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Role of lipids in the control of autophagy and primary cilium signaling in neurons

Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-Cáceres Daniela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco Díaz-Castro alfre.o criollo Maria Jose Yañez Eugenia Morselli Instituto de Investigación en Ciencias odontológicas(ICoD) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPCR lysosomal storage diseases neurons NPC1 phosphoinositides primary cilium

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Detection of leaf structures in close-range hyperspectral images using morphological fusion

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Geo-Spatial Information Science 2017年第4期20卷 325-332页

作者： Gladys Villegas Wenzhi Liao Ronald criollo Wilfried Philips Daniel ochoa Department of Telecommunications and Information Processing Ghent University-imec Ghent Belgium Facultad de Ingeniería en Eléctrica y Computación ESPOL Polytechnic University Escuela Superior Politécnica del Litoral Guayaquil Ecuador

Close-range hyperspectral images are a promising source of information in plant biology,in particular,for in vivo study of physiological *** this study,we investigate how data fusion can improve the detection of leaf elements by combining pixel reflectance and morphological *** detection of image regions associated to the leaf structures is the first step toward quantitative analysis on the physical effects that genetic manipulation,disease infections,and environmental conditions have in *** tested our fusion approach on Musa acuminata (banana) leaf images and compared its discriminant capability to similar techniques used in remote *** results demonstrate the efficiency of our fusion approach,with significant improvements over some conventional methods.

关键词： Hyperspectral fusion morphology plant biology

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Digital Intubation without Stylet: Myth or Reality? Case Report

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open Journal of Anesthesiology 2021年第5期11卷 156-163页

作者： Maya Christiam Mauricio Jesús Alberto Melendez ordoñez Ismael Bernardo Viveros Peralta Villanueva Verónica Juan José Dosta Herrera Andrea Carolina Jimenez Palacios Jimmy Andersson Delgado criollo Monserrat Escalante Rodríguez Dalia Fernanda Farrera Rámirez Maribel Méndez Suarez Pedro Sánchez Mata Residente de Anestesiología Hospital Juárez de México Ciudad de México México Médico adjunto al Servicio de Anestesiología Unidad Médica de Alta Especialidad (UMAE) Hospital General Doctor Gaudencio Jefe del Servicio de Anestesiología Unidad Médica de Alta Especialidad (UMAE) Hospital General Doctor Gaudencio González Garza (LA RAZA) Ciudad de México México

Digital intubation was discovered as one of the first methods to face a difficult airway without direct laryngoscopy. From the very beginning, this technique has been surrounded by much controversy, mainly because it required to be performed by an expert. Nowadays, it remains a useful technique when treating patients with difficult airways, so it is of utmost importance all personnel involved with airway management must know and perfect this technique when scenarios where conventional laryngoscopy or rescue devices for difficult airway are not available or contraindicated. The present work’s main objective is to suggest digital intubation as a safe and effective technique for the management of patients with difficult airways when there are no other devices available. The authors present a successful case of digital intubation on a patient with a difficult airway, demonstrating this technique is useful when performed by expert practitioners and when there is no other equipment available.

关键词： Intubation Intratracheal oxygenation Anesthesia Airway Management

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