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High-risk spatiotemporal patterns of cutaneous leishmaniasis:a nationwide study in Iran from 2011 to 2020

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Infectious Diseases of Poverty 2023年第3期12卷 93-93页

作者： Neda Firouraghi Robert Bergquist Munazza Fatima alireza mohammadi Davidson H.Hamer Mohammad Reza Shirzadi Behzad Kiani Department of Medical Informatics School of MedicineMashhad University of Medical SciencesMashhadIran Ingerod BrastadSweden Formerly with the UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases World Health OrganizationGenevaSwitzerland Department of Geography The Islamia University of BahawalpurBahawalpurPunjabPakistan Department of Geography and Urban Planning Faculty of Social SciencesUniversity of Mohaghegh ArdabiliArdabilIran Department of Global Health Boston University School of Public HealthBostonMAUSA Section of Infectious Diseases Department of MedicineBoston University School of MedicineBostonMAUSA Center for Disease Control and Prevention(CDC) Iran Ministry of Health&Medical EducationTehranIran Centre de Recherche en SantéPublique Universitéde Montréal7101Avenue du ParcMontréalCanada

Background Cutaneous leishmaniasis(CL)is a wide-reaching infection of major public health *** is one of the six most endemic countries in the *** study aims to provide a spatiotemporal visualization of CL cases in Iran at the county level from 2011 to 2020,detecting high-risk zones,while also noting the movement of high-risk *** On the basis of clinical observations and parasitological tests,data of 154,378 diagnosed patients were obtained from the Iran Ministry of Health and Medical *** spatial scan statistics,we investigated the disease’s purely temporal,purely spatial,spatial variation in temporal trends and spatiotemporal *** P=0.05 level,the null hypothesis was rejected in every *** In general,the number of new CL cases decreased over the course of the 9-year research *** 2011 to 2020,a regular seasonal pattern,with peaks in the fall and troughs in the spring,was *** period of September–February of 2014–2015 was found to hold the highest risk in terms of CL incidence rate in the whole country[relative risk(RR)=2.24,P<0.001)].In terms of location,six signifcant high-risk CL clusters covering 40.6%of the total area of the country were observed,with the RR ranging from 1.87 to *** addition,spatial variation in the temporal trend analysis found 11 clusters as potential high-risk areas that highlighted certain regions with an increasing ***,fve space-time clusters were *** geographical displacement and spread of the disease followed a moving pattern over the 9-year study period afecting many regions of the *** Our study has revealed signifcant regional,temporal,and spatiotemporal patterns of CL distribution in *** the years,there have been multiple shifts in spatiotemporal clusters,encompassing many diferent parts of the country from 2011 to *** results reveal the formation of clusters across counties that cover certain parts of provinces

关键词： Cutaneous leishmaniasis Spatial epidemiology Geographical Information Systems Spatiotemporal analysis SaTScan Spatial scan statistics Neglected tropical diseases Spatiotemporal clustering Iran

Measuring COVID-19 vaccination coverage: an enhanced age-adjusted two-step foating catchment area model

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Infectious Diseases of Poverty 2021年第5期10卷 84-84页

作者： alireza mohammadi Abolfazl Mollalo Robert Bergquist Behzad Kiani 不详 Department of Medical Informatics School of MedicineMashhad University of Medical SciencesMashhadIran

Background:There are only limited studies on access to COVID-19 vaccines and identifying the most appropriate health centres for performing vaccination in metropolitan *** study aimed to measure potential spatial access to COVID-19 vaccination centres in Mashhad,the second-most populous city in ***:The 2021 age structure of the urban census tracts was integrated into the enhanced two-step foating catchment area model to improve *** model was developed based on three diferent access scenarios:only public hospitals,only public healthcare centres and both(either hospitals or healthcare centres)as potential vaccination *** weighted decision-matrix and analytic hierarchy process,based on four criteria(*** area,accessibility index,capacity of vaccination centres and distance to main roads),were used to choose potential vaccination centres looking for the highest suitability for *** Moran’s index(GMI)was used to measure the spatial autocorrelation of the accessibility index in diferent scenarios and the proposed ***:There were 26 public hospitals and 271 public healthcare centres in the study *** the exclusive use of public healthcare centres for vaccination can provide the highest accessibility in the eastern and north-eastern parts of the study area,our fndings indicate that including both public hospitals and public healthcare centres provide high accessibility to vaccination in central urban ***,a combination of public hospitals and public healthcare centres is recommended for efcient vaccination *** value of GMI for the proposed model(accessibility to selected vaccination centres)was calculated as 0.53(Z=162.42,P<0.01).Both GMI and Z-score values decreased in the proposed model,suggesting an enhancement in accessibility to COVID-19 vaccination ***:The periphery and poor areas of the city had the least access to COVID-19 vaccination *** spatia

关键词： COVID-19 Spatial accessibility Spatial inequality Two-step foating catchment area Vaccination coverage Iran

A UNIFYING FRAMEWORK FOR ANALYSIS AND DESIGN OF EXTREMUM SEEKING CONTROLLERS

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A UNIFYING FRAMEWORK FOR ANALYSIS AND DESIGN OF EXTREMUM SEE...

