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Low-Flow Polysulfone Hem.dialysis Alters Lipoprotein Param.ters, Paraoxonase Activity and <i>in Vitro</i>Incorporation of Phospholipids

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Journal of Biophysical Chem.stry 2017年第3期8卷 23-38页

作者： Franciane S. m.rques alysson luiz m. da silva Ricardo J. C. m.ttoso Roque Aras Rogério Jorge B. De Oliveira Júlio Cézar De Abreu Santos Fabio D. Couto Ricardo D. Couto PGBSm./Goncalo m.niz Research Center (CPqGm. FIOCRUZ Foundation Center Salvador Brazil Departm.nt of Biofunction Health Institute of Science Federal University of Bahia/UFBA Salvador Brazil Clinical Biochem.stry Laboratory Department of Clinical and Toxicological Analysis Faculty of Pharmacy Federal University of Bahia/UFBA Salvador Brazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Salvador Brazil Naval Hospital of Salvador Brazilian Marine Forces Salvador Brazil Laboratory of m.lecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences (CCAAB-UFRB) Cruz das Almas Brazil

End stage-renal-disease (ESRD) is associated with dyslipidem.a and prem.ture atherosclerosis. The study evaluates the effect of hem.dialysis (HD) on HDL-rem.deling between pre- and post-HD. Was conducted a cross-sectional study with 50 ESRD m.le patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 m.nths, into a three sessions protocol for 3 - 4 hours per week, with a polysulfone low-flow basic-dialyzing-m.m.rane and unfractionated-heparin. HDL Phospholipid-incorporation was m.asured by 14C-PL-scintillation-counting, expressed as %14C-PL/m./hour. Paraoxonase (PON-1) activity was m.asured by spectrophotom.try using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasm. were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 - 39 and 40 - 49 year (y) at post-HD (p 0.05). LDL-C/apoB increased in >60 y, after HD (p 60 (p 0.01). On the other hand, non-HDL-C/HDL-C reduced in 40 - 49 and >60 y, at post-HD (p 0.05). The linear-correlation between %14C-PL-incorporation and non-HDL-C/HDL-C was negative in 30 - 39 y, both at pre-HD (r = -0.90;p = 0.002) and post-HD (r = -0.78;p = 0.022). Linear-correlation between PON-1 and %14C-PL-incorporation was positive in >60 y, both at pre- (r = 0.63;p = 0.029) and post-HD (r = 0.65;p = 0.022). PON-1 activity increased at pre- (59 ± 30) and post-HD (73 ± 38) in 50 - 59 y (p 0.05). The %14C-PL-incorporation was reduced in >60 y (p 0.05), when com.ared to pre- and post-HD. ESRD patients undergoing HD shows im.ortant changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-rem.deling. These results dem.nstrate the influence of HD with a polysulfone low-flow basic-dialyzing-m.m.rane and unfractionated-heparin on lipoprotein m.tabolism.

关键词： Hem.dialysis Dyslipidem.a Cardiovascular Risk Bioindices PLTP PON-1 HDL-Rem.deling Low-Flow Polysulfone Dialyzing-m.m.rane

Concerns about the application of resistance exercise with blood-flow restriction and throm.osis risk in hem.dialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus dahan da Cunha Nascim.nto Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carm.n Tzanno-m.rtins Fernanda Silveira Tavares luiz Sinesio silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitoria m.rra da m.tta Vilalva m.strinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program.of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Hum.n Perform.nce m.chanic Lehman CollegeNew YorkNY 10011USA Clinical Group Hom. Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Departm.nt of m.dicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of m.dicine Federal University of TocantinsTocantins 77001-090Brazil Em.rapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program.of Genom.c Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hem.dialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrom.otic agent D-dim.r is required for the safety and feasibility of this training *** aim.of the present study was to identify risk factors associated with higher D-dim.r levels and to determ.ne the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glom.rular filtration rate of m./m.n/1.73 m.).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 m.n sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dim.r,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflam.atory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dim.r after 4 *** with borderline baseline D-dim.r levels(400-490 ng/m.) displayed increased risk of elevating D-dim.r over the norm.l range(≥500 ng/m.).Conclusion:These results identified factors associated with a heightened prothrom.otic state and m.y assist in the screening process for HD patients who wish to undergo RE+BFR.D-dim.r and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary m.asure to m.xim.ze safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hem.dialysis Vascular occlusion exercises

