An Overview of Antiviral Peptides and Rational Biodesign Considerations

作     者：Ying-Chiang J.Lee Jaden D.Shirkey Jongbeom Park Karishma Bisht Alexis J.Cowan 

作者机构：Department of Molecular BiologyPrinceton UniversityPrincetonNew Jersey 08544USA 

出 版 物：《BioDesign Research》 (生物设计研究（英文）)

年 卷 期：2022年第2022卷第1期

页      面：276-294页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 0836[工学-生物工程] 10[医学] 

基　　金：the NIGMS of the National Institutes of Health under grant number T32GM007388 

主　　题：Rational drugs rational 

摘      要：Viral diseases have contributed significantly to worldwide morbidity and mortality throughout *** the existence of therapeutic treatments for many viral infections,antiviral resistance and the threat posed by novel viruses highlight the need for an increased number of effective *** addition to small molecule drugs and biologics,antimicrobial peptides(AMPs)represent an emerging class of potential antiviral *** AMPs have traditionally been regarded in the context of their antibacterial activities,many AMPs are now known to be *** antiviral peptides(AVPs)have been shown to target and perturb viral membrane envelopes and inhibit various stages of the viral life cycle,from preattachment inhibition through viral release from infected host *** design of AMPs has also proven effective in identifying highly active and specific peptides and can aid in the discovery of lead peptides with high therapeutic *** this review,we highlight AVPs with strong antiviral activity largely curated from a publicly available AMP *** then compile the sequences present in our AVP database to generate structural predictions of generic AVP ***,we cover the rational design approaches available for AVPs taking into account approaches currently used for the rational design of AMPs.