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Infectious Disease Modelling 2021年第1期6卷 751-765页

作者： Eduardo lima Campos Rubens Penha Cysne alexandre l.madureira Gelcio l.Q.Mendes EPGE Brazilian School of Economics and Finance(FGV EPGE) Rio de JaneiroRJBrazil ENCE-Escola Nacional de Ci^encias Estatísticas(ENCE/IBGE) Rio de JaneiroRJBrazil laboratorio Nacional de Computaç~ao Científica PetropolisRJBrazil INCA-Brazilian National Cancer Institute Coordination of AssistanceRio de JaneiroRJBrazil

We use an age-dependent SIR system of equations to model the evolution of the *** that measure the amount of interaction in different locations(home,work,school,other)are approximated from in-sample data using a random optimization scheme,and indicate changes in social distancing along the course of the *** allows the estimation of the time evolution of classical and age-dependent reproduction *** those parameters we predict the disease dynamics,and compare our results with out-of-sample data from the City of Rio de ***,we provide a numerical investigation regarding age-based vaccination policies,shedding some light on whether is preferable to vaccinate those at most risk(the elderly)or those who spread the disease the most(the youngest).There is no clear upshot,as the results depend on the age of those immunized,contagious parameters,vaccination schedules and efficiency.

关键词： COVID-19 Epidemiology Vaccination Compartmental modeling SIR

Impact of simulated in vitro gastrointestinal digestion on bioactive compounds,bioactivity and cytotoxicity of melon (Cucumis melo l. inodorus) peel juice powder

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Food Bioscience 2022年第3期47卷 1358-1367页

作者： Ricardo Gómez-García Ana A.Vilas-Boas Manuela Machado Débora A.Campos Cristóbal N.Aguilar Ana R.madureira Manuela Pintado Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina – Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal BBG-DIA.Bioprocesses and Bioproducts Group.Food Research Department School of ChemistryAutonomous University of CoahuilaSaltilloCoahuilaMexico

The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products,considering (i) the recovery and accessibility indexes,(ii) the changes on antioxidant activity,and (iii) the prebiotic *** exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were ***,these both parameters exhibited stable accessibility,accounting with 81.89%,76.55%,and 54.07% for TPC,ABTS and DPPH,*** gastrointestinal digestion,the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and lactobacillus strains,possibly associated with the high content of simple sugar (glucose and fructose).This fraction also showed to be safe on Caco-2 intestinal *** findings suggest that MPJ might be used as a potential food functional ingredient.

关键词： Melon by-products Functional ingredients Phenolic antioxidants Simulated digestion Prebiotic effect

Effect of Mucuna Defatted Bran Extracted with Supercritical CO2 on Soybean Seed Germination

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Journal of Food Science and Engineering 2013年第4期3卷 187-195页

作者： Vitor Augusto dos Santos Garcia Osvaldo Ferrarese-Filho Vladimir Ferreira Cabral Ed Hoffmann madureira Camila da Silva lucio Cardozo-Filho Department of Agronomy Universidade Estadual de Maringa Maringa PR 87020-900 Brazil Department of Biochemistry Universidade Estadual de Maringa Maringa PR 87020-900 Brazil Department of Chemical Engineering Universidade Estadual de Maringa Maringa PR 87020-900 Brazil Department of Animal Reproduction Universidade de Sao Paulo Pirassununga SP 13635-900 Brazil Department of Technology Universidade Estadual de Maringa Umuarama PR 87506-370 Brazil

In the present work, we investigated the effect of Mucuna deeringiana defatted bran on seed germination of soybean （Glycine max l. Merrill）. For this, the defatted bran was obtained from different operational conditions using CO2 under pressurized conditions as solvent. Oil extractions were carried out in a laboratorial scale unit at temperatures ranging from 310 to 330 K, pressure from 15 to 25 MPa and solvent flow set in 3 ml min^-1. The experiment was conducted in a germination chamber （25℃, 12：12 h light：dark photoperiod）, and the germination rate and germination speed index （GSI） were evaluated for seven days. The results showed that the oil extraction with supercritical CO2 concentrates the allelochemical l-3,4-dihydroxyphenylalanine （l-DOPA） in bran with levels from 1.86% to 4.65%. Subsequent experiments revealed that the rate of soybean seed germination was not affected by defatted bran whereas the GSI increased significantly after treatment. In brief, we concluded that the extraction process with supercritical CO2 is efficient to obtain l-DOPA of Mucuna, which influences the soybean seed germination.

关键词： l-DOPA Mucuna deeringiana soybean seed germination supercritical CO2 defatted bran

Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee lee Xerxes Seposo Yasushi Honda Michelle l.Bell Yuming Guo Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat