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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

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世界胃肠病学杂志:英文版 2023年第33期29卷 4942-4961页

作者： Joyce Wing Yan Mak alvin Wing Hin Law kimmy Wan Tung Law Rita Ho Carmen ka Man Cheung Man Fai Law Department of Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China West Island School Hong Kong 852China Department of Medicine North District HospitalHong Kong 852China

Hepatitis due to hepatitis B virus(HBV)reactivation can be serious and potentially fatal,but is *** reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell *** with inactive and even resolved HBV infection still have persistence of HBV genomes in the *** expression of these silent genomes is controlled by the immune *** or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved HBV ***,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core *** found to be positive for HBsAg should be given prophylactic antiviral *** patients with resolved HBV infection,there are two *** first is pre-emptive therapy guided by serial HBV DNA monitoring,and treatment with antiviral therapy as soon as HBV DNA becomes *** second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell *** and tenofovir are the preferred antiviral *** new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with HBV *** there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in HBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell *** studies are needed to determine the risk o

关键词： Hepatitis B Hematologic neoplasms Chimeric antigen receptor-T cell therapy Monoclonal antibodies Bruton’s tyrosine kinase inhibitors Antiviral agents

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Quantum hydrogen tunneling promoting halogen-atom and group transfer chemistry

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绿色合成与催化(英文) 2023年第3期4卷 187-189页

作者： Xiao Xiao Yi-Ping Yao Biao Chen Chuan Xiang alvin Tan Fen-Er Chen Institute of Pharmaceutical Science and Technology Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Department of Chemistry National University of Singapore3 Science Drive 3117543Singapore Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

A quantum-hydrogen-tunneling-controlled halogen-atom and group transfer strategy has been successfully developed to generate carbon radicals by using the substituted cyclohexadiene as the abstractor under mild photochemical conditions,in which alkyl and aryl halides as well as numerous alcohol and thiol analogues can be *** investigation unveiled that this process is inhibited from thermodynamic and kinetic effects but is rendered successful through quantum tunneling.

关键词： Quantum hydrogen tunneling Halogen-atom and group transfer Carbon radicals Substituted cyclohexadiene Photocatalysis

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Burning magnesium in carbon dioxide for highly effective phosphate removal

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Carbon Energy 2021年第2期3卷 330-337页

作者： Ying Yao Lei Yu Meiling Wang alvin Dai Yan Zhang Qiubo Guo Yulin Lin JianguoWen Feng Wu Xiulei Ji Jun Lu School of Materials Science and Engineering Beijing Key Laboratory of Environmental Science and EngineeringBeijing Institute of TechnologyBeijingChina Center for Nanoscale Materials Argonne National LaboratoryLemontIllinois Chemical Sciences and Engineering Division Argonne National LaboratoryLemontIllinois Department of Chemistry Oregon State UniversityCorvallisOregon

Magnesium oxide was found to have high-phosphate-affinity as an effective component to enhance the phosphate removal ability of common adsorbent ***,the currently prepared MgO-based hybrid adsorbents by conventional methods still suffer from the limited low loading of MgO and inferior removal performances,much far away from practical *** this study,an ingenious carbon coated MgO nanocomposite is designed by directly burning magnesium in CO_(2),a well-known textbook reaction.X-ray diffraction analysis,scanning electron microscope and aberration-corrected high-resolution transmission electron microscope demonstrate the sample is well ***,the high content of nanosized MgO combined with defect-rich carbon layer brings unprecedented phosphate removal capacity of 1135.0 mg/g,removal rate of 99% and benign compatibility with coexisting anions and solution ***,the removal mechanism is also investigated in detail by characterizing the sample before and after adsorption.

关键词： carbon dioxide carbon layer magnesium oxide nanocomposite phosphorus removal

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Search of inhibitors of aldose reductase for treatment of diabetic cataracts using machine learning

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Advances in Ophthalmology Practice and Research 2023年第4期3卷 187-191页

作者： Trevor Chen Richard Chen alvin You Valentina L.kouznetsova Igor F.Tsigelny MAP Program University of CaliforniaSan DiegoLa JollaCAUSA San Diego Supercomputer Center University of CaliforniaSan DiegoLa JollaCAUSA CureScience Institute San DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoLa JollaCAUSA

Purpose:Patients with diabetes mellitus have an elevated chance of developing cataracts,a degenerative visionimpairing condition often needing *** process of the reduction of glucose to sorbitol in the lens of the human eye that causes cataracts is managed by the Aldose Reductase Enzyme(AR),and it is been found that AR inhibitors may mitigate the onset of diabetic *** exists a large pool of natural and synthetic AR inhibitors that can prevent diabetic complications,and the development of a machine-learning(ML)prediction model may bring new AR inhibitors with better characteristics into clinical ***:Using known AR inhibitors and their chemical-physical descriptors we created the ML model for prediction of new AR *** predicted inhibitors were tested by computational docking to the binding site of ***:Using cross-validation in order to find the most accurate ML model,we ended with final cross-validation accuracy of 90%.Computational docking testing of the predicted inhibitors gave a high level of correlation between the ML prediction score and binding free ***:Currently known AR inhibitors are not used yet for patients for several *** think that new predicted AR inhibitors have the potential to possess more favorable characteristics to be successfully implemented after clinical *** new inhibitors can improve patient well-being and lower surgical complications all while decreasing long-term medical expenses.

