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Experimental study of friction dissipators for seismic protection of building structures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： F. López-Almansa S.T. de la cruz C. Taylor Technical University of Catalonia Architecture Structures Department Universidad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil Engineering Department University of Bristol

This paper presents the results from unidirectional shaking table tests of two reduced scale steel models of a building frame, with one and two floors, respectively. These frames incorporate friction dissipators at every floor. The inputs are sine-dwells and artificial and registered earthquakes. This study is part of a larger research project aiming to assess the seismic efficiency of friction dissipators by means of an integrated numerical and experimental approach. Inside this framework, the main objectives of these experiments are to：（i） collect a wide range of results to calibrate a numerical model derived within the project, （ii） clarify some of the most controversial issues about friction dissipators （including behavior for inputs containing pulses, capacity to reduce resonance peaks, introduction of high frequencies in the response, and self- generated eccentricities）, （iii） better understand their dynamic behavior, （iv） provide insight on the feasibility and reliability of using simple friction dissipators for seismic protection of building structures and （v） characterize the hysteretic behavior of these devices. Most of these objectives are satisfactorily reached and relevant conclusions are stated.

关键词： building structures earthquake engineering passive control friction energy dissipators experimentalverification shaking table tests

Validation of ERA5-Land temperature and relative humidity on four Peruvian glaciers using on-glacier observations

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Journal of Mountain Science 2022年第7期19卷 1849-1873页

作者： BONSHOMS Martí UBEDA Jose LIGUORI Giovanni KORNER Philipp NAVARRO Alvaro cruz Rolando Departamento de Geografía Universidad Complutense de MadridMadrid 28040Spain Guías de Espeleología y Montana Torremocha del Jarama 28189Spain Department of Physics and Astronomy University of BolognaBologna 40127Italy School of Earth Atmosphere and EnvironmentMonash UniversityMelbourne 3800Australia Institute of Hydrology and Meteorology Technische Universitat DresdenDresden 01737Germany ESRI-Espana Madrid 28037Spain Area de Evaluación de Glaciares y Lagunas.Autoridad Nacional del Agua Huaraz 02002Peru

Weather and climate conditions drive the evolution of tropical glaciers which play an important role as water reservoirs for Peruvian inhabitants in the arid coast and semi-arid Andean *** scarcity of long-term high-quality observations over Peruvian glaciers has motivated the extensive use of reanalysis data to describe the climatic evolution of these ***,the representativeness and uncertainties of these reanalysis products over these glaciers are still poorly *** study evaluates the ability of the ERA-Land reanalysis(ERAL)to reproduce hourly and monthly 2 m air temperature and relative humidity(T2m and Rh2m,respectively)over several Peruvian *** compared the ERAL with data from four on-glacier automatic weather stations(AWS),whose hourly time series were completed with nearby stations,for the period January 2017 to December *** indicates a better performance of the reanalysis for T2m(r>0.80)than for Rh2m(~0.4

关键词： ERA5 Land Tropical glaciers Temperature Relative humidity Peru Validation

In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

A surface electromyography controlled steering assistance interface

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Journal of Intelligent and Connected Vehicles 2019年第1期2卷 1-13页

作者： Edric John cruz Nacpil Rencheng Zheng Tsutomu Kaizuka Kimihiko Nakano Institute of Industrial Science The University of TokyoTokyoJapan

Purpose–Two-handed automobile steering at low vehicle speeds may lead to reduced steering ability at large steering wheel angles and shoulder injury at high steering wheel rates(SWRs).As aﬁrst step toward solving these problems,this study aims,ﬁrstly,to design a surface electromyography(sEMG)controlled steering assistance interface that enables hands-free steering wheel rotation and,secondly,to validate the effect of this rotation on path-following ***/methodology/approach–A total of 24 drivers used biceps brachii sEMG signals to control the steering assistance interface at a maximized SWR in three driving simulator scenarios:U-turn,908 turn and 458 *** comparison,the scenarios were repeated with a slower SWR and a game steering wheel in place of the steering assistance *** path-following accuracy of the steering assistance interface would be validated if it was at least comparable to that of the game steering ***–Overall,the steering assistance interface with a maximized SWR was comparable to a game steering *** the U-turn,908 turn and 458 turn,the sEMG-based human–machine interface(HMI)had median lateral errors of 0.55,0.3 and 0.2 m,respectively,whereas the game steering wheel,respectively,had median lateral errors of 0.7,0.4 and 0.3 *** higher accuracy of the sEMG-based HMI was statistically signiﬁcant in the case of the ***/value–Although production automobiles do not use sEMG-based HMIs,and few studies have proposed sEMG controlled steering,the results of the current study warrant further development of a sEMG-based HMI for an actual automobile.