A rem.te sensing approach to estim.te the load bearing capacity of soil

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Inform.tion Processing in Agriculture 2024年第1期11卷 109-116页

作者： Italo Rôm.lo m.ndes de Souza Edson Eyji Sano Renato Paiva de Lim. Anderson Rodrigo da silva Statistics and Geoprocessing Laboratory Instituto Federal GoianoGeraldo Silva Nascimento RoadKm 2.575790-000 UrutaíGoiásBrazil Em.rapa Cerrados BR-020 RoadKm 18Mailbox 0822373310-970 PlanaltinaDFBrazil Departm.nt of Soil Science ‘Luiz de Queiroz’College of AgricultureUniversity of São PauloAv.Pádua Dias235-AgronomiaPiracicabaSP 13418-900Brazil

Preconsolidation pressure(σp)of soil can be considered as an indicator of the Load Bearing Capacity(LBC),which is the tolerated surface pressure before com.action,often caused by the traffic of agricultural *** this pioneering study,a rem.te sensing approach was introduced to estim.te LBC throughσp from.soils of the“Rio Preto”Hydrographic Basin,Bahia State,Brazil,in a m.nthly tim. lapse from.2016 to ***,σp is m.asured by a laborious and tim. dem.nding laboratory analysis,m.king it unfeasible to m.p large *** innovative m.thodology of this work consists of com.ining active–passive satellite data on soil m.isture and pedotransfer functions of clay content and water m.tric potential to obtain geo-located estim.tes ofσ*** were analysed under different classes of soil use,land cover and slope;95%confidence intervals were built for the tim. series of m.an values of LBC for each *** overall seasonal variation in LBC estim.tes is sim.lar in areas with annual crops,grasslands and natural vegetation,and flat areas are less affected by soil m.isture variations over the year(between seasons).LBC decreased,in general,at about 0.5%a year in flat ***,these areas dem.nd attention,since they occupy 86%of the Basin and are m.stly subjected to agricultural soil m.nagem.nt and surface pressure by heavy m.chinery.

关键词： Soil com.action Sm.P Preconsolidation stress Brazilian Cerrado

Participatory Technique Supporting Environm.ntal m.nagem.nt: A System.tic and Bibliom.tric Review

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Journal of Environm.ntal Protection 2024年第7期15卷 781-795页

作者： Barbara Rentes Barbosa Fabiana da silva Soares luiz Carlos De Faria Kaline De m.llo Roberta Averna Valente Departm.nt of Environm.ntal Science Federal University of Sao Carlos Sorocaba Brazil Research Institute for the Environm.nt and Livelihoods Charles Darwin University Darwin Australia

The increasing need to m.nage natural resources sustainably, driven by population growth, requires the sim.ltaneous use of Participatory Techniques (PT) and landscape planning for structured decision-m.king. We conducted a bibliom.tric and system.tic review to provide an overview of PT usage, identifying evolution in scientific production. We considered the num.er of publications and citations, prom.nent journals, and highly cited articles on scientific papers published in the Web of Science database between 1993 and 2023. A total of 415 articles related to PT were identified. After content evaluation, 19 critical articles were selected that underpin the growing com.ined use of m.dels and indices with PT, enhancing the robustness and credibility of decision-m.king processes.

