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Building Simulation 2021年第4期14卷 1147-1161页

作者： Gabriele Vigne Wojciech Węgrzyński alexis cantizano Pablo Ayala Guillermo Rein cándido Gutiérrez-Montes Fluid Dynamics Division of the Department of Mining and Mechanical Engineering Universidad de JaénJaénSpain Institute for Research in Technology ICAIUniversidad Pontificia ComillasMadridSpain Building Research Institute(ITB) WarsawPoland Imperial college London LondonUK JVVA Fire&Risk MadridSpain

Fire in large-volume buildings poses separate and distinct challenges from compartmented *** particular,the risk it poses on life safety is mostly due to the smoke it produces,its effects on the evacuation process,and how it can affect the firefighters when they approach the building to fight the fire and rescue the *** is why smoke control in large-volume enclosures is of utter importance for life safety,property protection and business *** research presents an experimental and numerical study of the smoke dynamics from four fire sources(combined heat release rate of 5.2 MW)with different ignition times and under transient ventilation conditions,inside a 20 m high cubic *** measurements in the plume and close to the walls have been recorded using 59 *** data was used in the determination of the smoke layer interface height,with the least-square and the N-Percent *** show that significantly worse conditions are induced by multiple sources than those in a single fire of equal *** results have been obtained using the computational fluid dynamics code FDS(Fire Dynamics Simulator,v6.7.1).The comparison shows that in the far field the temperature predictions are accurate inside the smoke layer(10 m and 15 m)with discrepancies lower than 10%,whereas higher significant discrepancies were observed at the smoke layer interface,i.e.5 m high,with discrepancies up to 20%.Furthermore,a grid analysis has been performed showing that grid resolutions,D*/δ,based on the global HRR of the fire might be sufficient to predict the fire induced conditions far from the *** analysis confirmed the applicability of FDS to the assessment of the smoke dynamics under complex fire conditions away from ***,the present work shows the importance of considering fires with multiple sources due to the faster smoke production compared with single fires.

关键词： experiments simulation fire buildings FDS cFD

Impacts of pollution heterogeneity on population exposure in dense urban areas using ultra-fine resolution air quality data

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Journal of Environmental Sciences 2023年第3期125卷 513-523页

作者： Wenwei che Yumiao Zhang changqing Lin Yik Him Fung Jimmy c.H.Fung alexis KHLau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of collaborative Innovation for Environmental Quality Hong Kong University of Science and TechnologyClear Water BayHong KongChina

Traditional air quality data have a spatial resolution of 1 km or above, making it challenging to resolve detailed air pollution exposure in complex urban areas. combining urban morphology, dynamic traffic emission, regional and local meteorology, physicochemical transformations in air quality models using big data fusion technology, an ultra-fine resolution modeling system was developed to provide air quality data down to street level. Based on one-year ultra-fine resolution data, this study investigated the effects of pollution heterogeneity on the individual and population exposure to particulate matter(PM_(2.5)and PM_(10)),nitrogen dioxide(NO_(2)), and ozone(O_(3)) in Hong Kong, one of the most densely populated and urbanized cities. Sharp fine-scale variabilities in air pollution were revealed within individual city blocks. Using traditional 1 km average to represent individual exposure resulted in a positively skewed deviation of up to 200% for high-end exposure individuals. citizens were disproportionally affected by air pollution, with annual pollutant concentrations varied by factors of 2 to 5 among 452 District council constituency Areas(DccAs) in Hong Kong, indicating great environmental inequities among the population. Unfavorable city planning resulted in a positive spatial coincidence between pollution and population, which increased public exposure to air pollutants by as large as 46% among districts in Hong Kong. Our results highlight the importance of ultra-fine pollutant data in quantifying the heterogeneity in pollution exposure in the dense urban area and the critical role of smart urban planning in reducing exposure inequities.

关键词： Particulate matter Nitrogen dioxide Ozone Pollution heterogeneity Urban area

Substrate selection and seasonal variation in abundance and size composition of isopod Lirceus fontinalis in Ontario streams, canada

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chinese Journal of Oceanology and Limnology 2007年第2期25卷 215-220页

作者： ZHAO Xiaoxia Michael G FOX David c. LASENBY alexis c. ARMIT Dolly N. KOTHAWALA Watershed Ecosystems Graduate Program Trent University Peterborough Ontario K9J 7B8 Canada Environmental ＆ Resource Studies Program and Department of Biology Trent University Peterborough ON K9J 7B8 Canada Department of Biology Trent University Peterborough ON K9J 7B8 Canada

The abundance and size composition of stream isopods Lirceusfontinalis were investigated from April 2001 to August 2002 in 3 streams in southem Ontario, canada. Effects of current speed was released from the analysis by choosing slow flowing water. The effects of substrate, season and water depth on the abundance, distribution and size composition of the isopods were analyzed. It was found that substrate and season influence isopods the most. The rocky substrate with attached filamentous macro-algae contains an isopod abundance 7.05 times that of bare rock substrate and 14.6 times that of free-sand and mud substrate. There was a large variation with respect to seasonali .ty in both abundance and size composition of the isopods, with the highest abundance occumng in summer and the lowest in winter and spring; individual isopods also tend to be larger in the winter and spring. In all substrates, shallow areas tend to support higher densities of isopods than deeper areas.

