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Association between microRNA-21, microRNA-150, and micro- RNA-451 expression and clinical outcome of patients with acute lymphoblastic leukemia

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Frontiers in Biology 2017年第1期12卷 63-70页

作者： ali amin asnafi Elahe Khodadi Neda Golchin Arash Alghasi Yousef Tavakolifar Najmaldin Saki Health Research Institute Research Center of Thalassemia and Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Golestan hospital clinical research development unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Acute lymphoblastic leukemia （ALL） occurs owing to the defective maturation, increased proliferation, and lack of differentiation of lymphoid cells. Evaluation of the expression levels of microRNAs （miRNAs） could help in the prognosis and improve the clinical outcome of ALL patients. Given the role of miR-21, miR-150, and miR-451 as oncogenes and tumor suppressors in lymphocytes, this study explored the relation between the expression levels of these miRNAs and the clinical outcomes of ALL patients. METHODS： cDNA synthesis and RT-PCR were performed for peripheral blood samples from 41 patients with ALL, as well as for U937 and Jurkat cell lines to examine the expression of miR-451, miR-150, and miR-21 after miRNA purification. We also performed an epidemiological analysis in which Mann-Whitney and Chi-square tests were used to investigate the relationship between the expression of miRNAs and other clinical and laboratory data. Binary logistic regression models were used to estimate the odds ratio in univariate and multivariate analyses for clinical outcomes. RESULTS： miR-21 and miR-150 expression was found to be decreased, while miR-451 expression showed no difference compared to the control group. There was a significant relationship between miR-451 expression and hemoglobin （Hb） levels, as well as between miR-150 expression and clinical outcomes of ALL patients. CONCLUSION： Increased expression of miR-451 decreased the Hb levels; reduced expression of miR-150 was associated with increased relapse rate in patients. Age, increased WBC, and decreased Hb levels were associated with increased relapse rates in ALL patients. Therefore, miR-150 could be used as a biomarker to determine the clinical outcome of ALL patients.

关键词： acute lymphoblastic leukemia miRNA clinical outcome

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Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

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Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi ali amin asnafi Javad Mohammadi-Asl Seyed Ahmad Hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

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MicroRNAs in erythropoiesis and red blood cell disorders

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Frontiers in Biology 2015年第4期10卷 321-332页

作者： Javad Mohammdai-asl Abolfazl Ramezani Fatemeh Norozi Amal Saki Malehi ali amin asnafi Mohammad ali Jalali Far Seyed Hadi Mousavi Najmaldin Saki Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Healthresearch Institute Research Center of Thalassemia & Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Biostatistics and Epidemiology School of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Hematology Department Allied Medical School Tehran University of Medical Sciences Tehran Iran

MicroRNAs （miRNAs） are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways in niche of hematopoietic cells, transcription factors as well as miRNAs. Expression of different types of miRNAs during erythroid development provides a background for the study of these molecules to control erythroid differentiation and maturation as well as their use as diagnostic and prognostic markers to treat erythroid disorders like thalassemia, sickle cell disease and erythrocyte enzyme deficiencies. In this paper, with reference to biosynthesis of miRNAs, their function in normal and anemic erythropoiesis has been investigated. The target molecule of each of these miRNAs has been cited in an attempt to elucidate their role in erythropoiesis.

关键词： miRNA erythropoiesis red blood cell

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Modeling the dynamical behavior of the interaction of T-cells and human immunodeficiency virus with saturated incidence

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Communications in Theoretical Physics 2024年第3期76卷 1-14页

作者： Salah Boulaaras Rashid Jan amin Khan ali Allahem Imtiaz Ahmad Salma Bahramand Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia Institute of Energy Infrastructure(IEI) Department of Civil EngineeringCollege of EngineeringUniversiti Tenaga Nasional(UNITEN)Putrajaya CampusJalan IKRAM-UNITEN43000 KajangSelangorMalaysia Department of Mathematics University of SwabiSwabi 23561Pakistan Department of Mathematics College of SciencesQassim UniversitySaudi Arabia Institute of Informatics and Computing in Energy(IICE) Universiti Tenaga NasionalKajangSelangorMalaysia Department of Political Science Bacha Khan University CharsaddaCharsadda 24420KPK Pakistan

