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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de oliveira Silva Mariana Santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

Rainfall erosivity and erosivity density through rainfall synthetic series for Sao Paulo State,Brazil:Assessment,regionalization and modeling

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International Soil and Water Conservation Research 2022年第3期10卷 355-370页

作者： David Bruno de Sousa teixeira Roberto Avelino Cecílio Joao Paulo Bestete de oliveira Laura Thebit de Almeida Gabrielle Ferreira Pires department of Agricultural Engineering Federal University of ViçosaViçosaMG36570-900Brazil department of Forest and Wood Sciences Federal University of Espírito SantoJer^onimo MonteiroES29550-000Brazil Federal Institute of Espírito Santo Campus AlegreAlegreES29520-000Brazil

Rainfall is the main cause of erosion of Brazilian soils,which makes assessing the rainfall erosivity factor(RE)and the erosivity density(ED)fundamental for soil and water ***,the objectives of this study were:i)to estimate the RE and ED for Sao Paulo State,Brazil,using synthetic series of pluviographic data;ii)to define homogeneous regions regarding rainfall erosivity;and iii)to generate regression models for rainfall erosivity estimates in each of the homogeneous *** series of pluviographic data were initially obtained on a sub-daily scale from the daily rainfall records of 696 rainfall *** RE values were then estimated from the synthetic rainfall data,and ED was calculated from the relationship between erosivity and rainfall *** and annual maps for RE and ED were *** clustering analysis was used to define homogeneous regions in terms of rainfall erosivity,and regionalized regression models for estimating RE were *** results demonstrate high spatial variability of RE in Sao Paulo,where the highest annual values were observed in the coastal *** to March concentrate approximately 60%of the intra-annual *** highest values of annual ED were observed in regions with intense agricultural *** definition of five homogeneous regions concerning the rainfall erosive potential evidenced distinct seasonal patterns of the spatial distribution of ***,the high predictive accuracy of the regionalized models obtained characterizes them as essential tools for reliable estimates of rainfall erosivity,and contribute to better soil conservation planning.

关键词： Soil erosion Stochastic weather generator Homogeneous regions Modified Fournier index Regression models

Optimal cytokinin/auxin balance for indirect shoot organogenesis of Eucalyptus cloeziana and production of ex vitro rooted micro-cuttings

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Journal of Forestry Research 2022年第5期33卷 1573-1584页

作者： Leandro Silva de oliveira Gilvano Ebling Brondani Letícia Vaz Molinari Rafaella Zanetti Dias Gustavo Leal teixeira Antônio Natal Gonçalves Marcílio de Almeida Institute of Agricultural Science Federal University of Minas GeraisUniversity Campus1000Universitária Ave.Montes ClarosMG 39404-547Brazil Laboratory of In Vitro Culture of Forest Species Department of Forestry SciencesFederal University of LavrasUniversity CampusCentral AvenueLavrasMG 37200-900Brazil department of Biological Sciences “Luiz de Queiroz”College of AgricultureUniversity of São Paulo(ESALQ/USP)University Campus11Pádua Dias AvenuePiracicabaSP 13418-900Brazil

Shoot organogenesis is critical for the shortening of long breeding cycles and circumvent the barrier of cloning mature Eucalyptus cloeziana *** enables large-scale production of plants from transformed *** study evaluates the effect ofα-naphthaleneacetic acid(NAA),thidiazuron(TDZ)and benzylaminopurine(BAP)on the organogenesis of *** from hypocotyls and cotyledonary *** the induction stage,hypocotyls and cotyledonary leaves were established in a Murashige and Skoog(MS)culture medium supplemented with NAA or *** tissues were cultivated in a MS culture medium containing only BAP or different concentrations of BAP/NAA in the differentiation *** buds were multiplied in vitro and elongated in a WPM culture medium supplemented with 0.89μM BAP and 0.05μM *** leaves exhibited the best in vitro *** induction of adventitious buds occurred only in calluses induced from *** the differentiation stage,4.4μM BAP treatment promoted an increase of adventitious bud ***-cuttings from regenerated shoots were acclimatized and rooted ex vitro in *** results confirm the establishment of an efficient protocol for the in vitro regeneration of *** by indirect organogenesis,providing new insights regarding cloning of this species.

关键词： Micropropagation Recalcitrant species Plant growth regulator Explants source

Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

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Journal of Forestry Research 2022年第2期33卷 643-651页

作者： Raphael oliveira de Melo AymbiréAngeletti da Fonseca Nairam Félix de Barros Raphael Bragança Alves Fernandes Rafael da Silva teixeira Iago Nery Melo Ricardo Previdente Martins Soil Science department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACELL Company AlagoinhasBahiaBrazil

Eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease

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Neural Regeneration Research 2023年第12期18卷 2611-2614页

作者： Júlio César Claudino dos Santos Leandro Freitas oliveira Felipe Micelli Noleto Camilla teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana Christus University Center-UNICHRISTUS FortalezaCEBrazil Postgraduate Program in Morphofunctional Sciences Federal University of Ceará-UFCFortalezaCEBrazil Universidade Católica de Brasília-UCB BrasíliaDFBrasil Postgraduate Program in Physiology and Pharmacology department of the Federal University of Ceará-UFC FortalezaCEBrazil Physiology and Pharmacology department of the Federal University of Ceará-UFC FortalezaCEBrazil

This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's *** vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of *** can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous *** and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment *** findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's *** studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.