Design, synthesis, and nanoengineered modification of spherical graphene surface by layered double hydroxide (LDH) for removal of As (Ⅲ) from aqueous solutions

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作者： Dragan Nei Chris Manzie alireza mohammadi Will Moase the Department of Electrical and Electronic Engineering The University of Melbourne Parkville 3010 Victoria Australia the Department of Mechanical Engineering The University of Melbourne Parkville 3010 Victoria Australia

We summarize a unifying design approach to continuous-time extremum seeking that was recently reported by the authors. This approach is based on a feedback control paradigm that was to the best of our knowledge explicitly summarized for the first time in this form in our recent work. This paradigm covers some existing extremum seeking schemes, provides a direct link to off-line optimization and can be used as a unifying framework for design of novel extremum seeking schemes. Moreover, we show that other extremum seeking problem formulations can be interpreted using this unifying viewpoint. We believe that this unifying view will be invaluable to systematically design and analyze extremum seeking controllers in various settings.

关键词： Optimization extremum seeking convergence stability adaptive control.

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Chinese Journal of Chemical Engineering 2023年第1期53卷 374-380页

作者： Najma Kamali Jahan B.Ghasemi Ghodsi mohammadi Ziarani Sahar Moradian alireza Badiei School of Chemistry College of ScienceUniversity of TehranTehranIran Department of Organic Chemistry Faculty of ChemistryAlzahra UniversityVanak SquareTehranIran

In this study, new nano spherical graphene modified with LDH(Layered Double Hydroxide) was prepared and used to remove As(Ⅲ) ion from aqueous solutions. At first, graphene oxide was synthesized from graphite using a well-known Hammer method. The obtained graphene oxide solution was sprayed in octanol solution under different temperatures and sprayed speed as influenced variables. The structure and physical characterization of synthesized spherical graphene oxide were determined by various techniques,including FT-IR, N_(2) adsorption–desorption, SEM, TEM, and EDX. In the next step, the hydrothermal method was applied to deposition LDH on the spherical graphene oxide. The synthesized spherical graphene modified by LDH was used to remove As(Ⅲ) as a toxic heavy metal ion. The effect of influenced variables including p H, contact time, amount of sorbent, and type eluent studied and the optimum values were as 8, 30, 50, and HCl(0.5 mol·L^(-1)), respectively. After optimization, the studied sorbent was shown a high adsorption capacity(149.3 mg·g^(-1)). The adsorption mechanism and kinetic models exhibited good agreement with the Langmuir isotherm and pseudo-second-order trends, respectively. Besides, the synthesized product was tested for seven times without significant loss in its sorption efficiency.

关键词： Graphene-based spherical adsorbent Layered double hydroxide(LDH) Adsorption Spray-assisted deep-frying

The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes

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Chronic Diseases and Translational Medicine 2023年第4期9卷 329-335页

作者： Soghra Rabizadeh Seyed Arsalan Seyedi Seyed Ali Nabipoorashrafi Maryamossadat Omidvar Siahkalmahalleh Amirhossein Yadegar Fatemeh mohammadi Armin Rajab alireza Esteghamati Manouchehr Nakhjavani Endocrinology and Metabolism Research Center(EMRC) Vali-Asr HospitalSchool of MedicineTehran University of Medical SciencesTehranIran

Background:High concentrations of low-density lipoprotein cholesterol(LDL-C)have been a known risk factor for cardiovascular ***,the role of oxidized LDL(ox-LDL)in forming atherosclerosis plaque has been ***,it has not yet been proven that atherogenic LDL-C byproducts like ox-LDL will decrease by keeping the LDL levels at the desired *** study aimed to examine the relationship between LDL-C and ox-LDL in different LDL-C values in patients with type 2 diabetes(T2D).Methods:In this cross-sectional study,347 patients with T2D who received statins were ***-C values were defined into four groups as LDLC100 mg/dL in patients with ***,the revealed association of ox-LDL with TG level and TG/HDL ratio may be considered in the clinic.

