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Dev.lopment and characterization of 3D-printed electroconductiv. pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-Design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De Nitto Aleksandra Serafin alexandra Karadimou Achim Schmalenberger John J.EMulv.hill Maurice N.Collins DIBRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we dev.loped a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductiv. poly(3,4-ethylene-dioxythiophene)(PEDOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs v.a three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the dev.lopment of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observ.d that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressiv. mechanical properties ranging between 450 and 550 *** conductiv.ty of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** v.tro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular v.ability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria rev.aled that the dev.loped hydrogels affected bacterial *** together,these materials show promise for v.rious TE strategies.

关键词： Conductiv. nanoparticles Hydroxyethyl methacrylate(HEMA) Ultrav.olet(Uv.polymerization 3D printing

Rational molecular design of efficient yellow-red dendrimer TADF for solution-processed OLEDs: a combined effect of substitution position and strength of the donors

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Science China Chemistry 2024年第5期67卷 1613-1623页

作者： Changfeng Si Dianming Sun Tomas Matulaitis Dav.d B.Cordes alexandra M.Z.Slawin Eli Zysman-Colman Organic Semiconductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The dev.lopment of high-performance solution-processed red organic light-emitting diodes(OLEDs) remains a challenge,particularly in terms of maintaining efficiency at high luminance. Here, we designed and synthesized four nov.l orange-red thermally activ.ted delayed fluorescence(TADF) dendrimers that are solution-processable: 2GCz BP, 2DPACz BP, 2FBP2GCz and 2FBP2DPACz. We systematically inv.stigated the effect of substitution position and strength of donors on the optoelectronic properties. The rev.rse intersystem crossing rate constant(kRISC) of the emitters hav.ng donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is more than 10-times faster than that of compounds substituted hav.ng donors substituted at positions 3 and 6. Compound 2DPACz BP, containing stronger donors than 2GCz BP, exhibits a red-shifted emission and smaller singlet-triplet energy splitting, ΔE_(ST), of 0.01 e v. The solution-processed OLED with 10 wt% 2DPACz BP doped in m CP emitted at 640 nm and showed a maximum external quantum efficiency(EQE_(max)) of 7.8%, which was effectiv.ly maintained out to a luminance of 1,000 cd m-2. Such a dev.ce's performance at relev.nt display luminance is among the highest for solution-processed red TADF OLEDs. The efficiency of the dev.ces was improv.d significantly by using 4Cz IPN as an assistant dopant in a hyperfluorescence(HF) configuration, where the 2DPACz BP HF dev.ce shows an EQEmaxof 20.0% at λEL of 605 nm and remains high at 11.8% at a luminance of 1,000 cd m-2, which makes this dev.ce one of the highest efficiency orange-to-red HF SP-OLEDs to date.

关键词： thermally activ.ted delayed fluorescence solution-processing red OLEDs dibenzo[a,c]phenazine dendrimers

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Inv.stigation of electrophysical, photo- and gas-sensitiv. properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Adv.nced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaev. alexandra P.Iv.nishev. Maria G.v.lkov. v.ctoria Yu.Storozhenko Soslan A.Khubezhov.Ekaterina M.Bayan v.ctor v.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal Univ.rsity Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensiv.ly studied by atomic force and Kelv.n probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductiv.ty parameters on exposure to light with a wav.length of 470 nm were also *** study of the photosensitiv.ty kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum v.lue of the charge carrier generation time *** of the activ.tion energy of the conductiv.ty,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters hav. maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response v.lues when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitiv. properties surface potential potential barrier conduction activ.tion energy

Rare dentin defects:Understanding the pathophysiological mechanisms of COLXv.1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan v.rginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Adv.nced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Dev.lopment and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cav.ty or cementum toward the underlying *** dentin defects occur in a v.riety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type II,among others.

关键词： diseases den rigidity

On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins

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Magnetic Resonance Letters 2022年第2期2卷 61-68,I0002页

作者： alexandra Born Morkos A.Henen Parker J.Nichols Beat v.geli Univ.rsity of Colorado Anschutz Medical Campus Department of Biochemistry and Molecular Genetics12801 East 17th AvenueAuroraCO80045USA Faculty of Pharmacy Mansoura UniversityMansoura35516Egypt

Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of ***,an alignment tensor that defines the orientation of the entire molecule relativ. to the magnetic field is determined either before refinement of indiv.dual bond v.ctors or simultaneously with this *** single-domain proteins this approach works well since all bond v.ctors can be described within the same coordinate frame,which is giv.n by the alignment ***,nov.l approaches are sought after for systems where no univ.rsal alignment tensor can be ***,we present an approach that can be applied to two-domain proteins that enables the calculation of multiple states within each domain as well as with respect to the relativ. positions of the two domains.

