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Levels of Radon Activity Concentration in Air of Coal Mines in bosnia and Hercegovina

材料科学与工程（中英文b版） 2013年第4期3卷 239-243页

作者： Zejnil Tresnjo Feriz Adrovic alma Trumic University Dzemal bijedic of Mostar Mostar Bosnia and Herzegovina University of Tuzla Faculty of Natural Sciences and Mathematics Tuzla Bosnia and Herzegovina The International School of The Hague Den Haag Nederlands

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Influence of catalytic systems on process of model object hydrogenation

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International Journal of Coal Science & Technology 2014年第1期1卷 88-92页

作者： Murzabek Ispolovich baikenov Gulzhan Gausilevna baikenova bolat Shaimenovich Sarsembayev alma baimagambetova Tateeva almas Tusipkhan Aisha Zharasovna Matayeva Karaganda State University Karaganda 100028Kazakhstan

On the basis of b-FeOOH,Fe(OA)_(3),Fe_(3)O_(4) iron and spherical catalysts NiO/SiO_(2),Fe_(2)O_(3)/SiO_(2) derived from slag waste coals of heating electrical stations,the hydrogenation of model polycyclic hydrocarbon at presence of nanodimensioned catalysts antracene was *** the example of conversion of anthracene,it was shown that upon release of hydrogenation of the product yield and degradation of polycyclic hydrocarbons in the hydrogenation,the mentioned catalyst systems appeared to be in the following order:nanoparticles b-FeOOH,Fe(OA)_(3) and Fe_(3)O_(4)[spherical catalysts NiO/SiO_(2),Fe_(2)O_(3)/SiO_(2)[commercial cobalt-molybdenum *** results showed that the catalysts studied are promising catalysts for the hydrogenation of polycyclic hydrocarbons and may be used for direct coal liquefaction.

关键词： Antracene Multi-ring hydrocarbons Nanocatalysts Spherical catalysts Hydrogenation

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HCV infection, b-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions

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World Journal of Gastrointestinal Oncology 2012年第3期4卷 46-53页

作者： Maria Christina Cox Maria Antonietta Aloe-Spiriti Elena Cavalieri Eleonora alma Elia Gigante Paola begini Caterina Rebecchini Gianfranco Delle Fave Massimo Marignani Department of Haematology Sant'Andrea Hospital La Sapienza University Department of Gastroenterology and Liver Disease Sant'Andrea Hospital La Sapienza University

There is plenty of data confirming that hepatitis C virus (HCV) infection is a predisposing factor for a b-cell non-Hodgkin's lymphoma (b-NHL) outbreak, while relatively few reports have addressed the role of HCV in affecting b-NHL patients' outcome. HCV infection may influence the short-term outcome of b-NHL because of the emergence of severe hepatic toxicity (HT) during immunochemotherapy. Furthermore, the long term outcome of HCV-related liver disease and patients' quality of life will possibly be affected by Rituximab maintenance, multiple-lines of toxicity during chemotherapy and hematopoietic stem cell transplantation. In this review, data dealing with aggressive and low-grade b-NHL were separately analyzed. The few retrospective papers reporting on aggressive b-NHL patients showed that HCV infection is a risk factor for the outbreak of severe HT during treatment. This adverse event not infrequently leads to the reduction of treatment density and intensity. Existing papers report that low-grade b-NHL patients with HCV infection may have a more widespread disease, more frequent relapses or a lower ORR compared to HCV-negative patients. Notwithstanding, there is no statistical evidence that the prognosis of HCV-positive patients is inferior to that of HCV-negative subjects. HCV-positive prospective studies and longer follow-up are necessary to ascertain if HCV-positive b-NHL patients have inferior outcomes and if there are long term sequels of immunochemotherapies on the progression of liver disease.

