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Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 488-496,I0002页

作者： Muhammad Asif Ayesha Safdar Chaudhry ambreen ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz Department of Veterinary Surgery University of Veterinary and Animal SciencesLahorePunjabPakistan TECS Department Wilson College of TextilesNC State UniversityRaleigh 27606USA Department of Veterinary Medicine University of Veterinary and Animal SciencesLahorePunjabPakistan Institute of Microbiology University of Veterinary and Animal SciencesLahorePunjabPakistan Department of Veterinary Clinical Sciences University of PoonchRawalakot 12350Pakistan

Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA *** was started from the fourth day *** healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ***:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 *** revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 ***-dispersive X-ray analysis confirmed the purity of ***,the particle size ranged from 100-700 nm with a high agglomeration *** with ZnONPs promoted MRSA-infected wound *** addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of ***:ZnONPs accelerate the healing of MRSA-infected ***,it can be explored for the treatment of MRSA infection.

关键词： MRSA Wound healing ZnO Nanoparticles Ointment

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Single thiolate replacement of metal nanoclusters

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Science China Chemistry 2024年第2期67卷 523-528页

作者： ambreen ambreen Yue Zhou Wanmiao Gu Qing You Liang Fang Guoqing Bian Nan Yan Nan Xia Zhikun Wu Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHefei Institutes of Physical Science(HFIPS)Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230601China Institute of Physical Science and Information Technology Anhui UniversityHefei230601China

Surface thiolates play important roles in evincing the structures and properties of thiolated metal nanoclusters—one type of recently emerging inorganic-organic hybrids,and thus the thiolate substitution,especially single thiolate substitution,is highly desirable for subtly tailoring the structures and properties of metal ***,such a single-thiolate substituting is challenging,and its influence on the metal-metal and metal-sulfur bonds remains mysterious due to the absence of the singlethiolate-substituted ***,we developed a combined method,concurrently synthesized the single-thiolate-substituted nanocluster and its parent nanocluster,and successfully resolved their structures by single crystal X-ray crystallography,which reveals that the single thiolate substitute has an obvious influence on the metal-metal and metal-sulfur bond lengths although it has no effect on the absorption ***,the metal-metal and metal-sulfur bonds show various thermal extensibility and even the negative thermal expansion phenomena of the Au–S bond were observed in the single-thiolate-substituted *** bond length-related stability was also ***,this study highlights a novel synthesis method and offers novel structural insights and an in-depth structure-property correlation of thiolated metal nanoclusters.

关键词： metal nanoclusters single thiolate replacement thermal expansion stability intercluster interaction

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Integrating artificial intelligence and high-throughput phenotyping for crop improvement

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Journal of Integrative Agriculture 2024年第6期23卷 1787-1802页

作者： Mansoor Sheikh Farooq Iqra Hamadani ambreen Kumar A Pravin Manzoor Ikra Yong Suk Chung Phenomics Laboratory Department of Plant Resources and EnvironmentJeju National UniversityJeju 63234Republic of Korea Council of Scientific&Industrial Research Indian Institute of Integrative MedicinePulwamaJ&K 192301India Animal and Dairy Science University of WisconsinMadisonWI 530706United States of America Division of Fruit Science Faculty of HorticultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirSrinagar 190025India

Crop improvement is crucial for addressing the global challenges of food security and sustainable *** advancements in high-throughput phenotyping(HTP)technologies and artificial intelligence(AI)have revolutionized the field,enabling rapid and accurate assessment of crop traits on a large *** integration of AI and machine learning algorithms with HTP data has unlocked new opportunities for crop *** algorithms can analyze and interpret large datasets,and extract meaningful patterns and correlations between phenotypic traits and genetic *** technologies have the potential to revolutionize plant breeding programs by providing breeders with efficient and accurate tools for trait selection,thereby reducing the time and cost required for variety ***,further research and collaboration are needed to overcome the existing challenges and fully unlock the power of HTP and AI in crop *** leveraging AI algorithms,researchers can efficiently analyze phenotypic data,uncover complex patterns,and establish predictive models that enable precise trait selection and crop *** aim of this review is to explore the transformative potential of integrating HTP and AI in crop *** review will encompass an in-depth analysis of recent advances and applications,highlighting the numerous benefits and challenges associated with HTP and AI.

