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Analytical and Observational Investigation of Colors Effects on Drag Reduction in Penguins

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Journal of Bionic Engineering 2022年第4期19卷 1036-1053页

作者： Grace Tenorio Anna Zagrai William allen Mostafa Hassanalian Department of Mechanical Engineering New Mexico TechSocorroNM87801USA Cottonwood Valley Charter School SocorroNM87801USA Depertment of Biosciences Swansea UniversitySwanseaSA28PPUK

All 18 extant species of penguin are strongly countershaded,having dark dorsal and light ventral *** this paper,the thermal effects of this body color in penguins are investigated through analytical and observational ***,a thermal analysis that takes into account the environmental characteristics of penguins’habitats,fluxes,and morphology is used to analytically calculate penguin dorsal surface ***,a turbulent analytical solution for a heated boundary layer over a flat plate is applied to show that the dark color on the top of the penguins’bodies is very effective at skin drag *** verify this result,a 2D model penguin is computationally analyzed at different temperatures,confirming in principle underwater skin drag reduction through color-based surface warming with efficiency savings of up to 30%.Finally,to study how color-based increases in body surface temperatures are maintained through foraging dives,thermal cameras are used to measure the surface temperature of captive penguins before and after *** study shows conceptually that dark dorsal coloration in penguins could have a significant influence on in-water drag.

关键词： Animal coloration Drag Energy balance Irradiation Penguin Thermal imaging Skin friction

The Paradigm of Power Bounded High-Performance Computing

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Journal of Computer Science & Technology 2023年第1期38卷 87-102页

作者： Rong Ge Xizhou Feng Pengfei Zou Tyler allen School of Computing Clemson UniversityClemsonSC 29634U.S.A. Meta Platform Inc.Menlo ParkCA 94025U.S.A. Amazon Inc.SeattleWA 98170U.S.A. University of North Carolina at Charlotte NC 27599U.S.A.

Modern computer systems are increasingly bounded by the available or permissible power at multiple layers from individual components to data *** cope with this reality,it is necessary to understand how power bounds im-pact performance,especially for systems built from high-end nodes,each consisting of multiple power hungry *** placing an inappropriate power bound on a node or a component can lead to severe performance loss,coordinat-ing power allocation among nodes and components is mandatory to achieve desired performance given a total power *** this article,we describe the paradigm of power bounded high-performance computing,which considers coordinated power bound assignment to be a key factor in computer system performance analysis and *** apply this paradigm to the problem of power coordination across multiple layers for both CPU and GPU *** several case studies,we demonstrate how the principles of balanced power coordination can be applied and adapted to the inter-play of workloads,hardware technology,and the available total power for performance improvement.

关键词： power bounded computing cross-component power coordination hierarchical power allocation

Wild dogma II： The role and implications of wild dogma for wild dog management in Australia

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Current Zoology 2011年第6期57卷 737-740页

作者： Benjamin L. allen Richard M. ENGEMAN Lee R. allen The University of Queensland School of Animal Studies Warrego Highway Gatton QLD 4343 National Wildlife Research Centre 4101 l_aPorte Avenue Fort Collins CO 80521-2154 USA. Richard.M.Engeman@aphis.usda.gov Biosecurity Queensland Robert Wicks Pest Animal Research Centre Tor Street Toowoomba QLD 4350. Lee.Allen@ deedi.qld.gov.au

The studies of allen （2011） and allen et al. （2011） recently examined the methodology underpinning claims that dingoes provide net benefits to biodiversity by suppressing foxes and cats. They found most studies to have design flaws and/or observational methods that preclude valid interpretations from the data, describing most of the current literature as ＇wild dogma＇. In this short supplement, we briefly highlight the roles and implications of wild dogma for wild dog management in Australia. We discuss nomenclature, and the influence that unreliable science can have on policy and practice changes related to apex predator management

关键词： Apex predator Canis lupus dingo Practice change Public perceptions Wild dog management

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan Kaiming Tang Jian-Piao Cai Kenn Ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin Kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2020年第9期15卷 1654-1655页

作者： Scott P.allen Sheffield Institute for Translational Neuroscience University of Sheffield

The role of metabolism in amyotrophic lateral sclerosis(ALS):ALS,is a predominantly sporadic,neurological disorder resulting in degeneration of both upper and lower motor neurons,resulting in the progressive failure of the neuromuscular *** lifetime risk factor for developing ALS sits between 1 in 300 and 1 in ***,due to the speed of the disease course(2–3 years post-diagnosis)and the lack of effective therapies,ALS is still classified as a rare disease.

