and power(CHP)systems,electric boilers(EBs),electric heat pumps(EHPs),and electric energy storage systems,participate in the electricity *** addition,CHP systems,gas boilers(GBs),EBs,EHPs,solar thermal panels,and thermal energy storage systems participate in the heat *** show that the formation of a coalition among H-MGs present in one grid will not only have a significant effect on programming and regulating the value of the power generated by the generation resources,but also impact the demand consumption and behavior of consumers participating in the DR program with a cheaper market clearing price.

关键词： Microgrids distributed energy resource(DER) electricity market heat market demand response(DR) coalition formation energy storage

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Techno-economic analysis of green hydrogen as an energy-storage medium for commercial buildings

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Clean Energy 2023年第1期7卷 84-98页

作者： Rahul Rajeevkumar Urs Assia Chadly ameena Al Sumaiti Ahmad Mayyas Department of Industrial and Systems Engineering Khalifa UniversityAbu Dhabi 127788UAE Department of Electrical Engineering and Computer Science Advanced Power and Energy CenterKhalifa UniversityAbu Dhabi 127788UAE

Green-hydrogen production is vital in mitigating carbon emissions and is being adopted *** its transition to a more diverse energy mix with a bigger share for renewable energy,United Arab Emirates(UAE)has committed to investing billions of dollars in the production of green *** study presents the results of the techno-economic assessment of a green-hydrogen-based commercial-building microgrid design in the *** microgrid has been designed based on the building load demand,green-hydrogen production potential utilizing solar photovoltaic(PV)energy and discrete stack reversible fuel cell electricity generation during non-PV *** the current market conditions and the hot humid climate of the UAE,a performance analysis is derived to evaluate the technical and economic feasibility of this *** study aims at maximizing both the building microgrid’s independence from the main grid and its renewable *** results indicate that the designed system is capable of meeting three-quarters of its load demand independently from the main grid and is supported by a 78%renewable-energy *** economic analysis demonstrates a 3.117-$/kg levelized cost of hydrogen production and a 0.248-$/kWh levelized cost for storing hydrogen as ***,the levelized cost of system energy was found to be less than the current utility costs in the *** analysis shows the significant impact of the capital cost and discount rate on the levelized cost of hydrogen generation and storage.

关键词： fuel cell electrolyser green hydrogen microgrid photovoltaic

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Numerical Modeling of the Interaction Between Severe Slugging Parameters and Dynamic Behavior of Steel Flexible Risers

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Numerical Modeling of the Interaction Between Severe Sluggin...

作者： GAJI ameena ABBA（阿米娜）中国石油大学(北京)

学位级别：硕士

Severe slugging is a transient and unsteady flow regime that occurs in offshore flowlines-riser production systems,most prevalently on aged oil fields which are proned to heavier oil deposits,low flow rates and the peculiar nature of the unevenness of the seabed *** phenomenon is characterized with pressure fluctuations and instabilities of the flow *** behaviour of this flow regime poses a threat on the structural integrity,reliability and safety of the offshore production facilities due to its fatigue loading behaviour and damage of the material *** researchers in China and abroad have made contributions towards describing the dynamic behavior of pipeline-riser structures induced by severe slug ***,due to the complicated nature of severe slugging,no study has fully understood the dynamic behavior of steel lazy-wave risers induced by a full-staged severe slug flow which this research draws its originality *** is therefore in the interest of the offshore oil and gas industry to improve and optimize the fatigue design of deepwater riser structures by including the fatigue loads from severe *** study presents the numerical modelling and simulation of the interaction between the full-staged severe slug flow and the dynamic behavior and stress impact of a steel lazy-wave *** fluid analysis,structural analysis and the FSI coupling were carried out using FLUENT,ABAQUS and Mp CCI software programs,*** two-phase flow system is modelled with a comingling flow of water and air with liquid and gas velocities of 0.382m/s and 1.37m/s *** 2D steel lazy-wave riser was modelled with material properties of API Grade X-65 steel with an inner diameter of 0.05 m,outer diameter of 0.075 m,pipe length of 1.8m and a pipe inclination of-5 *** uniform meshes with wall refinement were used to generate15,599 mesh elements for the fluid *** volume of fluid(VOF)model,kepsilon turbulence

关键词： Severe slugging steel flexible riser fluid-structure interaction Abaqus MpCCI

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified