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Microbia. Degra.a.ion of Orga.ic Conta.ina.ts in Strea.bed/Floodpla.n Sediments in Pa.sa.c River—New Jersey a.ea

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a.erica. Journa. of a.a.ytica. Chemistry 2024年第4期15卷 139-150页

作者： Ta.eim Eva.s English Megha.n Trombetta.alyssa Beres Yusuf Yildiz Depa.tment of Science Manchester Regional High School Haledon USA Depa.tment of Ea.th a.d Science Montclair University Montclair USA

This pa.er is intended to explore soil orga.ic ma.ter a.d ca.bon isotope fra.tiona.ion a. three loca.ions of the Pa.sa.c River to determine if microbia. degra.a.ion of orga.ic conta.ina.ts in soil is correla.ed to the surrounding physica. environment. Microbia. degra.a.ion of orga.ic conta.ina.ts is importa.t for the detoxifica.ion of toxic substa.ces thereby minimizing sta.na.ion in the environment a.d a.cumula.ing in the food cha.n. Since orga.ic conta.ina.ts a.e not ea.ily dissolved in wa.er, they will penetra.e sediment a.d end up enriching the a.ja.ent soil. The hypothesis tha. we a.e testing is microbia. a.tivity a.d ca.bon isotope fra.tiona.ion will be grea.er in preserved soils tha. urba. soils. The rea.on why this is expected to be the ca.e is the expecta.ion of higher microbia. a.tivity in preserved environments due to less exposure to polluta.ts, better soil structure, higher orga.ic ma.ter content, a.d more fa.ora.le conditions for microbia. growth. This is contra.ted with urba. soils, which a.e impa.ted by polluta.ts a.d disturba.ces, potentia.ly inhibiting microbia. a.tivity. We wish to collect soil sa.ples a.ja.ent to the Pa.sa.c River a. a.pristine loca.ion, Grea. Swa.p Wildlife Refuge, a.suburba. loca.ion, Goffle Brook Pa.k, Ha.thorne NJ, a.d a. urba. loca.ion, Pa.erson NJ. These soil sa.ples will be weighed for soil orga.ic ma.ter (SOM) a.d weighed for isotope ra.io ma.s spectrometry (IRMS) to test orga.ic ca.bon isotopes. High SOM a.d δ13C depletion a.tivity indica.e microbia. growth ba.ed on the cha.a.teristics of the soil horizon ra.her tha. the loca.ion of the soil sa.ple which results in degra.a.ion of orga.ic compounds.

关键词： Orga.ic Conta.ina.t PCBs Microbia. Degra.a.ion Pa.sa.c River

Conserva.ive ma.a.ement of spina. pa.hology with a.tologous conditioned serum: a.systema.ic review of the litera.ure

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World Journa. of Orthopedics 2024年第9期15卷 870-881页

作者： Christia. J Ra.kovic Ma.thew L Merckling alyssa W Lee Ga.a.u Suba. a.ya. Ma.hotra.Za.ha.y D Thoma. Sa.rina.L Zeller John V Wa.nwright Merritt D Kinon Depa.tment of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

Ba.KGROUND Chronic infla.ma.ory pa.n is a.socia.ed with increa.ed expression of interleukin(IL)-1,a. infla.ma.ory cytokine,a.d a.tivity on its receptor(IL-1R).In response,the body produces IL-1R a.ta.onist(IL-1Ra.to reduce this *** conditioned serum(a.S)is the only biologic thera.y for spina. pa.hologies tha. enha.ces the a.tion of endogenous IL-1Ra.reserves to improve *** systema.ic review investiga.es the effectiveness of a.S in trea.ing pa.n a.d dis-a.ility ca.sed by spina. *** To eva.ua.e the use of a.S a. a.conserva.ive ma.a.ement option for spina. *** a.systema.ic review of PubMed/Medline wa. performed to identify studies inve-stiga.ing a.ministra.ion of a.S for trea.ment of a.y spina. *** Six a.ticles were included,comprising 684 pa.ients trea.ed with epidura.(n=133)or tra.sfora.ina.(n=551)a.S *** ha. a. a.era.e a.e of 54.0 yea.s with slight fema.e predomina.ce(53.2%).The lumba. spine wa. most com-monly trea.ed,with 567 pa.ients(82.9%)receiving injections for lumba. ra.icu-lopa.hy(n=67),degenera.ive disc disea.e(DDD)(n=372),or spina. stenosis(n=128);cervica. injections were performed in 109 pa.ients(15.9%).Mea.(SD)follow-up wa. 21.7(4.8)weeks from first a.S *** studies investiga.ing mecha.nica. lumba. a.d lumba. or cervica. ra.icula. pa.n reported significa.t pa.n re-duction a. fina. follow-up compa.ed to *** a.hieved compa.a.le or su-perior results to lumba. epidura. steroid *** events were reported in 21 pa.ients(3.1%),with no serious a.verse *** a.S injection is a.sa.e a.d effective intervention for pa.n reduction in ma.y spina. pa.hologies,including cervica. a.d lumba. ra.iculopa.hies.

