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A novel approach to Parkinson's disease treatment with a potentially dual-acting therapeutic agent that targetsα-synuclein aggregation and neuron death

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Neural Regeneration Research 2024年第12期19卷 2577-2578页

作者： allison RBalaj Hiroaki Kaku Department of Investigative Medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parkinson's disease(PD),a prevalent neurodegenerative disorder,is chara cterized by the loss of dopaminergic neurons and the aggregation ofα-synuclein protein into Lewy *** the current standards of therapy have been successful in providing some symptom relief,they fail to address the underlying pathophysiology of PD and as a result,they have no effect on disease progression.

关键词： aggregation death therapeutic

Promising use of metformin in treating neurological disorders:biomarker-guided therapies

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Neural Regeneration Research 2024年第5期19卷 1045-1055页

作者： allison Loan charvi Syal Margarita Lui Ling He Jing Wang Regenerative Medicine Program Ottawa Hospital Research InstituteOttawaONCanada Department of Biology Faculty of ScienceUniversity of OttawaOttawaONCanada Department of Pediatrics and Medicine Johns Hopkins Medical SchoolBaltimoreMDUSA Department of cellular and Molecular Medicine Faculty of MedicineUniversity of OttawaOttawaONCanada University of Ottawa Brain and Mind Research Institute OttawaONCanada

Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebrovascular conditions(stroke),and neurodevelopmental disorders(autism spectrum disorder).Although they affect millions of individuals around the world,only a limited number of effective treatment options are available *** most neurological disorders express mitochondria-related metabolic perturbations,metformin,a biguanide type II antidiabetic drug,has attracted a lot of attention to be repurposed to treat neurological disorders by correcting their perturbed energy ***,controversial research emerges regarding the beneficial/detrimental effects of metformin on these neurological *** that most neurological disorders have complex etiology in their pathophysiology and are influenced by various risk factors such as aging,lifestyle,genetics,and environment,it is important to identify perturbed molecular functions that can be targeted by metformin in these neurological *** molecules can then be used as biomarkers to stratify subpopulations of patients who show distinct molecular/pathological properties and can respond to metformin treatment,ultimately developing targeted *** this review,we will discuss mitochondria-related metabolic perturbations and impaired molecular pathways in these neurological disorders and how these can be used as biomarkers to guide metformin-responsive treatment for the targeted therapy to treat neurological disorders.

关键词： Alzheimer’s disease Huntington’s disease metformin mitochondrial perturbation multiple sclerosis neural degenerative diseases Parkinson’s disease stroke targeted therapy

Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

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World Journal of clinical cases 2024年第2期12卷 412-417页

作者： allison Akers Susan Read John Feldman casey Gooden Diana P English Department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radiology University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BAcKGROUND cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/cT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/cT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： cervical adenocarcinoma Breast metastases Immunotherapy Pembrolizumab carboplatin Paclitaxel case report

English Speaking Online in the Turkish Teaching context:A Theoretical Approach

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Sino-US English Teaching 2024年第5期21卷 222-226页

作者： Zehra Betul Turkmen Tzu Yu allison Lin Gaziantep University GaziantepTurkey

The world initiated a new era with the emergence of the covid-19 *** all around the globe,including Turkey,was impacted to a great *** teachers and learners were required to adapt to online education within a short period of *** previous studies had focused on the impacts of teaching English in general for teachers and learners,studies focusing on teaching of the speaking skills online particularly in the Turkish context was absent in the ***,the gap which was to be considered appropriate for this research is related to comprehending the perceptions and challenges EFL teachers confronted while attempting to teach the speaking skills online within the Turkish *** article aims to have a theoretical contribution to the current research,in order to see the significance of the Turkish context,as online teaching of English speaking was to be considered beneficial for learners,as it increased confidence for the interaction.

