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Left bundle branch pacing vs biventricular pacing in heart failure patients with left bundle branch block:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第1期16卷 40-48页

作者： Farah Yasmin Abdul Moeed Rohan Kumar Ochani Hamna Raheel Malik ali Ehtsham Awan Ayesha Liaquat arisha Saleem Muhammad Aamir Nael Hawwa Salim Surani Department of Internal Medicine Yale University School of MedicineNew HavenCT 06511United States Department of Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Medicine SUNNY Upstate Medical UniversitySyracuseNY 13210United States Department of Cardiovascular Medicine Lehigh Valley Heart and Vascular InstituteAllentownPA 18105United States Department of Medicine Cleveland ClinicClevelandOH 44195United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Left bundle branch pacing(LBBP)is a novel pacing modality of cardiac resynchronization therapy(CRT)that achieves more physiologic native ventricular activation than biventricular pacing(BiVP).AIM To explore the validity of electromechanical resynchronization,clinical and echocardiographic response of LBBP-CRT.METHODS Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology section.RESULTS In our analysis,the success rate of LBBP-CRT was determined to be 91.1%.LBBP CRT significantly shortened QRS duration,with significant improvement in echocardiographic parameters,including left ventricular ejection fraction,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with BiVP-CRT.CONCLUSION A significant reduction in New York Heart Association class and B-type natriuretic peptide levels was also observed in the LBBP-CRT group vs BiVP-CRT group.Lastly,the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.

关键词： Left bundle branch pacing Biventricular pacing QRS duration Left ventricular ejection fraction Heart failure

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Predicting resilient modulus of recycled concrete and clay masonry blends for pavement applications using soft computing techniques

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Frontiers of Structural and Civil Engineering 2019年第6期13卷 1379-1392页

作者： Mosbeh R.KALOOP Alaa R.GABR Sherif M.EL-BADAWY ali arisha Sayed SHWALLY Jong Wan HU Department of Civil and Environmental Engineering Incheon National UniversityIncheon 22012South Korea Incheon Disaster Prevention Research Center Incheon National UniversityIncheon 22012South Korea Department of Public Works and Civil Engineering Mansoura UniversityMansoura 35516Egypt

To date,very few researchers employed the Least Square Support Vector Machine(LSSVM)in predicting the resilient modulus(Mr)of Unbound Granular Materials(UGMs).This paper focused on the development of a LSSVM model to predict the MT of recycled materials for pavement applications and comparison with other different models such as Regression,and Artificial Neural Network(ANN).Blends of Recycled Concrete Aggregate(RCA)with Recycled Clay Masonry(RCM)with proportions of 100/0,90/10,80/20,70/30,55/45,40/60,20/80,and 0/100 by the total aggregate mass were evaluated for use as UGMs.RCA/RCM materials were collected from dumps on the sides of roads around Mansoura city,Egypt.The investigated blends were evaluated experimentally by routine and advanced tests and the Mr values were detennined by Repeated Load Triaxial Test(RLTT).Regression,ANN,and LSSVM models were utilized and compared in predicting the Mr of the investigated blends optimizing the best design model.Results showed that the Mx values of the investigated RCA/RCM blends were generally increased with the decrease in RCM proportion.Statistical analyses were utilized for evaluating the performance of the developed models and the inputs sensitivity parameters.Eventually,the results approved that the LSSVM model can be used as a novel tool to estimate the Mx of the investigated RCA/RCM blends.

关键词： Least Square Support Vector Machine Artificial Neural Network resilient modulus Recycled Concrete Aggregate Recycled Clay Masonry

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Inhibition of miR397 by STTM technology to increase sweetpotato resistance to SPVD

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Journal of Integrative Agriculture 2022年第10期21卷 2865-2875页

作者： LI Chen LIU Xuan-xuan ABOUELNASR Hesham MOHAMED HAMED arisha KOU Meng TANG Wei YAN Hui WANG Xin WANG Xiao-xiao ZHANG Yun-gang LIU Ya-ju GAO Run-fei MA Meng LI Qiang Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District/Sweetpotato Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Biology and Genetic Breeding of SweetpotatoMinistry of Agriculture and Rural AffairsXuzhou 221131P.R.China School of Life Science Jiangsu Normal UniversityXuzhou 221116P.R.China Plant Pathology Department Agriculture and Biology Research DivisionNational Research CenterGiza 12622Egypt Department of Horticulture Faculty of AgricultureZagazig UniversityZagazig 44511Egypt

