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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

Food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang Shu Li Han Li Ghulam Jilany khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical Research Center， Anhui Wanbei Coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics， Faculty of Pharmacy， University of Central Punjab College of Biological and Food Engineering， Anhui Polytechnic University School of Biological and Food Engineering， Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province， Suzhou University School of Food and Biological Engineering， Hefei University of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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Comparison of fungal vs bacterial infections in the medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： Sarah khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar T Sims Christine E Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** To investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,P<0.001).The majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,P<0.001),and dialysis due to acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health Evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for End-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).There was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

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Economic and Social Impact Assessment of Chronic Diseases Among the Low-Income Population in Southern Punjab,Pakistan

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Proceedings of Anticancer Research 2024年第4期8卷 67-74页

作者： Mehran khan Muhammad Arbab Nasir Muhammad Umar Asadullah Faiz Mirza Muhammad Abdul Bari Ayesha Saeed Fiza Nazeer khan Saliha Mehboob Malik Akashah Usama Tayyab Bahawalpur College of Pharmacy BMDC Complex63100BahawalpurPunjabPakistan

Introduction:Chronic diseases are becoming more prevalent *** effects of chronic illnesses are disastrous not only for the diagnosed person but also for their entire *** study explores chronic diseases’social and economic impact on low-income *** study aims to determine the economic and social implications of various chronic diseases and the loss of income due to these conditions among low-income individuals in Southern Punjab,***:A sample of 424 patients was selected from different areas of Southern *** were collected using a questionnaire that included questions about economic status,self-reported health status,social status,management strategies,and health insurance,among other ***:The mean monthly income of the respondents was found to be 57,097.6 Pakistani rupee(PKR),and the mean monthly expenses for treatment were 8,256.1 *** loss of income was calculated at 15%.Additionally,62%of patients spent more than 10%of their monthly income on managing their *** 85%of the respondents reported that chronic diseases affected their social ***,80%of patients lacked health ***:Chronic diseases impose significant economic and social burdens on patients and their families in Southern *** reduce the burden of chronic diseases,the government should enhance healthcare services in this region and provide health insurance to low-income families.

关键词： Chronic diseases Low-income families Economic impact Punjab Pakistan

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Botulinum toxin type A for treating chronic low back pain:A double blinded randomized control study

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World Journal of Methodology 2024年第3期14卷 119-125页

作者： Mantu Jain Shahnawaz khan Paulson Varghese Sujit Kumar Tripathy Manaswini Mangaraj Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Biochemistry All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia

BACKGROUND Low back pain(LBP)is a prevalent issue that orthopedic surgeons frequently address in the outpatient *** can arise from various causes,with stiffness in the paraspinal muscles being a notable *** administration of Botulinum toxin type A(BoNT-A)has been found to alleviate back pain by relaxing these stiff *** BoNT-A is approved for use in numerous conditions,a limited number of randomized clinical trials(RCTs)validate its efficacy specifically for treating *** To study the safety and the efficacy of BoNT-A in minimizing pain and improving functional outcomes in patients of chronic LBP(CLBP).METHODS In this RCT,adults aged 18-60 years with mechanical LBP persisting for at least six months were *** were allocated to either the Drug group,receiving 200 Ipsen Units(2 mL)of BoNT-A,or the Control group,which received a 2 mL *** a 2-month follow-up period,both groups were assessed using the Visual Analog Scale(VAS)for pain intensity and the Oswestry Disability Index(ODI)for disability at the start and conclusion of the study.A decrease in pain by 50%was deemed clinically *** The study followed 40 patients for two months,with 20 in each group.A clinically significant reduction in pain was observed in 36 *** was a statistically significant decrease in both VAS and ODI scores in the groups at the end of two ***,when comparing the mean score changes,only the reduction in ODI scores(15 in the placebo group vs 16.5 in the drug group,clinically insignificant)was statistically significant(P=0.012),whereas the change in mean VAS scores was not significant(P=0.45).CONCLUSION The study concludes that BoNT-A does not offer a short-term advantage over placebo in reducing pain or improving LBP scores in CLBP patients.

