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Sex and season explain spleen weight variation in the Egyptian mongoose

Current Zoology 2019年第1期65卷 11-20页

作者： Victor BANDEIRA Emilio Virgos alexandre azevedo Joao Carvalho Monica V. CUNHA Carlos Fonseca Dartment of Biology Centro de Estudos do Ambiente e do Mar (CESAM) University of Aveiro Campus Universitario de Santiago Aveiro 3810-193 Portugal Departamento de Biologia Geologia Fisica y Qufmica Inorganica Area Biodiversidad y Conservacion Escuela Superior de Ciencias Experimentales y Tecnologia (ESCET) Universidad Rey Juan Carlos c/Tulipan s/n Mostoles Madrid E-28933 Spain Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Straβe 17 Berlin 10315 Germany Instituto de Ciencias Biomedicas Abel Salazar R. Jorge de Viterbo Ferreira 228 Porto 4050-313 Portugal Instituto Nacional de Investigaqao Agraria e Veterinaria (INIAV) IP-National Institute for Agrarian and Veterinary Research Rua dos Lagidos Lugar da Madalena Vairao 4485-655 Portugal cE3c-Centre for Ecology Evolution and Environmental Changes Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal BiolSI-Biosystems & Integrative Sciences Institute Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal Wildlife Ecology & Health group (WE&H) and Servei d'Ecopatologia de Fauna Salvatge (SEFaS) Departament de Medicina i Cirurgia Animals Universitat Autonoma de Barcelona 08193-Bellaterra Barcelona Spain

The Egyptia n mon goose (Herpestes ichneumon Linn aeus, 1758) is a medium-sized car nivore that experienced remarkable geographic expansion over the last 3 decades in the Iberian Peninsula. In this study, we investigated the association of species-related and abiotic factors with spleen weight (as a proxy for immunocompete nee) in the species. We assessed the relationship of body con dition, sex, age, seas on, and envir onmental conditi ons with splee n weight established for 508 hunted specimens. Our results indicate that the effects of sex and season outweigh those of all other variables, including body condition. Spleen weight is higher in males than in females, and heavier spleens are more likely to be found in spring, coinciding with the highest period of investment in reproduction due to mating, gestation, birth, and lactation. Coupled with the absence of an effect of body condition, our findi ngs suggest that splee n weight variation in this species is mostly influe need by lifehistory traits linked to reproduction, rather than overall energy availability, winter immunoenhancement, or energy partitioning effects, and prompt further research focusing on this topic.

关键词： body condition carnivore Herpestes ichneumon Iberian Peninsula mongoose spleen weight

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Influence of Fertilizer Type on Beet Production and Post-Harvest Quality Characteristic

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Agricultural Sciences 2018年第5期9卷 557-565页

作者： Carmen Rosa da Silva Curvêlo Layane Hyasmin Bernardes Diniz alexandre Igor de azevedo Pereira Luiz Leonardo Ferreira Goiano Federal Institute Campus Urutaí Urutaí Brasil University Center of Mineiros—UNIFIMES Mineiros Brasil

The beet (Beta vulgaris L.) vegetable is of great importance in the Brazilian market, mainly by having high nutritional values in consumer diet. Thus, the objective of this work was to evaluate the effects of organic and mineral fertilization on the production and post-harvest quality of beet. The experiment was conducted in the field, in the municipality of Urutaí-GO. The experimental design was a randomized block (DCB), where treatments were applied to two types of fertilizer: organic (chicken manure) and conventional (mineral fertilizer) with six replicates (using six tubers per plot). The following evaluations were made: horizontal and vertical diameters of the tubers (cm) weight (kg) Protein (g) Lipid (%) Ash humidity (%), electrical conductivity (μS·cm-1), pH, Titratable Acidity and Brix. The organic surpassed conventional treatment for all variables, except for the ash content, wherein the organic treating poultry litter base, showed 1.40% of ash and pH (6.48).

