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Species Account of Anura ns from the Western Slope of Mt. Kita nglad, Mindanao Island, Philippines

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Asian Herpetological Research 2021年第1期12卷 76-87页

作者： Elsa May Delima BAROn Mark Oliver D.MARIn Benjo A.LOGRAMOnTE alma B.MOHAGAn Biology Natural Sciencesand Math Division.Arts and Sciences DepartmentSan Pedro CollegeDavao City 8000MindanaoPhilippines Biology Department College of Arts and SciencesCentral Mindanao UniversityMusuanBukidnon 8714MindanaoPhilipines

The Mt. Kitanglad Range is one of the country’s important key biodiversity sites;however, information about anuran diversity in this protected area remains depauperate. Herein we provided accounts of anuran species from high-elevation forests, in three sites of the western slope of Mt. Kitanglad range. The combined belt-transect sampling and microha bitat searches accounted for 13 species representing five families. The most represented family was Rhacophoridae with five representative species of the genus Philautus. Twelve out of the 13 species documented in the current survey are endemic. Four previously unaccounted species(Pelophr yne brevipes, Pulchrana grandocula, Sanguirana mearnsi, and Philautus surrufus) were added and brought the total anurans known from Mt. Kitanglad to 26 species. Most of the species were also recorded in forested sites, suggestive of their lesser affinity to non-forested ecosystems. The additional species detected during our survey may also imply that full understanding of anuran diversity of Mt. Kitanglad remains far from complete.

关键词： key biodiversity area Mindanao faunal region Philippine endemic anurans upper elevation forests wildlife inventory in Mindanao

A Brassinosteroid-Signaling Kinase Interacts withMultiple Receptor-Like Kinases in Arabidopsis

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Molecular Plant 2014年第2期7卷 441-444页

作者： Peng Xu ShouLing Xu ZiJing Li Wenqiang Tang alma L Burlingame ZhiYong Wang Institute of Molecular and Cell Biology Hebei Key Laboratory of Molecular and Cellular Biology College of Life Sciences Hebei Normal University Shijiazhuang Hebei 050024 China.

Dear Editor, Higher plants have evolved hundreds of genes encodingreceptor-like kinases （RLKs）, which function as cell surfacereceptors perceiving developmental and environmental sig-nals （Shiu et al., 2004）. Many RLKs have been shown to playspecific roles in hormone responses, developmental regula-tion, defense against pathogen infection, and adaptationto abiotic stresses （Chae et al., 2009; Antolin-Llovera et al.,2012）. The mechanisms that ensure specific signal transduc-tion from each RLK to target cellular responses remain poorlyunderstood. Recent studies revealed that many RLKs trans-duce signals by phosphorylating receptor-like cytoplasmickinases （RLCKs）, which lack the transmembrane domainsbut are anchored at the plasma membrane through lipidmodification （Tang et al., 2008; Zhang et al., 2010; Shi et al.,2013）. There are over 400 RLKs and only about 150 RLCKs inArabidopsis （Shiu et al., 2004）. One outstanding question iswhether each RLCK mediates signaling downstream of a spe-cific RLK, participates in multiple RLK pathways, or mediatescrosstalk between RLK pathways.

关键词： IMMUnITY FAMILY BSKS

The role of gap junctions in cell death and neuromodulation in the retina

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neural Regeneration Research 2021年第10期16卷 1911-1920页

作者： Gergely Szarka Marton Balogh Adam J.Tengolics alma Ganczer Bela Volgyi Tamas Kovacs-Oller Janos Szentagothai Research Centre University of PecsPecsHungary Retinal Electrical Synapses Research Group National Brain Research Program(NAP 2.0)Hungarian Academy of SciencesBudapestHungary Department of Experimental Zoology and neurobiology University of PecsPecsHungary Medical School University of PecsPecsHungary

Vision altering diseases,such as glaucoma,diabetic retinopathy,age-related macular degeneration,myopia,retinal vascular disease,traumatic brain injuries and others cripple many lives and are projected to continue to cause anguish in the foreseeable *** junctions serve as an emerging target for neuromodulation and possible regeneration as they directly connect healthy and/or diseased cells,thereby playing a crucial role in *** they are permeable for macromolecules,able to cross the cellular barriers,they show duality in illness as a cause and as a therapeutic *** this review,we take recent advancements in gap junction neuromodulation(pharmacological blockade,gene therapy,electrical and light stimulation)into account,to show the gap junction’s role in neuronal cell death and the possible routes of rescuing neuronal and glial cells in the retina succeeding illness or injury.

