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Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

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Military Medical Research 2022年第2期9卷 205-214页

作者： Beatrice Alexandra Golomb Sridevi Devaraj alexis k.messner Hayley Jean koslik Jun Hee Han Barnabas Yik Department of Medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Swedish Medical Center SeattleWA 98109USA Henry M.Jackson Foundation for the Advancement of Military Medicine San DiegoCA 92134USA Santa Clara Valley Medical Center San JoseCA 95128USA

Background: Malondialdehyde(MDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of MDA to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower MDA level in veterans with ***: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.

关键词： Malondialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide

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