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Pyrona.idine combined with dimina.ene a.etura.e inhibits Ba.esia.in vitro a.d in vivo

a.ia. Pa.ific Journa. of Tropica. Biomedicine 2024年第3期14卷 93-99页

作者： Shima. a.d el-Sa.am el-Sa.ed Mohamed Z.Sa.ed-a.med Sha.ma. a.med awad a.i Noura. a.sada.n Na.a.ish a.am Ma.moud S.a.khouda.y Ikuo Iga.a.hi Mohamed a.do Rizk Na.iona. Resea.ch Center for Protozoa. Disea.es Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Depa.tment of Biochemistry a.d Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Depa.tment of Clinica. Pha.ma.y College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medica.-Surgica. Depa.tment College of NursingJouf UniversitySakaka 72388Saudi Arabia Critica. Ca.e a.d Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Fa.ulty of Pha.ma.y Mansoura UniversityMansoura 35516DakahliaEgypt Depa.tment of Interna. Medicine a.d Infectious Disea.es Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To eva.ua.e the combina.ion thera.y of pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e a.a.nst Ba.esia.in vitro a.d in ***:Bioinforma.ic a.a.ysis wa. performed using a.om pa.r *** in vitro combina.ion test wa. performed a.a.nst Ba.esia.bovis a.d Theileria.***,the in vivo chemothera.eutic effica.y of pyrona.idine tetra.hospha.e in combina.ion with dimina.ene a.etura.e wa. investiga.ed a.a.nst the growth of Ba.esia.microti in mice using a.fluorescence inhibitory ***:Pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e exhibited nea.ly simila. molecula. *** in vitro combina.ion of pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e wa. synergistic on Ba.esia.bovis a.d additive on Theileria.*** addition,5 mg/kg pyrona.idine tetra.hospha.e combined with 10 mg/kg dimina.ene a.etura.e inhibited Ba.esia.microti growth significa.tly compa.ed with those observed a.ter trea.ment with 25 mg/kg dimina.ene a.etura.e a.one from da. 6 post trea.ment to da. 12 post *** combina.ion thera.y a.so norma.ized the hema.ologica. pa.ameters of infected ***:a. ora. dose of pyrona.idine tetra.hospha.e combined with a.subcuta.eous dose of dimina.ene a.etura.e inhibits Ba.esia.in vitro a.d in mice,suggesting it might be a.new pa.adigm for the trea.ment of ba.esiosis.

关键词： Ba.esia Pyrona.idine tetra.hospha.e Dimina.ene a.etura.e Ba.esiosis Theileria

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a.Comprehensive Review on Cha.ging Topologies a.d Power electronic Converter Solutions for electric Vehicles

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Journa. of Modern Power Systems a.d Clea. Energy 2024年第3期12卷 675-694页

作者： a.delfa.a. a.i Hossam H.H.Mousa.Mosta.a.F.Sha.ba. Ma.er a.a.zouz a.med S.a.awad the Depa.tment of electrica. Engineering American University of Sharjah26666 SharjahUnited Arab Emirates the Depa.tment of electrica. Engineering South Valley University83523 QenaEgypt the Depa.tment of electrica. a.d Computer Engineering University of WindsorWindsorON N9B 3P4 Canada electrica. Engineering Depa.tment Qatar UniversityDoha 2713Qatar Depa.tment of electrica. a.d Computer Engineering Sultan Qaboos UniversityMuscat123Oman

electric vehicles(EVs)a.e becoming more popula. worldwide due to environmenta. concerns,fuel security,a.d price *** performa.ce of EVs relies on the energy stored in their ba.teries,which ca. be cha.ged using either a.(slow)or DC(fa.t)***,EVs ca. a.so be used a. mobile power stora.e devices using vehicle-to-grid(V2G)*** electronic converters(PECs)ha.e a.constructive role in EV a.plica.ions,both in cha.ging EVs a.d in ***,this pa.er comprehensively investiga.es the sta.e of the a.t of EV cha.ging topologies a.d PEC solutions for EV *** examines PECs from the point of view of their cla.sifica.ions,configura.ions,control a.proa.hes,a.d future resea.ch prospects a.d their impa.ts on power *** ca. be cla.sified into va.ious topologies:DC-DC converters,a.-DC converters,DC-a. converters,a.d a.-a. *** address the limita.ions of traditiona. DC-DC converters such a. switching losses,size,a.d high-electroma.netic interference(EMI),resona.t converters a.d multiport converters a.e being used in high-volta.e EV ***,power-tra.n converters ha.e been modified for high-efficiency a.d relia.ility in EV *** pa.er offers a. overview of cha.ging topologies,PECs,cha.lenges with solutions,a.d future trends in the field of the EV cha.ging sta.ion a.plica.ions.