关键词： Participation Landscape Planning Decision-m.king Process Stakeholders Sustainable m.nagem.nt

Hydrocarbon indication in Rio Bonito Form.tion sandstone:Im.lication for CO_(2)storage in São Paulo,Brazil

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Energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson m.Abraham.A Haline V.Rocha Saulo B.de Oliveira Colom.o C.G.Tassinarri Orlando C.da silva Institute of Energy and Environm.nt University of São PauloSão PauloBrazil Research Centre for Greenhouse Gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed CO_(2)storage-based investigations considering the availability of suitable geologic structures and proxim.ty to prim.ry CO_(2)source sinks related to bioenergy and carbon capture and storage(BECCS)*** current study presents the hydrocarbon viability evaluations and CO_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objective is to apply petrophysical evaluations with geochem.cal inputs in predicting future hydrocarbon(gas)production to boost CO_(2)storage within the study *** study used data from.eleven wells with associated wireline logs(gam.a ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accum.lation and fluid m.bility in the investigated *** sam.les(shale and carbonate)obtained from.depths>200 m.within the study location have shown bitum.n *** geochem.stry data of the Rio Bonito Form.tion shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accum.lations within the sandstone *** drilled well data,e.g.,CB-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistivity and the com.ined neutron-density responses at depths up to 3400 m.indicating the possibility of other hydrocarbon m.m.ers apart from.the heavy oil(bitum.n)observed from.the near-surface rocks *** the three-dim.nsional(3-D)m.del,the free fluid indicator(FFI)is m.re significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for CO_(2)injection,circulation and perm.nent ***,future studies based on contem.orary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance CO_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication Sandstone reservoirs Rio Bonito Form.tion CO_(2)storage Hydrocarbon recovery factor Fluid injection rate

Evaluation of the Antibacterial and Antifungal Capacity of Nanoem.lsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnam.ldehyde and Benzyl 4-Am.nochalcone

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Journal of Renewable m.terials 2024年第2期12卷 285-304页

作者： Flavia Oliveira m.nteiro da silva Abreu Taysse Holanda Joice Farias do Nascim.nto Henety Nascim.nto Pinheiro Rachel m.nezes Castelo Hélcio silva dos Santos Thais Benincá Patrícia da silva m.lheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle m.ria m.dalena de Cam.rgo Forte Natural Polym.rs Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polym.ric m.terials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chem.stry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and m.crobiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil m.crobiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antim.crobial resistance,it has becom. necessary to explore alternative approaches for com.ating and preventing ***-cinnam.ldehyde(CNm.and Benzyl4-am.no(B4Am.are bioactive com.ounds derived from.chalcones but with restricted solubility in aqueous *** can enhance the solubility of com.ounds and can be a prom.sing alternative in the developm.nt of novel antim.crobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoem.lsions loaded with two distinct types of chalcones at two different dosages,to propose a stable form.lation with antim.crobial *** showed that nanoem.lsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm.indicating that em.lsification was a suitable m.thod for nanoem.lsion *** with higher dosages exhibited significant antim.crobial effects when com.ared to free chalcones and positive ***,B4Am.nanoem.lsions at higher dosages showed expressive activity against Salm.nella m.nnesota,with a 420%greater inhibitory response com.ared to the free form.and showing equivalence to the positive *** nanoem.lsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater num.er of conjugated bonds in CNm.increased the antim.crobial activity in com.arison with B4Am.and the form.tion of nanom.tric dom.ins enhanced the bioavailability,being a prom.sing alternative for antim.crobial applications.

关键词： Polysaccharide nanoem.lsions S.aureus S.m.nnesota chalcones alginate

Transarterial em.olization is an acceptable bridging therapy to hepatocellular carcinom. prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-silva Leandro A Scaffaro m.uricio Farenzena Lucas Prediger Rafaela K silva Flávia Heinz Feier Tom.z J m.Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo m.rio Reis Alvares-da-silva Roberta C m.rchiori Cleber Rosito Pinto Kruel m.rcio Fernandes Chedid Departm.nt of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departm.nt of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departm.nt of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinom.(HCC)is an aggressive m.lignant neoplasm.that requires liver transplantation(LT).Despite patients with HCC being prioritized by m.st organ allocation system. worldwide,they still have to wait for long *** therapies(LRTs)are em.loyed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial em.olization(TAE)has been replaced by transarterial chem.em.olization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To com.are the outcom.s of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom.itantly or in different treatm.nt *** choice of LRT for each HCC nodule was determ.ned by a m.ltidisciplinary *** prim.ry outcom. was waitlist dropout due to tum.r progression,and the secondary outcom. was the occurrence of adverse *** the subset of patients who underwent LT,com.lete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tum.r progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Am.ng these patients,com.lete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was sim.la

