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Physicochemical properties of proton-conducting SmNiO3 epitaxial films

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journal of Materiomics 2019年第2期5卷 247-251页

作者： Xing Xu Chen Liu jing Ma allan j.jacobson Cewen Nan Chonglin Chen School of Material Science and Engineering Tsinghua UniversityBeijing100086China Department of Chemistry and Texas Center for Superconductivity University of HoustonHoustonTX77204USA Department of Physics and Astronomy University of Texas at San AntonioSan AntonioTX78249USA

Proton conducting SmNiO_(3)(SNO)thin films were grown on(001)LaAlO_(3)substrates for systematically investigating the proton transport properties.X-ray Diffraction and Atomic Force Microscopy studies reveal that the as-grown SNO thin films have good single crystallinity and smooth surface *** electrical conductivity measurements in air indicate a peak at 473 K in the temperature dependence of the resistance of the SNO films,probably due to oxygen loss on heating.A Metal-Insulator-Transition occurs at 373 K for the films after annealing at 873 K in *** a hydrogen atmosphere(3%H_(2)/97%N_(2)),an anomalous peak in the resistance is found at 685 K on the first heating *** Impedance Spectroscopy studies as a function of temperature indicate that the SNO films have a high ionic conductivity(0.030 S/cm at 773 K)in a hydrogen *** activation energy for proton conductivity was determined to be 0.23 eV at 473-773 K and 0.37 eV at 773e973 K *** findings demonstrate that SNO thin films have good proton conductivity and are good candidate electrolytes for low temperature proton-conducting Solid Oxide Fuel Cells.

关键词： SmNiO_(3) Thin film Transport properties Ionic conductivity Impedance measurements

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： jeremy P.Tervo Patricia T.jacobson Brandon j.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher joseph B.Gary David A.Gudis Paule V.joseph D.P.Devanand Terry E.Goldberg jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

The effect of EMG magnitude on the masseter vestibular evoked myogenic potential(mVEMP)

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journal of Otology 2022年第4期17卷 203-210页

作者： Daniel j.Romero Gary P.jacobson Richard A.Roberts Department of Hearing and Speech Sciences Division of Vestibular SciencesVanderbilt University Medical Center121521st Ave.South6308 Medical Center EastNashvilleTN37232-8718USA

Introduction:The masseter vestibular evoked myogenic potential(mVEMP)is a bilaterally generated,electromyographically(EMG)-mediated response innervated by the trigeminal *** purpose of the present investigation was to 1)determine whether subjects could accurately achieve and maintain a range of EMG target levels,2)to examine the effects of varied EMG levels on the latencies and amplitudes of the mVEMP,and 3)to investigate the degree of side-to-side asymmetry and any effects of EMG ***:Subjects were nine neurologically and otologically normal young adults.A high-intensity tone burst was presented monaurally while subjects were seated upright and asked to match a range of EMG target levels by clenching their *** were made from the ipsilateral and contralateral masseter muscles referenced to the ear being monaurally ***:We found that the tonic EMG target had no effect on mVEMP ***,although mVEMP amplitudes“scaled”to the EMG target,there was a tendency for the subjects’EMG level to“undershoot”the EMG target levels greater than 50 *** some individuals did generate differences in EMG activation between sides,there were no significant differences on average EMG activation between ***,while average corrected amplitude asymmetry was similar across EMG targets,some individuals demonstrated large,corrected amplitude asymmetry ***:The results of this investigation suggest that,as with cVEMP recordings,the underlying EMG activation may vary between subjects and could impact mVEMP amplitudes,yet could be mitigated by amplitude correction *** it is important to be aware that even young normal subjects have difficulty maintaining large,tonic EMG activity during the mVEMP recording.

关键词： Vestibular evoked myogenic potentials (VEMPs) Masseter VEMPs Electromyography(EMG) Vestibulomasseteric reflex(VMR) EMG target Level

利用虚拟世界及基于代理的模型学习科学探究——计算机化科学探究模型浅析

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中国电化教育 2017年第7期 33-41页

作者：曹鹭 Michael j.jacobson 徐光涛悉尼大学教育与社会工作学院杭州师范大学教育学院教育技术系浙江杭州311121

目前,针对中学课堂科学学科的学习,长期以来的问题之一是教师认为很难开展教学活动以帮助学生学习科学探究(Scientific Inquiry)这一复杂的知识。为了帮助中学生更好地学习科学探究,该文提供并介绍了一种名为计算机化科学探究(Computati... 详细信息

