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国际医学放射学杂志 2022年第3期 367-368页

作者： D.Hy.n H.y.Lee J.H.Cho H.K.Kim y.S.choi J.Kim 孙素晔

摘要目的明确非增强MR淋巴管(结)成像(MRL)在治疗术后乳糜胸或颈部乳糜漏中的作用。方法 2016年5月—2020年4月间共有50例病人先后接受了非增强MRL和胸

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深海褐藻和益生菌制剂对断奶仔猪的生长性能、养分消化率、免疫指标和肠道健康的影响

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中国畜牧兽医 2016年第8期43卷 2214-2214页

作者： choi y.夏冰

本试验旨在研究深海褐藻、益生菌以及两者复合物对早期断奶仔猪生长性能和肠道健康的影响。试验选用240头平均体重为(7.04±0.23)kg的杜×长×大三元杂交断奶仔猪,分为4个处理组:对照组,饲喂基础日粮;EC组,在基础日粮中添加1.5g/kg深海... 详细信息

本试验旨在研究深海褐藻、益生菌以及两者复合物对早期断奶仔猪生长性能和肠道健康的影响。试验选用240头平均体重为(7.04±0.23)kg的杜×长×大三元杂交断奶仔猪,分为4个处理组:对照组,饲喂基础日粮;EC组,在基础日粮中添加1.5g/kg深海褐藻;PR组,在基础日粮中添加3.0g/kg发酵益生菌;ECP组,在基础日粮中添加1.5g/kg深海褐藻和3.0g/kg发酵益生菌,试验期分为2个阶段。结果表明,在第1、2阶段,EC、PR和ECP组仔猪的平均日增重(ADG)均升高,PR和EC组饲料利用率显著升高(P<0.05)。PR和EC组在2个试验阶段的干物质(DM)、总能(GE)和粗蛋白质(CP)消化率均显著提高(P<0.05)。PR和EC组的盲肠乳酸杆菌含量极显著升高(P<0.01),而在ECP组中大肠杆菌含量显著降低。EC组仔猪血清IgG、IgM和IgA水平显著升高(P<0.05),在第2阶段,深海褐藻与益生菌对于血液IgG水平有显著的互作效应。在EC和PR组中,十二指肠、空肠和回肠绒毛高度显著升高(P<0.05),而各处理对仔猪隐窝深度没有影响。以上结果表明,益生菌和深海褐藻均对断奶仔猪有益生作用,但二者没有互作效应。

关键词：深海褐藻益生菌生长性能肠道健康断奶仔猪

断奶前仔猪经胎盘感染猪圆环病毒2型对猪流行性腹泻病毒引起的肠炎的影响

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国外畜牧学（猪与禽） 2007年第2期27卷 51-53页

作者： K. Jung J. Kim y. Ha C. choi C. Chae 李春华（译）魏晓锋（译）汉城国立大学农业生物技术学院和兽医学院兽医病理系不详

本文报道了经胎盘感染猪圆环病毒2型对猪流行性腹泻病毒引起新生仔猪肠炎的影响。6头怀孕母猪被随机分为感染组和对照组,每组3头。感染组3头怀孕母猪在分娩前3周鼻内接种6mLPCV2组织培养毒(病毒含量为1.2×105TCID50/mL,毒株为SNUVR0004... 详细信息

本文报道了经胎盘感染猪圆环病毒2型对猪流行性腹泻病毒引起新生仔猪肠炎的影响。6头怀孕母猪被随机分为感染组和对照组,每组3头。感染组3头怀孕母猪在分娩前3周鼻内接种6mLPCV2组织培养毒(病毒含量为1.2×105TCID50/mL,毒株为SNUVR000470);对照组3头怀孕母猪同时接种正常细胞培养上清液。PCV2感染母猪所产的30头仔猪被随机分为A、B两组,每组15头;对照组非感染母猪所产的30头仔猪被随机分为C、D两组,每组15头。A和C组仔猪在3日龄口服2mLPEDV第3次传代病毒液(病毒含量为1×106.5TCID50/mL,毒株为SNUVR971496)。在感染后36、48和72h测量绒毛高度与隐窝深度的平均比值,A组PCV2感染母猪所产的仔猪感染PEDV与C组PCV2阴性母猪所产的仔猪感染PEDV差异显著。在感染后24h,A组PEDV感染仔猪的空肠组织中比C组检测到更多的PEDV核酸。此后,在感染后36、48、60和70h,C组PCV2阴性母猪所产的PEDV感染仔猪的空肠组织中比A组检测到更多的PEDV核酸。由此推断,经胎盘感染PCV2显著影响PEDV所致疾病的临床进程。