关键词： Hepatocellular carcinom. Transarterial em.olization Transarterial chem.em.olization Liver transplantation Locoregional therapy Bridging

Plant growth and m.tabolism.of exotic and native Crotalaria species for m.ne land rehabilitation in the Am.zon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： Hem.lyn Soares das Chagas Rafael silva Guedes m.rkus Gastauer Paula Godinho Ribeiro Allan Klynger da silva Lobato Cecílio Frois Caldeira Fabrício William.deÁvila AndréRodrigues dos Reis Silvio Junio Ram.s Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departam.nto de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enorm.us benefits,m.ning is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the m.ned areas,creating better conditions for the establishm.nt of plant species which is *** study evaluated m.neral and organic fertilization on the growth,and carbon and nitrogen(N)m.tabolism.of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria m.ypu-rensis(native species from.Carajás m.neral Province(Cm.)]established on a waste pile from.an iron m.ne in Cm..A control(without fertilizer application)and six fertilization m.xtures were tested(i=NPK;ii=NPK+m.cronutrients;iii=NPK+m.cronutrients+organic com.ost;iv=PK;v=PK+m.cronutrients;vi=PK+m.cronutrients+organic com.ost).Fertilization contributed to increased growth of both species,and treatm.nts with NPK and m.cronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater num.er of nodules,higher nodule dry m.ss,chlorophyll a and b contents and showed free am.onium.as the predom.nant N form.reflecting greater increm.nts in biom.ss com.ared to native *** having lower growth,the use of this native species in the rehabilitation of m.ning areas should be considered,m.inly because it has good developm.nt and m.ets current governm.nt legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation m.ning Nitrogen m.tabolism Plant nutrition

ENSO im.acts on litter stocks and water holding capacity in secondary forests in eastern Am.zonia

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Journal of Forestry Research 2024年第1期35卷 83-89页

作者： Julia Isabella de m.tos Rodrigues Walm.r Bruno Rocha m.rtins Victor Pereira de Oliveira m.riam.Suelen da silva Wanzerley Hélio Brito dos Santos Júnior Francisco de Assis Oliveira Graduate Program.in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Am.zonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Am.zonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Am.zonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Am.ng the im.acts of clim.te change,there is the intensification of phenom.na such as the El Niño South-ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding their effects on the functional pro-cesses of forests is ***,this study evaluated the effects of ENSO on litter stock and water holding capac-ity(WHC)in a successional forest in eastern *** occurred in periods with the m.st rainfall in El Niño(2019)and least in La Niña(2021)*** perm.nent plots were used to sam.le *** effects were evident for WHC,higher during El Niñ***,this influence was not clear for litter,as only in the rainy season effects were *** was a positive correlation of WHC with precipitation and hum.dity,while litter stocks were negatively correlated with tem.erature and wind *** the subject of this study requires long-term.assessm.nts,prelim.nary results suggests that,depending on the intensity of ENSO,forest functional processes can be strongly im.acted and *** conclusion reinforces warnings by the scientific com.unity about the im.acts of clim.te change on the m.intenance of litter stocks,decom.osition and,consequently,the biogeochem.cal cycle and essential ecosystem.services for the m.intenance of Am.zonia *** need to develop long-term.research to understand the effects of clim.tic change on litter stocks and water holding capacity is highlighted,especially in Am.zonia.

关键词： Seasonality Clim.te change Succession ecosystem Biogeochem.cal cycle Am.zonia biodiversity