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Hierarchy of mesenchymal stem cells: Comparison of multipotentmesenchymal stromal cells with fibroblast colony forming units

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Journal of Biomedical Science and Engineering 2013年第8期6卷 66-73页

作者： Irina N. Shipounova Natalia A. Petinati alexey E. Bigildeev Natalia v. Sats Nina J. Drize Larisa A. Kuzmina Elena N. Parovichnikova valery G. Savchenko Bone Marrow Transplantation Department FGBI National Hematological Scientific Center Moscow Russia Laboratory for Physiology of Hematopoiesis FGBI National Hematological Scientific Center Moscow Russia

The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units (CFU-F). The aim of this study was to compare the main characteristics of MMSC and CFU-F derived from the bone marrow of 24 healthy donors. Growth and differentiation parameters, as well as relative expression levels of different genes were analyzed in MMSC and CFU-F. MMSC were cultivated for 5 passages. CFU-F concentration was determined for each bone marrow sample. The data obtained demonstrated the heterogeneity and hierarchical organization of both studied populations of stromal precursor cells-MMSC and CFU-F. These two types of stromal precursor cells turned to be different in most parameters studied. Altogether MMSC seemed to be more immature cells than CFU-F and took up the higher position in hierarchical tree of mesenchymal stem cells. The rate of differentiation and proliferative potential decreased with the donor’s age in both populations MMSC and CFU-F.

关键词： Mesenchymal Multipotent Stromal Cells (MMSC) Fibroblast Colony Forming Units (CFU-F) Real-Time Polymerase Chain Reaction Gene Expression Level Aging

Test of Materials for High-power Neutron Target

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Test of Materials for High-power Neutron Target

The Effects of Nanodiamonds at the Action of Colored Metal Ions on the Skin of Guinea Pigs

The Second Asian Particle Accelerator Conference

作者： M.Avilov K.gubin N.Kot P.Logatchev P.Martyshkin S.Morozov S.Shiyankov A.Starostenko v.Plokhoi S.Samarin v.Menshenin Y.Kandiev A.Andrighetto L.Stroe L.Tecchio BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly

＜正＞ A number of materials is considered in terms of possibility of high intense neutron target fabrication on the basis of proton *** calculations of neutron yield are presentedfor thick targets made of high temperature carbon-and boron-containing materials as well *** and results of thermo-mechanical test are presented when materials areirradiated by intense electron beam with the energy up to 5 Mev,that simulated the thermal

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Journal of Biomaterials and Nanobiotechnology 2016年第4期7卷 214-224页

作者： Ekaterina Yu. vasilyeva victor I. Prokhorenkov alexey P. Puzyr vladimir S. Bondar Krasnoyarsk State Medical University Named Prof. v.F. voyno-Yasenetsky Krasnoyarsk Russia Institute of Biophysics SB RAS Krasnoyarsk Russia

The protective effect of modified nanodiamonds (MND) under the action of cobalt and nickel ions on the skin of Guinea pigs was shown. At the action of chromium ions on the skin of animals, the protective effect of MND was not found. The differences are related to different adsorption properties of MND to the investigated colored metal ions. It is shown in vitro that MND can adsorb ions of cobalt and nickel and don’t bind ions of chromium from aqueous medium. The perspectives using of MND as a new drug for the prevention allergic dermatitis caused by action of bivalent ions of metals are discussed.

关键词： Nanodiamonds Allergic Contact Dermatitis Colored Metal Ions Clinical-Morphological Study

Simulation of Curing Process for Propargyl Terminated Novolac Resins

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Journal of Chemistry and Chemical Engineering 2014年第8期8卷 805-809页

作者： Boris Bulgakov Denis Kalugin Alexander Babkin Irina Makarenko Artem Malakho alexey Kepman victor Avdeev Department of Chemistry Division of Chemical Technology and New Materials M. V. Lomonosov Moscow State UniversityMoscow 119991 RussiaDepartment of Chemistry Division of Chemical Technology and New Materials M. V. Lomonosov Moscow State UniversityMoscow 119991 Russia

Non-isothermal kinetic simulation analysis was carried for CFRP （carbon fiber reinforced plastic） based on PN （propargylated novolac） resins with various curing enthalpy. The simulation study was performed for CFRP with 40% mass resin content. It was shown that, curing enthalpy of PN resin must be less than 600 J/g to avoid uncontrolled heat emission causing destruction of composite sample.

