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Development of Primary Percutaneous Coronary Intervention as a National Reperfusion Strategy for Patients with ST-elevation Myocardial Infarction and Assessment of Its Use in Egypt

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Cardiovascular Innovations and Applications 2020年第2期4卷 269-278页

作者： Mohamed Sobhy Ahmed elshal Noha Ghanem Hosam Hasan-Ali Nabil Farag Nireen Okasha el Sayed Farag Mohamed Sadaka Hisham Abo el Enein Sameh Salama Hazem Khamis Khaled Shokry Hany Ragy amany elshorbagy Radwa Mehanna Cardiology Department Faculty of MedicineAlexandria University HospitalAlexandriaEgypt International Center for Organization and Marketing AlexandriaEgypt Cardiology Department Faculty of Medicine Assiut University HospitalAssiut GovernorateEgypt Cardiology Department Faculty of Medicine Ain Shams University HospitalHeliopolisEgypt Cardiology Department Nasser InstituteCairoEgypt Cardiology Department Faculty of MedicineZagazig University HospitalZagazigEgypt Cardiology Department Faculty of MedicineBanha University HospitalBanhaEgypt Cardiology Department Faculty of MedicineKasr El Ainy HospitalKasr Al AinyEgypt Cardiology Department Wady El Nile HospitalZeitounEgypt Cardiology Department Military HospitalHeliopolisCairoEgypt Cardiology Department National Heart InstituteHeliopolisCairoEgypt Physiology Department Faculty of MedicineAlexandria UniversityAlexandriaEgypt

Objective:Early treatment of acute ischemia of the heart by performing immediate percutaneous coronary intervention(PCI)to restore blood fl ow in patients with the clinical presentation of an acute coronary syndrome and more specifi cally with ST-elevation myocardial infarction(STEMI)can save *** study aims to identify the mean time(door to balloon time and fi rst contact to balloon time)to primary PCI for STEMI patients and to assess the percentage of primary PCI and its success rate in ***:A registry study of patients presenting to cardiac centers in Egypt was designed,where patients’basic characteristics,the treatment strategy,and the door to balloon time and the fi rst contact to balloon time were ***:One thousand six hundred fi fty STEMI patients with a mean age of 57 years were included in the *** transfer for primary PCI was the most used treatment strategy,representing 74.6%of all treatment strategies *** door to balloon time and the fi rst contact to balloon time were 50 and 60 minutes,respectively,with a primary PCI success rate of 65.1%.Conclusion:The registry study results showed a marked improvement by implementation of the best treatment strategy with respect to the time factor to achieve a better outcome for STEMI patients in Egypt.

关键词： ST-elevation myocardial infarction primary percutaneous coronary intervention door to balloon time fi rst medical contact to balloon time

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Preventive effects of cannabis on neurotoxic and hepatotoxic activities of malathion in rat

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Asian Pacific Journal of Tropical Medicine 2018年第4期11卷 272-279页

作者： Omar M.E.Abdel-Salam amany A Sleem Eman R Youness Fatma A.Morsy Department of Toxicology and Narcotics National Research Centre Department of Pharmacology National Research Centre Department of Medical Biochemistry National Research Centre Department of Pathology National Research Centre

Objective: To investigate the effect of Cannabis sativa extract on the development of neuroand hepato-toxicity caused by malathion injection in rats. Methods: The extract of Cannabis sativa was obtained from the plant resin by chloroform treatment. Δ~9-Tetrahydrocannabinol content of the extract(20%) was quantified using gas chromatography–mass spectrometry. The doses of cannabis extract were expressed as Δ~9-tetrahydrocannabinol content of 10 or 20 mg/kg. Malathion(150 mg/kg) was intraperitoneally administered followed after 30 min by the cannabis extract(10 or 20 mg/kg, subcutaneously). Rats were euthanized 4 h later. Malondialdehyde(MDA), reduced glutathione(GSH), nitric oxide and paraoxonase-1(PON-1) activity were determined in brain and liver. Brain 5-lipoxygenase and butyrylcholinesterase(BChE) activity were measured as well. Histopathological examination of brain and liver tissue was also performed. Results: Compared to controls, malathion resulted in increased oxidative stress in brain and liver. MDA and nitric oxide concentrations were significantly increased(Pels(Pels of liver MDA, nitric oxide and PON-1 activity compared with the malathion control group. Rats treated with only malathion exhibited spongiform changes, neuronal damage in the cerebral cortex and degeneration of some Purkinje cells in the cerebellum. There were also hepatic vacuolar degeneration and dilated an

