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拉米夫定治疗慢性乙型肝炎生存质量评价

肝脏 2003年第4期8卷 3-5,68页

作者：姚光弼 alison T m 黄瑛籍纳新杨莉上海市静安区中心医院 200040 葛兰素史克中国投资有限公司复旦大学公共卫生学院卫生经济教研室

目的　评价拉米夫定治疗慢性乙型肝炎生存质量的改善状况。方法　分别于拉米夫定治疗前、治疗半年、1年采用SF 3 6量表测定 2 44例病人的生存质量评分。结果　与治疗前相比 ,拉米夫定治疗半年及 1年后在躯体角色RP( 9.6)、社会功能SF( 8... 详细信息

目的　评价拉米夫定治疗慢性乙型肝炎生存质量的改善状况。方法　分别于拉米夫定治疗前、治疗半年、1年采用SF 3 6量表测定 2 44例病人的生存质量评分。结果　与治疗前相比 ,拉米夫定治疗半年及 1年后在躯体角色RP( 9.6)、社会功能SF( 8.2 )、情绪角色RE( 11.8)和活力VT( 6.2 ) 4个领域得分有显著提高 (P mCS( 3 .6)。结论　拉米夫定治疗慢性乙型肝炎病人能有效改善病人生存质量。

关键词：拉米夫定药物治疗慢性乙型肝炎生存质量质量评价

Simultaneous whole body ^(18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging for evaluation of pediatric cancer: Preliminary experience and comparison with ^(18)F-fluorodeoxyglucose positron emission tomography computed tomogra

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World Journal of Radiology 2016年第3期8卷 322-330页

作者： Brian S Pugmire Alexander R Guimaraes Ruth Lim alison m Friedmann mary Huang David Ebb Howard Weinstein Onofrio A Catalano Umar mahmood Ciprian Catana michael S Gee Department of Radiology Cincinnati Children’s Hospital Medical Center Division of Body Imaging Oregon Health Sciences University Division of Abdominal Imaging Massachusetts General Hospital martinos Center for Biomedical Imaging Division of Nuclear medicine and molecular Imaging Massachusetts General Hospital Division of Pediatric Imaging Mass General Hospital for Children Division of Pediatric Hematology-Oncology Mass General Hospital for Children

AIm: To describe our preliminary experience with simultaneous whole body ^(18)F-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography and magnetic resonance imaging(PET-mRI) in the evaluation of pediatric oncology ***: This prospective, observational, singlecenter study was Health Insurance Portability and Accountability Act-compliant, and institutional review board approved. To be eligible, a patient was required to:(1) have a known or suspected cancer diagnosis;(2) be under the care of a pediatric hematologist/oncologist; and(3) be scheduled for clinically indicated ^(18)F-FDG PETCT examination at our institution. Patients underwent PET-CT followed by PET-mRI on the same day. PET-CT examinations were performed using standard department protocols. PET-mRI studies were acquired with an integrated 3 Tesla PET-mRI scanner using whole body T1 Dixon, T2 HASTE, EPI diffusion-weighted imaging(DWI) and STIR sequences. No additional radiotracer was given for the PET-mRI examination. Both PET-CT and PETmRI examinations were reviewed by consensus by two study personnel. Test performance characteristics of PETmRI, for the detection of malignant lesions, including FDG maximum standardized uptake value(SUVmax) and minimum apparent diffusion coefficient(ADCmin), were calculated on a per lesion basis using PET-CT as a reference ***: A total of 10 whole body PET-mRI exams were performed in 7 pediatric oncology patients. The mean patient age was 16.1 years(range 12-19 years) including 6 males and 1 female. A total of 20 malignant and 21 benign lesions were identified on PET-CT. PET-mRI SUVmax had excellent correlation with PET-CT SUVmax for both benign and malignant lesions(R = 0.93). PETmRI SUVmax > 2.5 had 100% accuracy for discriminating benign from malignant lesions using PET-computed tomography(CT) reference. Whole body DWI was also evaluated: the mean ADCmin of malignant lesions(780.2 + 326.6) was significantly lower than that of benign lesions(1