关键词： Marginal zone lymphoma Diffuse large b cell lymphoma Hepatitis C virus Non-Hodgkin’s lymphomas Hepatotoxicity Chemotherapy Immunochemotherapy Prognosis Rituximab

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Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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Neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de Neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de Neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de Investigación en Ciencias biomédicas (IICb) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en Neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(brdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRNA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

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Hepatitis b Virus Genotype H and Environmental Factors Associated to the Low Prevalence of Hepatocellular Carcinoma in Mexico

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Journal of Cancer Therapy 2013年第2期4卷 367-376页

作者： Sonia Roman Nora alma Fierro Laura E. Moreno-Luna Arturo Panduro Department of Molecular biology in Medicine Hospital Civil de Guadalajara Fray Antonio Alcalde Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara Mexico

Purpose: Hepatocellular carcinoma (HCC) is a leading health problem worldwide. Any agent causing chronic liver damage and cirrhosis is a risk factor for HCC. Genetic and environmental factors may be responsible for regional variations in the occurrence of HCC worldwide. The aim of this review was to describe the risk factors that may be contributing to low prevalence of HCC in the Mexican population. Methods: An electronic systematic search was conducted in four databases to retrieve studies on hepatocellular carcinoma inMexico. Results: Eighteen publications gave a total of 1042 HCC cases with a percentage that ranged from 0.25% to 1.87%. Cirrhosis was registered in 7 studies while the main etiologies were: HCV (66%), HbV (11%) and alcoholism (6.6%). Conclusions: In the last 50 years, the studies performed inMexicohave shown a very low incidence and/or mortality rate of HCC. These findings contrast from those reported in high endemic regions, such asAsia, where viral hepatitis and HCC are prevalent. One significant difference is the predominance of HbV genotype H in Mexico and HbV/b and C in Asia. InMexico, high endemic areas of HbV infection have been detected, mainly among the native population;however, infection seems to resolve very quickly, due to a prominent immunological response among the population. Other factors are that patients with liver cirrhosis die prematurely before that HCC can be detected. Furthermore, an environmental factor that may exert a protective effect against HCC, in spite of the high consumption of potentially aflatoxin-contaminated food products, is the neutralization of these substances by alkaline treatment. This study shows that genetic and environmental factors associated to HCC among the Mexican population are different from others reported worldwide.

关键词： HbV Genotype H HCV Alcoholism Aflatoxins Cirrhosis Nixtamalization

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The brassinosteroid-Activated bRI1 Receptor Kinase Is Switched off by Dephosphorylation Mediated by Cytoplasm-Localized PP2A b＇ Subunits

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Molecular Plant 2016年第1期9卷 148-157页

作者： Ruiju Wang Mengmeng Liu Min Yuan Juan A. Oses-Prieto Xingbo Cai Ying Sun alma L. burlingame Zhi-Yong Wang Wenqiang Tang Hebei Collaboration Innovation Center for Cell Signaling College of Life Sciences Hebei Normal University Shijiazhuang Hebei 050024 China Key Laboratory of Molecular and Cellular biology of Ministry of Education College of Life Sciences Hebei Normal University Shijiazhuang Hebei 050024 China Hebei Key Laboratory of Molecular and Cellular biology College of Life Sciences Hebei Normal University Shijiazhuang Hebei 050024 China Department of Pharmaceutical Chemistry University of California San Francisco CA 94143 USA Department of Plant biology Carnegie Institution of Washington Stanford CA 94305 USA These authors contributed equally to this article Present address: Center for Genomics and Computational biology College of Life Sciences North China University of Science and Technology Tangshan Hebei063000 China