关键词： Cannabis sativa Malathion Liver damage Brain damage Oxidative stress Paraoxonase 5-Lipoxygenase

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Physiological Role of Humic Acid and Nicotinamide on Improving Plant Growth, Yield, and Mineral Nutrient of Wheat (<i>Triticum durum</i>) Grown under Newly Reclaimed Sandy Soil

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Agricultural Sciences 2014年第8期5卷 687-700页

作者： Hala Safwat Mohamed el-Bassiouny Bakry Ahmed Bakry amany Abd el-Monem Attia Maha Mohamed Abd Allah Agronomy Department Agriculture and Biology Division National Research Center Cairo Egypt Botany Department Agriculture and Biology Division National Research Center Cairo Egypt

Humic acid is not a fertilizer as it does not directly provide nutrients to plants, but is a compliment to fertilizer. Nicotinamide (Vitamin pp) is a stress-associated compound that can induce and regulate secondary metabolic accumulation and/or the manifestation of defense metabolism in plants. A field experiment was conducted at the experimental station of National Research center at el-Nubaria region, Egypt, to study the role of foliar application of humic acid (as soil conditioner 13 cm/l) and/or priming grains in nicotinamide (vitamin pp 5 mg/l) in saving irrigation water, decreasing fertilizer dose of NPK and at the same time increasing durum wheat (Triticum durum) cultivars’ (Beni Sweif-1 and Beni Sweif-3) productivity grown under newly reclaimed sandy soil exposed to drought for three weeks continuously. The results showed that plant treated with humic acid or nicotinamide increased significantly all morphological criteria (plant height, leaves number, fresh and dry weights of shoots), metabolism (photosynthetic pigment, total soluble sugar, total carbohydrates, total amino acids and proline), mineral contents (N, P, K, Ca and Mg) and yield (grain, straw and biology) of both cultivars amended with either recommended or half recommended doses of NPK. Foliar application of humic acid to plant priming in Vitamin pp induced significant increases in all studied parameters (morphology, chemical and yield) of plants amended with recommended or half recommended doses of NPK as compared with control plants. The maximum yields of grain, straw and biology of both cultivars were obtained in response to triple treatment (humic acid + nicotinamide + recommended dose of NPK) or (humic acid + nicotinamide + half recommended dose of NPK) respectively.

关键词： Humic Acid Metabolism Mineral Ions Nicotinamide Wheat

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Characterization of Radiation Prepared Copolymer and Studies of Their Biodegradability

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Journal of Biosciences and Medicines 2018年第2期6卷 33-56页

作者： Nabila Ahmed Maziad amany Badr el-Deen Abd el-Aziz Sabrnal el-Hamouly Maher Abd el-Aziz Mahmoud el-Hashish Sameh A. Rizk Nada Rabie Nasef Department of Polymer Chemistry National Centre for Radiation Research and Technology Atomic Energy Authority Nasr City Egypt Microbiology Department National Centre for Radiation Research and Technology Atomic Energy Authority Nasr City Egypt Department Polymer Chemistry Faculty of Science Manoufia University Al Minufya Egypt Department Organic Chemistry Faculty of Science Ain Shams University Cairo Egypt

Blends of biodegradable copolymer based on starch, poly lactic acid (PLA), poly vinyl alcohol (PVA) and natural rubber (NR) have been prepared. Gamma radiation induced synthesis and modification of polymer hydrogel was studied. The polymer blends have been chemically surface modified by glycerol. The modified polymer blends have been investigated for swelling ratio, tensile strength and 9 scanning electron microscopy. The swelling ratio of polymer blends increased significantly after surface modification with glycerol. The swelling of polymer was decreased as a function of (NR) content in polymer blends. The gel fraction (PVA-starch-PLA) and (PVA-starch-NR) blends increased by increasing the radiation doses (kGy) to reach the maximum amount of (~99%) and (~88.2%), respectively. Addition of 2.5% (PLA) led to greater increase of the swelling ratio than 10% (NR) to blends and the maximum swelling was found at dose (5 kGy). At concentration of glycerol (5.0% w/w), tensile strength decreased and elongation at break % increased. The polymers degrading microorganisms were isolated from soil samples. The degradation ability of the microbial isolates for each polymeric material was tested on agar plates. Among these isolates, the most efficient degrader isolates for prepared blends in MSM shaking flasks were selected and the degradation was confirmed by scanning electron microscopy.

