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Evaluating a combined bowel preparation for small-bowel capsule endoscopy:a prospective randomized–controlled study

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Gastroenterology Report 2020年第1期8卷 31-35,I0001,I0002页

作者： Stephanie L.hansel Joseph A.Murray Jeffrey A.alexander David h.Bruining Mark V.Larson Thomas F.Mangan Ross A.Dierkhising Ann E.Almazar Elizabeth Rajan Division of Gastroenterology and hepatology Mayo ClinicRochesterMNUSA Division of Biomedical Statistics and Informatics Mayo ClinicRochesterMNUSA

Background:Capsule endoscopy(CE)is frequently hindered by intra-luminal *** aim was to determine whether a combination bowel preparation would improve small-bowel visualization,diagnostic yield,and the completion rate of ***:Single-blind,prospective randomized–controlled study of outpatients scheduled for ***-preparation subjects ingested 2 L of polyethylene glycol solution the night prior to CE,5mL simethicone and 5mg metoclopramide 20 minutes prior to CE and laid in the right lateral position 30 minutes after swallowing *** had no solid food after 7 *** night prior to CE and no liquids 4 hours prior to *** completed a satisfaction *** readers completed a small-bowel-visualization ***:Fifty patients were prospectively enrolled(56%female)with a median age of 54.4 years and 44 completed the study(23 patients in the control group and 21 in the preparation group).There was no significant difference between groups on quartile-based small-bowel visualization(all P>0.05).There was no significant difference between groups in diagnostic yield(P=0.69),mean gastric(P=0.10)or small-bowel transit time(P=0.89).The small-bowel completion rate was significantly higher in the preparation group(100%vs 78%;P=0.02).Bowel-preparation subjects reported significantly more discomfort than controls(62%vs 17%;P=0.01).Conclusions:Combined bowel preparation did not improve small-bowel visualization but did significantly increase patient *** CE completion rate improved in the preparation group but the diagnostic yield was *** on our findings,a bowel preparation prior to CE does not appear to improve CE performance and results in decreased patient satisfaction(***,***01243736).

关键词： bowel preparation capsule endoscopy small-bowel visualization patient satisfaction

Clustering of Pathogen-Response Genes in the Genome of Arabidopsis thaliana

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Journal of Integrative Plant Biology 2011年第10期53卷 824-834页

作者： Olga A.Postnikova Natalia Y.Minakova alexander M.Boutanaev Lev G.Nemchinov United States Department of Agriculture Agricultural Research ServicePlant Sciences InstituteMolecular Plant Pathology Laboratory Institute of Basic Biological Problems Russian Academy of Sciences

Previously, we used heterologous expressed sequence tag （EST） mapping to generate a profile of 4 935 pathogen-response genes of Arabidopsis thaliana. In this work, we performed a computer analysis of this profile, revealing 1594 non-homologous clustered genes distributed among all A. thafiana chromosomes, whose co-regulation may be related to host responses to pathogens. To supplement computer data, we arbitrarily selected two clusters and analyzed their expression levels in A. thaliana ecotypes Col-0 and C24 during infection with the yellow strain of Cucumber mosaic virus CMV（Y）. Ecotype Col-0 is susceptible to CMV（Y）, whereas C24 contains the dominant resistance gene RCY1. Upon infection with CMV（Y）, all clustered genes were significantly activated in the resistant ecotype C24. In addition, we demonstrated that posttranslational histone modifications associated with trimethylation of histone h3 lysine 27 are most likely involved in regulation of several cluster genes described in this study. Overall, our experiments indicated that pathogen-response genes in the genome of A. thaliana may be clustered and co-regulated.

关键词： CMV h3K27me3 heterologous EST mapping clustering of defense-related genes.

Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

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Chinese Chemical Letters 2015年第4期26卷 464-468页

作者： alexander K.Wolf Yu Qin Terry C.Major Mark E.Meyerhoff Department of Chemistry University of Michigan Department of Chemistry Nanjing University Department of Surgery University of Michigan

In this work, nitric oxide （NO） release coatings designed for intravenous amperometric glucose sensors are optimized through the use ofa polylactic acid （PLA） layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An Elast-Eon E2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor＇s linear detection range towar. glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.