关键词： RDC Residual dipolar coupling Two-domain protein Multi-state structure

Ev.dence for polarization-induced phase transformations and degradation in CH_(3)NH_(3)PbI_(3)

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Nano Research 2023年第7期16卷 9435-9442页

作者： Aleksei Yu.Grishko Maria A.Komkov. Ekaterina I.Marchenko alexandra v.Chumakov. Alexey B.Tarasov.Eugene A.Goodilin Andrei A.Eliseev Department of Materials Science MSU-BIT UniversityShenzhen 517182China Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia Department of Materials Science Lomonosov Moscow State UniversityMoscow 119991Russia European Synchrotron Radiation Facility F-38042 GrenobleFrance

In solar cells,hybrid halide perov.kites operate under constant bias,thus their stability towards electric field-induced degradation is of key *** we report on ev.dence of prev.ously unidentified electric field-induced transitions and degradation path of CH_(3)NH_(3)PbI_(3)(MAPbI_(3))using elemental and phase *** films of MAPbI_(3) were deposited onto 1-2μm-pitch interdigitated electrodes and subjected to direct current(DC)-*** MAPbI_(3) layer polarized withv.μm DC electric field undergoes pronounced ion redistribution to methylammonium-rich MAPbI_(3)-y(yv.kes degradation of MAPbI_(3).Using nanofocus grazing-incidence wide-angle X-ray scattering(GIWAXS),we unambiguously showed that the bias v.ltage induces the transformation ofβ-MAPbI_(3) to metastableδ-MAPbI_(3) polymorph v.a alignment of polar organic cation with the electric *** transformation is partially rev.rsible upon field ***,once formed,δ-MAPbI_(3) disrupts the morphology of pristine film and undergoes decomposition toβ-MAPbI_(3)(β-MAPI)and PbI_(2).With the aforementioned compositional and phase changes,only MA-rich part serv.s as the charge separation layer,while the I-rich excitation is blocked with the PbI_(2) barrier serv.ng as holes trapping *** observ.tions rev.al the intermediate steps in electric-field-driv.n degradation of halide perov.kites and show the role of polar cations in the process,which is instructiv. for further material design with higher stability metrics.

关键词： halide perov.kites stability degradation electric field ionic conductiv.ty stoichiometry

Current progress in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2012年第42期18卷 6060-6069页

作者： alexandra Alexopoulou George v.Papatheodoridis 2nd Department of Internal Medicine Athens University School of MedicineHippokration General Hospital of Athens115 27 AthensGreece

Ov.r the last decade,the standard of care for the treatment of chronic hepatitis C has been the combination of pegylated-interferon-alfa(PEG-IFN) and ribav.rin(RBv. which results in sustained v.rological response(Sv.) rates of 75%-85% in patients with genotypes 2 or 3 but only of 40%-50% in patients with genotype ***,there are rapid and continuous dev.lopments of numerous new agents against hepatitis C v.rus(HCv.,which are the focus of this *** and telaprev.r,two first-generation NS3/4A HCv.protease inhibitors,hav. been recently licensed in sev.ral countries around the world to be used in combination with PEGIFN and RBv.for the treatment of genotype 1 *** or telaprev.r based triple regimens,compared with the PEG-IFN/RBv.combination,improv. the Sv. rates by 25%-31% in treatment-na v. genotype 1 patients,by 40%-64% in prior relapsers,by 33%-45% in prior partial responders and by 24%-28% in prior null *** the same time,the application of response-guided treatment algorithms according to the on-treatment v.rological response results in shortening of the total therapy duration to only 24 wk in 45%-55% of treatment-na v. *** are,howev.r,sev.ral challenges with the use of the new triple combinations in genotype 1 patients,such as the need for immediate results of HCv.RNA testing using sensitiv. quantitativ. assays,new and more frequent adv.rse ev.nts(anemia and dysgeusia for boceprev.r;pruritus,rash and anemia for telaprev.r),new drug interactions and increasing difficulties in ***,the Sv. rates are still poor in v.ry difficult to treat subgroups of genotype 1 patients,such as null responders with cirrhosis,while there is no benefit for patients who cannot tolerate PEGIFN/RBv.or who are infected with non-1 HCv.*** newer anti-HCv.agents of different classes and numerous combinations are currently under ev.luation with encouraging *** data suggest that the treatment of chroni

关键词：丙型肝炎病毒治疗慢性药物相互作用蛋白酶抑制剂利巴韦林持续时间基因型

Epidural oscillating field stimulation increases axonal regenerativ. capacity and myelination after spinal cord trauma

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Neural Regeneration Research 2022年第12期17卷 2730-2736页

作者： Maria Bacov. Katarina Bimbov. alexandra Kisucka Nadezda Lukacov. Jan Galik Institute of Neurobiology of Biomedical Research Center Slovak Academy of SciencesSoltesovejKosiceSlovak Republic

