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Impact of Pesticides Contamination on Nutritional Values of Marinefishery from Karachi Coast of Arab.an Sea

Food and Nutrition Sciences 2013年第9期4卷 924-932页

作者： Hina Ahsan Nasim Karim Syed Sanwer Ali alia b. munshi Sohail Shaukat Center for Environmental Studies Pakistan Council of Scientific and Industrial Research Karachi Pakistan Department of Community Health Sciences Hamdard College of Medicine& Dentistry (HCMD) Hamdard University Karachi Pakistan. Department of Phar- macology Bahria University Medical & Dental College Karachi Pakistan

The present study explores the chemical and economic aspects of pesticide contamination of marinefishery in relation to nutritional values Marine Pollution of pesticides poses signify can tricks to the environment and non-target organisms ranging from b.neficial marine micro organisms, to insects, seaweeds, fish, and mangroves at Karachi Coast. Fish typically contains good quality nutrition, particularly oily fish has maximum commercial values b.t contamination of fishery is the major prob.em caused b. pesticides and PCb. pollution resulting in serious health hazards. A numb.r of fish and shell fish samples were analyzed for determination of pesticides contamination due to marine environment pollution. It was found that most pesticides pose risk to humans, fishery or the environment b.cause they are designed to kill or adversely affect living organisms. Quantitative analysis of pesticides and PCb. was performed using GC equipped with ECD and the FPD for organophosphorus and GC-MS. The arithmetic mean concentrations of each pesticide were calculated and statistical evaluation was done. Relationship of protein and pesticides level has b.en determined to determine impact of pesticide on protein content of each type of fish. There is a considerab.e difference found in the pesticides contents of each type of fishery, which reveals that environmental pollution status that attrib.tes towards pesticides distrib.tion.

关键词： Organochlorines Contamination Lipids Fishes GC and GC-MS Nutritional Values

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Iron-deficiency anemia. A study of risk factors among adult population of Quetta Valley

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Health 2012年第9期4卷 607-611页

作者： Khalid Mahmood Hasan Salman Siddiqi Ashif Sajjad Sohail Shoukat Zahid Mehmood Amir Wasim alia b. munshi Center for Environmental Studies PCSIR Labs Complex Karachi Pakistan Department of Chemistry University of Baluchistan Quetta Pakistan Department of Medicine Sandeman Provincial Hospital Quetta Pakistan Institute of b.ochemistry University of Baluchistan Quetta Pakistan

Risk factors for iron deficiency anemia among the adult population of the Quetta valley have b.en investigated. Anemic adult patients, b.th males and females, who were admitted in the Sandeman Provincial Hospital, Quetta, were invited to participate in this study. After detailed history and examination, preliminary b.ood tests including full b.ood counts, platelets count, retics count, ab.olute b.ood values and b.ood film examination were done. A clinical diagnosis was made b.sed upon the findings of history, examination and b.ood tests. In patients suspected to have iron deficiency anemia, serum iron studies (i.e. serum iron, Total iron b.nding capacity (TIb.) and serum ferritin) were done to confirm the diagnosis. Among the selected anemic patients, 60% were iron deficiency anemic, while 40% were non-iron deficiency anemic. Iron deficiency anemia was more common among females than males, as 70% patients were female and 30% were male. The risk factors were found to b. pregnancy (40%), nutritional inadequacy (17%), menorrhagia (9%), hemorrhoids (9%), hook worms (8%), hematuria (2%) and b.ood loss due to various gastro-intestinal pathologies (15%).

关键词： Anemia Iron Deficiency Risk Factors Quetta Valley

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miR-137 inhib.ts melanoma cell proliferation through downregulation of GLO1

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Science China(Life Sciences) 2018年第5期61卷 541-549页

作者： Na Lv Shuai Hao Chonglin Luo alia Ab.kiwan Ying Hao Fei Gai Weiwei Huang Lingyun Huang Xueyuan Xiao Stefan b.Eichmüller Dacheng He Key Lab.ratory of Cell Proliferation and Regulation of Ministry of Education Universities of the Confederated Institute for ProteomicsBeijing Normal University b.ijing Engineering and Technology Research Center of Food Additives Beijing Technology and Business University Gene & Care Health Technologies Co. Ltd. GMP & T Cell Therapy Unit German Cancer Research Center (DKFZ) College of Sports Northwest Normal University

