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National Science Review 2019年第2期6卷 349-358页

作者： Ying Luo Yihe Lü Bojie Fu Paul Harris Lianhai Wu alexis Comber State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Joint Center for Global Change Studies Rothamsted Research North Wyke School of Geography University of Leeds

Environmental degradation has become one of the major obstacles to sustainable development and human well-being internationally. Scientific efforts are being made to understand the mechanism of environmental degradation and sustainability. Critical Zone(CZ) science and research on the multi-functional landscape are emerging fields in Earth science that can contribute to such scientific efforts. This paper reviews the progress, similarities and current status of these two scientific research fields, and identifies a number of opportunities for their synergistic integration through functional and multi-functional approaches,process-based monitoring, mechanistic analyses and dynamic modeling, global long-term and networked monitoring and systematic modeling supported by scaling and deep coupling. These approaches proposed in this paper have the potential to support sustainable human well-being by strengthening a functional orientation that consolidates multi-functional landscape research and CZ science. This is a key challenge for sustainable development and human well-being in the twenty-first century.

关键词： multi-functional landscapes Critical Zone ecosystem services sustainable development human well-being

Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation

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Neuroscience Bulletin 2013年第4期29卷 402-410页

作者： Katarina Vajn Jeffery A Plunkett alexis Tapanes-Castillo Martin oudega Departments of Physical Medicine & Rehabilitation University of Pittsburgh School of Science Technology and Engineering Management St. Thomas University Departments of Neurobiology University of Pittsburgh Departments of Bioengineering University of Pittsburgh

Spinal cord injury （SCl） in mammals results in functional deficits that are mostly permanent due in part to the inability of severed axons to regenerate. Several types of growth-inhibitory molecules expressed at the injury site contribute to this regeneration failure. The responses of axons to these inhibitors vary greatly within and between organisms, reflecting axons＇ characteristic intrinsic propensity for regeneration. In the zebrafish （Danio rerio） many but not all axons exhibit successful regeneration after SCI. This review presents and compares the intrinsic and extrinsic determinants of axonal regeneration in the injured spinal cord in mammals and zebrafish. A better understanding of the molecules and molecular pathways underlying the remarkable individualism among neurons in mature zebrafish may support the development of therapies for SCI and their translation to the clinic.

关键词： spinal cord injury axonal regeneration growth inhibition functional recovery zebrafish

Exosomes from adipose tissue-derived stem/stromal cells:A key to future regenerative medicine

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BIOCELL 2022年第12期46卷 2701-2704页

作者： JÉRÔME LALOZE alexis DESMOULIÈRE University of Limoges Neuropathies and Therapeutic Innovations(UR 20218)Faculties of Medicine and PharmacyLimogesF-87000France Department of Maxillo-Facial and Reconstructive Surgery and Stomatology University Hospital DupuytrenLimogesF-87000France

Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal *** range of therapeutic indications has also expanded over recent *** recent studies have highlighted the primary importance of paracrine secretion by these *** it is interesting to compare the different types of such secretions,we believe that exosomes(extra-cellular vesicles possessing the same properties as their source cells)will likely be the main key in tomorrow’s cell *** also have many advantages compared to the direct use of cells,making these particles amajor target in fundamental and translational research.

关键词： Adipose-derived mesenchymal stem/stromal cell Exosome Regenerative medicine Secretome

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第72号森林拯救行动

环球科学 2024年第9期 56-63页

作者：亚历克西斯·玛丽·亚当斯金乐薇(译) 不详

在雅克河流域的深处,一片巨大的原始森林已经默默立了上百年,然而这里正面临着被砍伐的威胁。在美国蒙大拿州的西北部,古老的雪松、巨大的铁杉,以及浓密蓬乱的云杉……这些已经有数百岁的古树赢立在九月末的天空下。寿命近千年的西美落... 详细信息

在雅克河流域的深处,一片巨大的原始森林已经默默立了上百年,然而这里正面临着被砍伐的威胁。在美国蒙大拿州的西北部,古老的雪松、巨大的铁杉,以及浓密蓬乱的云杉……这些已经有数百岁的古树赢立在九月末的天空下。寿命近千年的西美落叶松高高屹立,叶尖折射着金光。

关键词：蒙大拿州拯救行动原始森林河流域落叶松

Prime waterfront real estate： Apple snails choose wild taro for oviposition sites

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Current Zoology 2011年第5期57卷 630-641页

作者： Colin H. KYLE alexis W. KROPF Romi L. BURKS Department of Ecology and Evolution University of Chicago Chicago IL 60637 USA Department of Biology Southwestern University Georgetown TX 78626 USA

