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Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

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Regenerative Biomaterials 2021年第1期8卷 73-82页

作者： Isabel Pereira Jose Eduardo Pereira Luis Maltez alexandra rodrigues Catarina rodrigues Manuela Oliveira Dina MSilva Ana Rita Caseiro Justina Prada Ana Colette Mauricio Jose Domingos Santos Miguel Gama CEB Centre of Biological EngineeingUniversity of MinhoCampus de GualtarBraga 4710-057Portugal CECAV Animal and Veterinary Research CentreUniversity of Trias-os-Montes e Alto DouroVila Real 5001-801Portugal Department of Veterinary Sciences University of Tras-os-Montes e Alto DouroVila Real 5001-801Portugal Bios ckin Molecular and Cell Therapies S.A.Laboratorio CriovidaTecMaiaRua Engenheiro Frederico Ulrich 2650Moreira da Maia 4470-605Portugal Departamento de Clinicas Veterinarias Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreiran°228Porto 4050-313Portugal Centro de Estudos de Ciencia Animal(CECA) Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IApartado 55142Porto 4051-401 Portugal Centro de Investigaqao Vasco da Gama(CIVG)/Escola Universitaria Vasco da Gama(EUVG) Avenida Jose R.Sousa Femandesn°197 LordemaoCoimbra 3020-210Portugal REQUIMTE/LAQV Departamento de Engenharia Metalurgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRua Dr Roberto FriasPorto 4200-495Portugal

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular *** this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established ***,in situ forming hydrogels have arisen as a new IBS *** in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive *** this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and *** results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation *** multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the *** bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.

关键词： polysaccharide injec table hydrogel granular ceramics Bonelike' bone regen eration calvarial defect

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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Pressure-induced structural changes cause large enhancement of photoluminescence in halide perovskites: a quantitative relationship

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National Science Review 2021年第9期8卷 13-14页

作者： alexandra Navrotsky Center for Materials of the Universe Arizona State University

Halide perovskites containing both organic and inorganic cations are receiving extensive attention for their promising optoelectronic properties, including photoluminescence (PL)[1,2]. Tuning these properties for specific applications and designing and synthesizing perovskites with optimized properties are major goals of materials science. These goals will be achieved faster and more economically by harnessing a fundamental understanding of structure–property relations, rather than by random searches for better materials. Chemical composition,temperature and pressure are the major‘knobs’ one can turn to adjust properties such as conductivity and bandgap[1,3]. Each of these variables has the potential to change interatomic distances,

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Liquid biopsies in myeloid malignancies

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Cancer Drug Resistance 2019年第4期2卷 1044-1061页

作者： Bilal Abdulmawjood Catarina Roma-rodrigues alexandra R.Fernandes Pedro V.Baptista UCIBIO Department of Life SciencesFaculdade de Ciências e TecnologiaUniversidade NOVA de LisboaCampus CaparicaCaparica 2829-516Portugal

Hematologic malignancies are the most common type of cancer affecting children and young adults,and encompass diseases,such as leukemia,lymphoma,and myeloma,all of which impact blood associated tissues such as the bone marrow,lymphatic system,and blood *** diagnostics of these malignancies relies heavily on the use of bone marrow samples,which is painful,debilitating,and not free from risks for leukemia *** biopsies are based on minimally invasive assessment of markers in the blood(and other fluids)and have the potential to improve the efficacy of diagnostic/therapeutic strategies in leukemia patients,providing a useful tool for the real time molecular profiling of *** most promising noninvasive biomarkers are circulating tumor cells,circulating tumor DNA,microRNAs,and ***,we discuss the role of assessing these circulating biomarkers for the understanding of tumor progression and metastasis,tumor progression dynamics through treatment and for follow-up.