关键词： English teaching speaking online higher education covid-19 pandemic

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希腊:千年文明万顷碧波

初中生 2024年第6期 4-13页

作者： allison McDonald 不详

代代流传的希腊神话,影响至今的哲学思想,穿越千年的历史遗迹,都是人类文明发展的见证。蓝天、碧海,以及独具特色的白房子,构成了希腊蓝白相间的独特景观。本期《大千世界》,我们一起来感受希腊的历史、文化和美景。

关键词：蓝白相间万顷碧波历史遗迹希腊神话人类文明哲学思想 ,影响大千世界

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金城兰州,黄河明珠

初中生 2024年第21期 4-13页

作者： allison McDonald 不详

黄河流经兰州,如同一条巨龙婉蜓而过,为历史悠久的兰州城带来了无尽生机与活力。走在兰州,我们可以感受黄河的奔腾、中山桥的壮丽、白塔山的秀美,以及一碗牛肉面的香醇。本期《大千世界》,我们一起走进坐落在黄河之滨的兰州城。

关键词：中山桥黄河之滨牛肉面黄河明珠生机与活力兰州

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发现最好的墨西哥瓦哈卡

英语画刊(高中版) 2024年第5期 16-17页

作者： allison Green

充满活力的墨西哥城市瓦哈卡有着世界一流的美食充满活力的墨西哥城市瓦哈卡有着世界一流的美食、华丽的建筑和遗迹，以及丰富的自然美景景。Natural Wonder自然奇观At Hierve el Agua, you can find two stunning petrified waterfalls...

充满活力的墨西哥城市瓦哈卡有着世界一流的美食充满活力的墨西哥城市瓦哈卡有着世界一流的美食、华丽的建筑和遗迹，以及丰富的自然美景景。Natural Wonder自然奇观At Hierve el Agua, you can find two stunning petrified waterfalls. Adding to the magic are two spring-fed, infinity pools set into the rock, overlooking the blue-green mountain.在滚水石瀑布，你会发现两个令人惊叹的石化瀑布。更神奇的是，岩石中还有两个无边的泉源池，俯瞰着蓝绿色的山峦。

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哈里斯经济议程已现雏形

商业周刊（中文版） 2024年第13期 4-5页

作者： Steve Dennis Akayla Gardner Jennifer Dlouhy Bill allison 易语(译) 不详

哈里斯势在进行品牌重塑,重新聚焦关键成就,对现行计划作出一些调整而非推倒重来.空军二号在佐治亚州落地,美国卡玛拉·哈里斯(Kamala Harris)时代由此揭开惟幕。这位美国副总统此番吸引的民众比总统乔·拜登(Joe Biden)一年下来吸引的... 详细信息

哈里斯势在进行品牌重塑,重新聚焦关键成就,对现行计划作出一些调整而非推倒重来.空军二号在佐治亚州落地,美国卡玛拉·哈里斯(Kamala Harris)时代由此揭开惟幕。这位美国副总统此番吸引的民众比总统乔·拜登(Joe Biden)一年下来吸引的民众总数都多——这是哈里斯在南方,在一个她已重新唤起活力的南方州的实力展示。这是她的高光时刻。

关键词：美国副总统品牌重塑佐治亚州哈里斯推倒重来

Advances in endobariatrics:past,present,and future

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Gastroenterology Report 2023年第1期11卷 140-150页

作者： Abhishek Shenoy allison R.Schulman Division of Gastroenterology and Hepatology University of MichiganMichigan MedicineAnn ArborMIUSA Department of Surgery University of MichiganMichigan MedicineAnn ArborMIUSA

The obesity epidemic in the USA and worldwide is well documented and continues to *** metabolic and bariatric therapies may offer a less invasive approach than surgical *** article will review advances in endobariatrics over the last several decades,addressing the past and current state of bariatric and metabolic *** and Drug Administration-cleared devices and interventions currently under investigation are described including gastric devices,gastric remodeling procedures,small-bowel devices,duodenal ablation,as well as procedures to address weight regain after bariatric *** studies evaluating gastric and duodenal combination therapy,adjunctive pharmacotherapy,as well as individualized precision-health algorithms are underway.

关键词： metabolic devices endoscopic sleeve gastroplasty obesity endobariatrics bariatric therapy