关键词： Diabetic cataracts Aldose reductase inhibitor Machine learning Deep learning

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在线博物馆珠宝展览会是否会增强对奢侈品的评价——以印度尼西亚为案例研究

在线博物馆珠宝展览会是否会增强对奢侈品的评价——以印度尼西亚...

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作者： alvin Edbert 北京外国语大学

学位级别：硕士

这项研究的目的是探讨博物馆珠宝陈列对奢侈品的感知和消费者反应的影响:购买意向,咨询意向,在另一个网站上搜索以及重新访问该产品的意向。基于Maria等人(2019)的关于博物馆学商品展示的研究提高了奢侈品的产品评价,我建议在印度尼西... 详细信息

这项研究的目的是探讨博物馆珠宝陈列对奢侈品的感知和消费者反应的影响:购买意向,咨询意向,在另一个网站上搜索以及重新访问该产品的意向。基于Maria等人(2019)的关于博物馆学商品展示的研究提高了奢侈品的产品评价,我建议在印度尼西亚的在线商店或电子商务中,将博物馆学商品展示格式应用于珠宝。本文对113位女性受访者和78位男性受访者进行了两个实验,以测试拟议的研究框架。Hayes的配对T检验,线性回归和中介检验用于假设和中介效应检验。在两个实验中,博物馆学展示格式的表现优于非博物馆学产品展示。消费者展示了更高的购买意愿,咨询意向,在另一个网站上的搜索意向,以及通过首先被认为商品更豪华的过程来重新访问的意图。调解员的间接影响对于所有因变量都非常重要。这项研究的结果鼓励在线奢侈品零售商使用博物馆展示形式来吸引消费者。

关键词：博物馆学展示格式奢华感网上零售

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Epidural electrical stimulation for spinal cord injury

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Neural Regeneration Research 2021年第12期16卷 2367-2375页

作者： Elliot H.Choi Sandra Gattas Nolan J.Brown John D.Hong Joshua N.Limbo alvin Y.Chan Michael Y.Oh Department of Pharmacology School of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Ophthalmology Gavin Herbert Eye InstituteSchool of MedicineUniversity of CaliforniaIrvineCAUSA Department of Neurosurgery University of CaliforniaIrvineCAUSA

A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal *** advances in clinical management of spinal cord injury have significantly improved the prognosis,survival rate and quality of life in patients with spinal cord *** addition,a significant progress in basic science research has unraveled the underlying cellular and molecular events of spinal cord *** efforts enabled the development of pharmacologic agents,biomaterials and stem-cell based *** these efforts,there is still no standard care to regenerate axons or restore function of silent axons in the injured spinal *** challenges led to an increased focus on another therapeutic approach,namely *** multiple animal models of spinal cord injury,epidural electrical stimulation of the spinal cord has demonstrated a recovery of motor *** evidence regarding the efficacy of epidural electrical stimulation has further expanded the potential of epidural electrical stimulation for treating patients with spinal cord ***,most clinical studies were conducted on a very small number of patients with a wide range of spinal cord ***,subsequent studies are essential to evaluate the therapeutic potential of epidural electrical stimulation for spinal cord injury and to optimize stimulation ***,we discuss cellular and molecular events that continue to damage the injured spinal cord and impede neurological recovery following spinal cord *** also discuss and summarize the animal and human studies that evaluated epidural electrical stimulation in spinal cord injury.

关键词： central nervous system chondroitin sulfate proteoglycans epidural electrical stimulation glial scar gliosis neural activity neuromodulation oligodendrocyte spinal cord injury

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中西医结合护理杂志(英文) 2023年第3期5卷 179-187页

作者： alvin Duke R.SY Ma.krisstella D.GONZALES Rachel Camille C.RODRIGUEZ Department of Epidemiology and Biostatistics College of Public HealthUniversity of the PhilippinesManilaPhilippines Department of Nursing Research and Development Division of Nursing ServicesPhilippine General HospitalUniversity of the PhilippinesManilaPhilippines

Objective:The objective of the study is to describe the work-related quality of life(WRQOL)among nurses and explore its association with performance evaluation ***:A cross-sectional design was utilized measuring the WRQOL scale and the previous performance appraisal *** sampling approach was utilized with nurses stratified based on their position and then systematically random sampled based on their unit ***:One hundred and eighty-two nurses were *** half reported a high quality of work life(101;55.5%).Low scores were noted on the subscale working conditions(100;54.9%),low to average responses for home-work interface(109;59.9%),control at work(100;54.9%),and stress at work(90;49.5%).A higher proportion of nurses reported positive responses toward the areas of general well-being(113;62.1%)and job-career satisfaction(112;61.5%),than in the other *** were notable differences between WRQOL ratings:(1)Head nurses had the highest perceived quality of work life,followed by nurse supervisors and charge nurses(F=6.1,Pking life,while those in office and outpatient services had more positive scores(F=4.6,Pk life,some of its dimensions,particularly job and career satisfaction and working conditions,appeared to vary in the perceived degree across years in service,work hours,and *** assessment of the quality of work life may serve as an important tool to address staff burnout,absenteeism and other issues that affect job performance among health-care professionals.