目前,针对中学课堂科学学科的学习,长期以来的问题之一是教师认为很难开展教学活动以帮助学生学习科学探究(Scientific Inquiry)这一复杂的知识。为了帮助中学生更好地学习科学探究,该文提供并介绍了一种名为计算机化科学探究(Computational Scientific Inquiry,以下简称CSI)的模型。该模型由3D沉浸式虚拟世界(Virtual World)和基于代理的模型(Agent-Based Modeling)共同实现,并使用了名为有效失败(Productive Failure)的教学理念支撑学习活动的设计。根据CSI模型,我们打造了一个虚拟的3D星球Omosa Virtual World,2D基于代理的模型Omosa Netlogo,并根据有效失败设计了相应的教学活动,三者共同构成了一个基于课堂的短期课程,来帮助学生在生物学科背景下学习科学探究。悉尼两个八年级班级参与了实证研究。在课堂中获得的实证结果证明,学生明显提高了他们在科学探究方面的学习,CSI的应用是卓有成效的。

关键词：科学探究虚拟世界基于代理的模型有效失败

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电动汽车悬架运动学优化方法

同济大学学报（自然科学版） 2022年第S1期50卷 1-9页

作者： Y HUANG j KÖPLER A WAGNER j NEUBECK B jacobson 查尔默斯理工大学瑞典哥德堡41296 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

电池电动汽车(BEV)的主要挑战之一是续航里程是否足够,因此在任何最近的车辆概念中,最大化的电池体积是合乎需要的。悬架作为最大的电动汽车子系统之一,对这一点有着重要的影响。本研究目的是使用自动化方法进行悬架开发,主要是引入一... 详细信息

电池电动汽车(BEV)的主要挑战之一是续航里程是否足够,因此在任何最近的车辆概念中,最大化的电池体积是合乎需要的。悬架作为最大的电动汽车子系统之一,对这一点有着重要的影响。本研究目的是使用自动化方法进行悬架开发,主要是引入一种新的可转向后悬架概念与电力推进系统,即从配备内燃机(ICE)的传统汽车开始,开发一种悬架,以满足纯电动汽车的新装配要求,同时保持有关驾驶动力学的典型要求。悬架概念是为具有大电池尺寸的高级汽车而优化的,此外还考虑了先进的主动系统,如空气弹簧和大转向角的主动后轮转向。该概念还提出了一种具有良好调整运动学性能的封装解决方案,符合原始设备制造商的调整理念。为解决由此产生的高复杂性,使用了新开发的方法,即运动学优化是用一种创新的方法完成的,该方法根据给定的要求自动提出新的硬点。在设计中,使用简化模型来表示复杂零件的形状,因此可以从包装的角度自动判断运动学概念是否可行。结果表明,新的悬架概念可以处理具有挑战性的装配问题和复杂的运动学要求。

关键词：电动汽车(BEV) 开发过程运动学包装

Fundamentals of machine elements / Bernard j. Hamrock, Bo O. jacobson, Steven R. Schmid.

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MAGNETO RECRYSTALLIZATION OF GENOMIC AND ASSOCIATED STRUCTURES POTENTIALLY APPLICATIVE TO SUCH DIVERSE CONCERNS AS CANCER, AIDS, AND CNS REGENERATION

1999年

作者： Bernard j. Hamrock Bo O. jacobson Steven R. Schmid.

来源：畅想之星图书光盘版（南... 评论

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中华医学杂志(英文版) 1991年第12期104卷 1025-1032页

作者： j.I.jacobson PhD DMD 33458 Florida Institute of Theoretical Physics &amp Advanced Studies for Biophysical Research 153 Raintree Trail Jupiter

Physiologic magnetic fields on the order of magnitude 10-8gauss have been unified with their propitiators: quantum genetic particles, the gravitational potential of which is about a few ergs. As these fields are applied to the equations for solenoidal models, B=μNI/L, currents of about a microampere are derived; in perfect accord with recent clinical data indicating the therapeutic efficacy of weak currents in repair and growth of soft tissue, bone and nerve. The mechanism of reorientation of spin angular momentum of leptons and baryons influencing molecular magnetic domains to bring about "particle jumps" is presented to obtain a clinical picture. The clinical picture is that of an organism placed at right angles to flux lines in the midst of a solenoid immersed in water. The patient is then exposed to exogenously sourced resonant physiologic magnetic fields which convert malalligned atomic lattices of oncogenes and associated particles to homologous normal structures.

