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Salvage anastomosis in free PAP-flap breast reconstruction:What about free flap neovascularization?

Chinese Journal of Plastic and Reconstructive Surgery 2023年第4期5卷 178-181页

作者： Michael Hepp aline Berners Christine Deconinck Genevieve Pirson Maxime Servaes Philippe Fosseprez Department of Plastic Reconstructive and Aesthetic SurgeryCHU UCL NamurNamur 5000Belgium

Since the emergence of microsurgery in reconstructive surgery, free flaps have become a key tool in the management of patients with breast cancer. One such flap is the profunda artery perforator(PAP) flap. To date,there is no scientific consensus on whether voluminous free flaps remain dependent on their vascular pedicle throughout their lifespan. Therefore, the pedicle should always be carefully protected during revision *** this article, we review the case of a middle-aged woman who suffered a pedicle transection needing reanastomosis during revision surgery six months after free-flap breast reconstruction. A 52-year-old woman who noticed a firm nodule in her right breast and armpit was referred to our department for surgical management. The Caucasian woman presented with no significant medical history or symptoms at the first consultation. Ultrasound-guided biopsy confirmed an invasive grade Ⅲ lobular carcinoma. Following staging,the patient underwent neoadjuvant chemotherapy before a right mastectomy with a complete homolateral axillary lymph node dissection and postoperative radiotherapy. One year after completing radiotherapy, free flap reconstruction with a PAP flap was performed, and six months later, revision surgery was required to enhance the volume of the reconstructed breast with a tissue expander and later an implant. Unfortunately,pedicle transection occurred during revision surgery, causing complete devascularization of the flap, which was confirmed by intraoperative Indocyanine Green imaging. The authors elected to perform salvage reanastomosis during the surgery. In keeping with the author’s 23-year experience with free flaps, the vascular pedicle should always be preserved in voluminous free flaps, as neovascularization alone may not ensure whole flap survival. The authors suggest always attempting re-anastomosis if vessels are compromised during revision surgery.

关键词： Free flap Autonomy Vascular pedicle Revascularization PAP flap Microsurgery

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Analysing the impact of migration on HIV/AIDS cases using epidemiological modelling to guide policy makers

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Infectious Disease Modelling 2022年第1期7卷 252-261页

作者： Ofosuhene O.Apenteng Prince P.Osei Noor Azina Ismail aline Chiabai Division for Global Surveillance Research Group for Genomic EpidemiologyNational Food InstituteTechnical University of DenmarkKongens LyngbyDenmark School of Mathematics and Statistics Carleton UniversityCanada Department of Statistics University of HaifaIsrael Department of Applied Statistics Faculty of Economics and AdministrationUniversity of MalayaKuala LumpurMalaysia Basque Centre for Climate Change(BC3) LeioaSpain

In this paper,we present the impact of migration on the spread of HIV and AIDS cases.A simple model for HIV and AIDS that incorporates migration and addresses its contributions to the spread of HIV and AIDS cases was *** model was calibrated to HIV and AIDS incidence data from *** explore the use of Markov chain Monte Carlo(MCMC)simulation method to estimate uncertainty in all the unknown parameters incorporated in our proposed *** the migrant population,1.5572e-01 were susceptible to HIV transmission,which constituted 67,801 migrants.A proportion of migrants,6.3773e-04,were estimated to be HIV infected,constituting 278 *** were 72(per 10,000)migrants estimated to have had AIDS,representing a proportion of *** result suggests that the disease-free steady state was unstable since the estimated basic reproduction number R0 was 2.0906 and 2.3322 for the models without and with migration,*** is not a good indicator from the public health point of view,as the aim is to stabilize the epidemic at the disease-free *** advantage of introduction of migration to the simple model validated the true R0 and the transmission rate b associated with HIV and AIDS epidemic disease in *** also indicates an approximately 12 percentage points increase in the rate of HIV infection with migration.