关键词： Positron emission tomography Radiology Pediatric imaging Oncology Cancer magnetic resonance imaging

Comparative phylogenomics and phylotranscriptomics provide insights into the genetic complexity of nitrogen-fixing root-nodule symbiosis

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Plant Communications 2024年第1期5卷 130-147页

作者： Yu Zhang Yuan Fu Wenfei Xian Xiuli Li Yong Feng Fengjiao Bu Yan Shi Shiyu Chen Robin van Velzen Kai Battenberg alison m.Berry marco G.Salgado Hui Liu Tingshuang Yi Pascale Fournier Nicole Alloisio Petar Pujic Hasna Boubakri m.Eric Schranz Pierre-marc Delaux Gane Ka-Shu Wong Valerie Hocher Sergio Svistoonoff Hassen Gherbi Ertao Wang Wouter Kohlen Luis G.Wall martin Parniske Katharina Pawlowski Philippe Normand Jeffrey J.Doyle Shifeng Cheng Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China Biosystematics Group Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Department of Plant Sciences University of CaliforniaDavisDavisCA 95616USA Department of Ecology Environment and Plant SciencesStockholm University10691 StockholmSweden Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesLanhei RoadKunming 650201China Universite´de Lyon Universite´Lyon 1CNRSUMR5557Ecologie MicrobienneINRAUMR 141843 bd du 11 novembre 191869622 VilleurbanneFrance Laboratoire de Recherche en Sciences Ve´ge´tales(LRSV) Universite´de ToulouseCNRSUPS24 chemin de Borde RougeAuzevilleBP4261731326 Castanet TolosanFrance Department of Biological Sciences University of AlbertaEdmontonAB T6G 2E9Canada French National Research Institute for Sustainable Development(IRD) UMR LSTM(IRD/CIRAD/INRAe/Montpellier University/Supagro)-Campus International BaillarguetTA A-82/J34398 Montpellier Cedex 5France National Key Laboratory of Plant molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologySIBSChinese Academy of SciencesShanghaiChina Laboratory of molecular Biology Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Laboratory of Biochemistry Microbiology and Soil Biological InteractionsDepartment of Science and TechnologyNational University of QuilmesCONICETBernalArgentina Faculty of Biology GeneticsLMU MunichGroßhaderner Strasse 2-482152 MartinsriedGermany School of Integrative Plant Science Sections of Plant Biology and Plant Breeding&GeneticsCornell UniversityIthacaNY 14853USA State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China Univer

Plant root-nodule symbiosis(RNS)with mutualistic nitrogen-fixing bacteria is restricted to a single clade of angiosperms,the Nitrogen-Fixing Nodulation Clade(NFNC),and is best understood in the legume *** species share many commonalities,explained either by divergence from a common ancestor over 100 million years ago or by convergence following independent origins over that same time ***,comparative analyses of diverse nodulation syndromes can provide insights into constraints on nodulation—what must be acquired or cannot be lost for a functional symbiosis—and the latitude for Plant Communications Genomic landscape of nodulation variation in the ***,much remains to be learned about nodulation,especially outside of ***,we employed a large-scale phylogenomic analysis across 88 species,complemented by 151 RNA-seq libraries,to elucidate the evolution of *** phylogenomic analyses further emphasize the uniqueness of the transcription factor NIN as a master regulator of nodulation and identify key muta-tions that affect its function across the *** transcriptomic assessment revealed nodule-specific upregulated genes across diverse nodulating plants,while also identifying nodule-specific and nitrogen-response *** 70%of symbiosis-related genes are highly conserved in the four representative species,whereas defense-related and host-range restriction genes tend to be lineage *** study also identified over 900000 conserved non-coding elements(CNEs),over 300000 of which are unique to sampled NFNC ***-specific CNEs are enriched with the active H3K9ac mark and are correlated with accessible chromatin regions,thus representing a pool of candidate regula-tory elements for genes involved in ***,our results provide novel insights into the evolution of nodulation and lay a foundation for engineering of RNS traits in agriculturally important crops.

