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World Journal of Cardiovascular Diseases 2013年第6期3卷 412-413页

作者： Habib Cakir Yüksel Besir Ismail Yurekli Koksal Donmez Ersin Celik Mert Kestelli Ufuk Yetkin ali gurbuz Department of Cardiovascular Surgery Katip Celebi University Izmir Ataturk Training and Research Hospital Izmir Turkey

Postopereative sternal dehiscence is one of the most important complications of median sternotomy which may cause pulmonary dysfunction and mediastinitis. We are reporting a patient with sternal dehiscence after coronary artery bypass surgery that underwent application of thermoreactive nitinol clips in addition to Robicsek procedure. Using thermoreactive nitinol clips method together with Robicsek procedure may be a valuable technique for preventing recurrent sternal dehiscence for patients who are candidates of noninfective recurrent sternal dehiscence.

关键词： Sternal Dehiscence Robicsek Procedure Thermoreactive Nitinol Clips

Falls from height： A retrospective analysis

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World Journal of Emergency Medicine 2018年第1期9卷 46-50页

作者： Kasim Turgut Mehmet Ediz Sarihan Cemil Colak Taner Giiven ali Gur Sukru gurbuz Department of Emergency Medicine Education and Research Hospital Adiyaman University Adiyaman Turkey Department of Emergency Medicine School of Medicine Inonu Universitu Malatya Turkey Department of Biostatistics and Medical Informatics School of Medicine Inonu UniversityMalatya Turkey

BACKGROUND: Emergency services manage trauma patients frequently and falls from height comprise the main cause of emergency service admissions. In this study, we aimed to analyse the demographic characteristics of falls from height and their relationship to the ***: A total of 460 patients, who admitted to the Emergency Department of Inonu University between November 2011 and November 2014 with a history of fall from height, were examined retrospectively. Demographic parameters, fall characteristics and their effect to mortality were evaluated statistically. RESULTS: The study comprised of 292(63.5%) men and 168(36.5%) women patients. The mean age of all patients was 27±24.99 years. Twenty-six(5.6%) patients died and the majority of them were in ≥62 years old group. The highest percentage of falls was at 0–5 years age group(28.3%). People fell mainly from 1.1–4 metres(m) level(46.1%). The causes of falls were ordered as unintentional(92.2%), workplace(8.1%) and suicidal(1.7%). Skin and soft tissue injuries(37.4%) were the main traumatic lesions. CONCLUSION: Age, fall height, fall place, linear skull fracture, subarachnoidal hemorrhage, cervical fracture, thoracic vertebra fracture and trauma scores had statistically significant effect on mortality. The casualties died because of subarachnoid hemorrhage mostly.

关键词： Trauma Falls Mortality Emergency medicine

Generalized Weighted Morrey Estimates for Marcinkiewicz Integrals with Rough Kernel Associated with Schrodinger Operator and Their Commutators

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 77-98页

作者： Ferit gurbuz Faculty of Education Department of Mathematics EducationHakkari UniversityHakkari 30000Turkey

Let L =-△+V(x) be a Schrodinger operator, where △ is the Laplacian on R^n,while nonnegative potential V(x) belonging to the reverse Holder class. The aim of this paper is to give generalized weighted Morrey estimates for the boundedness of Marcinkiewicz integrals with rough kernel associated with Schrodinger operator and their ***, the boundedness of the commutator operators formed by BMO functions and Marcinkiewicz integrals with rough kernel associated with Schrodinger operators is discussed on the generalized weighted Morrey spaces. As its special cases, the corresponding results of Marcinkiewicz integrals with rough kernel associated with Schrodinger operator and their commutators have been deduced, respectively. Also, Marcinkiewicz integral operators, rough Hardy-Littlewood(H-L for short) maximal operators, Bochner-Riesz means and parametric Marcinkiewicz integral operators which satisfy the conditions of our main results can be considered as some examples.

关键词： Marcinkiewicz operator Rough kernel Schrodinger operator generalized weighted Morrey space Commutator BMO

Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4-Methyl-2-aminophenol

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Chinese Journal of Chemistry 2012年第4期30卷 970-978页

作者： gurbuz, Demet Cinarli, Adem Tavman, Aydin Birteksoz, A. Seher Department of Chemistry Faculty of Engineering Istanbul University 34320 Avcilar Istanbul Turkey Department of Pharmaceutical Microbiology Faculty of Pharmacy Istanbul University 34452 Beyazit Istanbul Turkey

A series of N-（5-methyl-2-hydroxyphenyl）-（2/3/4/5-substituted）-benzaldimines （I--XlII） were synthesized us- ing appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H- and 13C-NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-methyl-2-hydroxyphenyl）- 3,4-dimethoxybenzaldimine （XIII） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumo- niae, Pseudomonas aeruginosa and Proteus mirabilis. Antifungal activities were reported for Candida albieans. Some of the Schiffbases showed considerable antimicrobial activity against S. aureus and C. albicans.