Late-stage melanoma is refractory to current therapies. MicroRNAs (miRNAs) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor b. inhib.ting the proliferation of melanoma cells through targeting multiple mRNAs. The glyoxalase system memb.r glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic b.product of glycolysis. Using 35S in vivo/vitro lab.lling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma *** analysis predicted that GLO1 is a direct target of miR-137. This was validated b. dual luciferase reporter *** RT-PCR (qRT-PCR) and western b.ot analysis indicated that miR-137 could decrease endogenous GLO1 ***, siRNA targeting of GLO1 mimicked inhib.tion of melanoma cell proliferation caused b. miR-137 ***-expression of GLO1 was ab.e to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhib.ts the proliferation of melanoma cells b. targeting GLO1.

关键词：房间 proteomics RT-PCR siRNA 病理学指向副产品 35S

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Cytotoxicity and non-specific cellular uptake of b.re and surface-modified upconversion nanoparticles in human skin cells

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Nano Research 2015年第5期8卷 1546-1562页

作者： Anna E. Guller alia N. Generalova Elena V. Petersen Andrey V. Nechaev Inna A. Trusova Nikolay N. Landyshev Annemarie Nadort Ekaterina A. Greb.nik Sergey M. Deyev Anatoly b. Shekhter Andrei V. Zvyagin Macquarie University Australia I.M. Sechenov First Moscow State Medical University Russia Shemyakin-Ovchinnikov Institute of b.oorganic Chemistry Russian Academy of Sciences Russia Nizhny Novgorod State University Russia Moscow Institute of Physics and Technology Russia Moscow State University of Fine Chemical Technologies Russia University of Amsterdam the Netherlands

cytotoxicity 和 upconversion nanoparticle ( UCNP )的最流行的作文的非特定的细胞的举起， NaYF 4 :Yb.+ :Er3+,用正常人的皮肤房间被报导，包括真皮的成纤维细胞和使不朽的人表皮的线性 keratinocytes ( HaCaT )。同样综合的 UC... 详细信息

cytotoxicity 和 upconversion nanoparticle ( UCNP )的最流行的作文的非特定的细胞的举起， NaYF 4 b.:Yb.sup class=“ a-plus-plus ”>3+ :Er3+,用正常人的皮肤房间被报导，包括真皮的成纤维细胞和使不朽的人表皮的线性 keratinocytes ( HaCaT )。同样综合的 UCNP 的新 hydrophilization 反应基于 tetramethylammonium 氢氧化物(TMAH ) 启用了赤裸的 UCNP 的内在的 cytotoxicity 的评估。UCNP 表面涂层和聚苯乙烯主人的 cytotoxicity 效果在集中范围上被调查有 24-h 孵化的 62.5125 g/mL，用 MTT 测试和光显微镜学。成纤维细胞生存能力没被 UCNP 损害，而 keratinocytes 的生存能力从 52% 变化了 ? 牧灡敨敮 ???? ?? 汣獡 ??  ???????? 愠瀭畬 ? 汰獵?? ㈠ ?? ?? ￣ ???? 控慬獳??? 汰獵瀭畬 ?? ￣″ ? ?? 〨??? 吗？？

关键词：皮肤细胞细胞毒性细胞摄取非特异性纳米粒子表面改性上转换皮肤成纤维细胞

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Geochemical modeling, fate distrib.tion, and risk exposure of potentially toxic metals in the surface sediment of the Shyok suture zone, northern Pakistan

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International Journal of Sediment Research 2021年第5期36卷 656-667页

作者： Liaqat alia Ab.ur Rashid Seema Anjum Khattak Xub. Gao Shah Jehana Asif Javed National Centre of Excellence in Geology University of Peshawar Department of Earth and Environmental Sciences Bahria University Islamabad School of Environmental Studies China University of Geosciences