关键词： atherosclerosis diabetes mellitus lipids lipoproteins low-density lipoprotein oxidized LDL

Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers

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World Journal of Experimental Medicine 2023年第5期13卷 102-114页

作者： Tagreed Qassim Alsbihawi Mojtaba Zare Ebrahimabad Fakhri Sadat Seyedhosseini Homa Davoodi Nafiseh Abdolahi alireza Nazari Saeed mohammadi Yaghoub Yazdani Department of Immunology Faculty of MedicineGolestan University of Medical SciencesGorgan 49341-74515Iran Metabolic Disorders Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Laboratory Sciences Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Immunology Golestan University of Medical SciencesGorgan ***Iran Golestan Rheumatology Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Surgery Faculty of MedicineRafsanjan University of Medical SciencesRafsanjan ***Iran Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical SciencesGorgan 49341-74515Iran

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder impacting multiple organs,influenced by genetic factors,especially those related to the immune ***,there is a need for new biomarkers in ***-125a(miR-125a)levels are decreased in T cells,B cells,and dendritic cells of SLE ***-125a plays a regulatory role in controlling the levels of tumor necrosis factor-alpha(TNF-α)and interleukin 12(IL-12),which are crucial pro-inflammatory cytokines in SLE *** To assess the levels of miR-125a,IL-12,and TNF-αin SLE patients’plasma,evaluating their diagnostic and prognostic *** The study included 100 healthy individuals,50 newly diagnosed(ND),and 50 SLE patients undergoing *** patients were monitored for a duration of 24 wk to observe and record instances of ***-125a expression was measured using real-time reverse transcription polymerase chain reaction,while ELISA kits were used to assess IL-12 and TNF-α*** The results showed significantly reduced miR-125a expression in SLE patients compared to healthy individuals,with the lowest levels in ND ***-αand IL-12 expression levels were significantly elevated in SLE patients,especially in the early stages of the *** operating characteristic curve analyses,and Cox-Mantel Log-rank tests indicated miR-125a,TNF-α,and IL-12 as proper diagnostic biomarkers for SLE.A negative correlation was found between plasma miR-125a expression and IL-12/TNF-αlevels in SLE *** Decreased miR-125a levels may be involved in the development of SLE,while elevated levels of IL-12 and TNF-αcontribute to immune *** findings offer new diagnostic and prognostic markers for ***,the negative correlation observed suggests an interaction between miR-125a,TNF-α,and *** research is necessary to uncover the underlying mechanisms that govern these relationships.

关键词： Systemic lupus erythematosus microRNA-125a Interleukin-12 Tumor necrosis factor alpha Biomarker

Aminobenzenesulfonamide functionalized SBA-15 nanoporous molecular sieve: A new and promising adsorbent for preconcentration of lead and copper ions

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Journal of Environmental Sciences 2012年第7期24卷 1347-1354页

作者： Leila Hajiaghababaei Babak Ghasemi alireza Badiei Hassan Goldooz Mohammad Reza Ganjali Ghodsi mohammadi Ziarani Department of Chemistry Islamic Azad UniversityShahre Rey Branch School of Chemistry College of ScienceUniversity of Tehran Center of Excellence in Electrochemistry Faculty of ChemistryUniversity of Tehran Department of Chemistry Alzahra University

A rapid method for the extraction and monitoring of nanogram level of Pbz＋ and Cuz＋ ions using uniform silanized mesopor （SBA-15） functionalized with aminobenzenesulfonamide groups and flame atomic absorption spectrometry （FAAS） is presented. Aminobenzenesulfonamide functionalized SBA-15 was synthesized according to procedure in the literature and the presence of organic groups in the silica framework was demonstrated by FT-IR spectra. The functionalized product showed the BET surface area 110 mZ/g and pore diameter 5. l nm, based on adsorption-desorption of N2 at 77 K. The effect of several variables such as （amount of adsorbent, stirring time, pH and presence of other ions in the medium） has been studied. Lead and copper were completely extracted at pH greater than 3 after stirring for 10 min. The maximum capacity of the adsorbent was found to be 191.3 ＋ 1.4 and 155.0 ＋ 1.0 ~xg of lead and copper ions/mg functionalized SBA-15, respectively. The preconcentration factor of the method was found to be 200. The detection limit of the technique was 3.4 and 0.4 ng/mL for Pb2＋ and Cuz＋, respectively. The applications of this methodology for real samples were examined by various water type, black tea and pepper samples.

