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A 30% incidence of renal cysts with varying sizes and densities in biomedical research swine is not associated with renal dysfunction

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Animal Models and Experimental Medicine 2020年第3期3卷 273-281页

作者： Belinda I.Gómez joshua S.Little alisa j.leon Ian j.Stewart David M.Burmeister United States Army Institute of Surgical Research JBSA Fort Sam HoustonTXUSA David Grant US Air Force Medical Center Travis Air Force BaseCAUSA Uniformed Services University of the Health Sciences BethesdaMDUSA

Background:Renal cystic disease arising from various etiologies results in fluid-filled cavities within the ***,preexisting renal dysfunction has been shown to exacerbate multiple *** swine bred for biomedical research are often clinically inspected for illness/parasites,more advanced diagnostics may aid in uncovering underlying renal ***:Computed tomography was performed in 54 female prepubertal Yorkshire swine to characterize renal cysts;urine and blood chemistry,and histology of cysts were also ***:Digital reconstruction of right and left kidneys demonstrated that roughly one-third of the animals(17/54;31%)had one or more renal *** biomarkers of renal function were not different between animals that had cysts and those that did ***,urinary glucose(P=.03)was higher and sodium(P=.07)tended to be lower in animals with cysts compared to animals without,with no differences in protein(P=.14)or potassium(P=.20).Aspiration of cystic fluid was feasible in two animals,which revealed that the cystic fluid urea nitrogen(97.6±28.7 vs 911.3±468.2 mg/dL),potassium(29.8±14.4 vs 148.2±24.85 mmol/L),uric acid(2.55±1.35 vs 11.4±5.65 mg/dL),and creatinine(60.34±17.26 vs 268.99±95.79 mg/dL)were much lower than in the *** demonstrated a cyst that markedly compresses the adjacent cortex and is lined by a single layer of flattened epithelium,bounded by fibrous connective tissue which extends into the *** is tubular atrophy and loss in these ***:This study provides valuable insight for future studies focusing on kidney function in swine bred for biomedical research.

关键词： computed tomography cyst kidney renal dysfunction swine

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Dividend or No Dividend in Delegated Blockchain Governance:A Game Theoretic Analysis

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journal of Systems Science and Systems Engineering 2021年第3期30卷 288-306页

作者： Dapeng Pan j.leon Zhao Shaokun Fan Ziqiong Zhang School of Management Harbin Institute of TechnologyHarbin150001China School of Management and Economics The Chinese University of Hong Kong(Shenzhen)Shenzhen518172China College of Business Oregon State University488 Austin HallCorvallisOR9733USA

Delegated blockchain governance is the frontier of blockchain design issues that is to improve the scalability of blockchain *** proof of stake(DPoS)blockchains such as EOS must select a few super nodes for transaction *** particular,the blockchain community has debated recently on whether dividend should be allowed when electing super nodes,which might be considered as unethical or unfair,leading to an open research topic and a new research gap that has theoretical value for both academia and *** this paper,we build a theoretical framework to study how dividend affects user decisions and welfare in a DPoS *** on game theory,we propose a three-player Hotelling model with two policies to study the behaviors of voters and *** first use a static game analysis to show that the benefits of dividend for voters and for candidates vary with the size of reward and there exists an interval,in which the zero dividend policy would be good for the welfare of both candidates and ***,we use an evolutionary game analysis to examine the process dynamics of super node selection,we find that the campaign strategy of candidates has to do with the size of platform reward given to the candidates by the blockchain *** in the asymmetric case,we find that higher level of platform reward turns to benefit candidates with large number of votes even *** findings are instrumental for designing dividend policies in DPoS blockchains and can stimulate more potential research in blockchain governance.