关键词： Spine a.tologous conditioned serum Orthokine Regenokine Epidura. steroid injection Interleukin-1 Inter-leukin-1 receptor a.ta.onist

Occult Hepa.itis C Virus Infection:a.Review

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Journa. of Clinica. a.d Tra.sla.iona. Hepa.ology 2018年第2期6卷 155-160页

作者： alyssa a.stria.George Y.Wu Division of Ga.troenterology-Hepa.ology Department of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA

Occult hepa.itis C virus(HCV)infection(OCI),first described in 2004,is defined a. the presence of HCV RNa.in hepa.ocytes or periphera. blood mononuclea. cells without detecta.le HCV RNa.in the ***,we a.med to review the epidemiology,dia.nostic methods,clinica. implica.ions a.d potentia. ma.-a.ement recommenda.ions currently described in the litera.ture,a. well a. the future directions for investiga.ion of this *** a.d Cochra.e da.a.a.es were sea.ched with combina.ion of the following keywords:"occult","hepa.itis C virus",a.d"occult HCV infection".There a.e da.a.to support OCI a. a.potentia. culprit in cryptogenic liver *** a.e a.so consistent da.a.demonstra.ing the existence of OCI in specific popula.ions,such a. dia.ysis,huma. immunodefi-ciency virus-infected a.d hepa.itis B virus-infected pa.ients,a.d a.so in the genera. *** the gold sta.da.d for dia.nosis is liver biopsy,exa.ina.ion of periphera. blood mononuclea. cells ma. be a.relia.le,sa.er a.terna.ive method of *** HCV infection is likely a.socia.ed with liver fibrosis a.d progression of liver *** studies a.e required to determine the infectivity of OCI pa.ients,a. well a. cla.ify the na.ura. course a.d specific clinica. implica.ions of ***,studies a.e needed to determine whether trea.-ment of OCI lea.s to decrea.ed morbidity a.d/or morta.ity.

关键词： Occult hepa.itis C virus OCI HCV infection

Reproductive beha.ior in horseshoe cra.s:Does density ma.ter?

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Current Zoology 2010年第5期56卷 634-642页

作者： Jennifer H.Ma.TEI Ma.k a.BEEKEY a.a. RUDMa. alyssa WORONIK Depa.tment of Biology Sacred Heart University Depa.tment of Biology Southern Connecticut State University

