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Adaptive pathways and emerging strategies overcoming treatment resistance in castration resistant prostate cancer

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Asian Journal of Urology 2016年第4期3卷 185-194页

The therapies available for prostate cancer patients whom progress from hormonesensitive to castration resistant prostate cancer include both systemic drugs,including docetaxel and cabazitaxel,and drugs that inhibit androgen signaling such as enzalutamide and ***,it is estimated that up to 30%of patients have primary resistance to these treatments and over time even those who initially respond to therapy will eventually develop resistance and their disease will continue to progress regardless of the presence of the *** the mechanisms involved in the development of resistance to these therapies has been the area of intense study and several adaptive pathways have been *** receptor(AR)mutations,expression of AR-V7(or other constitutively active androgen receptor variants),intracrine androgen production and overexpression of androgen synthesis enzymes such as Aldo-Keto Reductase Family 1,Member c3(AKR1c3)are among the many mechanisms associated with resistance to *** regards to the taxanes,one of the key contributors to drug resistance is increased drug efflux through ATP Binding cassette Subfamily B Member 1(ABcB1).Targeting these resistance mechanisms using different strategies has led to various levels of success in overcoming resistance to current *** instance,targeting AR-V7 with niclosamide or AKR1c3 with indomethacin can improve enzalutamide and abiraterone ***1 transport activity can be inhibited by the dietary constituent apigenin and antiandrogens such as bicalutamide which in turn improves response to docetaxel.A more thorough understanding of how drug resistance develops will lead to improved treatment *** review will cover the current knowledge of resistance mechanisms to castration resistant prostate cancer therapies and methods that have been identified which may improve treatment response.

关键词： Prostate cancer castration resistant prostate cancer Enzalutamide Abiraterone Docetaxel Drug resistance

In honor of Dr. Donald S. coffey-Prostate cancer biology and therapy

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Asian Journal of Urology 2019年第1期6卷 1-2页

作者： allen c.gao James L.Mohler Department of Urology University of CaliforniaDavisSacramentoCAUSA comprehensive cancer center University of CaliforniaDavisSacramentoCAUSA VA Northern california Health care System SacramentoCAUSA Department of Urology Roswell Park Comprehensive Cancer CenterBuffaloNYUSA

This special issue of the Asian Journal of Urology(AJU)is dedicated to Donald ***,*** passed away on Nov.9,***,professor at Johns Hopkins University,made monumental impacts on the advancement of urological research and the lives of people around him in and out of the urological research *** played an essential role in the Society for Basic Urologic Research(SBUR)as a devoted member and former *** have collected 11 articles written by former students,trainees,fellows and colleagues of *** that cover a wide range of topics considered to be of prime interest to ***,which include the genetics,diagnosis,and treatment of advanced prostate cancer(Pca).

关键词： diagnosis cancer Hopkins

甲基硒酸对人高转移大细胞肺癌细胞株L9981增殖和凋亡作用及其分子机制的初步研究

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中国肺癌杂志 2006年第2期9卷 103-108页

作者：刘洁薇钟晓蓉周清华 allen c.gao 王艳萍朱文马力张芷旋四川大学华西医院四川省肺癌分子重点实验室肿瘤中心成都610041 美国纽约州立Roswell Park癌症研究所医学与药学系

背景与目的已有的研究表明硒具有防癌作用和抑制乳腺癌、前列腺癌细胞株增殖的作用,但有关甲基硒酸(MSA)是否具有抗肺癌的作用目前尚不清楚。本研究的目的是探讨MSA对人高转移大细胞肺癌细胞株L9981是否具有生长抑制及诱导凋亡的作用,... 详细信息