关键词： Delegated proof of stake consensus algorithm blockchain Hotelling model evolutionary game

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Modeling and Control of Parallel Hybrid Electric Vehicle Using Sea-Lion Optimization

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Intelligent Automation & Soft Computing 2023年第2期35卷 1441-1454页

作者： j.leon Bosco Raj M.Marsaline Beno Department of EEE St.Xavier’s Catholic College of EngineeringChunkankadaiAnna UniversityChennaiIndia St.Xavier’s Catholic College of Engineering ChunkankadaiAnna UniversityChennaiIndia

This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving *** improve fuel efﬁciency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an electric motor(EM),a battery and an internal combustion engine(ICE).The electric motor assists the engine when accelerating,driving longer highways or climbing *** enables the use of a smaller,more efﬁcient *** also makes use of the concept of regenerative braking to maximize energy efﬁ*** a Hybrid Electric Vehicle(HEV),energy dissipated while braking is utilized to charge the *** proportional integral controller was used in this paper to analyze engine,motor performance and the New European Driving Cycle(NEDC)was used in the vehicle driving test using Matlab/*** proportional integral controllers were designed to track the desired vehicle speed and manage the vehi-cle’s energyﬂ*** Sea Lion Optimization(SLnO)methods were created to reduce fuel consumption in a parallel hybrid electric vehicle and the results were obtained for the New European Driving Cycle.

关键词： Hybrid electric vehicle(HEV) proportional integral controller parallel HEV fuel efﬁciency new European driving cycle(NEDC) sea lion optimization(SLnO)

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Business challenges and research directions of management analytics in the big data era

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journal of Management Analytics 2014年第3期1卷 169-174页

作者： j.leon Zhao Shaokun Fan Daning Hu City University of Hong Kong China West Texas A&M University CanyonUSA University of Zurich ZurichSwitzerland

Big data analytics have been embraced as a disruptive technology that will reshape business intelligence,particularly marketing intelligence,which has have traditionally relied on market surveys to understand consumer behavior and product *** this paper,we investigate how big data analytics will affect the landscape of business intelligence,leading to big data *** in the recent literature,we delineate business opportunities and managerial challenges brought forward by the emergence of big data analytics and outline a number of research directions in big data intelligence for business.

关键词： big data business intelligence data analytics data science marketing intelligence

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Government-incentivized crowdfunding for one-belt, one-road enterprises: design and research issues

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Financial Innovation 2016年第1期2卷 15-28页

作者： Chang Heon Lee j.leon Zhao Ghazwan Hassna Department of Information Systems City University of Hong KongKowloonHong Kong SAR

Background:Local,state,and federal governments have started exploring the potential of crowdfunding in transforming conventional financing methods used previously to fund public projects and *** crowdfunding has been applied to improve government financing methods in recent years,little is known about how this new model can be extended and applied in international collaboration among governmentincentivized ***:In this paper,we explores what roles crowdfunding can play as a financial intermediary to support government-incentivized multinational projects in the context of the One-Belt,One-Road ***:We conjecture that crowdfunding can offer an efficient mechanism to improve participatory budgeting and facilitate private-public collaboration while providing a high level of transparency in the budget decision ***:The paper also discusses research issues and challenges,including features of the crowdfunding platforms that can affect the adoption and use of the crowdfunding platforms in multinational initiatives.

关键词： Crowdfunding Government Incentivized Projects Participatory Budgeting Public-Private Collaboration One Belt One Road

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Editor's introduction

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Financial Innovation 2017年第1期3卷 476-477页

作者： j.leon Zhao College of Business City University of Hong KongKowloon TongHong Kong SARChina

The ninth issue of Financial Innovation(FIN),Volume 3,No.4(2017)presents eight papers contributed by sixteen authors from seven countries and areas:Canada,China,Hong Kong,India,Iran,Israel and United States as outlined below:The first paper is"Derived signals for S&P CNX nifty index futures"by *** *** effectiveness requires understanding key market signals such as trading margins,credit availability,and price *** study found that trading margins,credit availability.