关键词： aminobenzenesulfonamide functionalized SBA-15 preconcentration Pb2+ and Cu2+ions

Refractive surgery: the most cost-saving technique in refractive errors correction

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 1013-1019页

作者： Seyed-Farzad mohammadi Cyrus Alinia Maryam Tavakkoli alireza Lashay Hormoz Chams Eye Research Center Farabi Eye Hospital Tehran University of Medical Sciences Department of Public Health School of Public Health Urmia University of Medical Sciences Hormoz Chams Research Chair in Public Health Ophthalmology Farabi Eye Center of Excellence Tehran University of Medical Sciences Department of Health Management and Economics School of Public Health Tehran University of Medical Sciences

AIM： To compare the lifetime and annual economic burden of spectacles, contact lenses, and refractive surgery in correction of refractive ***： This is a cross-sectional study with convenience sampling which 120 patients were interviewed in a tertiary referral hospital in the Iranian health care system. The bottom-up based cost of illness approach was estimated using a face-to-face interview to assess the direct and indirect cost of different refractive errors correction of any correction technologies. RESULTS： Correction with spectacle imposes a total direct cost of US dollar （US$） 342.5 （±8.41） per year and US$9373.5 （±230.1） per lifetime to each patient. These figures for the contact lenses were obtained US$198.3 （±0.12） and US$5203.1 （±256.3） and for refractive surgery were obtained US$19.1 （±1.2） and US$568.1 （±64.6）, respectively. Overall, based on age-adjusted prevalence rates, astigmatism had the highest share of refractive errors economic burden with a lifetime direct cost of slightly less than US$5.49 billion, while hyperopia and myopia imposed less than US$5.24 and 4.2 billion on patients, respectively. The annually imposed cost on each individual Iranian patient with refractive errors is US$308.5. CONCLUSION： Based on 18mo post refractive surgery course observation, which is generalized to whole life, refractive surgery significantly imposed much less cost compared with spectacles and contact lenses. Refractive errors among Iranians result in considerable economic burden. Using the refractive surgery instead of other two correction methods has the ability to reduce this economic loss in the future.

关键词： refractive error economic burden refractive surgery spectacle contact lenses

Local effect of celecoxib on peripheral nerve repair com- bined with silicone tubulization in rat

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Chinese Journal of Traumatology 2013年第5期16卷 265-271页

作者： Rahim mohammadi Keyvan Amini alireza Yousefi Mehdi Abdollahi-Pirbazari Department of Clinical Sciences Faculty of VeterinaryMedicine Urmia University Urmia 57153 1177 Iran Department of Veterinary Pathology Western Collegeof Veterinary Medicine University of SaskatchewanSaskatoon Saskatchewan S7N 5B4 Canada

ObjectiveTo 在一只老鼠在神经新生上估计 celecoxib 的本地效果臀部的神经横断 *** -- 五只男健康白 Wistar 老鼠随机被划分成三个试验性的组(为各个的 n=15 ) ：假冒操作(假冒) ，控制(SIL ) 和对待的 celecoxib (SIL/CLX ) 组织。在... 详细信息

ObjectiveTo 在一只老鼠在神经新生上估计 celecoxib 的本地效果臀部的神经横断 *** -- 五只男健康白 Wistar 老鼠随机被划分成三个试验性的组(为各个的 n=15 ) ：假冒操作(假冒) ，控制(SIL ) 和对待的 celecoxib (SIL/CLX ) 组织。在在麻醉以后的假冒的组，左臀部的神经被暴露，在动态平衡以后，肌肉是 sutured。在 SIL 组，左臀部的神经以一样的方法和对离开 10 的 tibioperoneal 分叉近似的 transected 被暴露；公里差距。近似、远侧的树桩各被插入到一个硅酮试管并且用 10 µl 磷酸盐填满缓冲答案。在 SIL/CLX，组缺点用充满 .ResultsFunctional 学习和 gastrocnemius 肌肉质量证实了的 10 µl celecoxib (0.1 g/L ) 的一个硅酮试管被衔接在 SIL/CLX 的改革轴突的更快、更好的恢复比在 SIL 组(P < 0.05 ) 。改革纤维的 Morphometric 索引证明在 SIL/CLX 的 myelinated 纤维的数字和直径比在控制组的那些显著地大。在 immunohistochemistry，对在 SIL/CLX 的 S-100 的反应的地点在 SIL 清楚地是比那更积极的到 celecoxib 的本地处理的 *** 证明它影响并且改善外部神经新生的功能的恢复。

关键词： Wistar大鼠周围神经再生塞来昔布硅胶磷酸盐缓冲溶液套管修复坐骨神经