关键词： Nitric oxide release coatingsGlucose sensorsPolylactic acid layerQuantitative glucose measurements

MINOCA Resulting from Coronary Spasm Confirmed Angiographically without Ergonovine Stimulation: A Case Report

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World Journal of Cardiovascular Diseases 2022年第11期12卷 473-480页

作者： Serigne Cheikh Tidiane Ndao Mame Madjiguène Ka Waly Niang Mboup Khadidiatou Dia Djibril Marie Ba Demba war. Balde Mouhamed Chérif Mboup Cardiology Department H&ocirc pital Principal Dakar Dakar Senegal Cardiology Department H&ocirc pital Militaire de Ouakam Dakar Senegal

Introduction: Myocardial infarction with nonobstructive coronary arteries disease (MINOCA) encompasses a heterogeneous group of disorders. Multimodality imaging is crucial to figure out the underlying mechanism. Coronary artery spasm is a common cause of MINOCA and might be difficult to identify. Case Presentation: A 43-year-old male with no cardiovascular risk factor presented with prolonged acute chest pain at 5 am that resolved spontaneously. On admission, he was asymptomatic and clinical findings were unremarkable. The electrocardiogram showed an anterolateral negative T wave. The troponin was positive. Coronary angiography (CA) revealed a moderate lesion of the proximal left anterior descending (LAD) coronary artery. he was treated with dual antiplatelet therapy, statin, and beta-blocker with a favourable hospital course. One week later, he presented chest pain recurrences with anterior ST-segment elevation. CA, without intra-radial nitrate, owing to a vasospasm suspicion, showed a sub-occlusion of the proximal LAD which resolved after intracoronary nitrates. Chest pain and ST-segment elevation then disappeared. he remained asymptomatic and was discharged on CCB (calcium channel blocker), long-acting nitrates dual antiplatelet and statin. Cardiac magnetic resonance (CMR) demonstrated an ejection fraction (EF) of 45% with anterior ischemia. Conclusion: Our case is about a common cause of MINOCA, namely coronary spasm, diagnosed by coronary angiogram without provocative test.

关键词： MINOCA Coronary Spasm Case Report

Efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder and nocturia, current clinical features and outcomes: A systematic review

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Asian Journal of Urology 2022年第1期9卷 27-34页

作者： Bara Barakat Knut Franke Matthias May Ulrich Gauger Thomas-alexander Vogeli hospital Viersen Department of Urology and Pediatric UrologyViersenGermany hospital St.Elisabeth Department of UrologyStraubingGermany Institute for Medical Statistics BerlinGermany University hospital RWTh Aachen Department of Urology and Pediatric UrologyAachenGermany

Objective To evaluate the efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder(OAB)and *** A selective database search was conducted to validate the effectiveness of desmopressin in patients with OAB and *** Reporting Items for Systematic Reviews and Meta-Analyses guidelines were *** meta-analysis included 378 women(five studies)with *** clinical outcomes and adverse events were *** The treatment strategy of all the studies included can be divided into three categories:(1)The effect of desmopressin compared with baseline,(2)desmopressin compared with placebo,and(3)desmopressin and anticholinergic combination versus desmopressin *** was a significant(50%)reduction in nocturia and urgency episodes after using desmopressin *** desmopressin and anticholinergic led to a decrease in the frequency of nocturia voids when only using anticholinergic(65%vs.33.2%).The time increased in the middle to the first nightly voids in the combination arm(65.11 min;p=0.045).The mean incidence(standard deviation)of leak-free episodes was higher under desmopressin than under placebo in the first 4 h(62%[35%]vs.48%[40%])and in the first 8 h(55%[37%]vs.40%[41%]).The safety profile was comparable between *** Available data indicate that desmopressin is efficacious in significantly reducing nighttime urine production,episodes of nocturia,and urgency *** affectivity of the combination therapy was very high with least side effects for the treatment of OAB/nocturnal polyuria.

关键词： Overactive bladder Nocturia Desmopressin Urinary urgency Lower urinary tract

Reducing Threats by Using Bayesian Networks to Prioritize and Combine Defense in Depth Security Measures

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Journal of Information Security 2020年第3期11卷 121-137页

作者： Rodney alexander hutchinson Community College Hutchinson Kansas USA

Studied in this article is whether the Bayesian Network Model (BNM) can be effectively applied to the prioritization of defense in-depth security tools and procedures and to the combining of those measures to reduce cyber threats. The methods used in this study consisted of scanning 24 peer reviewed Cybersecurity Articles from prominent Cybersecurity Journals using the Likert Scale Model for the article’s list of defense in depth measures (tools and procedures) and the threats that those measures were designed to reduce. The defense in depth tools and procedures are then compared to see whether the Likert scale and the Bayesian Network Model could be effectively applied to prioritize and combine the measures to reduce cyber threats attacks against organizational and private computing systems. The findings of the research reject the h0 null hypothesis that BNM does not affect the relationship between the prioritization and combining of 24 Cybersecurity Article’s defense in depth tools and procedures (independent variables) and cyber threats (dependent variables).