关键词： artificial intelligence crop improvement data analysis high-throughput phenotyping machine learning precision agriculture trait selection

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Construction of robust and durable Cu_(2)Se-V_(2)O_(5) nanosheet electrocatalyst for alkaline oxygen evolution reaction

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 71-83页

作者： Tauseef Munawar ambreen Bashir Khalid Mujasam Batoo Saman Fatima Faisal Mukhtar Sajjad Hussain Sumaira Manzoor Muhammad Naeem Ashiq Shoukat Alim Khan Muammer Koc Faisal Iqbal Institute of Physics The Islamia University of BahawalpurBahawalpur 63100Pakistan King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia Hybrid Materials Center(HMC) Sejong UniversitySeoul 05006Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Institute of Chemical Sciences Bahauddin Zakariya UniversityMultan 60800Pakistan Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa UniversityQatar FoundationDoha 34110Qatar

Reducing the production costs of clean energy carriers such as hydrogen through scalable water electrolysis is a potential solution for advancing the hydrogen *** the various material candidates,our group demonstrated transition-metal-based materials with tunable electronic characteristics,various phases,and ***,electrochemical water oxidation using Cu_(2)Se-V_(2)O_(5) as a non-precious metallic electrocatalyst via a hydrothermal approach is *** water-splitting performance of all the fabricated electrocatalysts was evaluated after direct growth on a stainless-steel *** electrochemically tuned Cu_(2)Se-V_(2)O_(5) catalyst exhibited a reduced overpotential of 128 mV and provided a reduced Tafel slope of 57 mV·dec^(−1) to meet the maximum current density of 250 mA·cm^(−2).The optimized strategy for interfacial coupling of the fabricated Cu_(2)Se-V_(2)O_(5) catalyst resulted in a porous structure with accessible active sites,which enabled adsorption of the intermediates and afforded an effective charge transfer rate for promoting the oxygen evolution ***,the combined effect of the catalyst components provided long-term stability for over 110 h in an alkaline solution,which makes the catalyst promising for large-scale practical *** aforementioned advantages of the composite catalyst overcome the limitations of low conductivity,agglomeration,and poor stability of the pure catalysts(Cu2Se and V2O5).

关键词： oxygen evolution reaction Cu_(2)Se-V_(2)O_(5)composite nanosheets metal-diffused ions accessible adsorption sites

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Liver transplantation for hepatocellular carcinoma in India: Are we ready for 2040?

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World Journal of Transplantation 2024年第1期14卷 141-153页

作者： Hirak Pahari Amruth Raj ambreen Sawant Dipak S Ahire Raosaheb Rathod Chetan Rathi Tushar Sankalecha Sachin Palnitkar Vikram Raut Department of Liver Transplant and HPB Surgery Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Liver Transplant Anaesthesia Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210India Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsAurangabad 431003India Department of Gastroenterology and Hepatology Medicover HospitalsNashik 422009India Department of Gastroenterology and Hepatology Medicover HospitalsPune 411026India

BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established *** cornerstone of this treatment lies in the various criteria formulated by expert consensus and *** variations among the criteria are staggering,and the short-and long-term outcomes are *** To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the *** We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were *** centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was *** Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/*** 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the *** a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC ***-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied *** alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the *** criteria for successful downstaging v

关键词： Hepatocellular carcinoma Liver transplant India Downstaging Survey Milan University of California,San Francisco Portal vein tumor thrombus Expanded criteria

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Distributed Modeling of Extraterrestrial Solar Radiation Over the Rugged Terrains of Pakistan

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Journal of Mountain Science 2011年第3期8卷 427-436页