关键词：猪流行性腹泻病毒猪猪圆环病毒增强

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肝脏影像报告及数据系统:病人4和5类结节的预后

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国际医学放射学杂志 2018年第4期 471-472页

作者： S.H.choi J.H.By.n y.S.Lim S.J.Lee S.y.Kim H.J.Won 李彦橙 Department of Radiology.and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center

目的评估慢性肝病病人经基础治疗的预后情况,并回顾性分析肝脏影像报告和数据系统（LI-RADS;2014版）4类（LR-4）和5类（LR-5）结节的增强MR影像表现。材料与方法该回顾性研究包括260例经LI-RADS分类为LR-4（132例）或LR-5（128例）的... 详细信息

目的评估慢性肝病病人经基础治疗的预后情况,并回顾性分析肝脏影像报告和数据系统（LI-RADS;2014版）4类（LR-4）和5类（LR-5）结节的增强MR影像表现。材料与方法该回顾性研究包括260例经LI-RADS分类为LR-4（132例）或LR-5（128例）的小结节病人。病人在2012年1月—2012年12月间经Barcelona临床肝癌分期系统进行了结节切除、肝脏移植、射频消融（RFA）或经导管动脉化学栓塞术（TACE）治疗,并随访至2016年8月31日。比较LR-4和LR-5类病人局部肿瘤复发（ILR）及远处肿瘤复发的发生率（IDR）和复发生存率（RFS）。对每一类别,比较4种治疗方法的ILR、IDR、RFS。结果与LR-4类病人相比,LR-5类病人多采用手术切除治疗方案[分别为72.7%（93/128）和41.7%（55/132）;P<0.001],不采用RFA[分别为19.5%（25/128）和30.3%（40/132）;P=0.047]和TACE[分别为6.3%（8/128）和22.0%（29/132）;P<0.001]。LR-4和LR-5类病人治疗后的ILR和IDR差异均无统计学意义[0;8.3%（14/29）∶0;5.0%（2/8）,P≥0.423;0;5.2%（16/29）∶0;7.5%（3/8）,P≥0.447]。两类病人RFS差异无统计学意义（36.3个月∶41.7个月;P=0.084）。两类病人中经肝移植治疗者均无局部或远处肿瘤复发。在LR-4和LR-5病人中,与RFA和TACE治疗相比,肝切除病人具有较高的RFS、较低ILR和IDR。结论 LR-4类病人与LR-5类病人具有相似的ILR、LDR和RFS。4种基础治疗相比,肝脏移植和手术切除表现出更好的局部肿瘤控制能力,且其RFS要优于RFA或者TACE。

关键词：数据系统 LR

Design of new columns for capillary.electrochromatography.using a chiral stationary.phases with poly.accharide derivatives

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Design of new columns for capillary electrochromatography us...

Glide landmark detection using band-limited energy.ratio contours

30th International Sy.posium on Capillary.Chromatography.4th GC×GC Sy.posium、16th National Sy.posium and Exhibition on Chromatography.i.e. 1st Dalian International Sy.posium and Exhibition on Chromatography

作者： Oh,H.S. Kim,H.y. Bae,I.A. choi,S.H. Lee,K.P. Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.Graduate School Ky.ngpook National University Daegu 702-701Republic of Korea

＜正＞Capillary.electrochromatography.CEC）is hy.rid separation technique（combined advantages of both capillary.electrophoresis and HPLC）.It is an important technique in the pharmaceutical,agrichemical,and biomedical *** preparation of new chiral stationary.phases and their chromatographic behaviors are important methodology.in our research ***-based columns are popular for the direct separation of many.*** theses columns have good efficiency.and stability.under general chromatographic *** materials are very.useful for analy.ical and preparative scale enantioseparations.