In the last forty years,the rise of HIV has undoubtedly become a major concern in the field of public health,imposing significant economic burdens on affected ***,it becomes imperative to undertake comprehensive investigations into the mechanisms governing the dissemination of HIV within the human *** this work,we have devised a mathematical model that elucidates the intricate interplay between CD4^(+)T-cells and viruses of HIV,employing the principles of fractional *** production rate of CD4^(+)T-cells,like other immune cells depends on certain factors such as age,health status,and the presence of infections or ***,we incorporate a variable source term in the dynamics of HIV infection with a saturated incidence rate to enhance the precision of our *** introduce the fundamental concepts of fractional operators as a means of scrutinizing the proposed HIV *** facilitate a deeper understanding of our system,we present an iterative scheme that elucidates the trajectories of the solution pathways of the *** show the time series analysis of our model through numerical findings to conceptualize and understand the key factors of the *** addition to this,we present the phase portrait and the oscillatory behavior of the system with the variation of different input *** information can be utilized to predict the long-term behavior of the system,including whether it will converge to a steady state or exhibit periodic or chaotic oscillations.

关键词： HIV infection fractional-calculus dynamics of HIV iterative scheme dynamical behaviour mathematical model fractional derivatives

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Social Media-Based Surveillance Systems for Health Informatics Using Machine and Deep Learning Techniques:A Comprehensive Review and Open Challenges

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1167-1202页

作者： Samina amin Muhammad ali Zeb Hani Alshahrani Mohammed Hamdi Mohammad Alsulami Asadullah Shaikh Institute of Computing Kohat University of Science and TechnologyKohat26000Pakistan Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Information System College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia

Social media(SM)based surveillance systems,combined with machine learning(ML)and deep learning(DL)techniques,have shown potential for early detection of epidemic *** review discusses the current state of SM-based surveillance methods for early epidemic outbreaks and the role of ML and DL in enhancing their ***,every year,a large amount of data related to epidemic outbreaks,particularly Twitter data is generated by *** paper outlines the theme of SM analysis for tracking health-related issues and detecting epidemic outbreaks in SM,along with the ML and DL techniques that have been configured for the detection of epidemic *** has emerged as a promising ML technique that adaptsmultiple layers of representations or features of the data and yields state-of-the-art extrapolation *** recent years,along with the success of ML and DL in many other application domains,both ML and DL are also popularly used in SM *** paper aims to provide an overview of epidemic outbreaks in SM and then outlines a comprehensive analysis of ML and DL approaches and their existing applications in SM ***,this review serves the purpose of offering suggestions,ideas,and proposals,along with highlighting the ongoing challenges in the field of early outbreak detection that still need to be addressed.

关键词： Social media epidemic machine learning deep learning health informatics pandemic

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani Syed M Faiq Rahma Rashid Tariq ali Kalwar Rehan Mohsin Tahir Aziz Nida amin Khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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The global,prevalence,and risk factors of postoperative fever after percutaneous nephrolithotomy:A systematic review and meta-analysis

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Asian Journal of Urology 2024年第2期11卷 253-260页

作者： Reza Falahatkar Siavash Falahatkar Mohammad amin Khajavi Gaskarei Masoomeh Afzalipoor ali Mojtahedi Neda aligolighasemabadi Ahmad Deilami Samaneh Mirzaei Dahka Mohammad-Hossein Keivanlou alireza Jafari Urology Research Center Guilan University of Medical SciencesGuilanRashtIran Department of Surgery University of SaskatchewanSaskatoonCanada Microbiology Department School of MedicineGuilan University of Medical SciencesRashtIran Department of Internal Medicine School of MedicineGuilan University of Medical SiencesRashtIran School of Nursing and Midwifery Guilan University of Medical SciencesGuilanRashtIran