关键词： age-related macular degeneration bystander effect connexin diabetic retinopathy gap junction glaucoma neuromodulation retina retinal disease vision

Molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds

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Horticulture Research 2020年第1期7卷 1599-1610页

作者： Chiara Forti Valentino Ottobrino Laura Bassolino Laura Toppino Giuseppe Leonardo Rotino Andrea Pagano Anca Macovei alma Balestrazzi Department of Biology and Biotechnology‘Lazzaro Spallanzani’ University of PaviaPaviaItaly CREA-Research Centre for Genomics and Bioinformatics Montanaso LombardoLOItaly CREA-Research Centre for Cereal and Industrial Crops BolognaItaly Institute of Plant Genetics Polish Academy of SciencesPoznanPoland

Seed priming,a pre-sowing technique that enhances the antioxidant/DnA repair activities during the pre-germinative metabolism,still retains empirical *** explore for the first time the molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds in order to identify hallmarks(expression patterns of antioxidant/DnA repair genes combined with free radical profiles)useful to discriminate between high-and lowquality *** hydropriming protocol hereby developed anticipated(or even rescued)germination,when applied to lots with variable ***(reactive oxygen species)raised during hydropriming and dropped after *** of antioxidant/DnA repair genes was observed during hydropriming and the subsequent *** of SmOGG1(8-oxoguanine glycosylase/lyase)gene detected in primed seeds at 2 h of imbibition appeared as a promising *** the basis of these results,the investigation was restricted within the first 2 h of imbibition,to verify whether the molecular landscape was reproducible in different lots.A complex pattern of antioxidant/DnA repair gene expression emerged,reflecting the preponderance of seed lot-specific *** the low-quality eggplant seeds subjected to hydropriming showed enhanced ROS levels,both in the dry and imbibed state,and this might be a useful signature to discriminate among *** plasticity of eggplant pre-germinative metabolism stimulated by priming imposes a plethora of heterogeneous molecular responses that might delay the search for quality ***,the information hereby gained could be translated to eggplant wild relatives to speed-up their use in breeding programs or other agronomical applications.

关键词： metabolism dynamics gained

Addition of phenolic compounds to bread: antioxidant benefits and impact on food structure and sensory characteristics

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Food Production, Processing and nutrition 2021年第1期3卷 314-325页

作者： Yesica A.Czajkowska–González Emilio Alvarez–Parrilla nina del Rocío Martínez–Ruiz alma A.Vázquez–Flores Marcela Gaytán–Martínez Laura Ade la Rosa Departament of Chemical Biological Sciences Institute of Biomedical SciencesUniversidad Autónoma de Ciudad JuárezAnillo Envolvente del PRONAF y Estocolmos/nC.P.32310 Cd.JuárezMéxico Programa de Posgrado en Alimentos del Centro de la República(PROPAC) Research and Graduate Studies in Food ScienceSchool of ChemistryUniversidad Autónoma de QuerétaroCentro UniversitarioCerro de las Campanas S/NC.P.76010 Santiago de QuerétaroMexico

The use of flours or phenolic extracts obtained from non-traditional sources or agri-food industry by-products has been a strategy used to formulate new bakery products with characteristics of a functional ***,phenolic compounds present great structural diversity,as well as the ability to interact in a complex way with the macromolecules that constitute the bread ***,the addition of these flours,extracts or pure compounds produces various effects on the microstructure of bread,and several of its sensory *** is mainly due to interactions between phenolic compounds and gluten *** objective of this review is to analyze some of the most recent published works on the addition of phenolic compounds in wheat bread to identify the type of positive and negative effects that have been observed and how they can be related to the physicochemical interactions between phenolic compounds and the macromolecules that constitute the food matrix,mainly *** effect of monomeric and polymeric phenolic compounds on the strength of these interactions and on the properties of dough and bread are discussed.