关键词： Migration Mathematical transmission modeling HIV/AIDS Parameter estimation Basic reproduction number

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Hepatitis C virus: Promising discoveries and new treatments

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World Journal of Gastroenterology 2016年第28期22卷 6393-6401页

作者： Juliana Cristina Santiago Bastos Marina Aiello Padilla Leonardo Cardia Caserta Noelle Miotto aline Gonzalez Vigani Clarice Weis Arns Laboratory of Virology Institute of Biology State University of Campinas - UNICAMP Internal Medicine Department Infectious Diseases division FCM-UNICAMP

Despite advances in therapy, hepatitis C virus(HCV) infection remains an important global health issue. It is estimated that a significant part of the world population is chronically infected with the virus, and many of those affected may develop cirrhosis or liver cancer. The virus shows considerable variability, a characteristic that directly interferes with disease treatment. The response to treatment varies according to HCV genotype and subtype. The continuous generation of variants(quasispecies) allows the virus to escape control by antivirals. Historically, the combination of ribavirin and interferon therapy has represented the only treatment option for the disease. Currently, several new treatment options are emerging and are available to a large part of the affected population. In addition, the search for new substances with antiviral activity against HCV continues, promising future improvements in treatment. Researchers should consider the mutation capacity of the virus and the other variables that affect treatment success.

关键词： Hepatitis C infection Hepatitis C virus Treatments Antiviral research

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Enzymes inhibitory property,antioxidant activity and phenolics profile of raw and roasted red sorghum grains in vitro

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Food Science and Human Wellness 2019年第2期8卷 142-148页

作者： Emmanuel Anyachukwu Irondi Bosede Mofoluwake Adegoke Emy Sofie Effion Selimat Oluwakemi Oyewo Emmanuel Oladeji Alamu aline Augusti Boligon Department of Biochemistry Kwara State UniversityMaleteP.M.B.1530IlorinNigeria Department of Applied Sciences Osun State PolytechnicIreeOsun StateNigeria International Institute of Tropical Agriculture(IITA) Grosvenor HouseCroydonCR09 XPUnited Kingdom Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaSanta MariaCEP 97105-900Brazil

Whole grain cereals are important dietary sources for management of metabolic diseases due to the bioactive components they ***,this study investigated enzymes(pancreatic lipase,-amylase,-glucosidase,xanthine oxidase and angiotensin 1-converting enzyme)inhibitory property,antioxidant activity and phenolics profile of raw and roasted red sorghum(Sorghum bicolor)grains in *** of flours of raw and roasted(150◦C and 180◦C,for 20 min)grains were assayed for enzymes inhibitory and antioxidant activities using spectrophotometric methods;while their phenolic constituents were characterized using *** raw grains exhibited strong enzymes inhibitory and antioxidant activities,and contained phenolic acids(gallic,chlorogenic,caffeic,ellagic and p-coumaric acids)and flavonoids(quercetin,luteolin and apigenin).However,whereas the enzymes inhibitory activity and levels of the phenolic compounds in the grains decreased significantly(p<0.05)with increasing roasting temperature,the antioxidant activity ***,roasting at high temperature may not be recommended for the optimum retention of the enzymes inhibitory property and phenolic compounds of red sorghum grains.

关键词： Antioxidant activity Enzymes inhibition Metabolic diseases Phenolic compounds Sorghum grains

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Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro

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Food Science and Human Wellness 2016年第1期5卷 17-23页

作者： Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola aline Augusti Boligon Margareth Linde Athayde Biochemistry Unit Department of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeriaP.M.B.704Akure 340001Nigeria Department of Veterinary Physiology Biochemistry and PharmacologyUniversity of IbadanNigeria Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaBuilding 26Room 1115Santa Maria CEP 97105-900Brazil

The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in ***(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric *** extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to *** extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent *** half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(Pkidney>*** extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>*** fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids.