关键词： Cha.ging sta.ion cha.ging topology electric vehicle power electronic converter vehicle-to-grid

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a.a.ysis of the Drought Impa.t a. a. Extreme Clima.ic Event in Suda.

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Journa. of Geoscience a.d Environment Protection 2024年第6期12卷 38-47页

作者： awad Hussien School of a.mospheric Science Nanjing University of Information Science & Technology Nanjing China

This study a.med to investiga.e drought a. a. extreme clima.ic event in Suda. by utilizing the a.oma.y a.d Sta.da.d Precipita.ion Index (SPI). This resea.ch employed high-resolution Clima.e Ha.a.ds Group Infra.ed Precipita.ion with Sta.ion (CHIRPS) da.a.to a.a.yze the tempora. a.d spa.ia. distribution of ra.nfa.l in Suda. from 2001 to 2015. Nota.ly, the a.a.ysis compa.ed the a.nua. a.era.e precipita.ion to specific drought events a.d ca.cula.ed the Sta.da.dized Precipita.ion Index (SPI). The results indica.e a.striking frequency of drought occurrence in Suda., with SPI va.ues suggesting simila.ities between drought a.d wet yea.s. It is recommended to compute the SPI for individua. sta.ions ra.her tha. rely solely on a.ea.a.era.es. Despite the compa.a.le SPI va.ues between the drought a.d wet yea.s, this study empha.izes the profound impa.t of drought a. a.recurring phenomenon in Suda.. These findings empha.ize the urgent need for proa.tive drought ma.a.ement a.d mitiga.ion stra.egies in Suda. to effectively address the consequences of this clima.ic cha.lenge.

关键词： CHIRPS SPI a.oma.y Ra.nfa.l a.idity

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Single nucleotide polymorphism within chromosome 8q24 is a.socia.ed with prosta.e ca.cer development in Sa.di a.a.ia

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a.ia. Journa. of Urology 2024年第1期11卷 26-32页

作者： awad elsid Osma. Sa.a. a.ha.bi a.if a.i a.med a.im a.i elba.ir Pa.hology a.d Clinica. La.ora.ory Ma.a.ement Depa.tment(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Depa.tment of Pa.hology a.d La.ora.ory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

Objective: Genome-wide a.socia.ion studies ha.e demonstra.ed tha. single nucleotide polymorphisms (SNPs) a.e importa.t risk fa.tors for the development of prosta.e ca.cer (PCa.. Prelimina.y studies ha.e suggested tha. the incidence of PCa.in Sa.di ma.es is low but is proba.ly familia. or genetica.ly ***: To identify a.y possible a.socia.ion of SNP with PCa.development in Sa.di pa.ients, we investiga.ed a.group of SNPs in Sa.di PCa.pa.ients (n=85) a.d compa.ed the outcomes to hea.thy norma. controls (n=115) a.d nodula. hyperpla.ia.pa.ients (n=120). DNa.wa. extra.ted from pa.a.fin-embedded forma.in fixed tissue or whole blood from both pa.ients’ groups a.d hea.thy control group. a.tota. of thirteen SNPs were genotyped using Ta.Ma.® minor groove binder polymera.e cha.n rea.tion ***: The rs16901979a. s629242T a.d rs1447295a.a.leles were found a. significa.tly higher frequency in PCa.pa.ients tha. controls (pa.genotype wa. found a. significa.tly grea.er frequency in PCa.pa.ients tha. in hea.thy controls (43% vs. 14%, odds ra.io=4.6, p=0.0001) a.d benign hyperpla.ia.group (43% vs. 25%, odds ra.io=2.2, p=0.009).Conclusion: Our study ha. highlighted the a.socia.ion of rs16901979 SNP with PCa.in Sa.di ma.es. Such findings ha.e importa.t implica.ions in the PCa.dia.nosis a.d in screening una.fected family members of Sa.di pa.ients.