作者： Romana ambreen QIU Xinfa Iftikhar AHMAD Key laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science & Technology Nanjing 210044 China Department of Geography University of Balochistan Quetta Pakistan

In Pakistan,the solar analogue has been addressed but its surface geographical parameterization has given least *** density of stations and their spatial coverage particularly in difficult peripheral national territories,little or no solar radiation data,non-satisfactory sunshine hours data,and low quality of ground observed cloud cover data create a situation in which the spatial modeling of Extraterrestrial Solar Radiation(ESR) and its ground parameterization got sufficient *** Digital Elevation Model (DEM) input into Geographic Information System (GIS) is a compatible tool to demonstrate the spatial distribution of ESR over the rugged terrains of the study *** the first time,distributed modeling of ESR is done over the rugged terrains of Pakistan,based on DEM and ArcGIS..Results clearly depict that the complex landforms profoundly disrupt the zonal distribution of ESR in *** screening impact of topography is higher on spatial distribution of ESR in winter and considerably low in *** combined effect of topography and latitude is ***,the model was further testified by plotting Rb (ratio of ESR quantity over rugged terrain against plane surface) against azimuth at different latitudes with different angled *** results clearly support the strong screening effect of rugged terrain through out the country especially in Himalayas,Karakoram and Hindukush (HKH),western border mountains and Balochistan *** model can be instrumental as baseline geospatial information for scientific investigations in Pakistan,where substantial fraction of national population is living in mountainous regions.

关键词： Pakistan distributed modeling ESR DEM GIS rugged terrain

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A Multi-semantics Classification Method Based on Deep Learning for Incredible Messages on Social Media

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Chinese Journal of Electronics 2019年第4期28卷 754-763页

作者： WU Lianwei RAO Yuan YU Hualei WANG Yiming ambreen Nazir Lab of Social Intelligence and Complex Data Processing School of Software Engineering Xi'an Jiaotong University

How to classify incredible messages has attracted great attention from academic and industry nowadays. The recent work mainly focuses on one type of incredible messages(a.k.a rumors or fake news) and achieves some success to detect them. The existing problem is that incredible messages have different types on social media, and rumors or fake news cannot represent all incredible messages. Based on this, in the paper, we divide messages on social media into five types based on three dimensions of information evaluation metrics. And a novel method is proposed based on deep learning for classifying the five types of incredible messages on social *** specifically, we use attention mechanism to obtain deep text semantic features and strengthen emotional semantics features, meanwhile, construct universal metadata as auxiliary features, concatenating them for incredible messages classification. A series of experiments on two representative real-world datasets demonstrate that the proposed method outperforms the state-of-the-art methods.

关键词： Information credibility evaluation Rumor detection Social media Text classification

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Alkaloids, flavonoids, polyphenols might be responsible for potent antiarthritic effect of Solanum nigrum

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Journal of Traditional Chinese Medicine 2019年第5期39卷 632-641页

作者： Alamgeer Shanila Akhter ambreen Malik Uttra Umme Habiba Hasan Laboratory of Cardiovascular Research and Integrative Pharmacology College of Pharmacy University of Sargodha

OBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum). METHODS: Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluated in terms of its inhibition of protein denaturation and membrane stabilization. While, formaldehyde, complete Freund's adjuvant (CFA) and Collagen induced arthritis rat models were used to study in vivo antiarthritic activities of S. nigrum at dose level of 200, 400 and 800 mg/kg. RESULTS: The extract exhibited inhibition of protein denaturation and protected red blood cell by stabilizing the membranes in a concentration dependent manner, with maximum effect attained at 800 μg/mL. Moreover, there was a marked reduction in paw edema observed in extract treated animals, when compared to arthritic control animals in all in vivo models and 800 mg/kg dose got maximum reduction of paw edema. In CFA and collagen models, plant extract restored body weight, hematologic parameters, radiographic and histopathoOBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum). METHODS: Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluated in terms of its inhibition of protein denaturation and membrane stabilization. While, formaldehyde, complete Freund's adjuvant (CFA) and Collagen induced arthritis rat models were used to study in vivo antiarthritic activities of S. nigrum at dose level of 200, 400 and 800 mg/kg. RESULTS: The extract exhibited inhibition of protein denaturation and protected red blood cell by stabilizing the membranes in a concentration dependent manner, with maximum effect attained at 800 μg/mL. Moreover, there was a marked reduction in paw edema observed in extract treated animals, when compared to arthritic control animals in all in vivo models and 800 mg/kg dose got maximum reduction of paw edema. In CFA and collagen models, plant extract restored body weigh