关键词： HPLC Chiral stationary.phases Enantioseparation Pheny.carbamates Poly.accharides Silica gel

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Journal of Measurement Science and Instrumentation 2012年第4期3卷 352-356页

作者： Soojin Park Jeungy.on choi Honggoo Kang Dept.of Electrical and Electronic Engineering Yonsei University

A detection sy.tem for American English glides/w y.r 1] in a knowledge-based automatic speech recognition sy.tem is presented. The method uses detection of dips in band-limited energy.to total energy.ratios, instead of detecting dips along the unmodified band-limited energy.contours. By.using band-limited energy.ratio, the dip detection is applicable in not only.intervocalic regions but also in non-intervocalic regions. A Gaussian mixture model（GMM） based classifier is then used to separate the detected vowels and nasals. This approach is tested using the TIMIT corpus and results in an overall detection rate of 69.5 %, which is a 4.7 % absolute increase in detection rate compared with an hidden Markov model （HMM） based phone recognizer.

关键词： landmarks glide detection knowledge-based speech recognition

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韩国CADASIL特征:一种新的保留半胱氨酸的Notch3基因突变

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 58-59页

作者： Kim y.choi E.J choi C.G J.S. Kim 郭俊 Department of Neurology. Asan Medical Center 388-1 Pungnap-dong Songpa-gu Seoul 138-736 South Korea Dr.

OBJECTIVE: To elucidate the phenoty.e, genoty.e, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy.with subcortical infarcts and leukoencephalopathy.(CADASIL) and mutation carriers. METHODS: The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analy.is of Notch3, clinical and MRI findings were correlated in 27 mutation carriers. RESULT: Notch3 mutation sites were C174R (one family. n = 3), R133C (one family. n = 3), R587C (one family. n = 1), R544C (two families, n = 5), and R75P (four families, n = 15). The clinical features were ty.ical of CADASIL, but the frequency.of migraine in the Korean population appears low. MRI abnormalities were found in 54%of the mutant carriers, the most common being white matter hy.erintensities. The prevalence of lacunes and microbleeds increased with patient age. Anterior temporal areas were less often involved in subjects with R75P mutations than in those where mutations occurred in other sites (p = 0.02). Gradient echo imaging identified microbleedings in 33%of mutation carriers (64%of those with abnormal MRI), whereas diffusion weighted MRI showed abnormal findings in only.one patient. Neurologic disability.was related to the number of lacunar infarcts and the lesion volume of white matter hy.erintensities (p y.with subcortical infarcts and leukoencephalopathy.(CADASIL) mutation carriers show similar clinical and MRI findings, these abnormalities appear less frequently.than in other populations. Relatively.frequent microbleedings on gradient echo imaging suggest that treatment should be individualized according to MRI findings. The novel mutation of R75P, not involving a cy.teine residue, is related to less frequent involvement of the anterior temporal area, thus broadening the spectrum of CADASIL.

关键词： CADASIL Notch3 基因突变点突变半胱氨酸解毒药韩国

Sy.thesis of the CSP based on cellulose with crown ether group for capillary.chromatography

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Synthesis of the CSP based on cellulose with crown ether gro...

磁共振胰管成像:比较二维和三维成像序列对胰腺导管内乳头状黏液性肿瘤的评估能力

作者： Bae,I.A. Oh,H.S. Kim,H.y. choi,S.H. Lee,K.P. Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.BK 21 NanoBiosensor Research Team Hannam UniversityDaejeon 305-811Republic of Korea Department of Chemistry.Graduate School Ky.ngpook National University Daegu 702-701Republic of Korea

＜正＞Poly.accharides are the most abundant optically.active poly.ers on the earth and can be easily.modified to carbamate group through the reaction with isocy.nate *** carbamate group-modified poly.accharide can be used the CSP for enantioseparation of chiral *** this study.we firstly.prepared the CSP based on cellulose with crown ether group by.reaction of cellulose and 4-isocy.natebenzo-15-crown-5,which is prepared by.reaction of 4-aminobenzo-15-crown-5 and *** obtained CSP with crown ether group was characterized by.FT-IR,13C-NMR and element *** order to compare enantioseparation efficiency.of the CSP with crown ether group and that of commercial CHIRALCEL OD with pheny. group,cellulose tris（3,5-dimethy.pheny. carbamate）was also prepared according to Okamoto *** enantioseparation of chiral compounds including chiral drugs and amino acid is in progress.

关键词： Poly.accharides Enantioseparation Chiral compounds CSP Crown ether Cellulose

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国际医学放射学杂志 2009年第6期 594-595页

作者： J.y.choi J.M.Lee M.W.Lee S.J.Kim S.y.choi J.y.Kim 廖承德 Department of Radiology Research Institute of Radiological ScienceYonsei University Health SystemSeodaemun-ku Shinchon-dong 134Seoul120-752Korea

研究目的是比较二维(2D)磁共振胰管成像(MRP)与三维(3D)MRP对于胰腺导管内乳头状黏液性肿瘤(IPMN)的评估能力。34例病人(男性22例,女性12例;年龄45～80岁)罹患IPMN(n=40),同时接受2D和3D MRP序列扫描。2名医师独立阅片并对整体影像质量、

关键词：胰腺导管内乳头状黏液性肿瘤 MRP 胰管胰腺管 IPMN 磁共振

Single patient classifier as a prognostic biomarker in pT1N1 gastric cancer:Results from two large Korean cohorts

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Chinese Journal of Cancer Research 2021年第5期33卷 583-591页

作者： y.on y.ung choi Eunji Jang Hy.nki Kim Ky.ung-Mee Kim Sung Hoon Noh Tae Sung Sohn y.ng-Min Huh Ji y.ong An Jae-Ho Cheong Department of Surgery CHA Ilsan Medical CenterCHA University School of MedicineGoyang-si 1205Korea Department of Surgery Yonsei University Health SystemSeoul 03722Korea Department of Radiology Yonsei University Health SystemSeoul 03722Korea Department of Pathology Yonsei University Health SystemSeoul 03722Korea Department of Pathology.and Translational Genomics Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea y.HS-KRIBB Medical Convergence Research Institute Seoul 03722Korea Brain Korea 21 PLUS Project for Medical Science Yonsei University College of MedicineSeoul 03722Korea

Objective:Benefits of adjuvant treatment in pT1 N1 gastric cancer(GC)remain ***,an effective biomarker for early.GC is the need of the *** prognostic and predictive roles of single patient classifier(SPC)were validated in stageⅡ/Ⅲ*** this study.we aimed to elucidate the role of SPC as a biomarker for pT1 N1 ***:The present retrospective biomarker study.NCT03485105)enrolled patients treated for pT1 N1 GC between 1996 and 2012 from two large hospitals(the y.cohort and S cohort).For SPC,mRNA expression of four classifier genes(GZMB,WARS,SFRP4 and CDX1)were evaluated by.real-time reverse transcription-poly.erase chain reaction *** SPC was revised targeting pT1 stages and the prognosis was stratified as high-and lowrisk group by.the expression of SFRP4,a representative epithelial-mesenchy.al transition ***:SPC was evaluated in 875 patients(n=391 and 484 in the y.and S cohorts,respectively..Among 864 patients whose SPC result was available,41(4.7%)patients experience GC *** to revised SPC,254(29.4%)patients were classified as high risk[123(31.5%)and 131(27.1%)in the y.and S cohorts,respectively..The high risk was related to frequent recurrence in both y.and S cohort(log-rank P=0.023,Py.,while there was no difference by.GZMB and WARS *** analy.es of the overall-cohort confirmed the high risk of revised SPC as a significant prognostic factor[hazard ratio(HR):4.402(2.293-8.449),Py.SPC in the prognosis of patients in the presence and absence of adjuvant treatment(log-rank P=0.670).Conclusions:The present study.revealed the revised SPC as a prognostic biomarker of pT1 N1 GC and suggested the use of the revised SPC for early.stage GC as like stageⅡ/Ⅲ.

关键词： Gastric cancer biomarker prognosis chemotherapy

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