关键词： Radiation Biodegradation (NR) (PLA) Renewable Resources Mechanical Properties Scanning electron Microscopy

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Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 40-47页

作者： Omar M.E.Abdel-Salam amany A Sleem Eman R Youness Nadia A Mohammed Enayat A Omara Department of Toxicology and Narcotics National Research Centre Department of Pharmacology National Research Centre Department of Medical Biochemistry National Research Centre Department of Pathology National Research Centre

Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) *** concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(Pels(by 37.1%-40.7%)(Pely. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cereb

关键词： Misoprostol Rotenone Brain oxidative stress B cell/lymphoma-2 Paraoxonase

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Acetylcholinesterase,butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis,tramadol or both

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Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1066-1071页

作者： Omar M.E.Abdel-Salam Eman R.Youness Yasser A.Khadrawy amany A.Sleem Department of Toxicology and Narcotics National Research Centre Cairo Department of Medical Biochemistry National Research Centre Cairo Department of Physiology National Research Centre Cairo Department of Pharmacology National Research Centre Cairo

Objective:To investigate the effect of Cannabis sativa resin and/or tramadol,two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these ***:rats were treated with cannabis resin(5,10 or 20 mg/kg)(equivalent to the active constituent A'-tetrahydrocannabinol),tramadol(5,10 and 20 mg/kg) or tramadol(10 mg/kg)combined with cannabis resin(5,10 and 20 mg/kg) subcutaneously daily for 6 ***(AChE) and butyrylcholinesterase(BChE) activities were measured in brain and *** also measured the activity of paraoxonase-1(PONl) in serum of rats treated with these ***:(i) AChE activity in brain increased after 10-20 mg/kg cannabis resin(by 16.3%-36.5%).AChE activity in brain did not change after treatment with 5-20 mg/kg *** administration of both cannabis resin(5,10 or 20 mg/kg) and tramadol(10 mg/kg) resulted in decreased brain AChE activity by 14.1%,12.9%and 13.6%,respectively;(ii) BChE activity in serum was markedly and dose-dependenlly inhibited by cannabis resin(by 60.9%-76.9%).BChE activity also decreased by 17.6%-36.5%by 10-20mg/kg tramadol and by 57.2%-63.9%by the cannabis resin/tramadol combined treatment;(iii)Cannabis resin at dose of 20 mg/kg increased serum PONl activity by 25.7%.In contrast,tramadol given at 5,10 and 20 mg/kg resulted in a dose-dependent decrease in serum PON1 activity by 19%,36.7%,and 46.1%,***,treatment with cannabis resin plus tramadol resulted in 40.2%,35.8%,30.7%inhibition of PONl activity compared to the saline ***:these data suggest that cannabis resin exerts different effects on AChE and BChE activities which could contribute to the memory problems and the decline in cognitive function in chronic users.

关键词： Cannabis sativa Tramadol Cholinesterases Memory Cognitive decline

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Acute flaccid paralysis in a patient with sacral dimple

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World Journal of Clinical Pediatrics 2013年第3期2卷 26-30页

作者： Mohammed Mostafa Nehad Nasef Tarik Barakat amany K el-Hawary Hesham Abdel-Hady Faculty of Medicine Mansoura University Children’s Hospital Department of Pediatrics Faculty of MedicineUniversity of Mansoura

Sacral dimples are the most common cutaneous anomaly detected during neonatal spinal examination. Congenital dermal sinus tract, a rare type of spinal dysraphism, occurs along the midline neuraxis from occiput down to the sacral region. It is often diagnosed in the presence of a sacral dimple together with skin signs, local infection, meningitis, abscess, or abnormal neurological examination. We report a case of acute flaccid paralysis with sensory level in a 4 mo old female infant with sacral dimple, diagnosed by magnetic resonance imaging to be a paraspinal subdural abscess. Surgical exploration revealed a congenital dermal sinus tract extending from the subdural abscess down to the sacral dimple and open to the exterior with a minute opening.