关键词： nitrogen-fixing root-nodule symbiosis two competing hypotheses phylogenomics phylotranscrip-tomics conserved non-coding elements convergence deep homology

Spatial distribution of leprosy in India:an ecological study

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Infectious Diseases of Poverty 2018年第1期7卷 206-214页

作者： Kyra H.Grantz Winnie Chabaari Ramolotja Kagiso Samuel Buri Gershom Laura Blum Lee Worden Sarah Ackley Fengchen Liu Thomas m.Lietman alison P.Galvani Lalitha Prajna Travis C.Porco Department of Biology University of FloridaGainesvilleFLUSA Emerging Pathogens Institute University of FloridaGainesvilleFLUSA DST/NRF Center for Excellence in Epidemiological modeling and Analysis(SACEmA) StellenboschSouth Africa Stellenbosch University StellenboschSouth Africa African Institute of mathematical Sciences MuizenbergSouth Africa University of California BerkeleyCAUSA Francis I.Proctor Foundation for Research in Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCAUSA Yale University New HavenCTUSA Aravind Eye Hospital MaduraiTamil NaduIndia

Background:As leprosy elimination becomes an increasingly realistic goal,it is essential to determine the factors that contribute to its *** evaluate social and economic factors as predictors of leprosy annual new case detection rates within India,where the majority of leprosy cases ***:We used correlation and linear mixed effect regressions to assess whether poverty,illiteracy,nighttime satellite radiance(an index of development),and other covariates can explain district-wise annual new case detection rate and Grade 2 disability ***:We find only weak evidence of an association between poverty and annual new case detection rates at the district level,though illiteracy and satellite radiance are statistically significant predictors of leprosy at the district *** find no evidence of rapid decline over the period 2008-2015 in either new case detection or new Grade 2 ***:Our findings suggest a somewhat higher rate of leprosy detection,on average,in poorer districts;the overall effect is *** divide between leprosy case detection and true incidence of clinical leprosy complicates these results,particularly given that the detection rate is likely disproportionately lower in impoverished *** information is needed to distinguish the determinants of leprosy case detection and transmission during the elimination epoch.

关键词： Leprosy Hansen’s disease India Poverty Spatial

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餐饮类设计一等奖——Vong餐馆

室内设计与装修 1998年第5期 40-41页

作者： alison HENRY DESIGN LTD

Vong餐馆位于香港mandarin Oriental饭店的第25层,面积319.5m^2,1997年9月12日完工,餐馆前身是Harlequin酒吧和Prierrot餐馆。新的餐馆将二者结合一起,成为mandarin Oriental饭店中既精致,又充满活力的新餐厅。为了延续已有Vong餐馆的... 详细信息

Vong餐馆位于香港mandarin Oriental饭店的第25层,面积319.5m^2,1997年9月12日完工,餐馆前身是Harlequin酒吧和Prierrot餐馆。新的餐馆将二者结合一起,成为mandarin Oriental饭店中既精致,又充满活力的新餐厅。为了延续已有Vong餐馆的成功,设计者就以成功的Vong餐馆为基础,结合一些设计有趣的灯、花瓶、独特的桌面设计创造出一个全新的,轻松又活跃的就餐氛围。虽然强调精致,却毫无矫揉造作,餐馆轻松舒适,适合任何场合的需要。

关键词：餐馆室内设计室内装饰香港

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植物生物学

新疆农业科学 2012年第7期 1320-1320页

作者： alison m.Smith 瞿礼嘉

书号:978-7-03-034067-2/Q·2900作者:(英)alison ***等编著;瞿礼嘉等译定价:180内容简介:本书由欧洲著名植物分子生物学研究所JohnInnes Center的七位杰出植物生物学家合作撰写。全书共分九章,首先介绍现代植物起源研究,并简述植物基... 详细信息

