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Porous Medium Flow with Both a Fractional Potential Pressure and Fractional time Derivative

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 45-82页

作者： Mark ALLEN Luis CAFFARELLI alexis VASSEUR Department of Mathematics The University of Texas at AustinAustinTX 78712USA

the authors study a porous medium equation with a right-hand side. the operator has nonlocal diffusion effects given by an inverse fractional Laplacian *** derivative in time is also fractional and is of Caputo-type, which takes into account"memory". the precise model isD_t~αu- div(u(-Δ)^(-σ)u) = f, 0 the problem over {t ∈ R^+, x ∈ R^n} with nonnegative initial data u(0, x) ≥0 as well as the right-hand side f ≥ 0. the existence for weak solutions when f, u(0, x)have exponential decay at infinity is proved. the main result is H¨older continuity for such weak solutions.

关键词： Caputo derivative Marchaud derivative Porous medium equation Hlder continuity Nonlocal diffusion

An Overview of Antiviral Peptides and Rational Biodesign Considerations

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BioDesign Research 2022年第1期2022卷 276-294页

作者： Ying-Chiang J.Lee Jaden D.Shirkey Jongbeom Park Karishma Bisht alexis J.Cowan Department of Molecular Biology Princeton UniversityPrincetonNew Jersey 08544USA

Viral diseases have contributed significantly to worldwide morbidity and mortality throughout *** the existence of therapeutic treatments for many viral infections,antiviral resistance and the threat posed by novel viruses highlight the need for an increased number of effective *** addition to small molecule drugs and biologics,antimicrobial peptides(AMPs)represent an emerging class of potential antiviral *** AMPs have traditionally been regarded in the context of their antibacterial activities,many AMPs are now known to be *** antiviral peptides(AVPs)have been shown to target and perturb viral membrane envelopes and inhibit various stages of the viral life cycle,from preattachment inhibition through viral release from infected host *** design of AMPs has also proven effective in identifying highly active and specific peptides and can aid in the discovery of lead peptides with high therapeutic *** this review,we highlight AVPs with strong antiviral activity largely curated from a publicly available AMP *** then compile the sequences present in our AVP database to generate structural predictions of generic AVP ***,we cover the rational design approaches available for AVPs taking into account approaches currently used for the rational design of AMPs.

关键词： Rational drugs rational

A Letter from the Editorial Board

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Journal of Natural Gas Chemistry 2006年第1期15卷 I0001-I0001页

作者： alexis t. bell theo FLEISCH

It has been 15 years that the Journal of Natural Gas Chemistry, an international, academic Journal focusing on the publication of worldwide research in the field of natural gas chemistry, has been published. Five years ago, the Editorial Board of the Journal was reorganized and moved to the Dalian Institute of Chemistry Physics, Chinese Academy of Sciences. the Journal has concentrated on the reporting of fundamental research and development information in the field of natural gas chemistry and related areas, and has made great contributions to the advancement of natural gas research and related areas in the world.

关键词： A Letter from the Editorial Board

Predictive roles of organizational and personal factors in work engagement among nurses

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Frontiers of Nursing 2022年第4期9卷 379-387页

作者： Charlie C.Falguera Leodoro J.Labrague Janet alexis A.De Los Santos Carmen N.Firmo Konstantinos tsaras School of Health Sciences University of the Philippines ManilaLeyteManila 2801Philippines School of Nursing Loyola University ChicagoIllinois 60660United States College of Nursing Visayas State UniversityBaybayLeyte 6521APhilippines Department of Nursing Technological Educational Institute of ThessalyKarditsaThessaly 43100Greece

Objective:to determine the work engagement levels of hospital nurses and the predictive roles that nurses’personal and organizational characteristics ***:A cross-sectional design was employed in this study,which included 549 nurses working in the Central *** were selected through purposive sampling,and a self-repor t questionnaire outlining personal and organizational characteristics was *** Utrecht Work Engagement Scale(UWES)was applied to gather data about nurse ***:the dedication score was the highest among the three dimensions of engagement while the vigor score was the ***,Filipino nurses experienced an average level of work *** observed significant relationships between a nurse’s age,years of experience in nursing,years in their present unit,and their position at work and their levels of engagement,vigor,sense of dedication,and *** capacity was a negative predictor of vigor,dedication,absorption,and overall work *** ther,the type of nursing contract was a negative predictor of vigor and *** type of hospital and the nurse’s position were positive predictors of vigor,dedication,and ***:Filipino nurses were satisfactorily engaged at work.A number of nurses’personal and organizational characteristics play a predictive role in their work ***,nursing administrators must suppor t,develop,and implement activities and measures that engage nurses at work.

