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Nano Research 2018年第1期11卷 89-100页

作者： Celia Hernandez-Rentero Rafael Cordoba Noelia Moreno alvaro Caballero Julian Morales Mara Olivares-Marin Vicente Gomez-Serrano Dpto. Ouimica Inorgdnica e Ingenierfa Quimica Instituto de Quimica Fina y Nanoqufmica Universidad de C6rdoba 14071 C6rdoba Spain Dpto. Quimica Inorg6nica Facultad de Ciencias Universidad de Extremadura 06006 Badajoz Spain

A micro- and mesoporous carbon obtained from cherry pit waste and activated with HBPO4 acid has been studied as the sulfur host for Li/S batteries. The carbon has a high specific surface area of 1,662 m2·g-1 （SBET） and micropore and mesopore volumes of 0.57 and 0.40 cm3·g-1, respectively. The S/C composite, with a sulfur content of 57% deposited by the disproportionate reaction of a SaO2- solution in an acid medium without an additional heating step above the S melting point, delivers an initial specific capacity of 1,148 mah·g-1 at a current of C/16. It also has a high capacity retention of 915 mAh·g-1 after 100 cycles and a Coulombic efficiency close to 100%. The good performance of the composite was also observed under higher current rates and long-term cycling tests. The capacities delivered by the cell after 200 cycles were 707 and 410 mAh·g-1 at C/2 and 1C （1C = 1,675 mA·g-1）, respectively, maintaining the high Coulombic efficiency. The overall electrochemical response of this carbon as the sulfur matrix is among the best reported so far among the other biomass-derived carbons, probably because of the micro- and mesopore system formed upon activation.

关键词： activated carbon agricultural waste cherry stone sulfur composite lithium-sulfur batteries

Effect of treatment failure on the Cag A EPIYA motif in Helicobacter pylori strains from Colombian subjects

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World Journal of Gastroenterology 2017年第11期23卷 1980-1989页

作者： Javier Andres Bustamante-Rengifo Andres Jenuer Matta alvaro Jairo Pazos Luis Eduardo Bravo Department of Microbiology School of Basic ScienceUniversidad del Valle Registro Poblacional de Cáncer de Cali Department of PathologySchool of MedicineUniversidad del Valle Department of Biology Universidad de Narino

AIM To evaluate effect of treatment failure on cag A and vac A genotypes in Helicobacter pylori(H. pylori) isolates from *** One hundred and seventy-six participants infected with H. pylori from Colombia were treated during 14 d with the triple-standard therapy. Six weeks later, eradication was evaluated by 13C-Urea breath test. Patients with treatment failure were subjected to endoscopy control; biopsies obtained were used for histopathology and culture. DNA from H. pylori isolates was amplified using primers specific for cag A and vac A genes. The phylogenetic relationships among isolates obtained before and after treatment were established by conglomerate analysis based on random amplified polymorphic DNA(RAPD) *** Treatment effectiveness was at 74.6%. Of the par-ticipants with treatment failure, 25 accepted subjected to a second endoscopy. Prevalence of posttreatment infection was 64%(16/25) and 40%(10/25) by histology and culture, respectively. Upon comparing the cag A and vac A genotypes found before and after therapy, multiple cag A genotypes(cag A-positive and cag A-negative) were found before treatment; in contrast, cag A-negative genotypes decreased after treatment. vac A s1m1 genotype was highly prevalent in patients before and after therapy. The 3'cag A region was successfully amplified in 95.5%(21/22) of the isolates obtained before and in 81.8%(18/22) of the isolates obtained after treatment. In the isolates obtained from patients with treatment failure, it was found that 72.7%(16/22) presented alterations in the number of EPIYA motifs, compared to isolates found before *** Unsuccessful treatment limits colonization by lowvirulence strains resulting in partial and selective eradication in mixed infections, and acts on the cag A-positive strains inducing genetic rearrangements in cag A variable region that produces a loss or gain of EPIYA repetitions.