关键词： Liquid biopsy circulating tumor cells circulating tumor DNA exosomes microRNAs leukemia

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“Pachyostosis” in aquatic amniotes: a review

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Integrative Zoology 2009年第4期4卷 325-340页

作者： alexandra HOUSSAYE Department of Earth History Museum of Natural HistoryParisFrance

During the course of amniote evolution,numerous taxa secondarily adapted to an aquatic *** appears that many of these taxa primitively display“pachyostosis,”an osseous specialization characterized by an increase in bone compactness and/or *** term“pachyostosis”is used in morphological and histological descriptions to describe what in fact corresponds to different *** aim of this paper is to present the current state of knowledge relative to this adaptation among aquatic *** the taxa that have returned to an aquatic environ-ment are ***,their degree of adaptation to the marine environment,their life environment,and the nature of their“pachyostotic”pattern,when present,are *** inventory enables the evaluation of the current quality of the data relative to this specialization and provides an indication of the work that remains to be *** functional consequences of“pachyostosis,”and notably its importance for buoyancy control in the context of hydrostatic regulation of the body trim,are discussed and opposed to the requirement of improved swimming abilities in the case of a hydrodynamic mode of trim *** are posed about the significa-tion of the polymorphism displayed by this specialization between different taxa,different specimens of the same taxon and different bones of the same specimen,and the problem of quantification of pachyostosis is discussed.

关键词： buoyancy control life environment locomotion “pachyostosis”sensu lato polymorphism.

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Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy

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World Journal of Gastroenterology 2016年第36期22卷 8234-8241页

作者： alexandra Grosse Institute of Clinical Pathology University Hospital Zurich

Amebiasis is uncommon in developed countries. Several case reports in the literature emphasize that both the presenting symptoms and the radiological findings of colonic amebiasis closely resemble more common conditions, such as idiopathic inflammatory bowel disease and gastro-intestinal malignancy. We describe a unique case of colonic amebiasis(amebomas) coexisting with signet-ring cell carcinoma of the ileocecal valve, the cecum and the appendix. Endoscopically, the ulcerated tumor was indistinguishable from the ulcerations and pseudotumors(amebomas) detected in the ascending colon. Histological examination of biopsy specimens revealed the pathognomonic features of protozoa with ingested erythrocytes in combination with signet-ring cell infiltration. The author concludes that amebiasis may not only mimic carcinoma but, rarely, may coexist with carcinoma in the same patient. Clinicians and pathologists should be aware of this possibility in order not to delay diagnosis and treatment of malignant disease.

关键词： Colonic amebiasis Histopathology Parasitic disease Colorectal carcinoma Colonoscopy

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Pandemic prevention and personality psychology: Gender differences in preventive health behaviors during COVID-19 and the roles of agreeableness and conscientiousness

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Journal of Safety Science and Resilience 2022年第1期3卷 87-91页

作者： Tobias Otterbring alexandra Festila Department of Management University of AgderKristiansandNorway Freelancer CopenhagenDenmark

One of the greatest public health crises in recent times,the COVID-19 pandemic,has come with a myriad of challenges in terms of health communication and public cooperation to prevent the spread of the ***-derstanding which are the key determinants that make certain individuals more cooperative is key in effectively tackling pandemics and similar future *** the present study(N=800),we investigated whether gen-der differences in compliance with preventive health behaviors(PHB)at the onset of the COVID-19 pandemic could be established,and,if so,whether the personality traits of agreeableness and conscientiousness could help explain this presumed *** with our theorizing,we found women to score higher than men on agreeableness and conscientiousness,and to be more willing to comply with a set of ***,both per-sonality traits were found to mediate the gender-compliance *** means that women’s greater compliance levels with PHB could,at least in part,be attributed to their higher agreeableness and conscientiousness scores.A greater understanding of the determinants of PHB in terms of gender and associated personality traits may help identify options for developing more effective communication campaigns,both in terms of communication channel selection and message content.

关键词： Covid-19 Pandemics Gender,personality Psychology Agreeableness Conscientiousness Preventive health behaviors

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Lineage plasticity-mediated therapy resistance in prostate cancer

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Asian Journal of Andrology 2019年第3期21卷 241-248页

作者： alexandra M Blee Haojie Huang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine Rochester MN 55905 USA Biochemistry and Molecular Biology Graduate Program Mayo Clinic Graduate School of Biomedical Sciences Rochester MN 55905 USA Department of Urology Mayo Clinic College of Medicine Rochester MN 55905 USA Mayo Clinic Cancer Center Mayo Clinic College of Medicine Rochester MN 55905 USA