关键词： Botulinum toxin type A Chronic low back pain Randomized control study Double-blinded Pain management Therapeutic efficacy

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu Ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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Trust-based Intelligent Scheme for Mitigating Black Hole Attacks in IoT

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 39-50页

作者： Feroz khan A.B Weslin D Dilli Babu M Mohammed Muzaffar Hussain Department of Computer Science Syed Hameedha Arts and Science CollegeKilakarai 623806Tamil NaduIndia Department of Information Technology Mohamed Sathak AJ College of EngineeringSiruseriChennai 603103India Department of Information Technology Panimalar Engineering CollegeChennai 600123India Department of Information Technology C.Abdul Hakeem College of Engineering and TechnologyMelvisharam 632509India

Internet of Things(IoT)networks are characterized by a multitude of wireless,interconnected devices that can dynamically join or exit the network without centralized administration or fixed infrastructure for *** multipath routing in IoT networks can improve data transmission reliability and load balancing by establishing multiple paths between source and destination nodes,these networks are susceptible to security threats due to their wireless *** security solutions developed for conventional networks are often ill-suited to the unique challenges posed by IoT *** response to these challenges,this paper proposes the integration of the Ad hoc On-demand Multipath Distance Vector(AOMDV)routing protocol with a trust model to enhance network *** findings from this research demonstrate the successful fusion of AOMDV with a trust model,resulting in tangible improvements in network *** assessment of trustworthiness bolsters both security and routing capabilities in IoT *** trust model plays a crucial role in mitigating black hole attacks in IoT networks by evaluating the trustworthiness of nodes and helping in the identification and avoidance of malicious nodes that may act as black *** results validate the efficacy of the proposed trust-based routing mechanism in achieving its *** plays a pivotal role in decision-making and in the creation of secure distribution *** assessing the trustworthiness of nodes,both network security and routing efficiency can be *** effectiveness of the proposed trust-based routing mechanism is scrutinized through simulations,offering insights into its potential advantages in terms of improved network security and routing performance in the context of the IoT.

关键词： Mobile ad-hoc network(MANET) routing Ad hoc On-demand Multipath Distance Vector(AOMDV) trust model security

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Analysis of causes for revision in unicompartmental knee arthroplasty

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World Journal of Clinical Cases 2024年第25期12卷 5642-5645页

作者： Sujit Kumar Tripathy Siddharth Satyakam Pradhan Shahnawaz khan Hursch Patel Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Orthopedics All India Institute of Medical SciencesBhubaneswar 751019India Department of Medicine Kansas City University of Medicine and BiosciencesKansas CityMO 64106United States

The study by Zhao et al identifies the factors leading to the failure of unicompartmental knee arthroplasty(UKA)in their *** factors include substandard suturing of the wound,the presence of osteophytes and intra-articular loose bodies causing impingement,premature loosening of the tibial component,choosing unsuitable patients for the procedure,dislocation of the movable insert,and damage to the anterior cruciate ligament and medial collateral *** findings suggest that employing the correct surgical techniques and indications is essential for successful outcomes in the UKA.

关键词： Unicompartmental knee arthroplasty Arthroplasty Knee Failure Conversion TKA

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Driving pressure in mechanical ventilation:A review

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World Journal of Critical Care Medicine 2024年第1期13卷 15-27页

作者： Syeda Farheen Zaidi Asim Shaikh Daniyal Aziz khan Salim Surani Iqbal Ratnani Department of Medicine Queen Mary UniversityLondon E14NSUnited Kingdom Department of Medicine Aga Khan UniversitySindhKarachi 74500Pakistan Department of Medicine Jinnah Postgraduate Medical CenterSindhKarachi 75510Pakistan Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States Department of Anesthesiology and Critical Care Houston Methodist HospitalHoustonTX 77030United States

Driving pressure(ΔP)is a core therapeutic component of mechanical ventilation(MV).Varying levels ofΔP have been employed during MV depending on the type of underlying pathology and severity of ***,ΔP levels have also been shown to closely impact hard endpoints such as *** this,conducting an in-depth review ofΔP as a unique,outcome-impacting therapeutic modality is extremely *** is a need to understand the subtleties involved in making sureΔP levels are optimized to enhance outcomes and minimize *** performed this narrative review to further explore the various uses ofΔP,the different parameters that can affect its use,and how outcomes vary in different patient populations at different pressure *** better utilizeΔP in MV-requiring patients,additional large-scale clinical studies are needed.