关键词： Helicobacter pylori RAPD-PCR Treatment failure EPIYA motifs 3’ cag A variable region

Symptomatic accommodative and binocular dysfunctions from the use of flat-panel displays

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 501-505页

作者： Esteban Porcar Juan Carlos Montalt alvaro M. Pons Enrique Espana-Gregor Department of Optics Optometry and Vision Sciences Physics College University of Valencia Burjassot (Valencia) 46100 Spain Department of Surgery Ophthalmology Unit Faculty of Medicine and Odontology la Fe University and Polytechnic Hospital Valencia 46026 Spain

AIM： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （***） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. METHODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use. Then, a thorough eye examination excluded those subjects with a significant uncorrected refractive error or other problem, such as ocular motility disorders, vertical deviation, strabismus and eye diseases. Finally, the remaining participants underwent an exhaustive assessment of their accommodative and binocular vision status. RESULTS： Eighty-nine VDU users （46 females and 43 males） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented *** （22.5%）. Convergence excess was the most frequent non-strabismic binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accommodative dysfunctions, accommodative excess was the most common （4 subjects）, followed by accommodative insufficiency （2 subjects）. Moderate to severe eye symptoms were found in 13 subjects with ANSBD. CONCLUSION： Significant eye symptoms in VDU users with accommodative and/or non-strabismic binocular dysfunctions often occur and should not be underestimated; therefore, an appropriate evaluation of accommodative and binocular vision status is more important for this population,

关键词： general binocular dysfunctions accommodativedysfunctions non-strabismic binocular dysfunctions eyesymptoms video display unit

Ecdysis triggering hormone peptide in the African malaria mosquito Anopheles gambiae:The peptide structure for receptor activation

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Insect Science 2022年第5期29卷 1309-1317页

作者： Hawa Dembele Moritz Mating Rupinder Singh Soheila Fatehi alvaro I.Herrera Yoonseong Park Om Prakash Department of Biochemistry and Molecular Biophysics Kansas State UniversityManhattanKansas66506 Department of Entomology Kansas State UniversityManhattanKansas66506 Department of Chemistry&Biochemistry Auburn UniversityAuburnAlabamaUSA

Infections by mosquito-borne diseases represent one of the leading causes of death in third world *** rapid progression of resistance to conventional insecticide causes a significant threat to the highly efficient preventive methods currently in *** neuropeptidergic system offers potential targets to control the insect *** essential roles of the neuropeptide ecdysis triggering hormone(ETH)in insect development and reproduction led us to attempt understanding of the fundamentals of the biochemical interaction between ETH and its receptor in the African malaria mosquito Anopheles *** of two ETH peptides of the African malaria mosquito(AgETH1),a small peptide hormone with 17 amino acid residues(SESPGFFIKLSKSVPRI-NH2),was studied to elucidate its molecular structure.N-termini deletions and mutations of conserved amino acids in the ligand revealed the critical residues for the receptor *** solution structure of AgETH1 using 2D 1H-1H nuclear magnetic resonance(NMR)spectroscopy and nuclear overhauser effect(NOE)derived constraints revealed a short alpha helix between residues 3S and *** NMR solution structure of AgETH1 will be of significant assistance for designing a new class of insecticidal compounds that acts on the AgETH receptor aiming for in silico docking studies.

关键词： Anopheles gambiae ecdysis triggering hormone G protein-coupled receptor insect malaria neuropeptide NMR spectroscopy

Novel Mechanical Interface Design for Automotive Starting Systems

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Automotive Innovation 2019年第1期2卷 14-25页

作者： alvaro C.Michelotti Jonny C.da Silva Lauro C.Nicolazzi Research and Development Department Zen S.A.Industria MetalurgicaBrusqueSC 88355-100Brazil CTC-EMC-UFSC Universidade Federal de Santa Catarina(UFSC)P.O.Box 476FlorianópolisSC 88040-900Brazil

Stop-start vehicles(SSVs)represent a potential alternative for improving internal combustion engine(ICE)*** provide ICEs with the functionality of turning the engine off during traffic halts and restarting it without intervention by the *** strategy reduces fuel consumption,especially in dense urban traffic areas,and contributes to emissions reduction to meet green emissions *** most widely adopted SSV system has a mechanical interface to connect the electric starter motor to the ICE,which requires increased robustness compared with standard starting *** requirement allows the motor to withstand a higher number of engine start cycles compared with a standard starting ***,it is a critical problem for wider adoption of *** SSV systems usually are based on the conventional starting system,its durability and noise remains a critical issue to be addressed by *** typical pinion-ring gear interface uses intermittent gear meshing to form a transient coupling *** research reported here presents the development of an innovative mechanical interface for starting systems,called the permanent coupling(PC)-type interface,which reduces noise and increases durability compared with the existing *** results obtained by a functional prototype of the PC-type mechanical interface confirm the feasibility of the proposed *** methodology is based on a product development process integrated with lumped-parameter modeling and virtual simulation aimed at reducing failures during prototype *** new mechanical interface was proven to be a good candidate for increasing the use of SSVs in the automotive market.