背景与目的已有的研究表明硒具有防癌作用和抑制乳腺癌、前列腺癌细胞株增殖的作用,但有关甲基硒酸(MSA)是否具有抗肺癌的作用目前尚不清楚。本研究的目的是探讨MSA对人高转移大细胞肺癌细胞株L9981是否具有生长抑制及诱导凋亡的作用,并对其分子机制作初步探讨。方法应用体外细胞培养技术,以MSA处理L9981细胞株,应用台盼蓝计数法、克隆形成实验和流式细胞术检测MSA处理L9981细胞株前后细胞株体外增殖、克隆形成和凋亡水平的变化。应用流式细胞术检测MSA处理L9981细胞株前后细胞周期、细胞周期相关蛋白和凋亡相关蛋白表达水平的变化。结果①MSA在大于0.5μmol/L的浓度时可显著抑制L9981细胞株的增殖(P<0.05),细胞被阻滞于G0/G1期。②MSA浓度在2.5μmol/L时可诱导L9981细胞株进入凋亡(P<0.05)。③MSA在5μmol/L时可明显抑制L9981细胞株的克隆形成能力(P<0.05)。④MSA能显著上调P53、P21、Fas、FasL和Bax蛋白表达水平。结论①MSA可显著抑制人高转移大细胞肺癌细胞株L9981的体外增殖和克隆形成能力,并诱导细胞凋亡;②MSA的抗肺癌作用可能与其调控肺癌细胞株L9981细胞周期和细胞凋亡相关基因表达有关。

关键词：甲基硒酸人高转移大细胞肺癌细胞株L9981 生长抑制凋亡

血管内皮生长因子和表皮生长因子信号通路的联合抑制在非小细胞肺癌治疗中的应用

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中国肺癌杂志 2009年第12期12卷 1316-1324页

作者：南娟刘谦丁燕张占雀 allen c.gao 周清华天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境实验室天津300052 山西省芮城县人民医院芮城044600 Departmentof Urology and cancer center University of California School of Medicine at Davis

肺癌是全球癌症相关死亡的首位原因,已成为人类面临的日益严重的公共卫生问题,各国政府均投入了大量的人力物力,以期在肺癌研究领域有所突破。大约50%新诊断的肺癌已属晚期,对于这些患者可采用姑息性系统治疗法。系统化疗是目前治疗非... 详细信息

肺癌是全球癌症相关死亡的首位原因,已成为人类面临的日益严重的公共卫生问题,各国政府均投入了大量的人力物力,以期在肺癌研究领域有所突破。大约50%新诊断的肺癌已属晚期,对于这些患者可采用姑息性系统治疗法。系统化疗是目前治疗非小细胞肺癌（non—small cell lung cancer，NScLc）的主要措施。许多基于顺铂的联合方案和单药疗法常用于晚期NScLc患者不同阶段的治疗。

关键词：非小细胞肺癌血管内皮生长因子表皮生长因子治疗法联合抑制信号通路公共卫生问题 cell

Analysis of Oxides Formed on the Surface of the Alloy 690 in Hydrogenated Supercritical Water

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 774-781页

作者： Jin gao Fa-rong Wan Guo-ping cao Kumar Sridharan Todd allen School of Materials Science and Engineering University of Science and Technology Beijing Department of Materials Science and Engineering University of Wisconsin-Madison

The oxides formed on the surface of the alloy 690 in hydrogenated supercritical water at 400℃ for 1000 h were investigated using scanning electron microscopy,transmission electron microscopy,scanning transmission electron microscopy and energy-dispersive X-ray *** oxides on me surface of the alloy 690 exhibited multi-layer structure：an outer layer consisted of granular crystallites（NiO and NiFe_2O_4） and a compact inner layer（spinel and cr_2O_3）.chemical analysis indicated that the outer layer was enriched in nickel but depleted in chromium,whereas the inner layer was enriched in chromium and iron but depleted in *** inner layer was also characterized as layered structure by Fe-rich spinel on top of continuous cr_2O_3 ***,cr_2O_3 nodules were readily observed at the oxides/alloy interface.