While difficult to prevent introductions, scientific research can help guide control efforts of exotic, invasive species. South American island apple snails Pomacea insularum have quickly spread across the United States Gulf Coast and few control measures exist to delay their spread. Usually occupying cryptic benthic habitats, female apple snails crawl out of the water to de-posit large, bright pink egg clutches on emergent objects. To help identify the most likely place to find and remove clutches, we conducted four lab experiments to investigate what specific object qualifies （i.e. material; shape and height; plant species; natural and artificial） attracted P. insularum females to lay clutches. In our fourth experiment, we specifically examined the relationship between female size and reproductive output. To further understand reproductive output, we quantified experimental clutch chara-cteristics （height above water, dimensions, mass, approximate volume, number of eggs, hatching efficiency）. Pomacea insu-larum females laid more clutches on plant material, chose round over flat surfaces and failed to differentiate between tall and short structures. In comparison to a common native plant in the eastern US, Pontederia cordata, snails clearly preferred to lay clutches on a widely distributed exotic, invasive plant （wild taro, Colocasia esculenta）. Unexpectedly, smaller snails showed higher overall total fecundity as well as more eggs per clutch than larger snails. Therefore, hand removal efforts of large fe-males may not be enough to slow down clutch production. Collectively, our results indicate that conservationists and managers should search emergent plants for P. insularum clutches carefully to guard against established populations [Current Zoology 57 （5）： 630-641, 2011].

关键词： Colocasia Wild taro Fecundity Substrate Reproduction Facilitation

STRIPPED DOWN alexis Goodwin Peels Off Layers of Shanghai's Bustling Cityscape with His Dreamy Photo Series

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城市漫步（上海版、英文） 2019年第1期 10-14页

作者： Dominic Ngai alexis Goodwin(Photos) 不详

The sun has just risen,and several Shanghainese aunties are enjoying a lively conversation in between their coordinated tai chi sword routines,taking turns firing proximately 60 syllables per minute in the local dialect at one another One block ovei;vendors at a bustling wet market are having a good start to their day;with a range of produce,seafood and freshly cut meat flying off the shelves.

关键词： turns routine IPP

Preliminary Studies on Composition, Quality and Oxidative Stability of Commercial Avocado Oil Produced in Chile

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Journal of Food Science and Engineering 2014年第1期4卷 21-26页

作者： Marcos alexis Flores Maria Del Carmen Perez-Camino jose Troca Basic Science Department Faculty of Science University of Santo Tom6s Avda. Carlos Schorr 255 Talca 3473620 Chile Instituto de la Grasa (CSIC) Avda. Padre Tejero 4 Seville 41012 Spain

Avocado oil is a relatively new oil in the market and is highly appreciated by the consumers because of its fine aroma, pleasant taste and health benefits. A study on the characterization of commercial avocado oils produced in Chile was conducted in order to discuss their quality parameters. The study was applied to two marketed avocado oils. The main analytical parameters evaluated to the oils were： fatty acid composition, total chlorophylls, total carotenoids, tocopherols, acid value, peroxide value, total phenolic compounds, polar compounds, oil stability, UV absorption and 3.5-stigmastadiene content. The fatty acid compositions of the studied oils were according with oil composition of pulp pure of avocado fruit. The analysis of tocopherols by high performance liquid chromatography （HPLC） revealed significant differences between the avocado oils studied. Total phenolic compounds, oil stability, UV absorption characteristics, peroxide value, acid value, tocopherols content, total chlorophylls, total carotenoids and polar compounds were also significantly different between the commercial studied oils. All the above results show a different quality between both commercial avocado oils, showing that the sample C has worse values for the parameters of quality as those required by legislation in many countries. Also, 3.5-stigmastadiene content shows high concentration for one of the commercial avocado oil evaluated which demonstrates the presence of refined oil or that the oil has been submitted to high temperatures. On the other hand it is remarkable that despite the fact that there are many differences in quality parameters, both oils are labeled and marketed as extra virgin quality oils, demonstrating the need to regulate the classification of appreciated oils by the consumers.

关键词： Avocado oil 3.5-estigmastadiene polar compounds quality parameters.

Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2022年第2期17卷 246-250页

作者： alexis D.Rickman Addison Hilyard Bradlee L.Heckmann Department of Cell Biology Microbiology&Molecular Biology University of South FloridaTampaFLUSA USF Health Byrd Alzheimer’s Center and Neuroscience Institute Morsani College of MedicineTampaFLUSA Department of Molecular Medicine Morsani College of MedicineTampaFLUSA

Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease(AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3 lipidation yet are distinct from traditional macro-autophagy. One such pathway that utilizes components of the autophagy machinery to target LC3 to endosomes, a process termed LC3-associated endocytosis(LANDO), has recently been identified and regulates neuroinflammation. abrogation of LANDO in microglia cells results in a propensity for elevated neuroinflammatory cytokine production. Using the well-established 5 xFAD model of AD to interrogate neuroinflammatory regulation, impairment of LANDO through deletion of a key upstream regulator Rubicon or other downstream autophagy components, exacerbated disease onset and severity, while deletion of microglial autophagy alone had no measurable effect. Mice presented with robust deposition of the neurotoxic AD protein β-amyloid(Aβ), microglial activation and inflammatory cytokine production, tau phosphorylation, and aggressive neurodegeneration culminating in severe memory impairment. LANDO-deficiency impaired recycling of receptors that recognize Aβ, including TLR4 and TREM2. LANDO-deficiency alone through deletion of the WD-domain of the autophagy protein ATG16 L, revealed a role for LANDO in the spontaneous establishment of age-associated AD. LANDO-deficient mice aged to 2 years presented with advanced ADlike disease and pathology correlative to that observed in human AD patients. Together, these studies illustrate an important role for microglial LANDO in regulating CNS immune activation and protection against neurodegeneration. New evidence is emerging that demonstrates a putative linkage between pathways such as LANDO and cell death regulation via apoptosis and possibly necroptosis. Herein, we provide a

