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The Fertilizer-Effect on Al, Ba, Fe, Mn and Ni Released in a Watershed with Influence of Sugar Cane Crops in the São Paulo State, Brazil

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Journal of Water Resource and Protection 2019年第5期11卷 638-650页

作者： Eder Paulo Spatti Jú nior Fabiano Tomazini da Conceiç o Amauri Antonio Menegá rio alexandre martins fernandes Diego de Souza Sardinha Instituto de Geociê ncias e Ciê ncias Exatas UNESP-Universidade Estadual Paulista S&#227 o Paulo Brasil Centro de Estudos Ambientais UNESP-Universidade Estadual Paulista S&#227 o Paulo Brasil UNIFAL-Universidade Federal de Alfenas Po&#231 os de Caldas Brasil

S?o Paulo State is the main sugar cane producer and these agricultural activities are carried out in predominantly sandy soils, which require large amounts of phosphate fertilizers and amendments. This work evaluated the fertilizer-effect on the Al, Ba, Fe, Mn and Ni released in a watershed with influence of sugar cane crops in the S?o Paulo State, Brazil, namely the Monjolo Grande Stream basin. Five surface water sampling campaigns were carried out at the mouth of Monjolo Grande Stream in February, April, June, September and November 2010, characterizing the following parameters: discharge, pH, temperature, electric conductivity, dissolved oxygen and total and dissolved concentrations of Al, Ba, Fe, Mn and Ni. Approximately 99% of Al and Fe are transported annually in association with suspended sediments carried to the Monjolo Grande Stream by sheet erosion. The results also demonstrated that the increasing Al, Ba, Fe and Mn concentrations dissolved in the waters of the Monjolo Grande Stream basin in the wet season are associated to phosphate fertilizers and amendments that are used extensively in agrichemical activities. However, with the current application rates, there has been no increase in the dissolved concentrations of these metals at levels that could pose risks to human health.

关键词： Sugar Cane Crops Phosphate Fertilizers and Amendments Total and Dissolved Metal Environmental Management

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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Biochar Increases Diuron Sorption and Reduces the Potential Contamination of Subsurface Water with Diuron in a Sandy Soil

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Pedosphere 2019年第6期29卷 801-809页

作者： Fabiano APETTER Tamara SFERREIRA Adilson PSINHORIN Larissa BLIMA fernandes AALMEIDA Leandro PPACHECO alexandre FSILVA Universidade Federal de Mato Grosso Instituto de Ciências Agrárias e AmbientaisSinop 78557-267(Brazil Universidade Federal do Piauí Programa de Pós-Graduaçño em AgronomiaBom Jesus 64900-000(Brazil Universidade Federal de Mato Grosso Instituto de Ciencias NaturaisSociais e HumanasSinop 78557-267(Brazil Universidade Federal de Mato Grosso Instituto de Engenharia Agrícola e AmbientalRondonópolis 78735-000(Brazil Embrapa Milho e Sorgo Sete Lagoas 35701-970(Brazil

The herbicide diuron is widely used in agricultural areas in Brazil, whereas it has high potential for subsurface water contamination due to its physicochemical characteristics. Recent studies have demonstrated the potential of biochar as a sorbent and possible pesticide leaching mitigation. The objective of this study was to investigate the long-term effect of biochar application on the kinetics of sorption and desorption of diuron in a Cerrado Haplic Plinthosol. Samples were collected in an experiment conducted in the field in a randomized block design consisting of the combination of two levels of fertilizer application (0 and 300 kg ha −1 of 5-25-15 formula of NPK fertilizers) and three doses of biochar (0, 16, and 32 Mg ha −1 ). The Freundlich isotherm accurately described the sorption of diuron in all treatments. Biochar application increased the sorption and reduced the desorption of diuron. This effect was attributed to the contribution of biochar to total organic carbon (C) and C in the humin fraction and to the increase in the reactivity of the humic acid and humin fractions, which was significantly highly correlated with the sorption coefficient ( K f ). A positive correlation between the partition coefficient of organic C and K f confirmed the importance of the soil organic compartment for the sorption of diuron. The higher diuron sorption and lower diuron desorption capacities of sandy soils after biochar application could reduce the potential risk of diuron leaching and contamination of subsurface water.