关键词： Prosta.eca.cer Sa.di Singlenucleotide polymorphism a.lele

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Compa.a.ive Studies between Pica.d’s a.d Ta.lor’s Methods of Numerica. Solutions of First Ordina.y Order Differentia. Equa.ions a.ising from Rea.-Life Problems

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Journa. of a.plied Ma.hema.ics a.d Physics 2024年第3期12卷 877-896页

作者： Kha.id a.d elra.ig awad a.la.elnour Depa.tment of Ma.hema.ics Preparatory Deanship Najran University Najran Kingdom of Saudi Arabia

To solve the first-order differentia. equa.ion derived from the problem of a.free-fa.ling object a.d the problem a.ising from Newton’s la. of cooling, the study compa.es the numerica. solutions obta.ned from Pica.d’s a.d Ta.lor’s series methods. We ha.e ca.ried out a.descriptive a.a.ysis using the Ma.La. softwa.e. Pica.d’s a.d Ta.lor’s techniques for deriving numerica. solutions a.e both strong ma.hema.ica. instruments tha. beha.e simila.ly. a.l first-order differentia. equa.ions in sta.da.d form tha. ha.e a.consta.t function on the right-ha.d side sha.e this simila.ity. a. a.result, we ca. conclude tha. Ta.lor’s a.proa.h is simpler to use, more effective, a.d more a.cura.e. We will contra.t Rung Kutta.a.d Ta.lor’s methods in more deta.l in the following section.

关键词： First-Order Differentia. Equa.ions Pica.d Method Ta.lor Series Method Numerica. Solutions Numerica. Examples Ma.La. Softwa.e

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The Influence of Informa.ion Technology(IT)on a.crua. a.counting adoption:The Ca.e of the Jorda.ia. Public Sector

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Journa. of Modern a.counting a.d a.diting 2024年第2期20卷 40-48页

作者： Moa.ia. awad a.ghizza.i Rosnia.Ma.ruki University of Bura.mi Al BuraimiOman Universiti Sa.ns Islam Ma.a.sia NilaiMalaysia

Jorda. is one of ma.y countries tha. intends to reform its public sector by adopting a.crua. a.counting,which is prima.ily ca.ried out through the Interna.iona. Public Sector a.counting Sta.da.ds(IPSa.)implementa.ion pla.,scheduled to be completed by *** the difficulties of adoption,this process ca.not be completed without a. a.propria.e Informa.ion Technology(IT)system ca.a.le of providing the a.counting informa.ion required for this ***,this study a.ms to examine the influence of IT on a.crua. a.counting adoption in the Jorda.ia. public *** study employed the qua.tita.ive survey *** on 331 usa.le questionna.res,the descriptive findings showed tha. the use of IT in the Jorda.ia. public sector is releva.t to da.ly a.counting tra.sa.tions in genera. a.d to a.crua. a.counting in *** regression a.a.ysis showed a.positive,significa.t rela.ionship between IT use a.d a.crua. a.counting *** IT specia.ist should be a.le to understa.d the needs of public sector in adopting a.crua.-ba.ed *** line with toda.’s digita.iza.ion a.e,which integra.es adva.ced technologies a.d numerous techniques,this study suggests tha. a.combina.ion of a.counting a.d IT experts is a.va.ue added to sha.pen the competitiveness of public sector *** study contributes to the exta.t litera.ure in public sector,concerning the rela.ionship between IT a.d a.crua. a.counting adoption in the context of Jorda..

关键词： public sector a.crua. a.counting adoption informa.ion technology Jorda.

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Phishing a.ta.ks Detection Using EnsembleMa.hine Lea.ning a.gorithms

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Computers, Ma.eria.s & Continua 2024年第7期80卷 1325-1345页

作者： Nisreen Inna. a.med a.delgader Fadol Osma. Mohammed awad Mohammed a.a.lfadiel Ma.wa. a.u-Za.ona.Ba.sam Moham.ad elza.hmouri Fa.a. H.Za.a.deh Mouiad Fadeil a.a.neh Depa.tment of Computer Science a.d Informa.ion Systems College of Applied SciencesAlmaarefa UniversityDiriyahRiyadh13713Saudi Arabia a.plied College King Faisal UniversityAl-Ahsa31982Saudi Arabia Depa.tment of Ma.a.ement Informa.ion Systems College of Business AdministrationKing Faisal UniversityAl-Ahsa31982Saudi Arabia Depa.tment of Computer Science Faculty of Computer Science and Information TechnologyJerash UniversityJerash26110Jordan Depa.tment of Business Intelligence a.d Da.a.a.a.ysis Faculty of Financial Sciences and BusinessIrbid National UniversityIrbid21110Jordan Fa.ulty of Informa.ion Technology Ajloun National UniversityAjloun26767Jordan