关键词： peroxidation kidney inhibited

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Some disturbances in course of experimental sthort—timed electrostimulation

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中国临床康复 2002年第8期6卷 1212-1213页

作者： IreneuszM.kowalski JozefSzarek

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Fractional Order for Food Gums: Modeling and Simulation

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Applied Mathematics 2013年第2期4卷 305-309页

作者： Sergio ADavid aline HKatayama Department of Basic Sciences University of Sao PauloSao PauloBrazil

Fractional order calculus can represent systems with high-order dynamics and complex nonlinear phenomena using few coefficients, since the arbitrary order of the derivatives provides an additional degree of freedom to fit a specific behavior. Numerous mathematicians have contributed to the history of fractional calculus by attempting to solve a fundamental problem to the best of their understanding. Each researcher sought a definition and therefore different approaches, which has led to various definitions of differentiation and anti-differentiation of non-integer orders that are proven equivalent. Although all these definitions may be equivalent, from one specific standpoint, i.e., for a specific application, some definitions seem more attractive. Furthermore, it is well known that food gums are complex carbohydrates that can suit for a wide variety of functions in the context of food engineering. The viscoelastic behavior of food gums is crucial for these applications and formulations of new or improved food products. Small progress has been made to understand the viscoelastic behavior of food gums and there are few studies in the literature about these models. In this paper, we applied the Riemann-Liouville approach and the Fourier transform in order to obtain numerical simulations results of a fractional derivative model based on previous literature that to make a quantitative description of the viscoelastic properties behavior for a food gum. The results reveal that the fractional model shows good simulation capability and can be an attractive means for predicting and to elucidate the dynamic viscoelastic behavior of food gums.

关键词： Fractional Calculus Mathematical Model Food Gums Viscoelasticity

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Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases

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World Journal of Gastroenterology 2010年第46期16卷 5830-5837页

作者： Johannes W Rey Andrea Noetel aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal Institute for Pathology University Hospital of Freiburg Department of Gastroenterology and Hepatology University Hospital of Essen Department of General Visceral and Cancer SurgeryUniversity Hospital of Cologne

AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific ***:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy *** NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver ***,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory *** linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of ***:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis.

关键词： Single nucleotide polymorphism Peroxisome proliferator-activated receptor γ Non-alcoholic steatohepatitis Alcoholic steatohepatitis Inflammation Fibrosis Hepatitis Steatosis Steatohepatitis

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两种炉料结构的高炉冶炼试验

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钢铁 1993年第6期28卷 7-11页

作者：龙世刚 W. kowalski 华东冶金学院 Thyssen Stahl AG

本文叙述了烧结矿配加Bong球团矿和配加Samarco球团矿两种炉料结构的高炉冶炼对比试验。结果表明,后者较前者产量增加197 t/d,焦比降低7.86 kg/t,煤气能量利用得到改善,η_(co)提高1.1％。还对两种炉料结构进行了理论焦比计算。

关键词：炉料结构高炉冶炼焦比配加烧结矿球团矿煤气增加产量理论

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Esophagogastric anastomosis with invagination into stomach:New technique to reduce fistula formation

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World Journal of Gastroenterology 2010年第45期16卷 5722-5726页

作者： Alexandre Cruz Henriques Carlos Alberto Godinho Roberto Saad Jr Daniel Reis Waisberg aline Biral Zanon Manlio Basilio Speranzini Jaques Waisberg Department of Surgery University HospitalABC Medical SchoolSanto AndréSo Paulo09060-870Brazil

AIM: To present a new technique of cervical esophagogastric anastomosis to reduce the frequency of fistula formation. METHODS: A group of 31 patients with thoracic and abdominal esophageal cancer underwent cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube. In the region elected for anastomosis, a transverse myotomy of the esophagus was carried out around the entire circumference of the esophagus. Afterwards, a 4-cm long segment of esophagus was invaginated into the stomach and anastomosed to the anterior and the posterior walls. RESULTS: Postoperative minor complications occurred in 22 (70.9%) patients. Four (12.9%) patients had serious complications that led to death. The discharge of saliva was at a lower region, while attempting to leave the anastomosis site out of the alimentary transit. Three (9.7%) patients had fistula at the esophagogastric anastomosis, with minimal leakage of air or saliva and with mild clinical repercussions. No patients had esophago- gastric fistula with intense saliva leakage from either the cervical incision or the thoracic drain. Fibrotic stenosis of anastomoses occurred in seven (22.6%) patients. All these patients obtained relief from their dysphagia with endoscopic dilatation of the ***: Cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube presented a low rate of esophagogastric fistula with mild clinical repercussions.

关键词： Esophageal cancer Esophagectomy Constriction Pathologic Fistula Gastroplasty

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