关键词： Herbicide Leaching Partition coefficient Persistence Pyrogenic carbon Soil organic matter Sorption coefficient

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Vitamin D deficiency,functional status,and balance in older adults with osteoarthritis

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World Journal of Clinical Cases 2021年第31期9卷 9491-9499页

作者： Cláudia N Montemor Marcos Tadeu P fernandes Audrey S Marquez Regina Célia Poli-Frederico Rubens alexandre da Silva Karen B P fernandes Laboratory of Rehabilitation Research Doctoral Program of Rehabilitation SciencesUniversity Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Department of Anesthesiology Irmandade da Santa Casa de LondrinaLondrina 86010-160ParanaBrazil Health Sciences Research Center University Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Doctoral Program of Rehabilitation Sciences University Pitagoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Département des Sciences de la Santé Centre intersectoriel en santédurableLaboratoire de recherche BioNRUniversitédu QuébecàChicoutimi(UQAC)SaguenayG7H 2B1QuébecCanada Centre intégréde santéet services sociaux du Saguenay-Lac-Saint-Jean(CIUSSS SLSJ) Hôpital de La Baie-Services gériatriques spécialisésSaguenayQuébecG7H 7K9Canada

BACKGROUND Low vitamin D levels are associated with a more severe case of knee osteoarthritis(OA).However,there are few published reports concerning an association between vitamin D deficiency and functional status of individuals with OA and no reports about postural balance in this *** To analyze the relationship between vitamin D deficiency and severity,functional status,and balance in elderly patients with *** In this cross-sectional study,105 elderly patients with hip and knee OA were *** severity was assessed by the Kellgren-Lawrence *** functional status was assessed with the Lequesne *** balance was assessed using a force platform,and center-of-pressure parameters(velocity at anteroposterior and mediolateral axis)were used as the balance *** 25(OH)vitamin D levels were measured using a chemiluminescence *** Most of the patients(mean age:70.6±6.5 years)were female(n=78,74.3%).In the group with vitamin D deficiency,43 patients(56.6%)had severe OA,while 33 patients(43.4%)had mild or moderate OA(χ^(2) test,P=0.04).Patients with vitamin D deficiency showed a higher Lequesne index score(Mann-Whitney test,P=0.04),indicating a worse functional impairment when compared to individuals with normal vitamin D ***,patients with vitamin D deficiency had worse postural balance according to the Mann-Whitney test(P=0.03).CONCLUSION Vitamin D deficiency is associated with worse severity,functional status,and postural balance in patients with OA.

关键词： Osteoarthritis Elderly Vitamin D Disability Severity Balance

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Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus

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Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva fernandes Daniela Tendler Leibel Bacellar Cleber Hooper alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil Laboratory of Diphtheria and Corynebacteria of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil Laboratory of Clinical Research and Molecular Diagnostic Prof.Marcílio Dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil Laboratory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific *** study seeks to establish reference values for hematological and biochemical parameters of four lineages of ***:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6D2F1 BALB/c biochemical C57BL/6 hematological Swiss

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Evaluation of Impairment Caused by MPEG Video Frame Loss

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Engineering（科研） 2017年第5期9卷 493-503页

作者： Carlos alexandre Gouvea da Silva Guilherme fernandes de Souza Miguel Joao Guilherme Sauer Carlos Marcelo Pedroso Department of Electrical Engineering Federal University of ParanaCuritibaBrazil

This article presents a study on the impact of video frame losses on the quality perceived by users. Video compression standards, such as MPEG, use a sequence of frames called Group of Pictures (GOP), which is a video compression method which a frame is expressed in terms of one or more neighboring frames. This dependence between frames impacts directly in the quality because a loss of a reference frame prevents the decoding of other frames in GOP, thereby reducing the user-perceived quality. The assessment of quality in this article is estimated by Peak Signal Noise Ratio (PSNR), which compares the original and the received images. Computer simulations were used to show that the degradation on the quality may vary for different patterns of GOPs and type of lost frames.

关键词： MPEG-4 Video Streaming PSNR Frame Loss

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Brazilian biosafety law and the new breeding technologies

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno fernandes Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao Paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

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Infections Following Kidney Transplant in Children: A Single-Center Study

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Open Journal of Nephrology 2014年第3期4卷 117-124页

作者： alexandre fernandes Liliana Rocha Teresa Costa Paula Matos Maria Sameiro Faria Laura Marques Conceicao Mota Antonio Castro Henriques Pediatric Infectious Diseases and Immunodeficiency Department Centro Hospitalar do PortoOportoPortugal Pediatric Nephrology Department Centro Hospitalar do PortoOportoPortugal Kidney Transplant Department Centro Hospitalar do PortoOportoPortugal