Phishing,a. Internet fra.dwhere individua.s a.e deceived into revea.ing critica. persona. a.d a.count informa.ion,poses a.significa.t risk to both consumers a.d web-ba.ed *** indica.es a.persistent rise in phishing ***,these fra.dulent schemes a.e progressively becoming more intrica.e,thereby rendering them more cha.lenging to ***,it is impera.ive to utilize sophistica.ed a.gorithms to address this *** lea.ning is a.highly effective a.proa.h for identifying a.d uncovering these ha.mful *** lea.ning(ML)a.proa.hes ca. identify common cha.a.teristics in most phishing *** this pa.er,we propose a. ensemble a.proa.h a.d compa.e it with six ma.hine lea.ning techniques to determine the type of website a.d whether it is norma. or not ba.ed on two phishing *** tha.,we used the norma.iza.ion technique on the da.a.et to tra.sform the ra.ge of a.l the fea.ures into the same *** findings of this pa.er for a.l a.gorithms a.e a. follows in the first da.a.et ba.ed on a.cura.y,precision,reca.l,a.d F1-score,respectively:Decision Tree(DT)(0.964,0.961,0.976,0.968),Ra.dom Forest(RF)(0.970,0.964,0.984,0.974),Gradient Boosting(GB)(0.960,0.959,0.971,0.965),XGBoost(XGB)(0.973,0.976,0.976,0.976),ada.oost(0.934,0.934,0.950,0.942),Multi La.er Perceptron(MLP)(0.970,0.971,0.976,0.974)a.d Voting(0.978,0.975,0.987,0.981).So,the Voting cla.sifier ga.e the best *** in the second da.a.et,a.l the a.gorithms ga.e the same results in four eva.ua.ion metrics,which indica.es tha. ea.h of them ca. effectively a.complish the prediction ***,this a.proa.h outperformed the previous work in detecting phishing websites with high a.cura.y,a.lower fa.se nega.ive ra.e,a.shorter prediction time,a.d a.lower fa.se positive ra.e.

关键词： Socia. engineering a.ta.ks phishing a.ta.ks ma.hine lea.ning security a.tificia. intelligence

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Cerebra. sma.l vessel disea.e modifies outcomes a.ter minima.ly inva.ive surgery for intra.erebra. ha.morrha.e

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Stroke & Va.cula. Neurology 2024年第4期9卷 446-456,I0147页

作者： Yunke Li Sung-Min Cho Radhika.a.adha.i Ha.sa. a.i Yi Ha. Sa.tosh B Murthy Joshua.N Goldstein Fa. Xia.Xin Hu Na.a.ie L Ullma. Issam awad Da.iel Ha.ley Wendy C Zia. The George Institute for Globa. Hea.th BeijingChina Depa.tment of Neurology Division of Neurocritical CareJohns Hopkins Medical InstitutionsBaltimoreMarylandUSA Depa.tment of Neurology Division of Brain Injury OutcomesJohns Hopkins Medical Institutions CampusBaltimoreMarylandUSA Depa.tment of Neurology Weill Cornell Medical CollegeNew YorkNew YorkUSA Depa.tment of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Depa.tment of Neurosurgery West China Hospital of MedicineChengduSichuanChina Depa.tment of Neurosurgery University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Ba.kground Minima.ly inva.ive surgery(MIS)for sponta.eous supra.entoria. intra.erebra. ha.morrha.e(ICH)is controversia. but ma. be beneficia. if end-of-trea.ment(EOT)ha.ma.oma.volume is reduced to≤15 *** explored whether MRI findings of cerebra. sma.l vessel disea.e(CSVD)modify the effect of MIS on long-term *** Prespecified blinded subgroup a.a.ysis of 288 subjects with qua.ified ima.ing sequences from the pha.e 3 Minima.ly Inva.ive Surgery Plus a.tepla.e for Intra.erebra. Ha.morrha.e Eva.ua.ion(MISTIE)*** tested for heterogeneity in the effects of MIS a.d MIS+EOT volume≤15 mL on the tria.’s prima.y outcome of good versus poor function a. 1 yea. by the presence of single CSVD fea.ures a.d CSVD scores using multiva.ia.le *** Of 499 pa.ients enrolled in MISTIE III,288 pa.ients had MRI,149(51.7%)ra.domised to MIS a.d 139(48.3%)to sta.da.d medica. ca.e(SMC).Media.(IQR)ICH volume wa. 42(30–53)*** the full MRI cohort,there wa. no sta.istica.ly significa.t heterogeneity in the effects of MIS versus SMC on 1-yea. outcomes by a.y specific CSVD fea.ure or by CSVD scores(a.l P_(intera.tion)>0.05).In 94 MIS pa.ients with EOT ICH volume≤15 mL,significa.t reduction in odds of poor outcome wa. found with cerebra. amyloid a.giopa.hy scorea.tion)=0.006),a.sence of la.unes(OR,0.37(0.18–0.80);P_(intera.tion)=0.02)a.d a.sence of severe white ma.ter hyperintensities(WMHs)(OR,0.22(0.08–0.58);P_(intera.tion)=0.03).Conclusions Following successful ha.ma.oma.reduction by MIS,we found significa.tly lower odds of poor functiona. outcome with lower tota. burden of CSVD in addition to a.sence of la.unes a.d severe *** fea.ures ma. ha.e utility for prognostica.ion a.d pa.ient selection in clinica. tria.s of MIS.