Therapy resistance is a significant challenge for prostate cancer treatment in clinic. Although targeted therapies such as androgen deprivation and androgen receptor (AR) inhibition are effective initially, tumor cells eventually evade these strategies through multiple mechanisms. Lineage reprogramming in response to hormone therapy represents a key mechanism that is increasingly observed. The studies in this area have revealed specific combinations of alterations present in adenocarcinomas that provide cells with the ability to transdifferentiate and perpetuate AR-independent tumor growth after androgen-based therapies. Interestingly, several master regulators have been identified that drive plasticity, some of which also play key roles during development and differentiation of the cell lineages in the normal prostate. Thus, further study of each AR-independent tumor type and understanding underlying mechanisms are warranted to develop combinational therapies that combat lineage plasticity in prostate cancer.

关键词： lineage plasticity neuroendocrine prostate cancer therapy resistance transdifferentiation

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Imposing temporal consistency on deep monocular body shape and pose estimation

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Computational Visual Media 2023年第1期9卷 123-139页

作者： alexandra Zimmer Anna Hilsmann Wieland Morgenstern Peter Eisert Fraunhofer Heinrich-Hertz-Institut 10587 BerlinGermany Technische Universit¨at Berlin 10623 BerlinGermany Humboldt Universit¨at zu Berlin 10117 BerlinGermany

Accurate and temporally consistent modeling of human bodies is essential for a wide range of applications,including character animation,understanding human social behavior,and AR/VR *** human motion accurately from a monocular image sequence remains challenging;modeling quality is strongly influenced by temporal consistency of the captured body *** work presents an elegant solution to integrating temporal constraints during *** increases both temporal consistency and robustness during *** detail,we derive parameters of a sequence of body models,representing shape and motion of a *** optimize these parameters over the complete image sequence,fitting a single consistent body shape while imposing temporal consistency on the body motion,assuming body joint trajectories to be linear over short *** approach enables the derivation of realistic 3D body models from image sequences,including jaw pose,facial expression,and articulated *** experiments show that our approach accurately estimates body shape and motion,even for challenging movements and ***,we apply it to the particular application of sign language analysis,where accurate and temporally consistent motion modelling is essential,and show that the approach is well-suited to this kind of application.

关键词： motion capture surface reconstruction face modeling body model estimation

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Optimisation of zeolite LTA synthesis from alum sludge and the influence of the sludge source

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Journal of Environmental Sciences 2021年第1期33卷 130-142页

作者： alexandra Rozhkovskaya Jay Rajapakse Graeme J.Millar School of Civil and Enuironmental Engineering Science and Engineering FacultyQueensland University oTechnologyBrisbaneQueensland 4000Australia Institute for Future Environments and School of Mechanical Medical and Process EngineeringQueensland Uniuersity of TechnologyBrisbaneQueensland 4000Australia

Generation of alum sludge(AS)at drinking water treatment plants represents an environmental liability and adds to the cost of water ***,this study explored the feasibility of using low and high carbon containing alum sludge from two water treatment plants to synthesize zeolite *** hypothesis was that zeolite LTA synthesis was dependant upon alum sludge source and that a range of strategies may be required to optimize zeolite *** characteristics such as morphology,phase composition,crystallinity,and particle size distribution were recorded."One pot"hydrothermal synthesis of precursor gel with molar composition 4.2 Na2O:Al2O3:1.2 SiO_(2):168 H2O at 80℃ for 3 hr resulted in 25 and 46 wt.%zeolite LTA from high and low carbonaceous sludge,*** to hydrothermal reaction stage it was discovered that ageing of the gel,addition of zeolite LTA seeds,ultrasonic treatment and calcination all promoted zeolite LTA *** of the alum sludge at 700℃ for 2 hr before hydrothermal synthesis resulted in particle size reduction and the highest amount of crystalline zeolite LTA:79 wt.%from low carbon sludge and 65 wt.%from high carbon ***,the zeolite crystallinity reported in this study was the higher than previous studies on this *** outlined approach may allow value adding of alum waste and produce a commodity which could be used locally by the water treatment plant as a water softener.

关键词： Alum sludge Zeolite LTA Ultrasonic Ageing Waste conversion

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