关键词： Schiffbases methylhydroxyphenyl spectroscopy X-ray diffraction antimicrobial

Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4-Chloro-2-aminophenol and Various Salicylaldehyde Derivatives

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Chinese Journal of Chemistry 2012年第2期30卷 449-459页

作者： Cinarli, Adem gurbuz, Demet Tavman, Aydin Birteksoz, A. Seher Istanbul University Faculty of Engineering Department of Chemistry 34320 Avcilar Istanbul Turkey Istanbul University Faculty of Pharmacy Department of Pharmaceutical Microbiology 34452 Beyazit Istanbul Turkey

A series of N-（5-chloro-2-hydroxyphenyl）-（3/4/5-substituted）-salicylaldimines （I--XI） were synthesized using appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H and 13C NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-chloro-2-hydroxyphenyl）-5-bromo- salicylaldimine （V） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds was examined. Antimicrobial activity of the compounds was evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis. Antifungal activities were reported for Candida albicans. Schiff bases showed considerable antimicrobial activity against S. aureus, S, epidermidis and C. albicans. N-（5-Chloro-2-hydroxyphenyl）-3-hydroxy-salieylaldimine （II） has the broadest and highest antimicrobial activity according to the others.

关键词： salicylaldimine Schiffbases X-ray diffraction spectroscopy antimicrobial

Evaluating bioactivity and bioaccessibility properties of the propolis extract prepared with L-lactic acid: An alternative solvent to ethanol for propolis extraction

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FOOD BIOSCIENCE 2023年第3期53卷 2351-2358页

作者： Atayoglu, ali Timucin Atik, Didem Sozeri Boluk, Esra gurbuz, Basak Ceylan, Fatma Duygu Capanoglu, Esra Atayolu, Rumeysa Paradkar, Anant Fearnley, James Palabiyik, Ibrahim Istanbul Medipol Univ Tradit & Complementary Med Dept Istanbul Turkiye Tekirdag Namik Kemal Univ Food Engn Dept Tekirdag Turkiye Istanbul Tech Univ Food Engn Dept Istanbul Turkiye Istanbul Medipol Univ Nutr & Dietet Dept Istanbul Turkiye Univ Bradford Ctr Pharmaceut Engn Sci Sch Pharm Bradford W Yorkshire England Apiceut Res Ctr Whitby N Yorkshire England

Ethanol readily solubilizes the active components of propolis. Due to certain disadvantages of ethanolic extracts, developing new non-ethanolic extraction methods is highly desirable. This study aimed to determine the content of phenolic compounds and antioxidant activity of propolis by using lactic acid extraction compared to ethanol. Various concentrations of ethanol and lactic acid were utilized to produce extracts, and an in vitro digestion procedure was applied to the extracts to compare the bioaccessibility of phenolic compounds by using LC-MS/MS in extracts and HPLC-DAD in digested samples. The compounds detected in the lactic acid-based propolis so-lution had similar values to those in the ethanol solution at a propolis concentration of 10%. The propolis-lactic acid solution had a significantly higher antioxidant activity against DPPH radical than the one prepared with ethanol at the same concentration (p < 0.05). Chrysin and naringenin were found as the most abundant phenolic compounds in the initial samples during in vitro digestion experiments. Pinocembrin was the most bioaccessible component among the dialyzed IN fractions of ethanol and lactic acid-based solutions, whereas some compounds were not detected. The results suggest that lactic acid may be used as an alternative to ethanol for propolis extraction.

关键词： Antioxidant Extraction Lactic acid Propolis Phenolics

Effect of acupuncture therapy on fracture healing in rats with femur fractures

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Journal of Traditional Chinese Medicine 2020年第2期40卷 275-283页

作者： Seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman gurbuz Mustafa Ozkaraca Firat University Faculty of Veterinary MedicineDepartment of BiochemistryElazig 23119Turkey Firat University Faculty of MedicineDepartment of Orthopedics and TraumatologyElazig 23119Turkey Firat University Faculty of MedicineDepartment of AnatomyElazig 23119Turkey Ataturk University Faculty of Veterinary MedicineDepartment of PathologyErzurum 25240Turkey

OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur ***: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the ***: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone ***: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals.