brassinosteroid （bR） binding activates the receptor kinase bRI1 by inducing heterodimerization with its co- receptor kinase bAK1; however, the mechanisms that reversibly inactivate bRI1 remain unclear. Here we show that cytoplasm-localized protein phosphatase 2A （PP2A） b＇ regulatory subunits interact with bRI1 to mediate its dephosphorylation and inactivation. Loss-of-function and overexpression experiments showed that a group of PP2A b＇ regulatory subunits, represented by b＇η, negatively regulate bR signaling by decreasing bRI1 phosphorylation. bR increases the expression levels of these b＇ subunits, and b/TI interacts preferentially with phosphorylated bRI1, suggesting that the dynamics of bR signaling are modu- lated by the PP2A-mediated feedback inactivation of bRI1. Compared with PP2A b＇α and b＇β, which promote bR responses by dephosphorylating the downstream transcription factor bZR1, the bRI1- inactivating b＇ subunits showed similar binding to bRI1 and bZR1 but distinct subcellular localization. Alteration of the nuclear/cytoplasmic localization of the b＇ subunits revealed that cytoplasmic PP2A de- phosphorylates bRI1 and inhibits the bR response, whereas nuclear PP2A dephosphorylates bZR1 and ac- tivates the bR response. Our findings not only identify the PP2A regulatory b subunits that mediate the binding and dephosphorylation of bRI1, but also demonstrate that the subcellular localization of PP2A specifies its substrate selection and distinct effects on bR signaling.

关键词： brassinosteroid signal transduction receptor inactivation bRI1 dephophorylation PP2A

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Vacuumthermal Method of Mercury-Containing Materials Processing

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昆明工学院学报 1991年第1期16卷 88-96页

作者： Isakova R.A.,chelohsaev L.S.,Khrapunov V.E.,SpivakM.M.Tarasenko b.Z. (Institute of Metallurgy and Ore benefication of Kazakh Academy of Sciences,Shevchenko 29/33 alma-Ata USSR)

Monometallic mercury,mercury-antimony ores and concentrates and also intermediate productsof heavy non-ferrous metals prodnction are basic source of mercury production in *** of mercury-containing raw materials is made basically by oxidative roasting and partlyby hydrometallurgical *** is characterized by the formation of large quantity oftechnological gases,sanitary purification of which from mercury is an expensive and complexprocess,and by entrainment of large quantities of dust,leading to the formation of poor stupp,

关键词：真空量热法含汞材料加工工艺

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Lima bean(Phaseolus lunatus)Protein Hydrolysates with ACE-I Inhibitory Activity

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Food and Nutrition Sciences 2012年第4期3卷 511-521页

作者： Luis Chel-Guerrero Mario Domínguez-Magana alma Martínez-Ayala Gloria Dávila-Ortiz David betancur-Ancona Facultad de Ingeniería Química Universidad Autónoma de YucatánMéridaMéxico Escuela Nacional de Ciencias biológicas Instituto Politécnico NacionalMiguel HidalgoMéxico Centro de Investigación en biotecnología Aplicada Instituto Politécnico NacionalTlaxcalaMéxico

Several protein sources can be used to produce bioactive peptides with angiotensin I-converting enzyme (ACE) inhibittory activity. Protein concentrates from ungerminated and germinated lima bean Phaseolus lunatus seed flours were hydrolyzed with Alcalase 2.4 L or pepsin-pancreatin sequential hydrolysis, and ACE inhibitory activity measured in the different hydrolysis treatments. Protein hydrolysate production was analyzed with a 23 factorial design with four replicates of the central treatment. Evaluated factors were protein concentrate source (ungerminated seeds, PC1;germinated seeds, PC2), enzyme/substrate ratio E/S (1/50 or 1/10) and hydrolysis time (0.5 or 2.0 h for Alcalase;1 or 3 h for pepsin-pancreatin). Degree of hydrolysis (DH) was high for the Alcalase hydrolysates (24.12% 58.94%), but the pepsin-pancreatin hydrolysates exhibited the highest ACE inhibitory activity (IC50 = 0.250 0.692 mg/mL). Under the tested conditions, the hydrolysates with the highest ACE inhibitory activity were produced with sequential pepsin-pancreatin using either PC1 at 1 h hydrolysis time and a 1/10 E/S ratio or PC2 at 1 h hydrolysis time and a 1/50 E/S ratio. Lima bean protein hydrolysates prepared with Alcalase or pepsin-pancreatin are a potential ingredient in the production of physiologically functional foods with antihypertensive activity.