关键词： FIELDS THERAPY GROWTH

Temperature variable and the efficiency of sperm mediated transfection of HPV16 DNA into cells

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Asian journal of Andrology 2002年第3期4卷 169-173页

作者： Ruslana Kadze Philip j.Chan john D.jacobson johannah U.Corselli Alan King Center for Fertility and In Vitro Fertilization Department of Gynecology and Obstetricsand Department of Physiology and PharmacologyLoma Linda University School of MedicineLoma LindaCalifornia 92350USA

Aim:To pretreat sperm at various temperatures before exposure to human papillomavirus(HPV)16 DNA fragments and to assess the efficiency of HPV carrier sperm to transfect cumulus ***:Cumulus cells from follicular aspirates were obtained,pooled and divided into culture dishes containing Sybr Gold-stained HPV DNA carrying sperm that were either pretreated at 4℃,37℃or 40℃(n=5).The cells were incubated in 5%CO_(2) in air mixture at 37℃for 24 *** efficiency of sperm to take up fluorescent HPV DNA was determined at hour *** incubation,cumulus cell viability was assessed using the e0sin method and the percentages of fluorescent cumulus cells ***:Over half of all the cumulus cells became fluorescent with the highest percentage in the 37℃*** pretreated at 4℃had the greatest amount of HPV DNA *** sperm motility was similar for the 3 pretreatment *** were no differences in cumulus viability among the ***:Sperm pretreated at 37℃transferred the greatest amount of fluorescent HPV DNA fragments to the cumulus *** HPV DNA was observed in the nuclear and cytoplasmic *** data suggested the possibility of sperm as a vector for the transmission of HPV DNA to the cumulus cells surrounding ovulated oocytes,which might lead to early implantation failures.

关键词： spermatozoa human papillomavirus gene transfer cumulus fertility

Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway

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Synthetic and Systems Biotechnology 2022年第2期7卷 738-749页

作者： Francesca V.Gambacorta Ellen R.Wagner Tyler B.jacobson Mary Tremaine Laura K.Muehlbauer Mick A.McGee justin j.Baerwald Russell L.Wrobel john F.Wolters Mike Place joshua j.Dietrich Dan Xie jose Serate Shabda Gajbhiye Lisa Liu Maikayeng Vang-Smith joshua j.Coon Yaoping Zhang Audrey P.Gasch Daniel Amador-Noguez Chris Todd Hittinger Trey K.Sato Brian F.Pfleger DOE Great Lakes Bioenergy Research Center University of Wisconsin-MadisonMadisonWIUSA Department of Chemical and Biological Engineering University of Wisconsin-MadisonMadisonWIUSA Laboratory of Genetics Center for Genomic Science InnovationUniversity of Wisconsin-MadisonMadisonWIUSA Department of Bacteriology University of Wisconsin-MadisonMadisonWIUSA Department of Chemistry University of Wisconsin-MadisonMadisonWIUSA Wisconsin Energy Institute J.F.Crow Institute for the Study of EvolutionUniversity of Wisconsin-MadisonMadisonWIUSA Department of Biomolecular Chemistry University of Wisconsin-MadisonMadisonWIUSA

Metabolic engineering strategies have been successfully implemented to improve the production of isobutanol,a next-generation biofuel,in Saccharomyces ***,we explore how two of these strategies,pathway re-localization and redox cofactor-balancing,affect the performance and physiology of isobutanol producing *** equipped yeast with isobutanol cassettes which had either a mitochondrial or cytosolic localized isobutanol pathway and used either a redox-imbalanced(NADPH-dependent)or redox-balanced(NADH-dependent)ketol-acid reductoisomerase *** then conducted transcriptomic,proteomic and metabolomic analyses to elucidate molecular differences between the engineered *** localization had a large effect on isobutanol production with the strain expressing the mitochondrial-localized enzymes producing 3.8-fold more isobutanol than strains expressing the cytosolic ***-balancing did not improve isobutanol titers and instead the strain with the redox-imbalanced pathway produced 1.5-fold more isobutanol than the balanced version,albeit at low overall pathway *** genomic analyses suggested that the poor performances of the cytosolic pathway strains were in part due to a shortage in cytosolic Fe-S clusters,which are required cofactors for the dihydroxyacid dehydratase *** then demonstrated that this cofactor limitation may be partially recovered by disrupting iron homeostasis with a fra2 mutation,thereby increasing cellular iron *** resulting isobutanol titer of the fra2 null strain harboring a cytosolic-localized isobutanol pathway outperformed the strain with the mitochondrial-localized pathway by 1.3-fold,demonstrating that both localizations can support flux to isobutanol.

关键词： Saccharomyces cerevisiae Isobutanol Functional genomics analysis Pathway localization Fe incorporation