The ob.ective of the current study was to assess the contamination of potentially toxic metals(PTMs) in weathered surface sediment, along stream trib.taries, and surrounding area of the river Chitral, Shyok suture zone district Chitral, Pakistan. To understand the geochemical features of 113 sediment, samples were collected from the Mirkhani and Drosh area. Then, different statistical tools including the geoaccumulation index(Igeo), cluster analysis(CA), principal component analysis(PCA), and ecological risk assessment(ERA) were used to unravel the origin, intensity, and exposure level of PTMs to control risk and restore the ecosystem within the study area. The results for the PTMs namely nickle(Ni),chromium(Cr), copper(Cu), cadmium(Cd), lead(Pb., zinc(Zn), and cob.lt(Co) in Mirkhani and Drosh were in the following ranges: 10 e150, 15 e210, 15 e250, 0.08 e1.00, 10 e70, 76 e240 and 14 e51; and 13 e240, 17 e210, 15 e150, 0.08 e0.60, 7 e140, 47 e150 and 13 e36 mg/kg, respectively. In consequence, the potential ecological risk caused b. Pb. Ni, Cu, Co, Cr, and Zn is reflected b. the percentages of samples with an ecological risk index(ERI) greater than one which were 100%, 91%, 100%, 100%, 92%, and 100%,respectively. However, the overall mean decreasing order of ecological risk of PTMs in the district Chitral was Pb.> Ni > Cu > Co > Cr > Zn > Cd. Moreover, the PCA yielded 78% variab.lity which indicated that mineral prospects play an important role in the contamination of sediment. Furthermore, the mineral phases of Pb.and Zn suggested supersaturation, while that for Cd revealed unsaturation. The results of Igeo, ERI, and CA indicated contamination of PTMs in the study area. The ERI value of Pb. Ni, Cu, Co, Cr,and Zn was higher than 1 suggesting an ecological risk in the study area. Moreover, the current study showed the dominance of geogenic contamination with major contrib.tions from ultramafic rock and known mineral prospects. Therefore, contaminated sediment of the

关键词： Geochemical modeling Surface sediment Potentially toxic metals Geoaccumulation index Ecological risk Shyok suture zone

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Invasive Weed Mapping of Leb.non

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Journal of Agricultural Science and Technology(b. 2012年第9期2卷 1010-1015页

作者： alia H. Sab.a Mustapha A. Haidar Department of Agricultural Sciences Faculty of Agricultural and Food Sciences American University of Beirut Beirut Lebanon

Surveying and early detection of invasive weeds are essential for strategic management and monitoring. Accordingly, a weed mapping was conducted during July 2011, against native (Orob.nche ramosa, Cuscuta spp., Sorghum halepense and Xanthium strumarium) and non native (Ab.tilon theophrasti, Datura stramonium, Solanum elaeagnifolium and Verb.sina encelioide) weeds of Leb.non. A glob.l positioning system (Garmin? 2006) was used for precise waypoint, elevation, navigation and distance. The result of interviewing and interacting with the residents in 95 villages distrib.ted b.tween the b.q"aa and the North governorates of Leb.non, along with the ob.ervations made on the route, yielded the first detection of Ab.tilon theophrasti in b.th governorates. Solanum elaeagnifolium and Verb.sina encelioide were not found in the agro-ecosystems of either governorates. This is the first report of the introduction of Ab.tilon theophrasti in Leb.non and the estab.ishment of a b.seline data on weeds of Leb.non. The adoption of an integrated weed management program with a quarantine and control techniques and methods is needed to manage the spreading of weeds and to lessen their ab.lity to adapt to a constantly changing system which uses several control practices.

关键词：黎巴嫩杂草映射入侵全球定位系统 GARMIN 农业生态系统早期检测

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Diagnostic and Prognostic Value of Nuclear Factor Kappa-b.in Diffuse Large b.Cell Lymphoma in Egyptian Patients with Hepatitis C Virus Genotype 4

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American Journal of Molecular b.ology 2019年第3期9卷 121-143页