关键词： Lima bean Degree of Hydrolysis ACE Inhibition Protein Hydrolysates IC50

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Unilateral Impact of Altered Loading by Changing Teeth Height on the TMJ Fibrocartilage: Disc and Condyle of Wistar Rats

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Microscopy Research 2016年第2期4卷 20-31页

作者： Roxanne M. Olvera-Farias Jose Raymundo Cruz-Perez Rogelio Salinas-Gutierrez Jose Antonio Guerrero-Diaz de Leon Juan b. Kouri-Flores Raul Rosales-Ibañez David Masuoka Ito alma Lilian Guerrero barrera Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México Departamento de Infectómica y Patogénesis Molecular CINVESTAV-IPN Mexico City Mexico Departamento de Estadística Universidad Autónoma de Aguascalientes Aguascalientes México Departamento de Estomatología Universidad Autónoma de San Luis Potosí San Luis Potosi México Departamento de Estomatología Universidad Autónoma de Aguascalientes Aguascalientes México Laboratorio de biología Celular y Tisular Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México

Temporomandibular joint (TMJ) is sensitive to loading and mechanical stress that provokes morphological changes produced by the impact in the occlusal plane. Here, this impact is evaluated in TMJ articular disc and articular cartilage using an in vivo model of unilateral occlusal plane impact and by analysis of serial tissue sections stained with Hematoxylin-Eosin (H-E) or with Masson trichrome technique. Thus, six groups of 5 Wistar rats (200 - 250 g) are subjected to biomechanical dental stimulation by placing unilateral resin occlusal interference, or unilateral tooth wear made by upper left molars artificial mechanical devastation (1 control and 2 experimental groups for each treatment). Each treatment is evaluated two times at 1 and 15 days post-treatment. by H-E staining, control groups show chondrocytes arrangement as several cord cell groups in comparison with the experimental groups, which show an arrangement in one cord cell along of articular disc. However, this yields no significant difference (p ber between control and experimental groups. In contrast, in articular cartilage chondrocytes are random distributed along the superficial zone in control groups, while in experimental groups cell-free regions are observed in superficial zone. An image blue hue analysis for trichrome stain is performed to quantify collagen;this shows a significant collagen decrease (p biomechanically induced by unilateral occlusal plane modification, causes cell and tissue changes on the TMJ structures that remain the degenerative changes observed in early osteoarthritis.

关键词： Articular Disc Articular Cartilage Dental Occlusion Collagen Temporomandibular Joint

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昆虫病原真菌在当前和未来的温室生态系统中的作用(英文)

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安徽农业大学学报 2007年第2期34卷 157-161页

作者：马克.格特尔 Colleen alma Patricia Jaramillo Jeong Jun Kim David Gillespie bernard Roitberg Lethbridge Research Centre Agriculture and Agri-Food CanadaP.O.3000LethbridgeAB T1J 4B1Canada Department of biological Sciences Simon Fraser UniversityBurnabyBCV5A 1S6Canada Pacific Agri-Food Research Centre Agriculture and Agri-Food CanadaP.O.Box 1000AgassizBCV0M 1A0Canada

There are several biopesticides based on entomopathogenic fungi available in the market for use against insect pests in greenhouse *** most are compatible for use with predators and parasitoids in greenhouse ecosystems,much more research is needed to determine the intraguild interactions for each combination of host,pathogen,predator,and *** research has demonstrated that,although direct effects on the predators could be demonstrated in laboratory bioassays,different results were found under greenhouse conditions,indicating that results obtained in the laboratory may be a poor predictor of what occurs in the *** both cases,additive effects were obtained under greenhouse conditions,demonstrating *** addition,there is increasing evidence that entomopathogenic fungi have significant potential for dual management of invertebrate pests and plant *** studies demonstrated that 3 species of Lecanicillium had significant effects on both aphids and cucumber powdery mildew,Sphaerotheca fuliginea;that the fungus Paecilomyces fumosoroseus was compatible with a mirid predator,Disyphus hesperus,when used concurrently against greenhouse whitefly,Trialeurodes vaporariorum;and that Lecaniciullium longisporum was compatible with a predatory midge,Aphidoletes aphidimyza when used concurrently against green peach aphids.

关键词：昆虫病原真菌温室生态系统

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