Microglial depletion and repopulation:a new era of regenerative medicine?

作     者：Alexandra M.Barnett Fulton T.Crews Leon G.Coleman Alexandra M.Barnett;Fulton T.Crews;Leon G.Coleman

作者机构：Bowles Center for Alcohol StudiesThe University of North Carolina at Chapel HillSchool of MedicineChapel HillNCUSA Department of PharmacologyThe University of North Carolina at Chapel HillSchool of MedicineChapel HillNCUSA Department of PsychiatryThe University of North Carolina School of MedicineChapel HillNCUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第6期

页      面：1204-1205页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by the National Institutes of Health,National Institute on Alcoholism and Alcohol Abuse(P60AA011605-Fulton Crews,U01AA020023-Fulton Crews,U24AA020024-Fulton Crews,U54AA019767-Fulton Crews,T32AA007573-Fulton Crews K08AA024829-Leon G Coleman,Jr K08AA024829S1-Leon G Coleman,Jr,and the Bowles Center for Alcohol Studies) 

主　　题：al. pathology depletion 

摘      要：Microglia have multiple functions and phenotypes that can prevent or worsen *** depletion and repopulation methods provide a promising technique for understanding microglial *** utility as therapeutic modalities is now under *** resident immune cells in the central nervous system(CNS),microglia maintain the local environment and promote neuronal ***,persistent proinflammatory signaling due to aberrant microglial activation can be *** is seen in settings such as traumatic brain injury(TBI)(Henry et al.,2020),stroke(Li et al.,2017),and alcohol use disorder(AUD)(Coleman et al.,2020),when the loss of homeostatic control results in persistent proinflammatory signaling that contributes to ongoing neuropathology(Figure 1).Thus,selective replacement of chronically proinflammatory-activated microglia could improve functional outcomes.