关键词： aging Alzheimer's disease autophagy inflammation LC3-associated endocytosis microglia neurodegeneration neuroinflammation

Estimating Compositions and Nutritional Values of Seed Mixes Based on Vision Transformers

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Plant Phenomics 2023年第4期5卷 805-815页

作者： Shamprikta Mehreen Hervé Goëau Pierre Bonnet Sophie Chau Julien Champ alexis Joly Inria LIRMMUniversity MontpellierCNRSMontpellierFrance CIRAD UMR AMAPMontpellierOccitanieFrance Chambre d'Agriculture-Haute Vienne LimogesNouvelle-AquitaineFrance

The cultivation of seed mixtures for local pastures is a traditional mixed cropping technique of cereals and legumes for producing,at a low production cost,a balanced animal feed in energy and protein in livestock *** considerably improving the autonomy and safety of agricultural systems,as well as reducing their impact on the environment,it is a type of crop that responds favorably to both the evolution of the European regulations on the use of phytosanitary products and the expectations of consumers who wish to increase their consumption of organic ***,farmers find it difficult to adopt it because cereals and legumes do not ripen synchronously and the harvested seeds are heterogeneous,making it more difficult to assess their nutritional *** efforts therefore remain to be made to acquire and aggregate technical and economical references to evaluate to what extent the cultivation of seed mixtures could positively contribute to securing and reducing the costs of herd *** work presented in this paper proposes new Artificial Intelligence techniques that could be transferred to an online or smartphone application to automatically estimate the nutritional value of harvested seed mixes to help farmers better manage the yield and thus engage them to promote and contribute to a better knowledge of this type of *** this purpose,an original open image dataset has been built containing 4,749 images of seed mixes,covering 11 seed varieties,with which 2 types of recent deep learning models have been *** results highlight the potential of this method and show that the best-performing model is a recent state-of-the-art vision transformer pre-trained with self-supervision(Bidirectional Encoder representation from Image Transformer).It allows an estimation of the nutritional value of seed mixtures with a coefficient of determination R^(2)score of 0.91,which demonstrates the interest of this type of approach,for its possible use

关键词： transferred cultivation harvest

Efectrochemical Determination of Prednisolone at Ordered Mesoporous Carbon Modified Electrode:Application to Doping Monitoring

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Efectrochemical Determination of Prednisolone at Ordered Mes...

作者： alexis Munyentwali 东北师范大学

学位级别：硕士

碳材料是人类活动的友好材料。碳材料被广泛应用于分析和工业电化学,在这些应用中碳材料作为电极材料使用。碳电极常见的优点包括低廉的价格,广泛的电势窗口,相对稳定的电化学性能和对很多氧化还原反应的电化学催化。这些出众的特点已... 详细信息

碳材料是人类活动的友好材料。碳材料被广泛应用于分析和工业电化学,在这些应用中碳材料作为电极材料使用。碳电极常见的优点包括低廉的价格,广泛的电势窗口,相对稳定的电化学性能和对很多氧化还原反应的电化学催化。这些出众的特点已经吸引了全世界的研究者来开发新的碳基电极材料,以满足电化学传感器和生物传感器这些当代电化学的应用。.有序介孔碳是一种新的碳纳米结构材料,它的特点包括极其规则的孔结构、高效孔体积和高密度边缘平面缺陷网,这些特点对催化和传感的应用有非常重要意义,故而吸引了众多关注。.在这个研究中,基于方波伏安法和有序介孔碳改性玻璃电极被研发测定强的松(一种皮质甾醇,体育运动中的兴奋剂)是一个敏感而可靠的电化学方法。研究结果显示,与单纯的玻碳电极相比,有序介孔碳/玻碳电极通过增加还原峰电流值和降低还原电位对强的松的减少显示出了优秀的催化响应。.在最佳实验条件下,峰电流是强的松的线性浓度,范围是0.06-40μM。这种方法的灵敏度为0.644μA μM-1,检测线(3S/m)是0.057μM。它成功的应用于检测在制药配方和人类尿液中强的松的含量,并且不会被其它常见尿液代谢物干扰。这种方法的快速和方便性使它成为一种在兴奋剂检测,甚至是竞赛中兴奋剂检测的有前途的方法。

关键词：强的松有序介孔碳方波伏安法人体尿液兴奋剂