High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases

作     者：Mamie Gao Allen Zhong Neil Patel Chiraag Alur Dinesh Vyas 

作者机构：Department of SurgeryTexas Tech UniversityOdessaTX 79763United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第16期

页      面：2819-2825页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colon RNA sequencing Colon cancer Transcriptome Next generation sequencing high throughput 

摘      要：RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG s), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn s disease), and irritable bowel syndrome.