关键词： metabolism amyotrophic degeneration

Porous Medium Flow with Both a Fractional Potential Pressure and Fractional Time Derivative

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 45-82页

作者： Mark allen Luis CAFFARELLI Alexis VASSEUR Department of Mathematics The University of Texas at AustinAustinTX 78712USA

The authors study a porous medium equation with a right-hand side. The operator has nonlocal diffusion effects given by an inverse fractional Laplacian *** derivative in time is also fractional and is of Caputo-type, which takes into account"memory". The precise model isD_t~αu- div(u(-Δ)^(-σ)u) = f, 0 < σ <1/*** paper poses the problem over {t ∈ R^+, x ∈ R^n} with nonnegative initial data u(0, x) ≥0 as well as the right-hand side f ≥ 0. The existence for weak solutions when f, u(0, x)have exponential decay at infinity is proved. The main result is H¨older continuity for such weak solutions.

关键词： Caputo derivative Marchaud derivative Porous medium equation Hlder continuity Nonlocal diffusion

Nanoscale perspective： Materials designs and understandings in lithium metal anodes

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Nano Research 2017年第12期10卷 4003-4026页

作者： Dingchang Lin Yayuan Liu allen Pei Yi Cui Department of Materials Science and Engineering Stanford University Stanford California 94305 USA Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park California 94025 USA

Li metal chemistry is a promising alternative with a much higher energy density than that of state-of-the-art Li-ion counterparts. However, significant challenges including safety issues and poor cyclability have severely impeded Li metal technology from becoming viable. In recent years, nanotechnologies have become increasingly important in materials design and fabrication for Li metal anodes, contributing to major progress in the field. In this review, we first introduce the main achievements in Li metal battery systems fulfilled by nanotechnologies, particularly regarding Li metal anode design and protection, ultrastrong separator engineering, safety monitoring, and smart functions. Next, we introduce recent studies on nanoscale Li nucleation/deposition. Finally, we discuss possible future research directions. We hope this review delivers an overall picture of the role of nanoscale approaches in the recent progress of Li metal battery technology and inspires more research in the future.

关键词： lithium metal anodes nanoscale lithiumnucleation

Soil microbial response to waste potassium silicate drilling fluid

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Journal of Environmental Sciences 2015年第3期27卷 189-198页

作者： Linjun Yao M.Anne Naeth allen Jobson Department of Renewable Resources University of Alberta School of Land Science and Technology China University of Geosciences (Beijing)

Potassium silicate drilling fluids （PSDF） are a waste product of the oil and gas industry with potential for use in land reclamation. Few studies have examined the influence of PSDF on abundance and composition of soil bacteria and fungi. Soils from three representative locations for PSDF application in Alberta, Canada, with clay loam, loam and sand textures were studied with applications of unused, used once and used twice PSDF. For all three soils, applying ≥40 m^3/ha of used PSDF significantly affected the existing soil microbial flora. No microbiota was detected in unused PSDF without soil. Adding used PSDF to soil significantly increased total fungal and aerobic bacterial colony forming units in dilution plate counts, and anaerobic denitrifying bacteria numbers in serial growth experiments. Used PSDF altered bacterial and fungal colony forming unit ratios of all three soils.

关键词： Drilling waste Potassium silicate drilling fluid Soil Microbiota

LIS学科的未来:坚持社会福祉使命——UIUC信息科学学院前院长allen Renear教授学术访谈

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图书情报知识 2022年第5期39卷 20-30页

作者： allen Renear 韦景竹美国伊利诺伊大学厄巴纳-香槟分校信息科学学院伊利诺伊61801 中山大学信息管理学院广州510006

“全球iSchools院长专访”第六期与大家见面了。在本期专访中,我们非常荣幸邀请到了美国伊利诺伊大学厄巴纳-香槟分校(UIUC)信息科学学院前院长allen Renear教授。该学院拥有100多年的历史,是iSchools运动的发起学院之一。在《美国新闻... 详细信息

“全球iSchools院长专访”第六期与大家见面了。在本期专访中,我们非常荣幸邀请到了美国伊利诺伊大学厄巴纳-香槟分校(UIUC)信息科学学院前院长allen Renear教授。该学院拥有100多年的历史,是iSchools运动的发起学院之一。在《美国新闻与世界报道》排名中,UIUC的iSchool连续多年在LIS学科位居第一,在全球LIS领域发挥着引领的作用。作为iSchools运动的引领者之一,allen Renear教授一直活跃在国际LIS学科领域,并到访了中国多所iSchool院校,不仅极大地促进了学术交流合作,而且与中国学者建立了深厚的友谊。教授认为iSchools这一学术共同体取得了超出预期的成功,其未来的发展应“确保科技应用不仅在技术上成功,而且对社会有益和公平”,这也是对LIS学科更广阔的一种使命期待。

关键词： iSchool 学术共同体学术交流信息科学学院 LIS 学术访谈社会福祉