关键词： Surgery surgery a.sence

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Ta.gled web: a.ima.-huma. intera.tion a.d the rise of a.tibiotic resista.ce

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Infectious Disea.es Resea.ch 2024年第1期5卷 1-2页

作者： adel Kha.il Ibra.im a.eer a.delna.er awad Doa. Moham.ad Gha.th Fa.ulty of Veterina.y Medicine Cairo UniversityGiza square 12211Egypt Fa.ulty of Medicine Cairo UniversityAl-Manial 11559CairoEgypt.

Introduction Egypt is a.Low-Middle Income Country(LMIC)with a.popula.ion of 106,472,382 people in a.gust 2022(Worldometers&Depa.tment of Economic a.d Socia. a.fa.rs,2022).a.a.la.le evidence suggests tha. there a.e misuse/overuse of a.tibiotic in Egypt[1].On recognizing the globa. threa. of a.tibiotic resista.ce(amR),Egypt la.nched the Na.iona. a.tion Pla.(Na.)in *** comprehensive pla.,inspired by the Globa. a.tion Pla.(Ga.),united diverse sta.eholders like ministries,universities,a.d interna.iona. *** Na. ta.kled amR through four key stra.egies:boosting public understa.ding of a.tibiotics,optimizing their use a.ross huma.s a.d a.ima.s,embra.ing a.One Hea.th”a.proa.h,a.d implementing effective infection prevention pra.tices[2].

关键词： a.tion boosting resista.ce

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Ka.line-ba.ed ca.a.yst for a.high sta.ility desulfuriza.ion of sour hea.y na.htha.in a.three-pha.e oscilla.ory ba.fled rea.tor

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Pa.ticuology 2024年第1期84卷 249-260页

作者： Ha.sa. M.Hmood Sa.a.a.Gheni Sa.a. M.R.a.med Mudheher M.a.i Hamid Yonis Sa.eh Mohammed H.Mohammed awad E.Mohammed Ma.wa. a.Ma.omood Hiba.R.Mohammed a.med a.Ha.sa. adam Ha.vey North Refineries Compa.y Ministry of OilIraq Chemica. Engineering Depa.tment Tikrit UniversityIraq Ministry of Oil Iraq a.-Ha.ija.Technica. Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To meet the ra.idly increa.ing dema.d for energy a.d the drama.ic depletion of conventiona. crude oil,it is impera.ive to utilize sour *** no coke being produced,oxida.ive desulfuriza.ion(ODS)of na.htha.lowers its sulfur content a.d a.era.e molecula. *** this a.ticle,we outline a.method for hea.y na.htha.non-extra.tive ODS using a.very sta.le *** technique involves the use of a.solid ca.a.yst with oxygen ga. a. the *** necessita.ed rela.ively high mixing intensities;hence a.three-pha.e Oscilla.ory Ba.fled Rea.tor(OBR)wa. *** ca.a.yst wa. ba.ed on the zeolite ZSM-5,prepa.ed from na.ura. ka.lin by a.series of delamina.ion a.d a.tiva.ion steps a.d impregna.ed with Fe.a.TiO2 na.ola.er wa. a.plied,using the sol-gel method,to prevent ra.id *** rea.tor performa.ce wa. eva.ua.ed to minimize the sulfur content in the na.htha.*** to the protective coa.ing,the sulfur conversion sta.ilized a. 90%.The results of this work esta.lish the use of na.ura. cla.-ba.ed ca.a.ysts in a.continuous,three-pha.e ODS,pa.ticula.ly with rega.d to proving long-term *** a.so showed tha. modest ODS ca. be a.hieved using a. environmenta.ly friendly oxida.t,a. mild opera.ing conditions,whilst ma.nta.ning sta.ility.

关键词： Na.ura. ka.line Desulfuriza.ion Three-pha.e Oscilla.ory ba.fled rea.tor

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