关键词： Propargyl ether resins addition-cure phenolics heat resistance simulation curing.

All-optical generation of static electric field in a single metal-semiconductor nanoantenna

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Light(Science & Applications) 2023年第11期12卷 2350-2362页

作者： Yali Sun Artem Larin alexey Mozharov Eduard Ageev Olesia Pashina Filipp Komissarenko Ivan Mukhin Mihail Petrov Sergey Makarov Pavel Belov Dmitry Zuev School of Physics and Engineering ITMO UniversityLomonosova 9Saint Petersburg 191002Russia Center for Nanotechnologies Alferov UniversityKhlopina 8/3Saint Petersburg 194021Russia Higher School of Engineering Physics Peter the Great Saint Petersburg Polytechnic UniversityPolitekhnicheskaya 29Saint Petersburg 195251Russia

Electric field is a powerful instrument in nanoscale engineering,providing wide functionalities for control in various optical and solid-state *** development of a single optically resonant nanostructure operating with a charge-induced electrical field is challenging,but it could be extremely useful for novel nanophotonic ***,we show a resonant metal-semiconductor nanostructure with a static electric field created at the interface between its components by charge carriers generated via femtosecond laser *** study this field experimentally,probing it by second-harmonic generation signal,which,in our system,is time-dependent and has a non-quadratic signal/excitation power *** developed numerical models reveal the influence of the optically induced static electric field on the second harmonic generation *** also show how metal work function and silicon surface defect density for different charge carrier concentrations affect the formation of this *** estimate the value of optically-generated static electric field in this nanoantenna to achieve≈10^(8)v/*** findings pave the way for the creation of nanoantenna-based optical memory,programmable logic and neuromorphic devices.

关键词： antenna optical field

Boron nitride nanoresonators for phonon-enhanced molecular vibrational spectroscopy at the strong coupling limit

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Light(Science & Applications) 2017年第1期6卷 55-62页

作者： Marta Autore Peining Li Irene Dolado Francisco J Alfaro-Mozaz Ruben Esteban Ainhoa Atxabal Fèlix Casanova Luis E Hueso Pablo Alonso-González Javier Aizpurua alexey Y Nikitin Saül vélez Rainer Hillenbrand CIC nanoGUNE Donostia-San Sebastián 20018Spain Donostia International Physics Center(DIPC) Donostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain Departamento de Física Universidad de OviedoOviedo 33007Spain Centro de Física de Materiales(MPC CSIC-UPV/EHU)Donostia-San Sebastián 20018Spain Current address:Department of Materials ETH ZürichZürich 8093Switzerland CIC nanoGUNE and UPv/EHU Donostia-San Sebastián 20018Spain

Enhanced light-matter interactions are the basis of surface-enhanced infrared absorption(SEIRA)spectroscopy,and conventionally rely on plasmonic materials and their capability to focus light to nanoscale spot *** polariton nanoresonators made of polar crystals could represent an interesting alternative,since they exhibit large quality factors,which go far beyond those of their plasmonic *** recent emergence of van der Waals crystals enables the fabrication of highquality nanophotonic resonators based on phonon polaritons,as reported for the prototypical infrared-phononic material hexagonal boron nitride(h-BN).In this work we use,for the first time,phonon-polariton-resonant h-BN ribbons for SEIRA spectroscopy of small amounts of organic molecules in Fourier transform infrared ***,the interaction between phonon polaritons and molecular vibrations reaches experimentally the onset of the strong coupling regime,while numerical simulations predict that vibrational strong coupling can be fully *** polariton nanoresonators thus could become a viable platform for sensing,local control of chemical reactivity and infrared quantum cavity optics experiments.

