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New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract

Natural Products and Bioprospecting 2015年第6期5卷 277-285页

作者： Daniela Batista Pedro L.Falé Maria L.Serralheiro Maria E.Araújo Paulo J.A.Madeira Carlos Borges Isabel Torgal Margarida Goulart Jorge Justino alice martins Amélia P.Rauter Centro de Química e Bioquímica Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisbonPortugal Institute of Pharmaceutical Science King’s College London150 Stamford StreetLondon SE19NHUK Escola Superior Agrária de Santarém Quinta do Galinheiro2001-904 SantarémPortugal

The inhibition of a-glucosidase and glucose-6-phosphatase,two enzymes involved in the carbohydrate metabolism,is an important target to control glycaemia on individuals with type 2 *** this work we report for the first time the inhibition of both enzymes by the antihyperglycemic n-butanol extract from Genista tenera(Fabaceae).This extract decreased a-glucosidase and glucose-6-phosphatase activities to 0.97 and 80.25%,respectively,being more effective than acarbose,and phlorizin,the positive controls,which reduced enzymes activities only to 17.39 and 96.06%.Once inflammation and oxidative stress are related to diabetic impairments,the anti-inflammatory activity of the extract was also evaluated,through its inhibitory activity over COX-1 enzyme(47.5%inhibition).Moreover,after induction of oxidative stress by UV radiation,the viability of irradiated rat liver hepatoma cells exposed to the extract was significantly higher(67.82%)than that promoted by ascorbic acid,the positive control(45.05%).In addition,the stability of the extract under gastrointestinal conditions was evaluated by HPLC–DAD-ESI–MS/*** diglycosides were identified as the main constituents of the extract,and no alterations in the chemical composition nor in the antioxidant activity were observed after in vitro digestion with artificial gastric and pancreatic juices.

关键词： a-Glucosidase inhibition In vitro digestion HPLC-DAD-ESI-MS/MS Antioxidant activity Flavonoid glycosides

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Physicochemical and Thermal Characterization of the Spirulina platensis

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Journal of Agricultural Science and Technology(B) 2020年第5期10卷 298-307页

作者： Anny Manrich Juliano Elvis de Oliveira Maria alice martins Luiz Henrique Capparelli Mattoso Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoRua XV de Novembro 1452São Carlos 13561-206SPBrazil Engenharia de Materiais Departamento de EngenhariaUniversidade Federal de LavrasAv.Doutor Sylvio Menicucci1001Lavras 37200-900MGBrazil

Cyanobacterium Spirulina platensis is commercially produced as a nutrient source for food,animal feed and pharmaceutical industries,and is also explored in other applications in areas such as material sciences,materials engineering and for the production of biofuels and *** to the increasing interest in the use of this microalga,a complete characterization was intended,as to provide data to the insufficient *** this work,various techniques were used for thermal(thermogravimetric analysis(TGA)/derivative thermogravimetry(DTG),differential scanning calorimetry(DSC)),structural(scanning electron microscopy(SEM)and wide-angle X-ray diffraction(XRD))and chemical(atomic absorption spectroscopy(AAS),attenuated total reflection Fourier transform infrared spectroscopy(ATR-FTIR),energy dispersive X-ray spectroscopy(EDX))characterization of Spirulina cultivated in *** have shown that in addition to the high quantity of protein(over 50%),Brazilian Spirulina is a source for carbohydrates(33%)and also has good thermal stability up to 200°*** pigment protein Phycocyanin could be identified by FTIR and ultraviolet-visible(UV-vis)*** show favorable properties of Spirulina as a source for new materials and biomass.

关键词： Spirulina platensis characterization blue-green algae chemical composition amino acids

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