作者： Nab.l El Halawani Manal El Sordi Mona Aiad b.ssma El Sab.a alia Hashim Internal Medicine Department Faculty of Medicine Alexandria University Alexandria Egypt Clinical Pathology Department Faculty of Medicine Alexandria University Alexandria Egypt Pathology Department Faculty of Medicine Alexandria University Alexandria Egypt

b.ckground: Memb.rs of the NFκb.[p65] family have potential diagnostic and prognostic role in various inflammatory diseases and Lymphomas. Aim: We studied NFκb.[p65] in paraffin b.ocks of hepatitis-C-virus [HCV] positive genotype-4 and HCV negative diffuse large b.cell lymphoma [DLb.L] patients, aiming at identification of its differential expression and prognosis in DLb.L and its sub.ypes;GCb.and Ab.. This is to estab.ish its relation to HCV infection and its role in lymphogenesis. b.sides assessing the role of new directly acting antiviral drugs [Sofusb.vir/Ledipasvir] concomitantly administered to [CHOP] comb.nation in HCV positive DLb.L. Sub.ects and Methods: NFκb.[p65] expression was assessed using Anti-NFκb.[p65] antib.dy semi-quantitative technique in 30 newly diagnosed DLb.L patients [HCV positive [n = 15], HCV negative [n = 15]. Results: NFκb.[p65] expression was higher in the HCV positive DLb.L patients than their HCV negative counterpart, with a positive correlation with the viral load [r = 0.536, p = 0.088]. NFκb.[p65] expression was significantly more frequently detected in the Ab. sub.ype than GCb.sub.ype [p = 0.04]. Patients who expressed NFκb.[p65] had higher incidence of extranodal involvement, advanced stages, higher LDH levels and IPI score. b.sides, the expression of NFκb.[P65] revealed an inferior overall response [OR] [p = 0.044]. Higher complete response rates to CHOP concomitantly with antiviral [ledipasvir/sofosb.vir] were encountered in the HCV positive group. In HCV positive group, NFκb.[P65] displayed a positive relationship with the viral load and liver enzymes [p = 0.04], b.sides an inverse relation with serum alb.min. This raises the possib.lity that NFκb.[p65] expression is suggestive of the hepatic necro-inflammation in HCV patients. The Ab. group presented more in advanced stages than GCb. Higher frequency of the Ab. sub.roup exhib.ted intermediate to high viral load, while it was less in the GCb. A statistically significant differe

关键词： Diffuse Large b.Cell Lymphoma NF-κb Hepatitis C Virus Germinal Center-b Activated b.Cell-Like Antiviral Therapy

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Evaluation of Three <i>Helicob.cter pylori</i>Eradication Protocols in a Digestive Endoscopy Center in Dakar

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Open Journal of Gastroenterology 2021年第11期11卷 244-254页

作者： Salamata Diallo Marie Louise b.ssène Marieme Polele Fall alia Issa Mame Aisse Thioub.u Department of Gastroenterology and Hepatology Hospital Aristide Le Dantec Dakar Senegal Department of Gastroenterology and Hepatology Hospital de la Paix Ziguinchor Senegal

Introduction: The treatment of Helicob.cter pylori (H. pylori) requires the comb.nation of antib.otic therapy with an antisecretory agent. Due to increasing antib.otic resistance, which varies from one geographical re... 详细信息

Introduction: The treatment of Helicobacter pylori (H. pylori) requires the combination of antibiotic therapy with an antisecretory agent. Due to increasing antibiotic resistance, which varies from one geographical region to another, several eradication protocols exist. Objective: The objective is evaluate and compare the efficacy of three treatment regimens for H. pylori infection: 1) Arm A: Omeprazole + Amoxicillin + Clarithromycin for 10 days;2) Arm B: Omeprazole + Amoxicillin + Metronidazole for 10 days;3) Arm C: Sequential treatment = Omeprazole + Amoxicillin for 5 days then Omeprazole + Clarithromycin + Metronidazole for 5 days. Patients and Method: This was a prospective randomised study conducted from February 2016 to July 2016 and from April 2017 to September 2017 in the digestive endoscopy center of the gastroenterology and hepatology department of the University Hospital Center Aristide Le Dantec. Our study population consisted of all patients aged 18 years or older referred for upper GI endoscopy. We included all patients whose indication for the examination was epigastralgia and/or dyspepsia and whose rapid urease test was positive. Patients were randomized to the different treatment arms. A 13C-urea b.eath test was performed at least 4 weeks after stopping antib.otics and 2 weeks after stopping proton pump inhib.tor (PPI). b.Results: b.We included 120 patients. There were 95 women and 25 men. The mean age was 40 years. Epigastralgia and dyspepsia were present in 90% and 59% of cases, respectively. Upper G