关键词： condensed tannins hydrolysable tannins phenolic acids gluten food rheology food texture protein-phenolic interactions disulfide bonds non-covalent interactions

Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de Investigación en Ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRnA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

Depletion of tyrosyl-DnA phosphodiesterase 1a(MtTdp1a)affects transposon expression in Medicago truncatula

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Journal of Integrative Plant Biology 2016年第7期58卷 618-622页

作者： Maria Elisa Sabatini Mattia Dona Paola Leonetti Andrea Minio Massimo Delledonne Daniela Carbonera Massimo Confalonieri Giorgio Giraffa alma Balestrazzi Department of Biology and Biotechnology'L.Spallanzani'via Ferrata 1 27100 PaviaItaly Institute for Sustainable Plant Protection National Research Council(CNR)Via Amendola 165/a70126 BariItaly Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly Fodder and Dairy Production Research Centre Viale Piacenza 2929600 LodiItaly Gregor Mendellnstitute(GMI) Austrian Academy of SciencesVienna Biocenter(VBC)Dr.Bohr Gasse 31030 ViennaAustria

The role of plant tyrosyl-DnA phosphodiesteritdase 1a in genome stability is studied using a Medicago Etruncatula Mt Tdp1a-depleted line. Lack of Mt Tdp1 a results e in a 39% reduction of methylated cytosines as compared thto control. RnA-Seq analyses revealed that 11 DnA transto posons and 22 retrotransposons were differentially exrpressed in the Tdp1a-2a line. Among them all, DnA etttransposons（Mu DR, h AT, DnA3-11_Mad） and seven retroetransposons（LTR（Long Terminal Repeat）/Gipsy, LTR/Copia,LLTR and non LTR/L1） were down-regulated, while the15 retrotransposons were up regulated. Results suggest that the occurrence of stress-responsive cis-elements as well as changes in the methylation pattern at the LTR promoters might be responsible for the enhanced retrotransposon transcription.

关键词： DnA methylation Medicago truncatula RnA-Seq transposable elements tyrosyI-DnA phosphodiesterase

Constant-gain nonlinear adaptive observers revisited: an application to chemostat systems

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Frontiers of Information Technology & Electronic Engineering 2021年第1期22卷 68-78页

作者： Jorge A.TORRES Arno SOnCK Sergej CELIKOVSKY alma R.DOMInGUEZ Automatic Control Department CINVESTAVMexico City 07360Mexico The Czech Academy of Sciences Institute of Information Theory and AutomationPrague 18200Czech Republic Biotechnology and Bioengineering Department CINVESTAVMexico City 07360Mexico

This study deals with constant-gain adaptive observers for nonlinear systems,for which relatively few solutions are available for some particular *** introduce an asymptotic observer of constant gain for nonlinear systems that have linear *** allows the observer design to be formulated within the linear matrix inequality paradigm provided that a strictly positive real condition bet ween the inpu t disturbance and the output is *** proposed observer is t hen applied to a large class of nonlinear chemos tat dynamical systems that are widely used in the fermentation process,cell cultures,medicine,*** fact,under standard practical assumptions,the necessary change of the chemos tat state coordinates exis ts,allowing use of the const ant-gain ***,the developed theory is illustrated by estimating pollutant concentration in a Spirulina maxima wastewater treatment facility.

关键词： nonlinear observers Adaptive observers Coordinate change Chemos tat Pollu taut observation

Hepatitis B virus infection in Latin America:A genomic medicine approach

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World Journal of Gastroenterology 2014年第23期20卷 7181-7196页

作者： Sonia Roman Alexis Jose-Abrego nora alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-Lopez Arturo Puro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Immunovirology Unit Department of Molecular Biology in MedicineCivil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Viral Hepatitis Clinic Pediatric Infectious Disease UnitDepartment of Pediatric Hematology and OncologyCivil Hospital of Guadalajara "Juan I.Menchaca" and University of GuadalajaraGuadalajaraJalisco 44280Mexico

Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver *** article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin *** levels of evolutionary adaptation may correlate with the clinical outcomes of HBV *** in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous *** genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South *** contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian *** carcinoma is rare in Mexicans,but it has been associated with genotype F1b among *** observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world.

关键词： Genomic medicine Hepatitis B virus Hepatitis B virus genotypes Latin America Mexico Central America South America