关键词： Arthritis Solanum nigrum Protein denaturation Formaldehyde Freund's adjuvant Collagen

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The New Neutrosophic Double and Triple Exponentially Weighted Moving Average Control Charts

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 373-391页

作者： ambreen Shafqat Muhammad Aslam Muhammad Saleem Zameer Abbas Department of Statistics and Financial Mathematics School of ScienceNanjing University of Science and TechnologyNanjing210094China Department of Statistics University of SargodhaSargodha40100Pakistan Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21551Saudi Arabia Department of Industrial Engineering Faculty of Engineering-RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia Goverment Ambala Muslim Graduate College Sargodha40100Pakistan

The concept of neutrosophic statistics is applied to propose two monitoring schemes which are an improvement of the neutrosophic exponentially weighted moving average(NEWMA)*** this study,two control charts are designed under the uncertain environment or neutrosophic statistical interval system,when all observations are undermined,imprecise or *** are termed neutrosophic double and triple exponentially weighted moving average(NDEWMA and NTEWMA)control *** the proficiency of the proposed chart,Monte Carlo simulations are used to calculate the run-length characteristics(such as average run length(ARL),standard deviation of the run length(SDRL),percentiles(P_(25),P_(50),P_(75)))of the proposed *** structures of the proposed control charts are more effective in detecting small shifts while these are comparable with the other existing charts in detecting moderate and large *** simulation study and real-life implementations of the proposed charts show that the proposed NDEWMA and NTEWMA charts perform better in monitoring the process of road traffic crashes and electric engineering data as compared to the existing control ***,the proposed charts will be helpful in minimizing the road accident and minimizing the defective ***,the proposed charts are more acceptable and actual to apply in uncertain environment.

关键词： Exponentially weighted moving average(EWMA) double EWMA triple EWMA neutrosophic control chart run-length

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Risk estimation of chronic kidney disease in a leptospirosis endemic area: A case-control study from south Andaman Islands of India

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 463-471页

作者： ambreen Fatema Manjunatha Ramu Paluru Vijayachari ICMR-Regional Medical Research Centre Port BlairPost Bag No.13DollygunjPort Blair 744101Andaman&Nicobar IslandsIndia

Objective:To estimate the risk of chronic kidney disease in patients with ***:All reported(41890)and later confirmed leptospirosis(1990)cases from 2010-2020 were traced by universal sampling.386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age,gender,area,and occupation matched healthy persons were included as *** including socio-demographic characteristics,medical history,and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate(eGFR)was analyzed with multiple linear ***:The median of eGFR was 49.0(27.0,75.0)mL/min/1.73 m^(2) in the cases and 96.0(72.0,121.0)mL/min/1.73 m^(2) in the controls,showing significant differences(P<0.001).Bivariate analysis showed that leptospirosis seropositivitiy,repeat leptospirosis infection,diabetes,male gender,working in field(sun exposure),COVID-19 infection and smoking had statistically significant association with reduced *** seropositivity had negative effects on *** linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR(unstandardised β coefficients=−30.86,95%CI−49.7 to−11.9,P<0.001).Conclusions:Chronic kidney disease is a complex disease with multiple risk factors *** to leptospirosis is one of the essential factors in accelerating its progression.

关键词： Chronic kidney disease Endemic leptospirosis Estimated glomerular filtration rate(eGFR)

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