Objective:This study aimed to explore the global,prevalence,and risk factors of fever after percutaneous nephrolithotomy(PCNL)by conducting a systematic review and ***:The high-sensitivity searching was conducted without time limitation until December 30,2020 in Web of Sciences,Scopus,and PubMed based on inclusion and exclusion ***:The prevalence rates of fever and sepsis among patient undergoing PCNL were estimated 9.5%(95%confidence interval[CI]:9.3%-9.7%),and 4.5%(95%CI:4.2%-4.8%),*** tube was used in 9.96%(95%CI:9.94%-9.97%)of *** mean preoperative white blood cells of patients were 6.401×109/L;18.3%and 4.55%of patients were considered as the positive urinary culture and pyuria,*** 20.4%of patients suffered from residual *** odds ratios(ORs)of fever in patients who suffering from diabetes mellitus,hydronephrosis,staghorn stones,and blood transfusion were 4.62(95%CI:2.95-7.26),1.04(95%CI:0.81-1.34),2.57(95%CI:0.93-7.11),and 2.65(95%CI:1.62-4.35),*** who underwent PCNL in prone position were more likely to develop fever(OR:1.23;95%CI:0.75-2.00)than patients in supine ***:The current study showed that patients who suffer from diabetes mellitus,hydronephrosis,staghorn stones,nephrostomy tube or double-J stent,blood transfusion,and also patients who underwent PCNL in prone position surgery are more likely to develop a postoperative fever after PCNL.

关键词： Percutaneous nephrolithotomy Fever Hydronephrosis Diabetes Meta-analysis

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Advancing Crowd Object Detection: A Review of YOLO, CNN and ViTs Hybrid Approach*

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Journal of Intelligent Learning Systems and Applications 2024年第3期16卷 175-221页

作者： Mahmoud Atta Mohammed ali Tarek Aly Atef Tayh Raslan Mervat Gheith Essam A. amin Faculty of Graduate Studies for Statistical Research Software Engineering Department Cairo University Giza Egypt

One of the most basic and difficult areas of computer vision and image understanding applications is still object detection. Deep neural network models and enhanced object representation have led to significant progress in object detection. This research investigates in greater detail how object detection has changed in the recent years in the deep learning age. We provide an overview of the literature on a range of cutting-edge object identification algorithms and the theoretical underpinnings of these techniques. Deep learning technologies are contributing to substantial innovations in the field of object detection. While Convolutional Neural Networks (CNN) have laid a solid foundation, new models such as You Only Look Once (YOLO) and Vision Transformers (ViTs) have expanded the possibilities even further by providing high accuracy and fast detection in a variety of settings. Even with these developments, integrating CNN, YOLO and ViTs, into a coherent framework still poses challenges with juggling computing demand, speed, and accuracy especially in dynamic contexts. Real-time processing in applications like surveillance and autonomous driving necessitates improvements that take use of each model type’s advantages. The goal of this work is to provide an object detection system that maximizes detection speed and accuracy while decreasing processing requirements by integrating YOLO, CNN, and ViTs. Improving real-time detection performance in changing weather and light exposure circumstances, as well as detecting small or partially obscured objects in crowded cities, are among the goals. We provide a hybrid architecture which leverages CNN for robust feature extraction, YOLO for rapid detection, and ViTs for remarkable global context capture via self-attention techniques. Using an innovative training regimen that prioritizes flexible learning rates and data augmentation procedures, the model is trained on an extensive dataset of urban settings. Compared to solo YOLO,

关键词： Object Detection Deep Learning Computer Vision YOLO Convolutional Neural Networks (CNN) Vision Transformers Neural Networks Transfer Learning Autonomous Driving Self-Drive Vehicles