关键词： Paralysis Paraplegia Spinal dysraphism Spinal cord compression Spinal epidural abscess

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Biomarkers and Ultra Structural Evaluation of Marine Pollution by Polycyclic Aromatic Hydrocarbons

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Journal of Environmental Protection 2016年第10期7卷 1283-1304页

作者： Nehad M. Abd el Moneam Nabila E. Abd el Maguid amany M. el-Sikaily Marwa G. Zaki Mohamed A. Sheradah Biochemistry and Zoology Department Faculty of Science Alexandria University Alexandria Egypt Marine Pollution Research Lab. National Institute of Oceanography & Fisheries Alexandria Egypt Marine Biotechnology Lab. National Institute of Oceanography & Fisheries Alexandria Egypt

The present study is endeavored to study the oxidative stress and antioxidant response as well as the ultrastructural change of both liver and muscle tissues of Siganus rivulatus collected from polluted region (el-Mex Bay) and control region (Marsa Matrouh) to identify the significance of biomarkers. The results revealed that, el-Mex Bay was polluted by different types of chemicals including hydrocarbons comparing with the reference area (Matrouh area). Where, the concentration range of total hydrocarbons in sediment samples collected from Matrouh coast was 409.24 - 521.26 ng/g, dry weight, where as this range in sediment samples collected from el-MexBay was 4159.77 - 4589.81 ng/g, dry weight. In this context, the induction of antioxidant systems in fish collected from polluted area in response to oxidative stress should be considered as a clear indication of the presence of pollution and environmental health degradation. Also, The increase in lipid peroxidation was a useful indicator of the pollution load in the present study. The results suggest that chemical pollution is capable of inducing morphological alteration in liver offish collected from polluted area. The present study indicated that ultra-structural changes serveas biomarker of stress in aquatic environment.

关键词： Biomarkers Ultra Structural Evaluation Polycyclic Aromatic Hydrocarbons (PAHs)

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Ecological distribution of harmful epiphytic Oscillatoriales in Alexandria coast,Egypt,with special reference to DNA identification

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Journal of Coastal Life Medicine 2014年第4期 274-280页

作者： amany Abdel Hamid Ismael Eman Abdel Razak Mohamed Mostafa Mohamed el-Sheikh Wafaa Hassan Hegazy Oceanography Department Faculty of ScienceAlexandria UniversityAlexandria 21511Egypt Botany Department Faculty of ScienceDamanhuor UniversityEgypt Botany Department Faculty of ScienceTanta UniversityTantaEgypt

Objective:To identify the potentially harmful epiphytic Oscillatoriales species and follow up their distribution along Alexandria ***:Samples were collected bimonthly from April 2009 to February 2010 at three sites along Alexandria *** morphological and molecular analyses were used for identifying the dominant ***:Five species belonging to two families were identified;Oscillatoria acutissima,Oscillatoria nigroviridis,Oscillatoria sp.,Lyngbya majuscule and Phormidium *** cell density ranged from 10^(3)to 126×10^(3)filament g^(-1)fresh weight *** morphological study of the dominant species,Oscillatoria sp.(Oscillatoria sp.W1)showed much similarity with Planktothrix agardhii with no heterocysts and akinetes,while molecular ananlysis(16S rDNA)clustered the species in the same group with Anabaena ***:The 16S rDNA genes are not suitable for identifying Oscillatoriales during the present study and another molecular method should be used instead.

关键词： Harmful algae DNA analysis epiphytes Oscillatoriales Alexandria Egypt

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Effect of Partially Coherent Light on the Contrast of Speckle Patterns Obtained Using Digital Image Processing of Speckle Photography

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Optics and Photonics Journal 2013年第5期3卷 324-329页

作者： Nasser A. Moustafa Mohamad M. el-Nicklawy Amin F. Hassan amany K. Ibrahim Department of Physics Faculty of Science Helwan University Cairo Egypt

The paper is devoted to study theoretically, the effects of some parameters on the visibility of the speckle patterns. For this propose, a theoretical model for a periodic rough surface was considered. Using this theoretical model, the effects of grain height, its density, the band width and spectral distribution of the line profile (Gaussian and Lorentzian) illuminating a rough surface on the visibility of speckle pattern are investigated. An experimental setup was constructed to study the effect of surface roughness and coherence of the illuminating light beam on the contrast of speckle pattern. The general behavior of the experimental results, which agree with published data, is compatible with the new theoretical model.

关键词： Speckle Pattern Surface Roughness Partially Coherent Light

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