Introduction: Infections are a major cause of morbidity and mortality in pediatric patients undergoing kidney transplantation (KT). Aim and Methods: To determine the patterns of infectious complications during the first 6 months post transplantation, we report our single center experience with data from pediatric kidney recipients transplanted between 2006 and 2011. Results: Thirty-two children (20 males) were submitted to KT. The most common cause of end-stage renal disease (ESRD) was congenital anomalies of the kidney and urinary tract (CAKUT) accounting for 62%. Over the first 6 months post-transplant period, twenty-eight (87.5%) children developed a total of 77 infections, mainly urinary tract infections (UTI) (64.9%). CAKUT etiology of ESRD and UTI before KT increased the risk to develop more than one episode of UTI [71.4% vs. 14.3% and 81.8% vs. 18.2%, respectively;p < 0.05]. Twenty-three (29.9%) viral infections occurred. Cytomegalovirus (CMV) was the most common opportunistic pathogen, occurred in 11 patients and was more frequently in those with a donor (D)+/recipient (R)- CMV sero-status [74.5% vs. 25.5% (p < 0.05)]. A polyomaviruses (BKV) disease with nephropathy and meningitis was registered. The majority of infectious episodes had mild or moderate severity. No deaths occurred. Conclusion: A significant number of patients presented infectious complications during the first 6 months post transplantation. UTI are the most common type of infection, followed by viral infections, particularly CMV. Recognition, prevention and early treatment of infections are of major importance.

关键词： CMV Infection Immunosuppression Kidney Transplantation Urinary Tract Infections

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Acute cholestatic hepatitis caused by amoxicillin/ clavulanate

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World Journal of Gastroenterology 2013年第46期19卷 8789-8792页

作者： Daniel Oliveira Beraldo Joanderson fernandes Melo alexandre Vidal Bonfim Andrei Alkmim Teixeira Ricardo Alkmim Teixeira André Loyola Duarte Department of Internal Medicine Hospital Renascentista Escola Paulista de Medicina-UNIFESP Nephrology Department Escola Paulista de Medicina-UNIFESP Cardiology Department Cardiology Department Instituto do Cora o-FMUSP Pathology Department Hospital A.C.CamargoSo Paulo

Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used,especially for the treatment of respiratory and cutaneous *** general,it is a well-tolerated oral ***,amoxicillin/clavulanate can cause adverse effects,mainly cutaneous,gastrointestinal,hepatic and hematologic,in some *** here is a case report of a 63-yearold male patient who developed cholestatic hepatitis after recent use of amoxicillin/*** 6 wk of prolonged use of the drug,he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia(total bilirubin>300 mg/L).Diagnostic investigation was conducted by ultrasonography of the upper abdomen,serum tests for infection history,laboratory screening of autoimmune diseases,nuclear magnetic resonance(NMR)of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by *** duration of disease was approximately 4 mo,with complete resolution of symptoms and laboratory changes at the end of that time *** treatment was not instituted,only a combination of anti-emetic(metoclopramide)and cholestyramine for pruritus.

关键词： Hepatology Hepatitis Amoxicillin/Clavula-nate Drug reactions Hyperbilirubinemia

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River Network and the Risk of Flooding for the Railway and Subway Systems in the City of Sao Paulo, Brazil

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Journal of Geological Resource and Engineering 2016年第7期4卷 328-334页

作者： Daniel Nery dos Santos Marcos Antonio Maia de Oliveira alexandre Formigoni Joao Roberto Maiellaro Antonio Roberto Saad Marcelo Eloy fernandes Department of Logistics-NUPELOG Sao Paulo State Technological College Campus Guarulhos Sao Paulo Brazil Department of Geosciences University Guarulhos Campus Guarulhos Sao Paulo Brazil Department of lnformation Technology Management Sao Paulo State Technological College Campus Barueri Sao Paulo Brazil

This study investigated the risk of flooding along the Sao Paulo city＇s railway network and showed its latest technologies. To that end, we took into account topographic and hydrological features, as well as possible interferences of the flooding phenomenon with the optimal operation of the railway system. When preparing the maps and the flooding risk analysis, we used data from project SRTM （Shuttle Radar Topography Mission） integrated and processed in a GIS （geographical information system）, through version 2.14 of the geoprocessing software ＂QGis＂. Results showed risk exposure for logistics operations of the railway system for the transportation of passengers, especially in the Central and Eastern regions of the city, where there is a higher concentration of points of flooding, thus making it more difficult for passengers to come and go in the greatest city of Brazil.

关键词： Urban mobility rivers logistics Sao Paulo flooding railroads.

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