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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： marcos J.Arauzo-Bravo Daniela Gerovska matthias Schwab alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline Edwards Sarah Jeffrey Tamara may Nicole J.Rinehart Lisa m.barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar *** was a secondary ***: Actual(Test of Gross motor Development) and perceived OC skills(Pictorial Scale of Perceived movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was ***: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

Numerical Determination of Stress Fields of and Forces on Line Dislocations in Anisotropic multilayer Structures

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Numerical Determination of Stress Fields of and Forces on Li...

Lineage plasticity-mediated therapy resistance in prostate cancer

1996年中国青年学者物理学讨论会

作者： marun J.Abbudi David m.barnett Division of Applied mechanics Department of mechanical Engineering Stanford UniversityStanfordCA 94305-4040USA Division of Applied mechanics Department of mechanical Engineering Stanford UniversityStanfordCA 94305-4040USA

＜正＞most previous studies have dealt only with elastically isotropic layers;however,since the majority of materials used in high technology applicatins are anisotropic,the need to account for anisotropic effects becomes *** effects are dealt with in complete generality in the present work using the Stroh formalism coupled with a Fast Fourier Transform *** method is easily implemented for a dislocated multilayered structure,although in this work we present only a numerical example for the Peach- Koehler force on dislocation in a single thin film on a substrate.

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Asian Journal of Andrology 2019年第3期21卷 241-248页

作者： alexandra m Blee Haojie Huang Department of Biochemistry and molecular Biology Mayo Clinic College of Medicine Rochester MN 55905 USA Biochemistry and molecular Biology Graduate Program Mayo Clinic Graduate School of Biomedical Sciences Rochester MN 55905 USA Department of Urology Mayo Clinic College of Medicine Rochester MN 55905 USA mayo Clinic Cancer Center Mayo Clinic College of Medicine Rochester MN 55905 USA

Therapy resistance is a significant challenge for prostate cancer treatment in clinic. Although targeted therapies such as androgen deprivation and androgen receptor (AR) inhibition are effective initially, tumor cells eventually evade these strategies through multiple mechanisms. Lineage reprogramming in response to hormone therapy represents a key mechanism that is increasingly observed. The studies in this area have revealed specific combinations of alterations present in adenocarcinomas that provide cells with the ability to transdifferentiate and perpetuate AR-independent tumor growth after androgen-based therapies. Interestingly, several master regulators have been identified that drive plasticity, some of which also play key roles during development and differentiation of the cell lineages in the normal prostate. Thus, further study of each AR-independent tumor type and understanding underlying mechanisms are warranted to develop combinational therapies that combat lineage plasticity in prostate cancer.

关键词： lineage plasticity neuroendocrine prostate cancer therapy resistance transdifferentiation

Engineering mesenchymal stromal/stem cell-derived extracellular vesicles with improved targeting and therapeutic efficiency for the treatment of central nervous system disorders

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Neural Regeneration Research 2020年第12期15卷 2235-2236页

作者： alexandra m.Iavorovschi Aijun Wang Surgical Bioengineering Laboratory Department of SurgerySchool of MedicineUniversity of California-DavisInstitute for Pediatric Regenerative MedicineShriners Hospitals for Children-Northern CaliforniaSacramentoCAUSA Department of Biomedical Engineering University of CaliforniaDavis School of EngineeringDavisCAUSA

Treatment for central nervous system(CNS)disorders is known to be limited by the low regenerative potential of neurons,and thus neurodegenerative insults became known as nearly irreversible *** recovery for acquired CNS disorders,such as spinal cord injury(SCI),traumatic brain injury,ischemic stroke,Alzheimer’s disease,Parkinson’s disease,multiple sclerosis(mS),and for congenital CNS abnormalities,such as spina bifida,is not spontaneous and effective treatments are limited to *** in the past decades has proven the regenerative potential of stem cells,especially that of mesenchymal stromal/stem cells(mSCs)from various origins,such as bone marrow,placenta,and adipose tissue.

关键词： disorders treatment Alzheimer

Numerical Determination of Stress Fields of and Forces on Line Dislocations in Anisotropic multilayer Structures

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电子显微学报 1997年第4期 183-184页

作者： marun J.Abbudi \ L.Y.Pang\ David m.barnett (Division of Applied mechanics, Department of mechanical Engineering, Stanford University, Stanford, CA 94305 4040, USA)

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关键词： Stress Fields Determination

Effect of plastic deformation on microstructure and thermoelectric properties of mg_(2)Sn alloys

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Journal of magnesium and Alloys 2021年第1期9卷 123-129页

作者： Rameshkumar Varma Sitarama Kada matthew barnett Institute for Frontier materials Deakin UniversityGeelongVictoriaAustralia

In the present work,the effect of deformation on microstructure and thermoelectric properties of mg 2 Sn alloys having excess magnesium concentrations is *** cast alloys were prepared using radio-frequency(RF)induction melting under an argon *** alloys were thermo-mechanically processed via compression at different temperatures to various true *** room temperature,the alloys failed at a true strain of∼13%.However,at elevated temperatures,the alloys were observed to be highly *** alloys compressed at 673 K to a true strain of 1,a prominent substructure *** subgrain size was∼3-5μ*** is believed that the substructure arose from the action of dynamic *** deformation,the thermoelectric performance of alloy prepared with 6.7 wt.%excess mg was improved compared to the as cast *** can be ascribed to a reduction in the thermal conductivity due to phonon scattering at grain boundaries.

关键词： magnesium Thermoelectric Deformation Grain size

Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： alexandra Chovsepian Laura Empl Florence m.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

microbial community coalescence and nitrogen cycling in simulated mortality decomposition hotspots

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Ecological Processes 2023年第1期12卷 608-624页

作者： Sarah W.Keenan alexandra L.Emmons Jennifer m.DeBruyn Department of Geology and Geological Engineering South Dakota School of Mines and Technology501 East St.Joseph StreetRapidSD 57701USA Department of Anthropology University of TennesseeKnoxvilleTNUSA Department of Biosystems Engineering and Soil Science University of Tennessee2506 E.J.Chapman DriveKnoxvilleTN 37996USA

Background The pulsed introduction of dead plant and animal material into soils represents one of the primary mechanisms for returning organic carbon(C)and nitrogen(N)compounds to biogeochemical *** of animal carcasses provides a high C and N resource that stimulates indigenous environmental microbial communities and introduces non-indigenous,carcass-derived microbes to the ***,the dynamics of the coalesced microbial communities,and the relative contributions of environment-and carcass-derived microbes to C and N cycling are *** test whether environment-derived,carcass-derived,or the combined microbial communities exhibited a greater influence on C and N cycling,we conducted controlled laboratory experiments that combined carcass decomposition fluids and soils to simulate carcass decomposition *** selectively sterilized the decomposition fluid and/or soil to remove microbial communities and create different combinations of environment-and carcass-derived communities and incubated the treatments under three temperatures(10,20,and 30℃).Results Carcass-derived bacteria persisted in soils in our simulated decomposition scenarios,albeit at low *** communities had higher respiration rates at 10 and 30℃ compared to soil or carcass communities ***,at higher temperatures,mixed communities had reduced diversity,but higher respiration,suggesting functional *** communities treatments also provided evidence that carcass-associated microbes may be contributing to ammonification and denitrification,but that nitrification is still primarily carried out by native soil *** Our work yields insight into the dynamics of microbial communities that are coalescing during carcass decomposition,and how they contribute to recycling carcasses in terrestrial ecosystems.

关键词： Carcass decomposition microcosm Nitrogen Carbon Biogeochemical cycling Coalescence

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