关键词： Starting systems Internal combustion engines Stop-start vehicles Mechanical interface Lumped-parameter simulation

Design of microaerobically inducible miniR1 plasmids

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mLife 2023年第1期2卷 101-104页

作者： Fabiola Islas Andrea Sabido Juan-Carlos Sigala alvaro R.Lara Departamento de Procesos y Tecnología Universidad Autónoma MetropolitanaCiudad de MexicoMéxico

Plasmid DNA(pDNA)is the active pharmaceutical ingredient in the so-called DNA vaccines1 and in gene therapy *** first pDNA vaccine for use in humans,which has shown high protection against SARS-CoV-2,was recently appr... 详细信息

关键词： inducible products. template

Cambrian-early Ordovician volcanism across the South Armorican and Occitan domains of the Variscan Belt in France:Continental break-up and rifting of the northern Gondwana margin

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Geoscience Frontiers 2017年第1期8卷 25-64页

作者： Andre Pouclet J.Javier alvaro Jacques-Marie Bardintzeff Andres Gil Imaz Eric Monceret Daniel Vizcaino 3 rue des Foulques 85560 Longeville-sur-merFrance lnstituto de Geociencias(CSIC--UCM) c/fose Antonio Novais 1228040 MadridSpain Volcanology and Planetology UMR CNRS 8148 GEOPSUniversity of Paris-Saclay91405 OrsayFrance Departamento Ciencias de la Tierra Universidad de Zaragoza50009 ZaragozaSpain 18 rue des Fins 11570 CazilhacFrance 7 Jean-Baptiste Chardin Maquens11090 CarcassonneFrance

The Cambrian-lower Ordovician volcanic units of the South Armorican and Occitan domains are ana- lysed in a tectonostratigraphic survey of the French Variscan Belt. The South Armorican lavas consist of continental tholeiites in middle Camhrian-Furongian sequences related to continental break-up. A significant volcanic activity occurred in the Tremadocian, dominated by crustal melted rhyolitic lavas and initial rifting tholeiites. The Occitan lavas are distributed into five volcanic phases：（I） basal Cambrian rhyolites, （2） upper lower Cambrian Mg-rich tholeiites close to N-MORBs but crustal contaminated, （3） upper lower-middle Cambrian continental tholeiites, （4） Tremadocian rhyolites, and （5） upper lower Ordovician initial rift tholeiites. A rifting event linked to asthenosphere upwelling took place in the late early Cambrian but did not evolve. It renewed in the Tremadocian with abundant crustal melting due to underplating of mixed asthenospheric and lithospheric magmas. This main tectono-magmatic conti- nental rift is termed the ＂Tremadocian Tectonic Belt＂ underlined by a chain of rhyolitic volcanoes from Occitan and South Armorican domains to Central Iberia. It evolved with the setting of syn-rift coarse siliciclastic deposits overlain by post-rift deep water shales in a suite of sedimentary basins that fore- casted the South Armorican-Medio-European Ocean as a part of the Palaeotethys Ocean.

关键词： Gondwana margin Cambro-Ordovician volcanic activity Continental tholeiite Rheic Ocean Middle-European Ocean Palaeotethys Ocean

Quantifying water stress effect on daily light use efficiency in Mediterranean ecosystems using satellite data

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International Journal of Digital Earth 2017年第6期10卷 623-638页

作者： Sergio Sanchez-Ruiz alvaro Moreno Maria Piles Fabio Maselli Arnaud Carrara Steven Running Maria Amparo Gilabert Departament de Fisica de la Terra i Termodinamica Facultat de FisicaUniversitat de ValenciaBurjassotSpain Numerical Terradynamic Simulation Group University of MontanaMissoulaMTUSA Barcelona Expert Center Institut de Ciencies del MarICM-CSICBarcelonaSpain IBIMET-CNR Sesto FiorentinoItaly Fundacion CEAM PaternaSpain