As a critical food crop,sweetpotato(Ipomoea batatas(L.)Lam.)is widely planted all over the world,but it is deeply affected by Sweetpotato Virus Disease(SPVD).The present study utilized short tandem target mimic(STTM)technology to effectively up-regulate the expression of laccase(Ib LACs)by successfully inhibiting the expression of mi R397.The upstream genes in the lignin synthesis pathway were widely up-regulated by feedback regulation,including phenylalanine ammonialyase(PAL),4-coumarate-Co aligase(4 CL),hydroxycinnamoyl Co A:shikimatetransferase(HTC),caffeicacid O-methyltransferase(COMT),and cinnamyl alcohol dehydrogenase(CAD).Meanwhile,the activities of PAL and LAC increased significantly,finally leading to increased lignin content.Lignin deposition in the cell wall increased the physical defence ability of transgenic sweetpotato plants,reduced the accumulation of SPVD transmitted by Bemisia tabaci(Gennadius),and promoted healthy sweetpotato growth.The results provide new insights for disease resistance breeding and green production of sweetpotato.

关键词： sweetpotato miR397 STTM SPVD lignin content

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BLOC1S1促进山羊精原干细胞增殖

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生物工程学报 2023年第12期39卷 4901-4914页

作者：万仕成张梦菲陈文博韩苗杨栋慧王聪亮吴文萍王瑜琪李娜朱海鲸 Ahmed Hamed arisha 华进联西北农林科技大学动物医学院陕西省干细胞工程技术研究中心陕西杨凌712100 榆林学院陕西省绒山羊工程技术研究中心陕西榆林719000 开罗班达尔大学兽医学院开罗班达尔11829

随着基因编辑技术迅速发展,研究精原干细胞(spermatogonial stem cells,SSCs)对精子发生及其调控机制研究、转基因动物研发、基因治疗和不孕不育症的治疗以及珍稀物种的保护均具有重要意义。溶酶体相关细胞器生物合成复合体1亚基1(bioge... 详细信息

随着基因编辑技术迅速发展,研究精原干细胞(spermatogonial stem cells,SSCs)对精子发生及其调控机制研究、转基因动物研发、基因治疗和不孕不育症的治疗以及珍稀物种的保护均具有重要意义。溶酶体相关细胞器生物合成复合体1亚基1(biogenesis of lysosome-related organelles complex 1subunit 1,BLOC1S1)具有抗布鲁氏菌的潜能,研究BLOC1S1对山羊SSCs的影响不仅能探究BLOC1S1促进SSCs增殖的能力,还能为其抗病育种研究提供细胞学基础。本研究通过同源重组构建BLOC1S1过表达载体,通过慢病毒包装、转染与嘌呤霉素筛选成功构建了山羊精原干细胞BLOC1S1过表达细胞株。通过实时荧光定量PCR(real time quantitative PCR,RT-qPCR)检测BLOC1S1的过表达效率为18倍,同时细胞生长曲线、流式细胞术检测细胞周期、5-乙炔基-2’脱氧尿嘧啶核苷(5-ethynyl-2’-deoxyuridine,EdU)染色等实验结果表明,BLOC1S1能显著增加山羊SSCs的增殖活性。RT-qPCR、免疫荧光染色、Western blotting结果显示与增殖相关的基因(PCNA、CDK2、CCND1)上调,同时调控精原干细胞增殖的关键基因EIF2S3Y的表达量也上调。本研究成功构建了山羊精原干细胞BLOC1S1过表达细胞株,提高其增殖能力,并且这种促增殖能力可能是通过EIF2S3Y/ERK通路实现的。本研究为探究BLOC1S1对山羊精原干细胞的调控作用奠定了细胞学基础,并为进一步研究BLOC1S1的生物学功能提供细胞平台,为繁育BLOC1S1修饰抗病山羊奠定了基础。

关键词：山羊溶酶体相关细胞器生物合成复合体1亚基1(BLOC1S1) 精原干细胞增殖

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