关键词： Beta vulgaris L. Chicken Bed Productivity

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Antitumor Effect of Cationic INKKI Peptide from Bovine <i>β</i>-Casein on Melanoma B16F10

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Journal of Cancer Therapy 2012年第4期3卷 237-244页

作者： Ricardo alexandre azevedo Adilson Kleber Ferreira Aline Vivian Vatti Auada Kerly Fernanda Mesquita Pasqualoto Rafael Marques-Porto Durvanei Augusto Maria Ivo Lebrun Butantan Institute Biochemistry and Biophysical Laboratory Sao Paulo Brazil

Cationic peptide with the sequence INKKI 41-45 was isolated from bovine β-casein after tryptic hydrolysis and synthetized. The aim of this work was to evaluate the antiproliferative activity in vitro and antitumor effect in animal model. The in vitro cytotoxicity was evaluated on B16F10 melanoma cells by MTT assay. Detection of apoptosis was measured using the annexin V/PI double staining and cell cycle analysis performed flow cytometry. Caspase-3 activity was analyzed with substrate specific fluorogenic DEVD-MCA. In vivo, antitumor activity was evaluated in B16F10 melanoma tumor-bearing C57BL/6J mice. The animals were treated with 55 mg/kg INKKI administered into peritumoral region, while control group received saline solution. The following antitumor parameters were examined: tumor volume, number of metastases, tumor delayed time, tumor doubling time. Histological analyses were performed with H & E staining. The results showed that INKKI induced dose-response cytotoxicity selective for B16F10 melanoma cells (IC50 1.7 μM) and did not present cytotoxic effects for FN1 fibroblast cells. INKKI-induced apoptosis detected trough of annexin V/PI assay and it was accompanied with an increase of sub-G1 apoptotic fractions and significant increase of caspase-3 cleavage. The tumor-bearing mice treated with INKKI showed a significant reduction in tumor volume of 72.62% and decreased of metastasis number loci. In addition, INKKI caused a significant delay in tumor growth and prolonged the tumor doubling time. Histological analysis revealed an increased of necrosis areas and reduction of tumor cells in tumor treated with INKKI, it was a many hallmark of its antitumor effects observed from in vivo experiments. In conclusion, we show that INKKI is a peptide that could be considered a new putative candidate development to anticancer therapy drug.

关键词： β-Casein Peptide Apoptosis Metastasis Tumor Growth Melanoma

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An updated overview on the development of new photosensitizers for anticancer photodynamic therapy

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Acta Pharmaceutica Sinica B 2018年第2期8卷 137-146页

作者： Juan Zhang Chengshi Jiang Joao Paulo Figueiró Longo Ricardo Bentes azevedo Hua Zhang Luis alexandre Muehlmann School of Biological Science and Technology University of Jinan Institute of Biological Sciences University of Brasilia Faculty of Ceilandia University of Brasilia

Photodynamic therapy(PDT), based on the photoactivation of photosensitizers(PSs), has become a well-studied therapy for cancer. Photofrin~?, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology.

关键词： Anti-cancer Photosensitizers Photodynamic therapy Photochemical reactions Oncology BODIPY

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Diuretic window hypothesis in cirrhosis: Changing the point of view

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World Journal of Gastroenterology 2019年第26期25卷 3283-3290页

作者： Anderson Brito-azevedo Liver Transplant Unit S?o Lucas Hospital Liver Transplant Unit S?o Francisco na Providência de Deus Hospital Liver Transplant Unit Adventist Silvestre Hospital

Since the 1970s,non-selective beta-blockers(NSBB)have been used to prevent variceal upper bleeding in advanced cirrhotic ***,several recent studies have raised the doubt about the benefit of NSBB in end-stage cirrhotic *** fact,they suggested a detrimental effect in these patients that even reduced *** of these studies have been assembled to compose the“window therapy hypothesis”,in which NSBB would have traditional indication to be initiated to prevent variceal upper bleeding;however,treatment should be stopped(or not be initiated)in patients with end-stage *** would reduce the cardiac reserve of these patients,worsening systemic perfusion and ***,it should be emphasized that these studies present important bias issues,and their results also suggested that diuretic treatment may also be behind the effects *** this opinion review,we changed the point of view from NSBB to diuretic treatment,based on a physiopathogenic approach of circulatory parameters of cirrhotic patients studied,and based on diuretic effect in blood pressure lowering and in other hypervolemic disease,as heart *** suggest a“diuretic window hypothesis”,composed by an open window in hypervolemic phase,an attention window when patient present in a normal plasma volume phase,and a closed window during the plasma hypovolemic phase.