关键词： isopods Lirceusfontinalis, size abundance substrate seasonal variation Ontario

Tetrahydrohyperforin(IDN5706) targets the endoplasmic reticulum for autophagy activation： potential mechanism for Alzheimer＇s disease therapy

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Neural Regeneration Research 2016年第2期11卷 242-243页

作者： alexis gonzález viviana a.cavieres nibaldo c.inestrosa patricia v.burgos instituto de fisiología facultad de medicinacentro interdisciplinario de estudios del sistema nervioso(cisne)universidad austral de chileValdiviaChile centro de envejecimiento y regeneración(care) centro uc síndrome de downpontificia universidad católica de chilesantiagochile center for healthy brain ageing school of psychiatryfaculty of medicineuniversity of new south walessydneyaustralia centro de excelencia en biomedicina de magallanes(cebima) universidad de magallanesPunta ArenasChile

Alzheimer’s disease（AD）is the most common form of dementia worldwide among the older *** date,there is no therapy to stop the destruction of brain cells and all the available treatments only compensate for the loss... 详细信息

关键词： ERAD Tetrahydrohyperforin IDN5706 potential mechanism for Alzheimer’s disease therapy

cRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

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四川生理科学杂志 2024年第1期46卷 160-160页

作者： alexis c Komor Department of chemistry and chemical Biology Harvard University Cambridge MA 02138 USA Howard Hughes Medical Institute Harvard University Cambridge MA 02138 USA Broad Institute of MIT and Harvard Cambridge MA 02141 USA. Department of chemistry and chemical Biology Harvard University Cambridge MA 02138 USA Howard Hughes Medical Institute Harvard University Cambridge MA 02138 USA Broad Institute of MIT and Harvard Cambridge MA 02141 USA. Electronic address: drliu@fas.harvard.edu.

The cRISPR-cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living *** this Review,we summarize cRISPR-based tec... 详细信息

关键词： cRISPR cas9 Genome

Entropy corrections for a charged Black Hole of String Theory

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communications in Theoretical Physics 2011年第1期55卷 72-74页

作者： alexis Larraaga National University of colombia National Astronomical Observatory

We study the entropy of the Gibbons-Maeda-Garfinkle-Horowitz-Strominger （GMGHS） charged black hole, originated from the effective action that emerges in the low-energy of string theory, beyond semiclassical approxi- mations. Applying the properties of exact differentials for three variables to the first law thermodynamics we derive the quantum corrections to the entropy of the black hole. The leading （logarithmic） and non leading corrections to the area law are obtained.

关键词： quantum aspects of black holes thermodynamics strings and branes

Understanding lateral root formation,one cell at a time

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Molecular Plant 2021年第8期14卷 1229-1231页

作者： Anamarija Primc alexis Maizel center for Organismal Studies(cOS) University of HeidelbergHeidelbergGermany

Formation of lateral roots shapes the architecture of plant root systems and con tributes to their *** Arabidopsis,lateral roots follow a well-described sequenee of events that lead to the emergence of a new root complete with its own meristem and a set of tissue and cell types very similar to the ones found in the primary *** are the different cell types established?In a recent study,Serrano-Ron et al.(2021)used single-cell RNA sequencing(scRNA-seq)to profile the diversity of cell types in the forming lateral roots and revealed a hitherto unknown role for camalexins in controlling lateral root patterning.

关键词： roots Arabidopsis cell

On Thermodynamical Relation Between Rotating charged BTZ Black Holes and Effective String Theory

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communications in Theoretical Physics 2008年第12期50卷 1341-1344页

作者： alexis Larraaga National

In this paper we study the first law of thermodynamics for the （2＋1）-dimensional rotating charged BTZ black hole considering a pair of thermodynamical systems constructed with the two horizons of this solution. We show that these two systems are similar to the right and left movers of string theory and that the temperature associated with the black hole is the harmonic mean of the temperatures associated with these two systems.

关键词： quantum aspects of black holes thermodymics classical black holes strings and branes

On Hawking Radiation from a charged Black Hole of Heterotic String Theory

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communications in Theoretical Physics 2014年第4期61卷 491-494页

作者： alexis Larraaga National Astronomical Observatory National University of Colombia

We investigate the Hawking radiation of a GMGHS charged black hole from the heterotic string scenario by the massive particles turmeling method. We consider the spacetime background to be dynamical, incorporate the self-gravitation effect of the emitted particles and show that the tunneling rate is related to the change of Bekenstein- Hawking entropy and the derived emission spectrum does not deviate from the pure thermal spectrum of Schwrzschild＇s black hole.

关键词： quantum aspects of black holes thermodynamics strings and branes