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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： jean-Daniel Malcor Emma j.hunter Natalia Davidenko Daniel V.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

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Discrete composition control of two-dimensional morphologic all-inorganic metal halide perovskite nanocrystals

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journal of Energy Chemistry 2021年第8期30卷 257-275,I0006页

作者： Andrew hunter Davis Weiwei Zheng Department of Chemistry Syracuse University13244 SyracuseUnited States

Metal halide perovskite nanocrystals(NCs)exhibit impressive optical and electronic properties,making them an important class of functional materials with promising applications in solar cells,light emitting diodes(LEDs),photodetectors,and *** addition to the widely studied 0-dimensional(0 D)metal halide perovskite NCs,such as nanocubes,low dimensional perovskites,such as 2 D all-inorganic perovskite(AIP)NCs,subsist with directionally relevant quantum *** anisotropic NCs have the propensity to exhibit interesting optoelectronic properties that are exceedingly difficult to introduce into 0 D systems,yet as of late are largely *** this review,we discuss the recent synthetic progress of 2 D all-inorganic metal halide perovskite NCs with ABX3 ***,we highlight the discrete composition control of the cations(A and B sites)and anions(X site)by dopant incorporation and alloying in 2 D metal halide perovskite *** will also discuss more complex perovskite crystal structures,such as Ruddlesden-Popper double perovskites,and compare these materials to 0 D perovskite ***,our work culminates in the future interests and perspectives of this field with a focus on the wide applicability of 2 D systems and the large variance in structure capable with discrete compositional tuning.

关键词： All-inorganic perovskites Two-dimensional nanocrystals Composition Doping Alloying Ion exchange

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Design of two-dimensional carbon-nitride structures by tuning the nitrogen concentration

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npj Computational Materials 2020年第1期6卷 562-569页

作者： Saiyu Bu Nan Yao Michelle A.hunter Debra j.Searles Qinghong Yuan State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal University3663 N.Zhongshan RoadShanghai 200062PR China Centre for Theoretical and Computational Molecular Science Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbaneQLD 4072Australia College of Teacher Education East China Normal University3663 N.Zhongshan RoadShanghai 200062PR China School of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneQLD 4072Australia

Nitrogen-doped graphene(NG)has attracted increasing attention because its properties are significantly different to pristine graphene,making it useful for various applications in physics,chemistry,biology,and materials ***,the NGs that can currently be fabricated using most experimental methods always have low N concentrations and a mixture of N dopants,which limits the desirable physical and chemical properties.

关键词： dimensional carbon structures

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Hyperresolution information and hyperresolution ignorance in modelling the hydrology of the land surface

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Science China Earth Sciences 2015年第1期58卷 25-35页

作者： Keith BEVEN Hannah CLOKE Florian PAPPENBERGER Rob LamB Neil hunter Lancaster Environment Centre Lancaster UniversityLancaster LA1 4YQUK and Department of Earth SciencesUppsala UniversityUppsalaSweden Department of Geography and Environmental Science Department of MeteorologyUniversity of ReadingReadingUK European Centre for Medium-range Weather Forecasts ReadingUK School of Geographical Sciences University of BristolBristolUK College of Hydrology and Water Resources Hehai University jBA Trust South BarnBroughton HallSkipton BD23 3AEUK jBA Consulting South BarnBroughton HallSkipton BD23 3AEUK

There is a strong drive towards hyperresolution earth system models in order to resolve finer scales of motion in the *** problem of obtaining more realistic representation of terrestrial fluxes of heat and water,however,is not just a problem of moving to hyperresolution grid *** is much more a question of a lack of knowledge about the parameterisation of processes at whatever grid scale is being used for a wider modelling *** grid scales cannot alone solve the problem of this hyperresolution *** paper discusses these issues in more detail with specific reference to land surface parameterisations and flood inundation *** importance of making local hyperresolution model predictions available for evaluation by local stakeholders is *** is expected that this will be a major driving force for improving model performance in the future.

关键词： hyperresolution models epistemic uncertainties models of everywhere communicating uncertainty flood risk

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Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

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Asian journal of Andrology 2008年第1期10卷 14-22页

作者： Travis D. Strong Milena A. Gebska Arthur L. Bumett hunter C. Champion Trinity j. Bivalacqua The Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 USA

Erectile dysfunction （ED） commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 （PDE-5） inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

关键词： erectile dysfunction endothelial-specific gene endothelial dysfunction gene therapy

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Frankenstein

Frankenstein

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作者： Mary Shelley edited by j. Paul hunter.