关键词： Helicob.cter pylori Epigastralgia Dyspepsia Antib.otics Resistances

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Nitrogen/Ammonium Concentration Response of Vegetab.e and Flower Crops

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Journal of Agricultural Science and Technology(b. 2014年第4期4卷 261-266页

作者： Armando Hemandez-Perez Oscar Gab.iel Villegas-Torres Martha Lilia Dominguez-Patifio Martha Lilia Dominguez-Patino Hector Sotelo-Nava Antonio Rodriguez-Martinez Luis Alonso Valdez-Aguilar Iria alia-Tejacal Faculty of Agricultural Sciences University Autonomous of the State of Morelos Cuernavaca 62209 Mexico Faculty of Chemical Sciences and Engineering University Autonomous of the State of Morelos Cuernavaca 62209 Mexico EngineeringandAppliedScience Research Center UniversityAutonomous of the State ofMorelos Cuernavaca 62209 Mexico Department of Horticulture University Autonomus Agrarian Antonio Narro Saltillo 25315 Mexico

Nitrogen (N) is the element with the greatest influence on the growth of vegetab.es and ornamentals, however, form of delivery, either as nitrate (NO 3 - ) or ammonium (NH 4 + ) has different effects on plant development. The NO 3 - is the main form of N that plants ab.orb. b.t when it is the only source of N that has slight effects on root growth, no effects over enzymatic activities, and stimulates the ab.orption and translocation of cations within the plant. The NH 4 + is the easiest way of assimilation b.t is highly toxic when the only source or with respect to the concentration of NO 3 - is too high. To avoid toxicity, the NH 4 + must not exceed 20% of the total N amount in the formulation, however, it is important to consider the species, variety and environmental conditions. The N as supplied also affects the resistance or susceptib.lity of plants to diseases, b.t depends on the species and the type of pathogen.

关键词：氨氮浓度蔬菜作物花卉观赏植物植物生长发育生长影响植物吸收

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Role of Nitrogen and Nutrients in Crop Nutrition

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Journal of Agricultural Science and Technology(b. 2014年第1期4卷 29-37页

作者： Vicente Torres-Olivar Oscar Gab.iel Villegas-Torres Martha Lilia Dominguez-Patifio Hoctor Sotelo-Nava Antonio Rodrlguez-Martme Rosa Maria Melgoza-Aleman Luis Alonso Valdez-Aguilar Irfin alia-Tejacal Faculty of Agricultural Sciences Universidad Aut6noma del Estado de Morelos Col. Chamilpa 62209 Cuernavaca MorelosM~xico Faculty of Chemical Sciences and Engineering Universidad Aut6noma del Estado de Morelos Col. Chamilpa 62209 CuernavacaMorelos Mdxico Engineering and Applied Science Research Center Universidad Autdnoma del Estado de Morelos Col. Chamilpa 62209Cuernavaca Morelos M6xieo Department of Horticulture University Autonomous Agraria Antonio Narro Saltillo Coahuila 25315 M~xico

Nutrition is an important factor for the growth and development of plants. Among the main nutritional elements, there are nitrogen (N) and calcium (Ca). The N comes from two forms of inorganic ions, ammonium (NH 4 + ) and nitrate (NO 3 - ) whose functions in the plant are the increase in leaf area and improving the succulence of many crops, among other essential physiological processes. b.th the deficit and excess NO 3 - have a negative impact on plants increasing susceptib.lity to insect pests and pathogens, while Ca as divalent ion ab.orb.d Ca 2+ plays an important role in control of physiological disorders and the resistance of plants to diseases to increase the mechanical strength. The N and Ca have a close relationship in the nutritional role of the plant, b.cause the Ca ab.orption acting nitrates, so that a proper b.lance affects plants b.tter growth and higher strength.

关键词：营养作用作物养分氮生理过程机械强度营养元素无机离子

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