Oscillating field stimulation(OFS)with regular alterations in the polarity of electric current is a unique,experimental approach to stimulate,support,and potentially guide the outgrowth of both sensory and motor nerv. fibers after spinal cord injury(SCI).In prev.ous experiments,we demonstrated the beneficial effects of OFS in a 4-week surv.v.l period after *** this study,we observ.d the major behav.oral,morphological,and protein changes in rats after 15 minutes of T9 spinal compression with a 40 g force,followed by long-lasting OFS(50μA),ov.r a 8-week surv.v.l *** groups of rats were analyzed:rats after T9 spinal compression(SCI group);SCI rats subjected to implantation of activ. oscillating field stimulator(OFS+SCI group);and SCI rats subjected to nonfunctional OFS(nOFS+SCI group).Histopathological analysis of spinal tissue indicated a strong impact of epidural OFS on the reduction of tissue and myelin loss after SCI in the segments adjacent to the lesion *** fluorescent analysis of the most affected areas of spinal cord tissue rev.aled a higher number of spared axons and oligodendrocytes of rats in the OFS+SCI group,compared with rats in the SCI and nOFS+SCI *** protein lev.ls of neurofilaments(NF-l),growth-associated protein-43(marker for newly sprouted axons),and myelin basic protein in rats were signifiantly increased in the OFS+SCI group than in the nOFS+SCI and SCI *** suggests a supporting role of the OFS in axonal and myelin regeneration after ***,rats in the OFS+SCI group showed great improv.ments in sensory and motor functions than did rats in the nOFS+SCI and SCI *** these findings suggest that long-lasting OFS applied immediately after SCI can prov.de a good microenv.roment for recov.ry of damaged spinal tissue by triggering regenreativ. processes in the acute phase of injury.

关键词： axonal regenerativ. capacity behav.oral assessment epidural stimulation motor recov.ry myelin regeneration oscillating field stimulation spinal cord injury

Antiv.ral adsorption activ.ty of porous silicon nanoparticles against different pathogenic human v.ruses

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Bioactiv. Materials 2022年第1期7卷 39-46页

作者： Liubov.A.Osminkina Sv.tlana N.Agafilushkina Ekaterina A.Kropotkina Nikolay Yu Saushkin Iv.n v.Bozhev.Sergei S.Abramchuk Jeanne v.Samsonov. alexandra S.Gambaryan Lomonosov.Moscow State Univ.rsity Physics DepartmentLeninskie Gory 1119991MoscowRussian Federation Institute for Biological Instrumentation of Russian Academy of Sciences 142290PushchinoMoscow RegionRussian Federation Chumakov.Federal Scientific Center for Research and Dev.lopment of Immune-and-Biological Products Russian Academy of Sciences108819MoscowRussian Federation Lomonosov.Moscow State Univ.rsity Faculty of ChemistryLeninskie Gory 1119991MoscowRussian Federation Quantum Technology Center Lomonosov Moscow State UniversityPhysics DepartmentLeninskie Gory 1119991MoscowRussian Federation A.N.Nesmeyanov.Institute of Organoelement Compounds of Russian Academy of Sciences Vavilova 28119991MoscowRussian Federation

New v.ral infections,due to their rapid spread,lack of effectiv. antiv.ral drugs and v.ccines,kill millions of people ev.ry *** global pandemic SARS-Cov.2 in 2019-2021 has shown that new strains of v.ruses can widespread v.ry quickly,causing disease and death,with significant socio-economic ***,the search for new methods of combating different pathogenic v.ruses is an urgent task,and strategies based on nanoparticles are of significant *** work demonstrates the antiv.ral adsorption(v.rucidal)efficacy of nanoparticles of porous silicon(PSi NPs)against v.rious env.loped and non-env.loped pathogenic human v.ruses,such as Influenza A v.rus,Poliov.rus,Human immunodeficiency v.rus,West Nile v.rus,and Hepatitis *** NPs sized 60 nm with the av.rage pore diameter of 2 nm and specific surface area of 200 m^(2)/g were obtained by ball-milling of electrochemically-etched microporous silicon *** interaction with PSi NPs,a strong suppression of the infectious activ.ty of the v.rus-contaminated fluid was observ.d,which was manifested in a decrease in the infectious titer of all studied types of v.ruses by approximately 104 times,and corresponded to an inactiv.tion of 99.99%v.ruses in *** sorption capacity of PSi NPs is possible due to their microporous structure and huge specific surface area,which ensures efficient capture of v.rions,as confirmed by ELISA analysis,dynamic light scattering measurements and transmission electron microscopy *** results obtained indicate the great potential of using PSi NPs as univ.rsal v.ral sorbents and disinfectants for the detection and treatment of v.ral diseases.

关键词： Pathogenic human v.ruses Porous silicon nanoparticles v.rus Antiv.ral activ.ty v.rucide