关键词： trading Financial Israel

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Overview of business innovations and research opportunities in blockchain and introduction to the special issue

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Financial Innovation 2016年第1期2卷 363-369页

作者： j.leon Zhao Shaokun Fan jiaqi Yan City University of Hong Kong Hong KongChina Oregon State University CorvallisUSA Nanjing University NanjingChina

Blockchain has become a new frontier of venture capitals that has attracted the attention of banks,governments,and other business *** recent blockchain related attempts included legal blockchains by *** and Microsoft and pork tracking blockchains by Walmart and *** is poised to become the most exciting invention after the Internet;while the latter connects the world to enable new business models based on online business processes,the former will help resolve the trust issue more efficiently via network *** this paper,we give an overview on blockchain research and development as well as introduce the papers in this special *** show that while blockchain has enabled Bitcoin,the most successful digital currency,its widespread adoption in finance and other business sectors will lead to many business innovations as well as many research opportunities.

关键词： Bitcoin Blockchain Business innovation Public ledger Computational trust

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Formalisms to Support the Definition of Processes

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journal of Computer Science & Technology 2009年第2期24卷 198-211页

作者： leon j. Osterweil Department of Computer Science University of Massachusetts Amherst

This paper emphasizes the importance of defining processes rigorously, completely, clearly, and in detail in order to support the complex projects that are essential to the modern world. The paper argues that such process definitions provide needed structure and context for the development of effective software systems. The centrality of process is argued by enumerating seven key ways in which processes and their definitions are expected to provide important benefits to society. The paper provides an example of a process formalism that makes good progress towards the difficult goal of being simultaneously rigorous, detailed, broad, and clear. Early experience suggests that these four key characteristics of this formalism do indeed seem to help it to support meeting the seven key benefits sought from process definitions. Additional research is suggested in order to gain more insights into needs in the area of process definition formalisms.

关键词： processes process definition process language

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Blockchain and digital finance

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Financial Innovation 2022年第1期8卷 2611-2614页

作者： Wei Xu Daning Hu Karl Reiner Lang j.leon Zhao Renmin University of China BeijingChina Southern University of Science and Technology ShenzhenChina City University of New York New York CityUSA The Chinese University of Hong Kong ShenzhenChina

Blockchain technology and its applications in various business domains have attracted great attention from researchers and practitioners in recent ***,which is arguably the most promising and well-known application domain,has been significantly transformed into digital finance by various novel and open technological and business innovations rooted in blockchain technology,such as decentralized finance and *** finance innovations like digital payments,crowdfunding,supply chain finance,and robo-advising have made significant *** main goal of this special issue is to deepen and broaden our understanding of the impacts,values,and challenges brought by blockchain technology and digital finance.

关键词： finance transformed innovation

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Gene-environment interactions in male reproductive health： special reference to the aryl hydrocarbon receptor signaling pathway

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Asian journal of Andrology 2014年第1期16卷 89-96页

作者： leon j S Brokken Yvonne Lundberg Giwercman Department of Clinical Sciences Molecular Genetic Reproductive Medicine Lund University MalmO Sweden

Over the last few decades, there have been numerous reports of adverse effects on the reproductive health of wildlife and laboratory animals caused by exposure to endocrine disrupting chemicals （EDCs）. The increasing trends in human male reproductive disorders and the mounting evidence for causative environmental factors have therefore sparked growing interest in the health threat posed to humans by EDCs, which are substances in our food, environment and consumer items that interfere with hormone action, biosynthesis or metabolism, resulting in disrupted tissue homeostasis or reproductive function. The mechanisms of EDCs involve a wide array of actions and pathways. Examples include the estrogenic, androgenic, thyroid and retinoid pathways, in which the EDCs may act directly as agonists or antagonists, or indirectly via other nuclear receptors. Dioxins and dioxin-like EDCs exert their biological and toxicological actions through activation of the aryl hydrocarbon-receptor, which besides inducing transcription of detoxifying enzymes also regulates transcriptional activity of other nuclear receptors. There is increasing evidence that genetic predispositions may modify the susceptibility to adverse effects of toxic chemicals. In this review, potential consequences of hereditary predisposition and EDCs are discussed, with a special focus on the currently available publications on interactions between dioxin and androgen signaling.

关键词： androgen receptor aryl hydrocarbon receptor endocrine disrupter

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