关键词： Cirrhosis Non-selective beta-blockers Diuretic Window hypothesis Baveno Cardiac output

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Research and development of VUV optical coatings for micro mirror applications

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光学精密工程 2005年第4期13卷 465-470页

作者： alexandre Gatto Norbert Kaiser Fraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena Germany

This paper deals with vacuum UV optical coatings for micro mirror applications. High reflecting low-stress optical coatings have been developed for the next-generation of micro mechanical mirrors. The optimized metal systems are applicable in the VUV spectral region and can be integrated in the technology of MOEMS, such as spatial light modulators (SLM) and micro scanning mirrors.

关键词： VUV 光学涂覆技术微镜技术薄膜调节器

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Towards a modular and scalable holographic display

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Light(Science & Applications) 2022年第5期11卷 739-740页

作者： Pierre-alexandre Blanche Wyant College of Optical Sciences University of ArizonaTucsonAZUSA

Holographic three-dimensional(3D)display can be made very large using a modular system that allows seamless spatial tiling of multiple coarse integral holographic images.

关键词： holographic system integral

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Considerations for the Conduction and Interpretation of FAIRness Evaluations

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Data Intelligence 2020年第1期2卷 285-292页

作者： Ricardo de Miranda azevedo Michel Dumontier Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands

The FAIR principles were received with broad acceptance in several scientific ***,there is still some degree of uncertainty on how they should be *** self-report questionnaires have been proposed to assess the implementation of the FAIR ***,the FAIRmetrics group released 14,general-purpose maturity for representing ***,these metrics were conducted as open-answer ***,these metrics have been implemented into a software that can automatically harvest metadata from metadata providers and generate a principle-specific FAIRness *** so many different approaches for FAIRness evaluations,we believe that further clarification on their limitations and advantages,as well as on their interpretation and interplay should be considered.

关键词： FAIR metrics FAIR principles FAIR data FAIRness Implementation Maturity indicators Scientific community

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Colon mucus in colorectal neoplasia and beyond

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World Journal of Gastroenterology 2022年第32期28卷 4475-4492页

作者： alexandre Loktionov DiagNodus Ltd Cambridge CB40WSUnited Kingdom

Little was known about mammalian colon mucus(CM)until the beginning of the 21^(st) *** that time considerable progress has been made in basic research addressing CM structure and *** CM is formed by two distinct layers composed of gel-forming glycosylated mucins that are permanently secreted by goblet cells of the colonic *** inner layer is dense and impenetrable for bacteria,whereas the loose outer layer provides a habitat for abundant commensal *** barrier integrity is essential for preventing bacterial contact with the mucosal epithelium and maintaining homeostasis in the gut,but it can be impaired by a variety of factors,including CM-damaging switch of commensal bacteria to mucin glycan consumption due to dietary fiber *** is proven that impairments in CM structure and function can lead to colonic barrier deterioration that opens direct bacterial access to the ***-induced damage dysregulates epithelial proliferation and causes mucosal inflammatory responses that may expand to the loosened CM and eventually result in severe disorders,including colitis and neoplastic *** described formation of bacterial biofilms within the inner CM layer was shown to be associated with both inflammation and *** obvious gaps in our knowledge of human CM remain,its importance for the pathogenesis of major colorectal diseases,comprising inflammatory bowel disease and colorectal cancer,is already *** progress in CM exploration is likely to result in the development of a range of new useful clinical applications addressing colorectal disease diagnosis,prevention and therapy.

关键词： Colon Colon mucus Mucins Goblet cells Gut microbiota Inflammatory bowel disease Colorectal cancer

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Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： Luis alexandre Pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation

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