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On calculating glacial isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： L.m.Cathles Cornell University IthacaNY 14853USA

modeling the earth's fluid and elastic response to the melting of the glaciers of the last ice age is the most direct way to infer the earth's radial viscosity ***,we compare two methods for calculating the viscoelastic response to surface *** one,the elastic equation of motion is converted to a viscoelastic equation using the Correspondence *** the other,elastic deformation is added to the viscous flow as isostatic adjustment *** two modeling methods predict adjustment histories that are different enough to potentially impact the interpretation of the observed glacial isostatic adjustment(GIA).The differences arise from buoyancy and whether fluid displacements are subjected to hydrostatic *** methods agree if they use the same equations and boundary *** origin of the differences is determined by varying the boundary conditions and pre-stress application.

关键词： Glacial isostatic adjustment Viscoelastic normal modes Hydrostatic pre-stress Elastic buoyancy Correspondence principle

Enabling Technologies for Autonomous Robotic Systems in manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ János CSERTEG Tamás GODÓGábor HAJÓS mátyás HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEmÉny Zsolt KOVÁCS András NACSA János PANITI Imre PEDONE Gianfranco TAKÁCS Emma TIPARY Bence ZAHORÁN László VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs Nonprofit Ltd. BudapestHungary Eötvös Loránd University(ELTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah L.Apostolou Ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

Heart failure with preserved ejection fraction and the first law of thermodynamics

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World Journal of Cardiology 2024年第10期16卷 608-610页

作者： Robert m Peters Department of Cardiology Zucker School of MedicineHemsteadNY 11549United States

In heart failure with preserved ejection fraction,significant left ventricular diastolic abnormalities are present,despite a normal systolic ejection *** article will consider whether this is consistent with the law o... 详细信息

关键词： Diastolic dysfunction Heart failure with preserved ejection fraction Thermodynamics

Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa merchan-Ramirez Guillermo Sanchez-Delgado Lucas Jurado-Fasoli Francisco m Acosta manuel munoz-Torres Jose m.Llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(imUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKm supports antitumor immunity

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Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:massachusetts Institute of Technology BostonMA 02139USA Present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of PKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKm alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKm2

自主机器人使能技术在制造业中的应用（英文）

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期 403-431页

作者： ERD?S Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ János CSERTEG Tamás GODó Gábor HAJóS mátyás HáY Borbála HORVáTH Dániel HORVáTH Gergely JUNIKI ádám KEmény Zsolt KOVáCS András NACSA János PANITI Imre PEDONE Gianfranco TAKáCS Emma TIPARY Bence ZAHORáN László VáNCZA József 匈牙利研究网络计算机科学与控制研究所布达佩斯经济与技术大学制造科学与技术系 EPIC非盈利创新实验室厄特沃什·罗兰大学

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别... 详细信息

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别和预测、自动和自适应（重新）规划、团队合作，以及通过学习提高性能。本文总结了实现自主工业机器人技术的主要需求，提出了实现此类系统的通用工作流程，并介绍了HUN-REN SZTAKI最近在装配、焊接、打磨、拾取和放置以及机械加工等多个应用领域的广泛实践。这些解决方案的共同点是以通用的数字孪生概念为核心。最后，本文提出实现工业自主机器人解决方案的一般建议，并讨论了未来要研究的一些开放性问题。

关键词：工业机器人自动化数字孪生使能技术

A Theoretically Grounded Question Answering Data Set for Evaluating machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique Santos Ke Shen Alice m.mulvehill mayank Kejriwal Deborah L.mcGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstanding problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and *** benchmark is few-shot i.e.,only a few training and validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

Lesions requiring wound management in a central tertiary neonatal intensive care unit

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World Journal of Pediatrics 2017年第2期13卷 165-172页

作者： Angéla meszes Gyula Tálosi Krisztina máder Hajnalka Orvos Lajos Kemény Zsanett Renáta Csoma Department of Dermatology and Allergology University of SzegedSzegedHungary Department of Pediatrics University of SzegedSzegedHungary Department of Obstetrics and Gynecology University of SzegedSzegedHungary Department of Dermatology and Allergology University of SzegedSzegedHungary mTA-SZTE Dermatological Research Group SzegedHungary

Background:most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal *** iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic *** study was to review the neonates admitted to our neonatal intensive care unit who needed wound management,and to assess the most common skin injuries and wounds,and their ***:Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31,2012 and January 31,*** about gestational age,sex,birth weight,area of involvement,wound aetiology,and therapy were ***:among the 211 neonates observed,wound management was required in 10 cases of diaper dermatitis,7 epidermal stripping,6 extravasation injuries,5 pressure ulcers,1 surgical wound and infection,1 thermal burn,and 5 other ***:International guidelines in neonatal wound care practice are not available,and further research concerns are clearly *** and antiseptic agents should be chosen with great care for application to neonates,with particular attention to the prevention of adverse events in this sensitive *** work among dermatologists,neonatologists and nurses is crucial for the successful treatment of neonates.

关键词： epidermal stripping extravasation injury neonatal intensive care unit surgical wound wound care in neonates