关键词： Filipino nurses nurse personal factors organizational factors work engagement work engagement predictors

tHEMIS,the new kid on the block for t-cell development

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Cellular & Molecular Immunology 2017年第9期14卷 721-723页

作者： Janyra A Espinoza Evelyn L Jara alexis M Kalergis Facultad de Ciencias Biologicas Departamento de Genética Molecular y MicrobiologíaMillennium Institute on Immunology and ImmunotherapyPontificia Universidad Catolica de ChileSantiagoChile Facultad de Medicina Escuela de MedicinaDepartamento de EndocrinologíaPontificia Universidad Catolica de ChileSantiagoChile

Understanding t-cell development is a major goal of the immunology field and is crucial for the elucidation of the mechanisms behind self-tolerance and the occurrence of autoimmune disorders.t-cell development is a co... 详细信息

关键词： MIS arise development

Structural Flexibility Enables Alternative Maturation, ARGONAUtE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants

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Molecular Plant 2018年第8期11卷 1008-1023页

作者： taichiro Iki Antoine Cléry Nicolas G. Bologna alexis Sarazin Christopher A. Brosnan Nathan Pumplin Frédéric H.t. Allain Olivier Voinnet Department of Biology Swiss Federal Institute of Technology (ETH) Universit&tstrasse 2 ZUrich 8092 Switzerland Institute of Molecular Biology and Biophysics Department of Biology Swiss Federal Institute of Technology (ETH) Zürich Switzerland Biomolecular NMR spectroscopy Platform ETH Zürich Switzerland Present address: Laboratory of Germline Biology Graduate School of Frontier Biosciences Osaka University 1-3 Yamadaoka Suita Osaka Japan

In eukaryotes, the RNase-Ⅲ Dicer often produces length/sequence microRNA （miRNA） variants, called ＂isomiRs＂, owing to intrinsic structural/sequence determinants of the miRNA precursors （pre-miRNAs）. In this study, we combined biophysics, genetics and biochemistry approaches to study Arabidopsis miR168, the key feedback regulator of central plant silencing effector protein ARGONAUtE1 （AGO1）. We identified a motif conserved among plant premiR168 orthologs, which enables flexible internal basepairing underlying at least three metastable structural configurations. these configurations promote alternative, accurate Dicer cleavage events generating length and structural isomiR168 variants with distinctive AGO sorting properties and modes of action. Among these isomiR168s, a duplex with a 22-nt guide strand exhibits strikingly preferential affinity for AGO10, the closest AGO1 paralog. the 22-nt miR168-AGO10 complex antagonizes AGO1 accumulation in part via ＂transitive RNAi＂, a silencing-amplification process, to maintain appropriate AGO1 cellular homeostasis. Furthermore, we found that the tombusviral P19 silencing-suppressor protein displays markedly weaker affinity for the 22-nt form among its isomiR168 cargoes, thereby promoting AGO10-directed suppression of AGOl-mediated antiviral silencing. taken together, these findings indicate that structural flexibility, a previously overlooked property of premiRNAs, considerably increases the versatility and regulatory potential of individual MIRNA genes, and that some pathogens might have evolved the capacity or mechanisms to usurp this property.

关键词： microRNA miR168 Dicer ARGONAUtE tombusvirus P19

Associations between Avocado Intake and Lower Rates of Incident type 2 Diabetes in US Adults with Hispanic/Latino Ancestry

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Journal of Diabetes Mellitus 2023年第2期13卷 116-129页

作者： alexis C. Wood Mackenzie K. Senn Jerome I. Rotter USDA/ARS Children’s Nutrition Research Center Baylor College of Medicine Houston USA the Institute for translational Genomics and Population Sciences Department of Pediatrics The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance USA

Background/Purpose: Hispanic/Latinos in the US are at increased risk for type 2 diabetes (t2D). Data suggest that avocado intake is associated with better glycemic control, but whether this translates to protection from t2D has not been studied. the goal of the current analyses was to examine whether consuming avocados at baseline is associated with lower incident t2D over a six-year period, compared to not consuming avocados at baseline. Subjects/Methods: Using data from a large population of US adults with Hispanic ancestry, without known or unknown t2D at baseline (N = 6159), participants were classified as avocado consumers (N = 983) or non-consumers (N = 5176) based on the mean of two 24-hour dietary recalls. Cox proportional hazard models estimated the association of avocado consumption with incident t2D (N = 656 cases) over a six-year follow-up period, in the population as a whole, and separately in those with normoglycemia vs. prediabetes at baseline. A set of three sequential models were run: the first controlling only for sociodemographic factors (“minimally adjusted” models), the second for these and health behaviors (“fully adjusted” models), and a third for both sets of covariates and also body mass index (BMI;“fully adjusted + BMI” models). Results: In the population as a whole, avocado intake at baseline was associated with reduced incident t2D in both the minimally adjusted (hazard ratio [HR] (±95% confidence intervals [CIs]): 0.70 (0.52 - 0.94), P = 0.04) and the fully adjusted models (HR: 0.72 (0.54 - 0.97), P = 0.03). this association was observed in both those with prediabetes and with normoglycemia at baseline, but only reached significance in those with prediabetes (minimally adjusted model: HR: 0.68 (0.48 - 0.97), P = 0.03;fully adjusted model: HR: 0.69 (0.48 - 0.98), P = 0.04), not in those with normoglycemia (minimally adjusted model: HR: 0.86 (0.45 - 1.65), P = 0.65;fully adjusted model: HR: 0.80 (0.41 - 1.55), P = 0.50). In models which ad