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Daytime-nighttime variations in the concentration of PM_(0.1) carbonaceous particles during a biomass fire episode in Chiang Mai,Thailand

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Particuology 2024年第4期87卷 316-324页

作者： Worradorn Phairuang Thaneeya Chetiyanukornkul Phuchiwan Suriyawong Sotasing Ho Phakphum Paluang Masami Furuuchi Muhammand amin Mitsuhiko Hata Faculty of Gesciences and CivilEngineering Institute of Science and Enginering Kanazawa UniverityKanazawaIshkawa92192Japan Department of Geography Faculty of Social SciencesChiang Mai UniversityMuangChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityMuangChiang Mai50200Thailand Research Unit for Eergyonomics and Eological Management Multidisciplinary Research Insttute Chiang Mai UniversityChiang Mai50200Thailand Management and Development Training Program Office National Institute of ScienceTechnology and Innovation120601Cambodia Faculty of Engineering Maritim University of Raja Ali HajTanjung PinangKepulauan Riau29115Indonesia

Carbonaceous aerosols affect air quality adversely,affect global warming,and human ***,our understanding of the impact of ultrafine(PM_(0.1))carbonaceous particulate matter is incomplete,particularly the effects during haze *** study monitored diurnal variations in PM_(0.1) in Chiang Mai,Thailand,from March to April *** investigated carbonaceous PM_(0.1) collected by an ambient nano-sampler and evaluated their effect by using a carbon analyzer(IMPROVE_TOR).The results showed that burning large open areas in the dry season was crucial for increasing the particle mass concentration because of the large open burnings that occurred in this *** majority of biomass fires near the sampling site occurred during the night,which would allow more particles to be released thus resulting in higher concentrations of PM_(0.1).Hence,the release of PM_(0.1) during the night would obviously result in higher concentrations than that during the *** the eight carbon profiles,organic carbon 3(OC3)was predicted to be a marker of biomass *** carbon indices displayed that PM_(0.1) was influenced by biomass burning both daytime and *** findings reported herein should be of great impor-tance in terms of establishing biomass burning control policies for mitigating heavy haze pollution in Thailand and elsewhere.

关键词： Biomass burning Carbon Forest fires Nanoparticles Ultrafine particles

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A Critical Review of Community Resilience Building Framework: Contexts of Climate Change and Disasters in Bangladesh

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Journal of Geoscience and Environment Protection 2024年第9期12卷 315-334页

作者： Abdul alim Shaikh Mousumi Halder Muhammad Ramzan ali Ruhul amin Md Saifur Rahman Md. Kamruzzaman Khulna University Khulna Bangladesh Climate Change Program Christian Commission for Development in Bangladesh (CCDB) Dhaka Bangladesh International Rescue Committee-UK Coxs Bazar Bangladesh Tropical and International Forestry Technical University Dresden Cotta Bau Pienner Strae 7 01737 Tharandt Germany Forestry and Wood Technology Discipline Khulna University Khulna Bangladesh

The concept of community resilience in the contexts of climate change and disasters draws increasing attention and interest from practitioners and researchers in recent development discourse. This paper provides a critical review of six selected frameworks of community resilience building operationalized in Bangladesh over the span of years. In other words, this study aims to contribute to the understanding of resilience through a systematic analysis of the dimensions and indicators of community resilience frameworks. The analysis shows that comprehensive and effective community resilience frameworks should incorporate the missing components linked to fundamental elements of good governance, economic growth, environmental sustainability, social transformation, and capacity development. The paper concludes by highlighting a few other areas of grave concern that need more appropriate attention, considering the severe threats posed by climate change and natural disasters in line with sustainable development goals. Finally, this study recommends further research regarding the effectiveness of these frameworks in different climatic and disaster contexts that can lead the concept into a new dimension of community resilience and sustainability.

关键词： Community Resilience Resilience Building Framework Resilience Indicators Climate Change Disaster Bangladesh

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