关键词： alpha-synuclein enteric microbiota gastrointestinal tract Parkinson's disease vagus nerve

Biochar influences the cane fields’microbiota and the development of pre-sprouted sugarcane seedlings

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Waste Disposal and Sustainable Energy 2023年第1期5卷 75-88页

作者： Bruna Cristina Pinto Adriana Barboza Alves Osania Emerenciano Ferreira Gustavo Henrique Gravatim Costa Magno Andréde oliveira Augusto Cesar da Silva Bezerra Alan Rodrigues teixeira Machado Postgraduate Program in Environmental Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38202-436Brazil department of Agricultural and Biological Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38208-436Brazil Postgraduate Program in Geotechnical Engineering Federal University of Ouro PretoOuro PretoMinas Gerais35400-000Brazil department of Transport Engineering Federal Center for Technological Education of Minas GeraisBelo HorizonteMinas Gerais30421-169Brazil department of Exact Sciences State University of Minas GeraisJoão Monlevade UnityJoão MonlevadeMinas Gerais35930-314Brazil

This research investigates the soil conditioning effect of sugar cane fields with biochar produced from sugarcane *** influence on the physicochemical and microbiological conditions of the soil and the agronomic performance of sugarcane seedlings was *** this end,the biochar from sugarcane bagasse was produced by pyrolysis in a double drum oven and mixed with soil at rates of 0,1%,3%,and 5%(in weight).The experiment was installed in a greenhouse with two evaluation periods(30 days and 60 days)and five *** pot received a pre-sprouted cane seedling,and the analysis of colony-forming units(bacteria and fungi),physicochemical characteristics of the soil,and growth and development of sugarcane were performed per *** biochar showed a high fixed carbon content(72%)and a specific surface area estimated by the adsorption of methylene blue of 50 m2 g−***,its structure is porous and contains important nutrients(e.g.,CaO,K2O,and P2O5).In the periods evaluated,the applications of the 3%and 5%(in weight)rates of biochar reduced most of the soil fertility ***,the chemical analyses indicated that the sugarcane field soil collected already possessed high *** microbiota was influenced,but only the application of the 3%(in weight)rate at 60 days after planting showed a significant positive effect on the number of bacteria forming units,with an increase of approximately 385%.On the other hand,no significant positive effect on sugarcane development was ***,biochar application in high-fertility sugarcane plantation soil did not result in gains for sugarcane development in the periods evaluated.

关键词： Soil Biometry Microbiology Double drum oven Biochar

Antioxidant and Cytotoxic Activities of Clove Oil Nanoparticles and Evaluation of Its Size and Retention Efficiency

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Materials Sciences and Applications 2022年第1期13卷 39-53页

作者： Clara teixeira de oliveira Maria Inês Bruno Tavares Institute of Macromolecules Professor Eloisa Mano Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

A derivation of the nanoprecipitation technique without the presence of surfactants to reduce the nanoparticle size is herein proposed. The absence of surfactant in the nanoprecipitation technique allows capturing particles with a smaller diameter than nanoparticles containing surfactants, facilitating the migration of antioxidant nanoparticles in film packaging. Biodegradable PLA nanoparticles with clove oil were produced and characterized by dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, retention efficiency, cytotoxicity, and antioxidant activity. The particle sizes obtained were smaller than those commonly produced by nanoprecipitation, monodispersed and stable for 6 months. The antioxidant activity showed that the encapsulated form of clove oil had greater antioxidant activity than unencapsulated clove oil. The addition of PLA nanoparticles decreased the cytotoxic action of eugenol, the main antioxidant component of clove oil.

关键词： Nanoprecipitation PLA Clove Oil Antioxidant

Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries:A Systematic Review

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Maternal-Fetal Medicine 2023年第2期5卷 97-103页

作者： Marta Maria Silva Érica Alcântara Silva Caline Novais teixeira oliveira Maria Luísa Cordeiro Santos Cláudio Lima Souza Fabrício Freire de Melo Márcio Vasconcelos oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaBahia 45.029-094Brazil

Objective:This review aimed to compile scientific data on the distribution and prevalence of group BStreptococcus (GBS) serotypes isolated from pregnant women across 30 countries from 2010 to ***:This was a systematic review that addresses the distribution and prevalence of GBS in pregnant *** search included studies published between January 2010 and december 2019 in PubMed,Virtual Health Library (BVS),ScienceDirect,Scientific Electronic Library Online (SciELO),and LILACS *** also surveyed relevant articles published in English,Spanish,and Portuguese between February and April *** articles,communication,short report,theses,and dissertations were *** prevalence of GBS colonization,method for capsular serotyping,antimicrobial resistance,distribution and prevalence of serotypes were extracted from each ***:In all,795 publications were *** applying the eligibility criteria,48 articles were included for the final systematic analysis;most articles were from Asia and were published during the years 2014 to *** the identification of serotypes,most studies used the polymerase chain reaction *** were records of all 10 GBS serotypes,namely,Ia,Ib,and II–IX,among the countries *** susceptibility and resistance to antibiotics were addressed in 37.5% of the publications ***:This review showed that GBS serotypes are distributed differently in the 30 analyzed countries,with serotypes Ia,Ib,and II to V being the most ***,our results highlighted the relationship of GBS with maternal colonization,implications for neonates,and antibiotic resistance.

关键词： Streptococcus agalactiae Serotype Pregnant women