关键词： Nursing staff professional practice quality of life staff engagement work performance

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The Mechatronic Applications in Energy Efficiency in kowloon-Canton Railway Operations

The Mechatronic Applications in Energy Efficiency in Kowloon...

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第二届亚洲机械电子学学术会议

作者： Warren W.L.Choi Jonathan Y.k.Ip alvin k.W.Chan Railway Systems Department Capital Project Division Kowloon-Canton Railway Hong Kong

Despite rail is more energy efficient than most other transport modes,the enhancement of energy efficiency is an important issue for Hong kong Railways to reduce energy consumption and,by this way,it means reducing energy costs and reducing the emissions of the pollutants and carbon dioxide whilst further growth of rail traffic in Hong kong. This paper aims to explore the applications of mechatronic for possible energy efficiency improvements on existent and future railway equipment/systems in mainly the following three aspects:- (1)Train Control and Operations;(2)Utilization of Regenerated Energy;and (3)Rail Systems Energy Management.

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Can intravesical prostatic protrusion predict bladder outlet obstruction even in men with good flow?

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Asian Journal of Urology 2016年第1期3卷 39-43页

作者： alvin Lee Han Jie Lee kok Bin Lim Hong Hong Huang Henry Ho keong Tatt Foo Department of Urology Singapore General HospitalSingapore Urology Centre Raffles HospitalSingapore

Objective:Men with benign prostate hyperplasia(BPH)with good urinary flow may still have bladder outlet obstruction(BOO).Intravesical prostatic protrusion(IPP)has been shown to be able to predict *** aim to investigate the use of IPP to predict BOO in men with good urinary ***:One hundred and fourteen consecutive men(>50 years old)presenting with lower urinary tract symptoms suggestive of BPH were recruited in 2001 and *** were evaluated with serum prostate specific antigen(PSA),uroflowmetry and transabdominal ultrasound measurement of IPP and prostate volume(PV).Pressure-flow urodynamic studies were performed on all men and BOO was defined by BOO index>*** with Qmax12.0 mL/s were considered to have good ***:Among the 114 men,61 patients had good urinary *** median age,PV and Qmax were 66 years,32.9 mm3 and 14.5 mL/s respectively.14/61(23.0%)patients had BOO and their distribution of IPP were as follows:Grade 1 e 0/20(0%)obstructed,Grade 2 e 6/22(27.3%)and Grade 3 e 8/19(42.1%).Sensitivity of Grade 2/3 IPP for BOO was 100% while specificity of Grade 3 IPP was 76.6%.The area-under-curve(AUC)for IPP was greater than that for PV(0.757 vs.0.696).Conclusion:Even in men with good flow,high grades of IPP were more likely to have BOO and hence,may be a useful adjunct to predict BOO.

关键词： Male Prostate hyperplasia Pathology Ultrasonography Urinary bladder Urodynamics

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通风管道内负离子传输的数值模拟及试验验证

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环境科学研究 2016年第12期29卷 1913-1920页

作者：杨艺周沛赖志强广东海洋大学机械与动力工程学院广东湛江524008 香港城市大学建筑学与土木工程学系

为能有效去除通风管道系统内颗粒及气溶胶微生物,解决通风空调系统因长期使用而缺少维护和清洁,造成气溶胶微生物在系统里滋生进而形成对人体有害的生物气溶胶病原体细菌等问题,采用欧拉方法建立模拟通风管道内负离子输运过程及分布的... 详细信息

为能有效去除通风管道系统内颗粒及气溶胶微生物,解决通风空调系统因长期使用而缺少维护和清洁,造成气溶胶微生物在系统里滋生进而形成对人体有害的生物气溶胶病原体细菌等问题,采用欧拉方法建立模拟通风管道内负离子输运过程及分布的数值模型.通过数值模拟和试验测量VI-2500型负离子发生器安装在0.2 m×0.2 m通风管道内送风速度为3~6 m/s时的负离子浓度,验证数值模型的准确性并分析负离子在通风管道内的分布规律.结果表明,负离子的模拟预测值与试验测量值误差很小.送风速度为3 m/s时,风管内负离子浓度的最低值和平均值分别为9.15×109和2.39×109ions/m^3,送风速度为6 m/s时,相应为2.37×1010和6.83×109ions/m^3.通风管道内负离子浓度随送风速度的增加而升高,送风速度一定时,通风管道内负离子浓度沿风速方向逐渐降低.当送风速度低至3 m/s时,风管内负离子浓度最低或平均值仍然可以达到有效净化细菌的负离子浓度最低数量级的推荐值(108~1010ions/m^3).研究显示,负离子数值模型能准确预测VI-2500型负离子发生器在0.2 m×0.2 m风管中产生的负离子浓度,并且发生器产生的负离子浓度能满足4.5 m长风管的净化要求.

关键词：负离子发生器负离子室内空气品质生物气溶胶病原体细菌

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