关键词： Driving pressure Acute respiratory distress syndrome Mortality Positive end-expiratory pressure Ventilator induced lung injury Mechanical ventilation

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Assessment of Physico-Chemical and Microbial Quality of Sugarcane Juice Sold by Street Vendors in Three Regions of Bangladesh

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Food and Nutrition Sciences 2024年第4期15卷 263-276页

作者： Nargis Akter khan Md. Murtaja Reza Linkon Munni Akter Md. Alamgir Hossain Md. Mahbubur Rahman Tayeba khan Md. Abdul Alim Md. Esrafil Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Tangail Bangladesh Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Tangail Bangladesh

Sugar cane juice is a popular refreshing drink in most part of Bangladesh. It has great taste and health benefits;also it is available most of the public places at reasonable prices which consumed by road side customers including general public, shopping personals, tourists, students. In our country, street vendors crushing sugarcane between roller crusher and sold without any heat treatment or preservative, also served with or without added ice and lemon juice. The study aimed to identify and compare the physico-chemical and microbial quality of sugarcane juice. The chemical qualities of juices including moisture, PH, ash, total soluble solid, total sugar, reducing sugar and titrable acidity were found slightly different in Mymensingh, Gazipur and Narayangonj areas. The highest and lowest value of moisture, ash, PH, total soluble solids, total sugar, reducing sugar and titrable acidity were found in 84.33% - 79.26% (Gazipur-Mymensingh), 0.57% - 0.04% (Mymensingh-Gazipur), 5.9 - 2.9 (Gazipur-Narayangonj), 17.48% - 4.98% (Mymensingh-Narayangonj), 21.9% - 6.56% (Mymensingh-Gazipur), 3.7 - 2.1 (Gazipur-Mymensingh) and 0.523% - 0.007% (Narayangonj-Gazipur) respectively. For microbiological analysis, the total viable count of sugar cane juice in Mymensingh, Gazipur and Narayangonj were ranged from 0.6 × 105 - 43.6 × 105 cfu/ml, 4.6 × 105 - 21.6 × 105 cfu/ml and 3.6 × 105 - 36.6 × 105 cfu/ml respectively, where the permitted value is 1.0 × 104 cfu/ml, whereas the total coliform count was ranged from 0.4 × 105 - 6.4 × 105 cfu/ml, 0.6 × 105 - 8.4 × 105 cfu/ml and 0.00 - 8.4 × 105 cfu/ml, where the permitted value is 100 cfu/ml and total fungal count was ranged from 5.5 × 105 - 56.5 × 105 cfu/ml, 21.5 × 105 - 54.5 × 105 cfu/ml and 32.5 × 105 - 68.5 × 105 cfu/

关键词： Sugarcane Street Vendors Microbial Quality Reducing Sugar

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CR340轧制差厚板纵梁成形性能研究

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精密成形工程 2024年第10期16卷 182-189页

作者：汪志远 Habib Ullah khan 王一霏付秀娟武汉工程大学材料科学与工程学院武汉430205

目的研究复杂应力状态下轧制差厚板塑性变形行为和韧性损伤机理,获得轧制差厚板成形性能规律,促进轧制差厚板在汽车工业轻量化中的应用。方法应用细观损伤理论,采用有限元逆向法构建轧制差厚板GTN细观损伤模型,进一步结合有限元数值模... 详细信息

目的研究复杂应力状态下轧制差厚板塑性变形行为和韧性损伤机理,获得轧制差厚板成形性能规律,促进轧制差厚板在汽车工业轻量化中的应用。方法应用细观损伤理论,采用有限元逆向法构建轧制差厚板GTN细观损伤模型,进一步结合有限元数值模拟技术研究轧制差厚板塑性变形行为和韧性损伤机理,对比分析差厚板与等厚板塑性变形特点,研究CR340轧制差厚板纵梁成形性能规律。结果将有限元逆向法和实验相结合,获得了损伤参数值,建立了描述轧制差厚板韧性损伤行为的GTN细观损伤模型,结合有限元分析可知,孔洞体积分数在过渡区变形最大的区域增加最为明显,孔洞最先在此处聚集发展;相比于等厚板,轧制差厚板成形纵梁时,在和厚区交界处的过渡区产生了显著的应力集中,引起过渡区应变急剧增大,使应力和应变整体分布的不均匀性增加。结论应用细观损伤理论和有限元数值模拟分析了轧制差厚板成形纵梁时韧性损伤最先产生的区域,结合应力和应变分布特点可知,与薄区相邻的过渡区在最大应变处最易出现成形缺陷。

关键词：轧制差厚板成形性能 GTN模型数值模拟

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