While the four species of horseshoe cra.s sha.e ma.y common reproductive tra.ts with respect to their reproductive systems, they do differ with respect to their ma.ing beha.ior （monoga.y vs. polygyna.dry）. Pa.t resea.ch ha. a.tributed these differences to a.number of fa.tors including： spa.ning densities, opera.iona. sex ra.ios （OSR＇s）, ma.e condition （or a.e）, environmenta. a.d/or genetic fa.tors, or a.combina.ion thereof. Ma.ing beha.iors in the three a.ia. horseshoe cra. species （Ta.hy-pleus giga., T. tridenta.us, a.d Ca.cinoscorpius rotundica.da. with low spa.ning densities a.d 1：1 opera.iona. sex ra.ios a.e typica.ly monoga.ous. In Limuluspolyphemus, ma.ing beha.ior is more va.ia.le ra.ging fi＇om monoga.y to polygyna.dry. Here we provide evidence, through a.long term beha.iora. study, tha. va.ia.ion in ma.ing beha.ior is influenced by popula.ion density in L. polyphemus. Our study popula.ion on two bea.hes in Connecticut （Long Isla.d Sound） ha.e a.spa.ning density 400 times less tha. tha. found in Dela.a.e Ba. （0.002 fema.es/m2 vs. 0.8 fema.es/m2） but simila. opera.iona. sex ra.ios. Between 90%-95% of a.l spa.ning fema.es in CT were pa.red with only one ma.e, thus exhibiting monoga.ous beha.ior. In contra.t, between 30 a.d 60% of spa.ning fema.es in Dela.a.e Ba. ha.e more tha. one ma.e a.d produce clutches of eggs with multiple pa.ernities. Ma.e condition pla.ed no role in ma.ing beha.ior in CT popula.ions. We a.so observed tha. on a.era.e 18% of the fema.es on the spa.ning bea.hes a.e single. These results suggest tha. popula.ion density is a. importa.t condition tha. determines ma.ing beha.ior. a.so, low popula.ion density ma. lea. to decrea.ed ma.e finding a.ility a.d lost opportunities for spa.ning

关键词： Limulus Ma.ing beha.ior Popula.ion density Monoga.y Polygyna.dry

Ontogenetic shifts in perceptions of sa.ety a.ong structura. complexity gra.ients in a.territoria. da.selfish

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Current Zoology 2019年第2期65卷 183-188页

作者： Yinny CHa. Sa.a.LO alyssa QUa. Da.iel T. BLUMSTEIN Depa.tment of Ecology a.d Evolutiona.y Biology University of California Los Angeles CA USA

a.e a.d body size ca. influence preda.ion risk a.d hence ha.ita. use. Ma.y species undergo ontogenetic shifts in ha.ita. use a. individua.s grow la.ger a.d ha.e different a.e-specific preda.ion pressures. On cora. reefs, a.number of fish species a.e more tolera.t of threa.s in structura.ly complex ha.ita.s tha. conta.n more refuges tha. in less structura.ly complex ha.ita.s. However, we do not know how risk perception va.ies with a.e, a.d whether a.e intera.ts with ha.ita. complexity. a.ults a.d juveniles, beca.se of their size, ma. fa.e different risks in structura.ly simple versus complex ha.ita.s. We used flight initia.ion dista.ee a. a.metric to a.a.yze perceptions of risk in a.species of da.selfish Stega.tes nigrica.s. a.l else being equa., fish fleeing a. grea.er dista.ces a.e inferred to perceive higher risk. We ta.geted juvenile a.d a.ult da.selfish to a.sess whether there a.e ontogenetic shifts in perceptions of sa.ety in rela.ion to structura. complexity, inferred ba.ed on percent cora. cover a.d rugosity. We found tha. a.ult da.selfish tolera.ed closer a.proa.h in more complex ha.ita.s a. mea.ured by percent cora. cover, but not rugosity, wherea. juvenile fish a.wa.s a.lowed closer a.proa.h tha. a.ult fish rega.dless of complexity. This ontogenetic shift in ha.ita. use ma. result from juvenile fish ta.ing bigger risks to ma.imize growth, wherea. older a.ima.s, who a.e closer to their ma.imum body size, ca. a.ford to ta.e fewer risks a.d protect their a.sets.

关键词： Stega.tes nigrica.s ha.ita. complexity risk a.sessment ontogenetic shifts a.tipreda.or beha.ior flight initia.ion dista.ee

a.ricultura. growing sea.on ca.enda.s derived from MODIS surfa.e reflecta.ce

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Interna.iona. Journa. of Digita. Ea.th 2015年第3期8卷 173-197页

作者： alyssa K.Whitcra.t Inba. Becker-Reshef Christopher O.Justice Depa.tment of Geogra.hica. Sciences University of MarylandCollege ParkMDUSA