书号:978-7-03-034067-2/Q·2900作者:(英)alison ***等编著;瞿礼嘉等译定价:180内容简介:本书由欧洲著名植物分子生物学研究所JohnInnes Center的七位杰出植物生物学家合作撰写。全书共分九章,首先介绍现代植物起源研究,并简述植物基因组和遗传学的特征,随后阐述植物细胞代谢和发育等方面的基础知识和研究进展,以及植物对环境信号的接受和应对生物胁迫和非生物胁迫的策略,最后讨论植物学研究发展与人类社会的关系。本书内容全面、系统、权威,反映了当前人们对植物学在分子层

关键词：植物生物学植物学植物分子生物学

机器人义肢——可能颠覆未来的科技一名芝加哥男子参与研究,期望有朝一日可以改变病人预后

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空中英语教室（高级版．彭蒙惠英语） 2022年第3期 12-13,40,41页

作者： alison Bowen 马励(译) 不详

斯科特·英布里第一次为自己严重的伤势流泪是在芝加哥康复研究所的一间病房内,那时,他正眺望着密歇根湖。但眼泪流下的瞬间,决心也暗自下定。“我决定,无论结果如何,我都要想出一个新的办法来做事情,”58岁的英布里说。一场车祸使英布... 详细信息

斯科特·英布里第一次为自己严重的伤势流泪是在芝加哥康复研究所的一间病房内,那时,他正眺望着密歇根湖。但眼泪流下的瞬间,决心也暗自下定。“我决定,无论结果如何,我都要想出一个新的办法来做事情,”58岁的英布里说。一场车祸使英布里的腿和手臂无法完全发挥作用,之后数十年他都在寻找有创意的生活方式。

关键词：机器人布里芝加哥斯科特密歇根湖

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

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Nano Research 2015年第10期8卷 3307-3315页

作者： Daniela P. Lobo Alan m. Wemyss David J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul Pacheco-Gomez mark J. Simmons matthew R. Hicks David O. Bates alison Rodger Timothy R. Dafforn Kenton P. Arkill DepartmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK mOACDoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreformechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Schoolofmedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage m13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle m13 bacteriophage wall shear stress fluorescent microscopy

Deep data analytics for genetic engineering of diatoms linking genotype to phenotype via machine learning

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npj Computational materials 2019年第1期5卷 580-587页

作者： Artem A.Trofimov alison A.Pawlicki Nikolay Borodinov Shovon mandal Teresa J.mathews mark Hildebrand maxim A.Ziatdinov Katherine A.Hausladen Paulina K.Urbanowicz Chad A.Steed Anton V.Ievlev Alex Belianinov Joshua K.michener Rama Vasudevan Olga S.Ovchinnikova Center for Nanophase materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Scripps Institute of Oceanography University of CaliforniaSan DiegoLa JollaCA 92093USA Computer Science and mathematics Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA

Genome engineering for materials synthesis is a promising avenue for manufacturing materials with unique properties under ambient *** in diatoms,unicellular algae that use silica to construct micron-scale cell walls with nanoscale features,is an attractive candidate for functional synthesis of materials for applications including photonics,sensing,filtration,and drug ***,controllably modifying diatom structure through targeted genetic modifications for these applications is a very promising *** this work,we used gene knockdown in Thalassiosira pseudonana diatoms to create modified strains with changes to structural morphology and linked genotype to phenotype using supervised machine *** artificial neural network(NN)was developed to distinguish wild and modified diatoms based on the SEm images of frustules exhibiting phenotypic changes caused by a specific protein(Thaps3_21880),resulting in 94% detection *** activation maps visualized physical changes that allowed the NNs to separate diatom strains,subsequently establishing a specific gene that controls pores.A further NN was created to batch process image data,automatically recognize pores,and extract pore-related *** interrelationship of the extracted paraments was visualized using a multivariate data visualization tool,called CrossVis,and allowed to directly link changes in morphological diatom phenotype of pore size and distribution with changes in the genotype.

关键词： pores walls linking