关键词： Femur Fracture healing Acupuncture Malondialdehyde Antioxidants

Chronic administration of sildenafil improves erectile function in a rat model of chronic renal failure

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Asian Journal of Andrology 2015年第5期17卷 797-801,I0008-I0009页

作者： Nilgun gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta Department of Biochemistry Akdeniz University School of Medicine Antalya Turkey Department of Urology Section of Andrology Akdeniz University School of Medicine Antalya Turkey

The relationship between erectile dysfunction （ED） and chronic renal failure （CRF） has been reported in several studies. This study aimed to investigate whether the chronic use of sildenafil could enhance the erectile capacity in CRF-induced rats. In addition, we assessed the effect of that treatment on certain molecules, which have been suggested to play crucial roles in erectile physiology and CRF-related ED as well. Three groups of animals were utilized：（1） age-matched control rats, （2） CRF-induced rats, （3） CRF-induced rats treated with chronic administration of sildenafil （5 mg kg^-1 p.o. for 6 weeks [treatment started after 6 weeks of CRF induction]）. At 3 months, all animals underwent cavernosal nerve stimulation （CNS） to assess erectile function. Penile tissue advanced glycation end products （AGE＇s）/5-hydroxymethyl-2-furaldehyde, malondialdehyde （MDA）, cGMP （ELISA）, inducible nitric oxide synthase （iNOS） and neuronal NOS （nNOS）（Western blot） analyses were performed in all rat groups. CRF-induced rats had a significant decrease in erectile function when compared to control rats （P 〈 0.05）. The increase in both intracavernosal pressure （ICP） and area under the curve of CRF-induced rats treated with sildenafil （Group 3） was greater than CRF-induced rats （Group 2）. Additionally, sildenafil treatment decreased AGE, MDA and iNOS levels, while it preserved nNOS and cGMP contents in CRF-induced penile tissue. Decreased AGE, MDA, iNOS and increased nNOS, cGMP levels at the sildenafil-treated group increased both ICP and Total ICP to CNS, which led to improve erectile function in CRF-induced rats. The results of the present study revealed the therapeutic effect of chronic sildenafil administration on erectile function in CRF-induced rats.

关键词： chronic renal failure erectile function sildenafil

Hypogonadism and erectile dysfunction： an overview

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Asian Journal of Andrology 2008年第1期10卷 36-43页

作者： Nilgun gurbuz Elnur Mammadov Mustafa Faruk Usta Section of Andrology Department of Urology Akdeniz University School of Medicine Antalya 07070 Turkey

In humans androgen decline is presented as a clinical picture which includes decreased sexual interest, diminished erectile capasity, delayed or absent orgasms and reduced sexual pleasure. Additionally, changes in mood, diminished well being, fatigue, depression and irritability are also associated with androgen insufficiency. The critical role of androgens on the development, growth, and maintanence of the penis has been widely accepted. Although, the exact effect of androgens on erectile physiology still remains undetermined, recent experimental studies have broaden our understanding about the relationship between androgens and erectile function. Preclinical studies showed that androgen deprivation leads to penile tissue atrophy and alterations in the nerve structures of the penis. Furthermore, androgen deprivation caused to accumulation of fat containing cells and decreased protein expression of endothelial and neuronal nitric oxide synthases （eNOS and nNOS）, and phosphodiesterase type-5 （PDE-5）, which play crucial role in normal erectile physiology. On the light of the recent literature, we aimed to present the direct effect of androgens on the structures, development and maintanence of penile tissue and erectile physiology as well. Furhermore, according to the clinical studies we conclude the aetiology, pathophysiology, prevalance, diagnosis and treatment options of hypogonadism in aging men.

关键词： testosterone erectile physiology symptomatic late onset hypogonadism

Importance of Synergistic Value in the Context of Business Combination： A Case Study From Turkey

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Economics World 2018年第1期6卷 49-60页

作者： gurbuz Gokcen Ozgur Teraman Marmara University Istanbul Turkey Istanbul Aydm University Istanbul Turkey

Considering International Financial Reporting Standards （henceforth IFRS）, although fair value is suggested in the conceptual framework and related standards, concept of measurement is used instead of concept of valuation. Determining the fair value of the acquiree specific into business combination, is needed to identify the fair value of the valuation made beyond the measurement of either monetary items or non-monetary items in the financial statements. Essential reason of the difference between acquired entity＇s fair values as a basis of financial reporting standards and valuation standards, the fair value according to IFRS is equivalent to the market value according to International Valuation Standards （henceforth IVS）. The fair value in accordance with IVS, the combination of the market value, and the synergistic value of the asset are subject to valuation in terms of special purchaser. When business is concerned, considering parameters such as the position in the industry, brand awareness, intellectual capital, geography, cannot be expected to be equal to the fair value of business which simply consists of market value among market participants. The ultimate aim of the study is to illustrate how to determine synergistic value in the terms oflVS which shows the difference between the market value and fair value. Based on the findings of the study, if acquired assets and liabilities are recognized in accordance with IFRS, goodwill comes out during the acquisition. Though, when fair value is determined based on IVS, goodwill is not found, even profitable business combination is realized. This is the result of considered fair value based on IVS Framework, that is the combination of market value of an asset in question and total synergistic value.

关键词： international valuation standards international financial reporting standards business combination market value fair value synergistic value