关键词： boron nitride phonon polaritons strong coupling surface-enhanced infrared absorption spectroscopy SEIRA

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镉对生命活动的毒作用机制

环境与职业医学 2018年第5期35卷 460-470页

作者： alexey A.TINKOv Olga P.AJSUvAKOvA Jan AASETH Yordanka G.GLUHCHEvA Juliana M.IvANOvA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲林雪 Anatoly v.SKALNY 国立雅罗斯拉夫大学俄罗斯雅罗斯拉夫150003 俄罗斯科学院细胞与细包共生研究所俄罗斯奥伦堡460001 RUDN大学俄罗斯莫斯科117198 国立奥伦堡教育大学俄罗斯奥伦堡460000 黑得马克应用科学大学挪威艾佛伦2411 英兰德信托医院研究部挪威布鲁门达2380 保加利亚科学院实验形态学、病理学与人类学学院暨博物馆保加利亚索非亚1113 索非亚大学医学系保加利亚索非亚1113 营养与环境医学咨议会挪威莫伊拉娜8602 台湾大学中国台湾10617 台北医学大学万芳医院职业医学科中国台湾10675 湖南农业大学动物科学技术学院湖南长沙410128 联合国教科文组织微量元素研究所法国里昂69000 国立奥伦堡大学俄罗斯奥伦堡460000

镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉... 详细信息

镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。

关键词：镉氧化应激毒性炎症遗传毒性

茶叶和茶水中多环芳烃的测定液相色谱荧光检测方法

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茶叶和茶水中多环芳烃的测定液相色谱荧光检测方法

Intestinal injury can be reduced by intra-arterial postischemic perfusion with hypertonic saline

BCEIA2005分析仪器应用技术报告会

作者： alexey v.Shpak Dmitry A.Alexeenok Svetlana A.Gerassimova A.A.Krasheninnikov 莫斯科大学化学系

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World Journal of Gastroenterology 2013年第2期19卷 209-218页

作者： Oleg Kornyushin Michael Galagudza Anna Kotslova Gelfia Nutfullina Nina Shved alexey Nevorotin valeriy Sedov Timur vlasov Department of Surgery I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Department of Pathophysiology I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Institute of Experimental Medicine V.A.Almazov Federal HeartBlood and Endocrinology Centre197341 St.PetersburgRussia Department of Pathology I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Laboratory of Electron Microscopy I.P.Pavlov Federal Medical University197022 St.PetersburgRussia

AIM:To investigate the effect of local intestinal perfusion with hypertonic saline(HTS) on intestinal ischemia-reperfusion injury(IRI) in bothex vivo andin vivo rat ***:All experiments were performed on male Wistar rats anesthetized with pentobarbital sodium given intraperitoneally at a dose of 60 mg/*** vivo vascularly perfused rat intestine was subjected to 60-min ischemia and either 30-min reperfusion with isotonic buffer(controls),or 5 min with HTS of 365 or 415 mOsm/L osmolarity(HTS 365mOsm or HTS 415mOsm,respectively) followed by 25-min reperfusion with isotonic *** vascular intestinal perfusate flow(IPF) rate was determined by collection of the effluent from the portal vein in a calibrated *** intestinal contraction rate was monitored *** intestinal injury or area of necrosis(AN) was evaluated histochemically using 2.3.5-triphenyltetrazolium chloride *** vivo,30-min ischemia was followed by either 30-min blood perfusion or 5-min reperfusion with HTS 365mOsm through the superior mesenteric artery(SMA) followed by 25-min blood *** blood pressure(BP) was measured in the common carotid artery using a miniature pressure *** injury was evaluated in both preparations using the Chui ***:Ex vivo,intestinal IRI resulted in a reduction in the IPF rate during reperfusion(P vs sham).The postischemic recovery of the IPF rate did not differ between the controls and the HTS 365mOsm *** the HTS 415mOsm group,postischemic IPF rates were lower than in the controls and the HTS 365mOsm group(P ved during the first 10 min of reperfusion in the control group as compared to the sham-treated group,but no such increase was seen in the HTS 365mOsm *** controls,AN averaged 14.8% ± 5.07% of the total tissue *** of HTS 365mOsm for 5 mi

关键词： Intestinal ischemia-reperfusion injury Superior mesenteric artery Perfusion Hypertonic saline Acute mesenteric ischemia Intestinal perfusate flow rate