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Mind the “Gap”: A Comparison of the Weekly Training Loads of English Premier League Academy Soccer Players in Under 23, Under 18 and Under 16 Age-Groups

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journal of Science in Sport and Exercise 2023年第1期5卷 34-43页

作者： jonathan M.Taylor jonathan L.Madden Frances hunter Ben j.Thorne Shaun j.McLaren School of Health and Life Sciences Teesside UniversityMiddlesbroughUK Leeds United Football Club LeedsUK Middlesbrough Football Club MiddlesbroughUK Hintsa Performance LondonUK Department of Sport and Exercise Sciences Durham UniversityDurhamUK

Purpose The transition into full-time training represents a key period in the development of young soccer *** we compared the weekly training loads(matches,field-,and resistance-training)of English Premier-League Academy soccer players from under-16(U16),under-18(U18)and under-23(U23)age-groups during a training *** Forty players(U16 n=13,U18 n=15 and U23 n=12)were monitored using global navigation satellite systems and differential ratings of perceived exertion(dRPE).External load metrics were total distance,high-speed running distance,[absolute:≥19.8 km/h,relative:≥87%of 30-15 final-velocity(vIFT)],sprint distance(absolute:≥25.2 km/h,relative:≥80%maximal sprint speed),and dynamic stress *** load metrics were dRPE training *** Other than relative sprint distance,overall weekly external training loads were substantially greater for U18s and U23s when compared with U16s[effect size range:1.09-1.99(moderate to large);±90%confidence limits~0.45].When compared with U16s,overall internal loads were substantially greater for U18s[0.69-0.95(moderate);±~0.40],but not *** in weekly training loads between U18s and U23s were *** Substantial differences in training loads between elite U16 players and their older counterparts,indicates the need for planned increases in training loads in anticipation of the transition into full-time training.

关键词： Team-sports RPE LTAD Individualised training Training load

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Are we really“screening”movement?The role of assessing movement quality in exercise settings

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journal of Sport and Health Science 2020年第6期9卷 489-492页

作者： hunter Bennett john Arnold Kevin Norton Kade Davison Alliance for Research in Exercise Nutrition and ActivitySansom Institute for Health ResearchUniversity of South AustraliaAdelaideSA 5001 Australia

*** The assessment of movement quality became widespread in exercise settings following the introduction of Gray Cook’s Functional Movement Screen(FMS).1 Assessing muscle and joint function during real-world movement... 详细信息

关键词： movement assessing assessed

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GroESL protects superoxide dismutase (SOD)— Deficient cells against oxidative stress and is a chaperone for SOD

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Health 2013年第10期5卷 1719-1729页

作者： Gary j. hunter Thérèse hunter Department of Physiology and Biochemistry University of Malta Msida MSD 2080 Malta Department of Physiology and Biochemistry University of Malta Msida MSD 2080 Malta

Superoxide dismutase (SOD)-deficient Escherichia coli OX326Acells are protected against chemically-induced oxidative stress by expression of the chaperonin GroESL. This protection is equivalent to expression of superoxide dismutase even though GroESL has no inherent SOD activity. Co-overexpression of GroESL and SOD in the same cells results in higher protein yields of SOD and greater metallation of SOD when compared with expression of SOD alone. Greater metallation results in the higher specific activity of SOD that is observed in heat shock, and is not due to increased synthesis of SOD mRNA or protein.

关键词： Superoxide Dismutase Chaperone Heat Shock Oxidative Stress

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Transient thermal response of micro-thermal conductivity detector (μTCD) for the identification of gas mixtures:An ultra-fast and low power method

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Microsystems & Nanoengineering 2015年第1期1卷 52-58页

作者： Alireza Mahdavifar Milad Navaei Peter j.Hesketh Melvin Findlay joseph R.Stetter Gary W.hunter School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA KWj Engineering Inc. NewarkCA 94560USA NASA Glenn Research Center ClevelandOH 44135USA

Micro-thermal conductivity detector(μTCD)gas sensors work by detecting changes in the thermal conductivity of the surrounding medium and are used as detectors in many applications such as gas chromatography *** TCDs use steady-state resistance(i.e.,temperature)measurements of a *** this work,we developed a new measurement method and hardware configuration based on the processing of the transient response of a low thermal mass TCD to an electric current *** method was implemented for a 100-μm-long and 1-μm-thick micro-fabricated bridge that consisted of doped polysilicon conductive film passivated with a 200-nm silicon nitride *** resistance variations of theμTCD in response to a square current pulse were studied in multiple mixtures of dilute gases in *** and experimental results are presented and compared for the time resolved and steady-state regime of the sensor *** analysis and simulation show that the sensor response is exponential in the transient state,that the time constant of this exponential variation was a linear function of the thermal conductivity of the gas ambient,and that the sensor was able to quantify the mixture *** level of detection in nitrogen was estimated to be from 25 ppm for helium to 178 ppm for carbon *** this novel approach,the sensor requires approximately 3.6 nj for a single measurement and needs only 300μs of sampling *** is less than the energy and time required for steady-state DC measurements.

关键词： gas sensor MEMS micro-bridge micro-heater μTCD thermal conductivity sensor transient heat transfer modeling

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