The capacity of six water stress factors(ε′(i))to track daily light use efficiency(ε)of water-limited ecosystems was *** factors are computed with remote sensing operational products and a limited amount of ground data:ε′1 uses ground precipitation and air temperature,and satellite incoming global solar radiation;ε′(2) uses ground air temperature,and satellite actual evapotranspiration and incoming global solar radiation;ε′_(3) uses satellite actual and potential evapotranspiration;ε′_(4) uses satellite soil moisture;ε′_(5) uses satellite-derived photochemical reflectance index;and ε′_(6) uses ground vapor pressure *** factors were implemented in a production efficiency model based on Monteith’s approach in order to assess their performance for modeling gross primary production(GPP).Estimated GPP was compared to reference GPP from eddy covariance(EC)measurements(GPP EC)in three sites placed in the Iberian Peninsula(two open shrublands and one savanna).ε′_(i) were correlated to ε,which was calculated by dividing GPP EC by ground measured photosynthetically active radiation(PAR)and satellite-derived fraction of absorbed *** results were achieved by ε′(1),ε′(2),ε′(3) and ε′(4) explaining around 40% and 50% of ε variance in open shurblands and savanna,*** terms of GPP,R^(2)≈0.70 were obtained in these cases.

关键词： Light use efficiency water stress GPP Monteith Mediterranean ecosystems

A homozygous nonsense mutation in DNAJC30 causes Leber’s hereditary optic neuropathy with Leigh-like phenotypes

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Genes & Diseases 2023年第4期10卷 1165-1168页

作者： Chao Shen Kitty Wang Wei Li alvaro Serrano Kelly Powers Chengwan Zhang Jianjun Chen Miao Sun Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Division of Medical Genetics Department of PediatricsChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Division of Neurology Children’s Hospital Los AngelesLos AngelesCA 90027USA Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Nuclear encoded genes can cause early-onset mitochon-dria-related disorders such as Leigh or Leigh-like *** in DNAJC30 have been implicated in mitochondria-related diseases such as Leber’s hereditary optic neuropa-thy(LHON)and Williams syndrome(WS).However,the role of DNAJC30 in disease progression concerning mitochon-drial dysfunction has yet to be fully *** we report a 12-year-old boy with acute dystonia onset at age 10.

关键词： Leigh Leber acute

Cardiovascular impact of COVID-19 with a focus on children: A systematic review

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World Journal of Clinical Cases 2020年第21期8卷 5250-5283页

作者： Moises Rodriguez-Gonzalez Ana Castellano-Martinez Helena Maria Cascales-Poyatos alvaro Antonio Perez-Reviriego Pediatric Cardiology Division Puerta del Mar University HospitalCadiz 11009Spain Biomedical Research and Innovation Institute of Cadiz Puerta del Mar University HospitalCadiz 11009Spain Pediatric Nephrology Division Puerta del Mar University HospitalCadiz 11009Spain Pediatrics Division Motril-San Antonio Primary Care CenterMotril 18600Spain Pediatrics Division UGC Pediatria AG Sur GranadaSanta Ana HospitalMotril 18600Spain

BACKGROUND Since the beginning of the pandemic,coronavirus disease-2019(COVID-19)in children has shown milder cases and a better prognosis than *** the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection in *** To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic *** multiple searches in MEDLINE,PubMed were performed using the search terms“COVID-19”or“SARS-CoV-2"were used in combination with“myocardial injury”or"arrhythmia"or“cardiovascular involvement”or"heart disease"or"congenital heart disease"or“pulmonary hypertension”or"long QT"or“cardiomyopathies”or“channelopathies”or"multisystem inflammatory system"or"PMIS"or“MIS-C”or”Pediatric multisystem inflammatory syndrome"or"myocarditis"or"thromboembolism to identify articles published in English language from January 1st,2020 until July 31st,*** websites of World Health Organization,Centers for Disease control and Prevention,and the Johns Hopkins Coronavirus Resource Center were reviewed to provide up to date numbers and infection control *** lists from the articles were reviewed to identify additional pertinent *** manuscripts concerning the subject were reviewed by the authors,and the data were extracted using a standardized collection *** were subsequently analyzed with descriptive *** Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19(PMIS),multiple meta-analyses were conducted to summarize the pooled mean proportion of different cardiovascular variables in this population in pseudo-cohorts of observed *** A total of 193 articles were *** publications used in

关键词： COVID-19 SARS-CoV-2 Congenital heart diseases Myocardial dysfunction Pediatric multisystem Inflammatory Syndrome Cardiac Biomarkers