关键词： Alloy 690 Supercritical water Oxides corrosion

Plasma Epstein-Barr virus DNA as a biomarker for nasopharyngeal carcinoma

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chinese Journal of cancer 2014年第12期33卷 598-603页

作者： K.c.allen chan Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Department of chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital State Key Laboratory in Oncology in South china Sir Y.K. Pao Centre for Cancer The Chinese University of Hong Kong Prince of Wales Hospital

Nasopharyngeal carcinoma(NPc)is common in southern china and Southeast ***-Barr virus(EBV)infection is an important etiology for NPc,and EBV genome can be detected in almost all tumor tissues of NPc in this *** EBV DNA,when quantitatively analyzed using real-time polymerase chain reaction(PcR),has been developed as a biomarker for *** this review,the different clinical applications of plasma EBV DNA in the management of NPc,including screening,monitoring,and prognostication,are *** addition,the biological issues of circulating EBV DNA,including the molecular nature and clearance kinetics,are also explored.

关键词：病毒DNA 生物标志物鼻咽癌等离子体聚合酶链反应东南亚地区 EBV 中国南部

Assimilation of atmospheric infrared sounder radiances with WRF-GSI for improving typhoon forecast

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Frontiers of Earth Science 2018年第3期12卷 457-467页

作者： Yan-An LIU Zhibin SUN Maosi cHEN Hung-Lung allen HUANG Wei gao Key Laboratory of Geographic Information Science (Ministry of Education) East China Normal University Shanghai 200241 China School of Geographic Sciences East China Normal University Shanghai 200241 China EcNU-cSU Joint Research Institute for New Energy and the Environment East China Normal University Shanghai 200062 China Joint Laboratory for Environmental Remote Sensing and Data Assimilation East China Normal University Shanghai 200241 China Natural Resource Ecology Laboratory Colorado State University Fort Collins CO 80523 United States cooperative Institute for Meteorological Satellite Studies University of Wisconsin-Madison Madison WI 53706 United States

The Atmospheric Infrared Sounder （AIRS） can provide the profile information on atmospheric temperature and humidity in high vertical resolution. The assimilation of its radiances has been proven to improve the Numerical Weather Prediction （NWP） in global models. In this study, regional assimilation of AIRS radiances was carried out in a community assimilation system, using Gridpoint Statistical Interpolation （GSI） coupled with the Weather Research and Forecasting （WRY） model. The AIRS channel selection, quality control, and radiances bias correction were examined and illustrated for optimized assimilation. The bias correction scheme in the regional model showed that corrections on most of the channels produce satisfactory results except for several land surface channels. The assimilation and forecast experiments were carried out for three typhoon cases （Saola, Damrey, and Haikui in 2012） with and without including AIRS radiances. Results show that the assimilation of AIRS radiances into the WRF/GSI model improves both the typhoon track and intensity in a 72-hour forecast.

关键词： AIRS WRF/GSI model radiance assimilation typhoon forecast

High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases

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World Journal of Gastroenterology 2017年第16期23卷 2819-2825页

作者： Mamie gao allen Zhong Neil Patel chiraag Alur Dinesh Vyas Department of Surgery Texas Tech UniversityOdessaTX 79763United States

RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and crohn's disease), and irritable bowel syndrome.

关键词： colon RNA sequencing colon cancer Transcriptome Next generation sequencing high throughput

Adaptively controlled Hybrid Welding Using a High Brightness Laser

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稀有金属材料与工程 2011年第S4期40卷 1-5页

作者： c.M.allen P.A.Hilton TWI Ltd Granta ParkGreat AbingtonCambridgeCB21 6ALUnited Kingdom

Hybrid laser-MAG welding with real-time adaptive control has been *** welding conditions have been developed to produce ISO 13919-1 class B (stringent) quality butt welds between 8mm thickness steel plates,using a 5kW *** Yb fibre laser combined with conventional arc welding equipment.A laser vision seam tracking system has enabled a 7-axis robot,manipulating the hybrid welding head,to track butt joints in real time during *** laser vision system has also provided information on the variations in joint fit-up,in particular the width of any gaps,or height of any mismatches *** information has then been used to automatically adjust the robot position or speed,or arc welding parameters,depending on the fit-up *** this way,the tolerance of the hybrid process has been augmented,producing stringent quality welds over a wider range of joint fit-up cases than when using fixed conditions alone.

关键词： hybrid welding steel adaptive control fit-up tolerance