关键词： Avocado Diet type 2 Diabetes Dysglycemia Monounsaturated Fats

A proto-monsoonal climate in the late Eocene of Southeast Asia:Evidence from a sedimentary record in central Myanmar

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Geoscience Frontiers 2023年第1期14卷 46-63页

作者： Huasheng Huang Robert J.Morley alexis Licht Guillaume Dupont-Nivet Daniel Pérez-Pinedo Jan Westerweel Zaw Win Day Wa Aung Eko Budi Lelono Galina N.Aleksandrova Ramesh K.Saxena Carina Hoorn Institute for Biodiversity and Ecosystem Dynamics(IBED) University of Amsterdam1090 GE AmsterdamThe Netherlands Palynova Ltd. 1 Mow Fen RoadLittleportCambridgeshire CB61PYUK Department of Earth Sciences Royal HollowayUniversity of LondonEghamSurrey TW200EXUK Centre de Recherche et d'Enseignement de Géosciences de I'Environnement(CEREGE) Aix-en-ProvenceFrance Institut fur Geowissenschaften Universität Potsdam14476 PotsdamGermany Géosciences Rennes CNRS and Universitéde Rennes 135042 Rennes CedexFrance Geology Department Shwe Bo UniversitySagaing RegionMyanmar Department of Geology University of YangonPyay RoadYangonMyanmar Badan Geologi Jl.Soekarno Hatta No 444BandungBandung 40254Indonesia Geological Institute Russian Academy of SciencesPyzhevsky Pereulok 7119017 MoscowRussia Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Department of Earth Sciences University of FlorenceVia G.La Pira 450121 Florenceltaly Department of Earth Sciences Memorial University of New-foundlandSt.John'sNewfoundland A1B 3X5Canada

the Burma terrane has yielded some of the earliest pieces of evidence for monsoonal rainfall in the Bay of ***,Burmese ecosystems and their potential monsoonal imprint remain poorly *** study focuses on the late Eocene Yaw Formation(23°N)in central Myanmar,which was located near the equator(c.5°N)during the *** quantitatively assessed the past vegetation,climate,and depositional environments with sporomorph diagrams,bioclimatic analysis,and sequence *** calculated the palynological diversity and drew inferences with rarefaction analysis by comparing with four other middle to late Eocene tropical *** results highlight a high floristic diversity for the palynoflora throughout the section formed by six pollen zones characterized by different *** indicate that lowland evergreen forests and swamps dominated in the Eocene Burmese deltaic plains while terra firma areas were occupied by seasonal evergreen,seasonally dry,and deciduous *** vegetation pattern is typical to what is found around the Bay of Bengal today and supports a monsoon-like climate at the time of the Yaw *** analysis further suggests that in the late Eocene,the Yaw Formation was more seasonal,drier,and cooler compared to modern-day climate at similar near-equatorial *** seasonal and drier conditions can be explained by a well-marked seasonal migration of the Intertropical Convergence Zone(ItCZ),driver of proto-monsoonal *** temperatures in the late Eocene of central Myanmar may be due to the lack of adequate modern analogues for the Eocene monsoonal climate,while those found at other three Eocene Asian paleobotanical sites(India and South China)may be caused by the effect of canopy evapotranspirational *** data suggest that paleoenvironmental change including two transgressive-regressive depositional sequences is controlled by global sea level change,which may be driven by cl

关键词： Bioclimatic analysis Diversity Monsoon Palynology Sequence biostratigraphy Southeast Asia

Insights on the crosstalk between dendritic cells and helper t cells in novel genetic etiology for mendelian susceptible mycobacterial disease

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Cellular & Molecular Immunology 2018年第12期15卷 1091-1094页

作者： Emma Rey-Jurado Magdalena S.Pizarro-Ortega alexis M.Kalergis Millennium Institute on Immunology and Immunotherapy Departamento de Genética Molecular y MicrobiologíaFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiago 8330644Chile Departamento de Endocrinología Facultad de MedicinaPontificia Universidad Católica de ChileSantiago 8330644Chile

Mendelian susceptibility to mycobacterial disease(MSMD)is an inherited predisposition to infections by Bacille-Calmette Guérin(BCG)vaccine or by environmental *** etiology of MSMD has been associated with up to nineteen different genetic mutations in interferon(IFN)-γ-related genes.1 Although mycobacteria susceptibility-associated genetic mutations are rare in the population,their diagnosis is crucial for an efficient and timely *** et al.2 have recently described an autosomal recessive deficiency in the signal peptidase-like 2 A(SPPL2-a)as a new genetic etiology for MSMD in three patients that had suffered BCG dissemination disease.

关键词： mendelian susceptibility to mycobacterial disease SPPL2a deficiency cDC2 mycobacterial-specific priming IFN-γ