In order to secure the necessa.y ima.e a.quisitions for globa. a.ricultura. monitoring a.plica.ions,we must first a.ticula.e Ea.th observa.ion(EO)requirements for diverse a.ricultura. la.dsca.es a.d cropping *** to this ta.k is the identifica.ion of a.ricultura. growing sea.on timing a. a.mea.ingful spa.ia. sca.e,so a. to better define the necessa.y periods of ima.e *** this end,10 yea.s of MODIS Terra.Surfa.e Reflecta.ce ima.ery ha.e been used to determine phenologica. tra.sition da.es including sta.t of sea.on,pea. period,a.d end of sea.on a. 0.5°*** is the first set of globa.,sa.ellite-derived,cropla.d-specific ca.enda. da.es for ma.or field crops within a.0.5°,herein ca.led a.ricultura. growing sea.on ca.enda.s Prelimina.y compa.ison a.a.nst ground-ba.ed crop-specific ca.enda.s is performed,highlighting the utility of this a.proa.h for a.ticula.ing growing sea.on timing a.d its intera.nua. a.d within-region *** resea.ch provides critica. inputs for defining the EO requirements for the Globa. a.ricultura. Monitoring initia.ive(GEOGLa.),a. effort by the Group on Ea.th Observa.ions(GEO)to synergize existing na.iona. a.d regiona. observa.ion systems for improved a.ricultura. production a.d food security monitoring.

关键词： a.riculture vegeta.ion indices Ea.th observa.ion da.a.a.quisition remote sensing

Da.ly genetic profiling indica.es Ja./STa. signa.ing promotes ea.ly hepa.ic stella.e cell tra.sdifferentia.ion

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World Journa. of Ga.troenterology 2010年第40期16卷 5047-5056页

作者： a.hley M La.ner Ca.hy C Moore alyssa a.Gulledge La.ra.W Schrum Depa.tment of Biology University of North Carolina at Charlotte Digestive a.d Meta.olic Disorders La.ora.ory Carolinas Medical Center

a.M: To identify signa.ing pa.hwa.s a.d genes tha. initia.e a.d commit hepa.ic stella.e cells (HSCs) to tra.sdifferentia.ion. METHODS: Prima.y HSCs were isola.ed from ma.e Spra.ue-Da.ley ra.s a.d cultured on pla.tic for 0-10 d. Gene expression wa. a.sessed da.ly (quiescent to da. 10 culture-a.tiva.ion) by rea. time polymera.e cha.n rea.tion a.d da.a.clustered using a.a.a.softwa.e. The significa.ce of Ja./STa. signa.ing to HSC tra.sdifferentia.ion wa. determined by trea.ing cells with a.Ja.2 inhibitor. RESULTS: Genetic cluster a.a.yses, ba.ed on expression of these 21 genes, showed simila. expression profiles on da.s 1-3, da.s 5 a.d 6, a.d da.s 7-10, while freshly isola.ed cells (da. Q) a.d da. 4 cells were genotypica.ly distinct from a.y of the other da.s. a.ditiona.ly, gene expression clustering revea.ed strong upregula.ion of interleukin-6, Ja.2 a.d STa.3 mRNa.in the ea.ly sta.es of a.tiva.ion. Inhibition of the Ja./STa. signa.ing pa.hwa. impeded the morphologica. tra.sdifferentia.ion of HSCs which correla.ed with decrea.ed mRNa.expression of severa. profibrotic genes including colla.ens, α-SMa. PDGFR a.d TGFβR. CONCLUSION: These da.a.demonstra.e unique clustered genetic profiles during the da.ly progression of HSC tra.sdifferentia.ion a.d tha. Ja./STa. signa.ing ma. be critica. in the ea.ly sta.es of tra.sdifferentia.ion.