关键词： Advanced driver assistance systems Human–machine interface Myoelectric control system Path-following Steering assistance system Surface electromyography

Pixelated prompt gamma imaging detector for online measurement of proton beam: Monte Carlo feasibility study by FLUKA

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Radiation Detection Technology and Methods 2018年第1期2卷 25-31页

作者： Jin-Long Wang LAlberto cruz Michael Lu School of Astronomy and Space Science Nanjing UniversityNanjingChina NewRT Medical systems Inc.WuxiChina Peak Physics Consulting LLC.GuangzhouChina

Increased accuracy of proton beam delivery provides additional benefits to the patients undergo the treatment.A prompt gamma imaging detector can provide additional information during the treatment,as the prompt gammas produced by the interactions between protons and human tissues are related to the range and profile of the beam in the *** paper makes a Monte Carlo feasibility study for a pixelated prompt gamma imaging detector which can not only measure the proton range but also merge the beam profile and 3D beam image inside the *** simulation result shows that this detector can reduce background noise and measure the range and beam profile by using of grated shielding material,vertical gammas selection and a 5MeV energy window.

关键词： Proton therapy Beam range Prompt gamma FLUKA

Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration

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Neural Regeneration Research 2023年第5期18卷 991-995页

作者： Diogo Trigo Jose Joao Vitoria Odete A.B.da cruz e Silva Neuroscience and Signalling Laboratory Institute of Biomedicine(iBiMED)Department of Medical SciencesUniversity of AveiroAveiroPortugal

In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset neurodegenerative disorders. These are complex dynamic organelles that have a variety of functions in ensuring cellular health and homeostasis. The plethora of mitochondrial functionalities confers them an intrinsic susceptibility to internal and external stressors(such as mutation accumulation or environmental toxins), particularly so in long-lived postmitotic cells such as neurons. Thus, it is reasonable to postulate an involvement of mitochondria in aging-associated neurological disorders, notably neurodegenerative pathologies including Alzheimer’s disease and Parkinson’s disease. On the other hand, biological effects resulting from neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop further contributing to the progression of neuronal dysfunction and cellular death. This review examines state-of-the-art knowledge, focus on current research exploring mitochondrial health as a contributing factor to neuroregeneration, and the development of therapeutic approaches aimed at restoring mitochondrial homeostasis in a pathological setting.

关键词： Alzheimer’s disease axon energy homeostasis glymphatic system mitochondria mitostasis neurodegeneration neuroregeneration Parkinson’s disease therapeutical strategies

Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal

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Journal of Environmental Sciences 2015年第12期27卷 158-167页

作者： Xanel Vecino Rosa Devesa-Rey Salvador Villagrasa Jose M.cruz Ana B.Moldes Chemical Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende Defense University Center Naval AcademyUniversity of Vigo Materials Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende

In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried *** have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour *** experimental data were fitted to several kinetic models（pseudo-first order,pseudo-second order,Chien-Clayton model,intraparticle diffusion model and Bangham model）; being pseudo-second order the kinetic model that better described the adsorption of dyes onto both *** addition,a morphological study（roughness and shape） of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard *** techniques used to carry out this morphological study consisted of scanning electron microscopy（SEM）,perfilometry and 3D surface analysis.

关键词： Immobilized alginate-vineyard Dyes Kinetic studies Roughness Spherical shape

Antibacterial activities of mangrove leaf endophytic fungi from Luzon Island,Philippines

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Studies in Fungi 2020年第1期5卷 320-331页

作者： Ramirez CSP Notarte KIR dela cruz TEE The Graduate School University of Santo TomasEspaña Blvd.1008 ManilaPhilippines Fungal Biodiversity Ecogenomics and Systematics GroupResearch Center for the Natural and Applied SciencesUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines Department of Biological Sciences College of ScienceUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines

Fungi associated with mangroves are untapped sources of bioactive secondary *** this study,628 mangrove leaf endophytic fungi(MLEF)were recorded from 19 mangrove hosts collected from the provinces of Zambales,Batangas,Cavite,and Quezon in Luzon Island,*** MLEF morphospecies were identified as belonging to the genera Aspergillus,Cladosporium,Colletotrichum,Fusarium,Nigrospora,Penicillium,Pestalotiopsis,Phialophora,and *** revealed that the MLEF crude culture extracts were promisingly potent against the gram-positive bacteria Staphylococcus aureus and Micrococcus luteus(ZOI>19 mm)with no or partial activity against the gram-negative bacteria Klebsiella oxytoca and Pseudomonas *** findings showed that mangrove leaf endophytic fungi are potential sources of bioactive compounds.

关键词： bioactivities fungal endophytes mangrove forests secondary metabolites

Femtosecond laser-assisted cataract surgery(FLACS)in resident training

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Annals of Eye Science 2018年第1期3卷 393-402页

作者： Carmen Somavilla Bueno Jose de la cruz Department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoILUSA

This article reviews the history of the femtosecond laser in ophthalmology and its subsequent introduction into the field of cataract *** discusses the innovations that this technology has brought to the *** article also describes the current system of teaching cataract surgery to ophthalmology residents in the United States and then examines how femtosecond laser-assisted cataract surgery(FLACS)can be a beneficial part of residency education.

关键词： Femtosecond laser cataract surgery capsulorhexis optical coherence tomography