关键词： Cluster a.a.ysis Fibrosis Genetic profile Hepa.ic stella.e cell Interleukin-6

ezQTL:a.Web Pla.form for Intera.tive Visua.iza.ion a.d Coloca.iza.ion of QTLs a.d GWa. Loci

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Genomics, Proteomics & Bioinforma.ics 2022年第3期20卷 541-548页

作者： Tongwu Zha.g alyssa Klein Jia. Sa.g Jiyeon Choi Kevin M.Brown Division of Ca.cer Epidemiology a.d Genetics National Cancer InstituteBethesdaMD 20892USA

Genome-wide a.socia.ion studies(GWa.)ha.e identified thousa.ds of genomic loci a.socia.ed with complex disea.es a.d tra.ts,including *** va.t ma.ority of common tra.ta.socia.ed va.ia.ts identified via.GWa. fa.l in non-coding regions of the genome,posing a.cha.lenge in elucida.ing the ca.sa. va.ia.ts,genes,a.d mecha.isms *** qua.tita.ive tra.t locus(eQTL)a.d other molecula. QTL studies ha.e been va.ua.le resources in identifying ca.dida.e ca.sa. genes from GWa. loci through sta.istica. coloca.iza.ion *** QTL coloca.iza.ion is becoming a.sta.da.d a.a.ysis in post-GWa. investiga.ion,a. ea.y web tool for users to perform forma. coloca.iza.ion a.a.yses with either user-provided or public GWa. a.d eQTL da.a.ets ha. been ***,we present ezQTL,a.web-ba.ed bioinforma.ic a.plica.ion to intera.tively visua.ize a.d a.a.yze genetic a.socia.ion da.a.such a. GWa. loci a.d molecula. QTLs under different linka.e disequilibrium(LD)pa.terns(1000 Genomes Project,UK Bioba.k,or user-provided da.a..This a.plica.ion a.lows users to perform da.a.qua.ity control for va.ia.ts ma.ched between different da.a.ets,LD visua.iza.ion,a.d two-tra.t coloca.iza.ion a.a.yses using two sta.e-of-the-a.t methodologies(eCa.Ia. a.d HyPrColoc),including ba.ch *** is a.free a.d publicly a.a.la.le cross-pla.form web tool,which ca. be a.cessed online a. https://***/ezqtl.

关键词： Genome-wide a.socia.ion study Expression qua.tita.ive tra.t locus Coloca.iza.ion Linka.e disequilibrium Visua.iza.ion

Effects of hea.thy a.ing on huma. prima.y visua. cortex

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Hea.th 2012年第9期4卷 695-702页

作者： alyssa a. Brewer Bria. Ba.ton Depa.tment of Cognitive Sciences University of California Irvine USA

a.ing often results in reduced visua. a.uity from cha.ges in both the eye a.d neura. circuits [1-4]. In norma.ly a.ing subjects, prima.y visua. cortex ha. been shown to ha.e reduced responses to visua. stimula.ion [5]. It is not known, however, to wha. extent a.ing a.fects visua. field repre-senta.ions a.d popula.ion receptive sizes in huma. prima.y visua. cortex. Here we use func-tiona. MRI (fMRI) a.d popula.ion receptive field (pRF) modeling [6] to mea.ure a.gula. a.d ec-centric retinotopic representa.ions a.d popula.ion receptive fields in prima.y visua. cortex in hea.thy a.ing subjects a.es 57 - 70 a.d in hea.thy young volunteers a.es 24 - 36 (n = 9). Retinotopic stimuli consisted of bla.k a.d white, drifting checkerboa.ds comprising moving ba.s 11 deg in ra.ius. Prima.y visua. cortex (V1) wa. clea.ly identifia.le a.ong the ca.ca.ine sulcus in a.l hemispheres. There wa. a.significa.t decrea.e in the surfa.e a.ea.of V1 from 0 to 3 deg eccentricity in the a.ing subjects with respect to the young subjects (p = 0.039). The coherence of the fMRI% BOLD modula.ion wa. significa.tly decrea.ed in the a.ing subjects compa.ed to the young subjects in the more periphera. eccentricity ba.d from 7 to 10 deg (p = 0.029). Fina.ly, pRF sizes were significa.tly increa.ed within the 0 to 3 deg fovea. representa.ion of V1 in the a.ing subjects compa.ed to the young subjects (p = 0.019). Understa.ding the extent of cha.ges tha. occur in prima.y visua. cortex during norma. a.ing is essentia. both for understa.ding the norma. a.ing process a.d for compa.isons of hea.thy, a.ing subjects with a.ing pa.ients suffering from a.e-rela.ed visua. a.d cortica. disorders.

关键词： a.ing Vision Visua. Field Ma.ping Popula.ion Receptive Field Modeling