关键词： Information Assurance Bayesian Networks Influence Diagrams Defense in Depth Information Technology Network Security Cybersecurity

Bulbocavernosus muscle area measurement： a novel method to assess androgenic activity

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Asian Journal of Andrology 2014年第4期16卷 618-622页

作者： Ali A Dabaja Matthew S Wosnitzer Anna Mielnik alexander Bolyakov Peter N Schlegel Darius A Paduch Department of Urology and Reproductive Medicine Weill Cornell Medical College New York USA.

Serum testosterone does not correlate with androgen tissue activity, and it is critical to optimize tools to evaluate such activity in males. Ultrasound measurement of bulbocavernosus muscle （BCM） was used to assess the relationship between the number of CAG repeats （CAGn） in the androgen receptor （AR） and the BCM size; the changes in the number of CAGn over age were also evaluated. Transperineal ultrasound measurement of the BCM was also performed. AR CAGn were determined by high performance liquid chromatography, and morning hormone levels were determined using immunoassays. Forty-eight men had CAG repeat analysis. Twenty-five were 〈30 years of age, mean 23.7 years （s.d, = 3.24） and 23 were 〉45 years of age, mean 53years （s.d. = 5.58）. The median CAGn was 21 （13-29）. BCM area was greater when the number of CAGn were 〈18 as compared to the number of CAGn 〉24 （P= 0.04）. There was a linear correlation between the number of CAGn and the BCM area R^2= 16% （P= 0.01）. In the 45 to 65-years-old group, a much stronger negative correlation （R^2 = 29%, P= 0.01） was noticed. In the 19 to 29-years-old group, no such correlation was found （R2 = 4%, P = 0.36）. In older men, the number of CAGn increased with age （R^2 = 32%, P= 0.01）. The number of CAGn in the AR correlates with the area of the BCM. Ultrasound assessment of the BCM is an effective surrogate to evaluate end-organ activity of androgens. The number of CAGn may increase with age.

关键词： age androgen activity androgen receptor androgen sensitivity bulbocavernosus muscle CAG repeats

Interaction between Equatorial Plasma Bubbles and a Medium-Scale Traveling Ionospheric Disturbance,observed by OI 630 nm airglow imaging at Bom Jesus de Lapa,Brazil

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Earth and Planetary Physics 2021年第5期5卷 397-406页

作者： Cristiano Max Wrasse Cosme Alexandre Oliveira Barros Figueiredo Diego Barros hisao Takahashi alexander JoséCarrasco Luiz Fillip Rodrigues Vital Láysa Cristina Araujo Resende Fábio Egito Geângelo de Matos Rosa Antonio hélder Rodrigues Sampaio Space Weather Division National Institute for Space Research(INPE)São Josédos CamposBrazil University of Los Andes(ULA) MéridaVenezuela State Key Laboratory of Space Weather Beijing 100190China Federal University of Campina Grande(UFCG) Campina GrandeBrazil Federal Institute for Education Science and Technology Baiano(IF Baiano)Bom Jesus da LapaBrazil

OI 630.0 nm airglow observations,from a new observatory at Bom Jesus de Lapa,were used to study the interaction between EPBs(Equatorial Plasma Bubbles)and the MSTID(Medium-Scale Traveling Ionospheric Disturbance)over the Northeast region in *** the night of September 16 to 17,2020,an EPB was observed propagating eastwar.,in an apparent fossil stage,until it interacted with a dark band electrified MSTID(e MSTID).After the interaction,four EPBs merged,followed by an abrupt southwar. development and *** of the data suggests that an eastwar. polarization electric field,induced by the dark band e MSTID,forced the EPB into an upwar. drift,growing latitudinally along the magnetic field lines and then bifurcating.

关键词： Equatorial Plasma Bubbles Medium-Scale Traveling Ionospheric Disturbance ionosphere thermosphere EPB and MSTID interaction

Using Linear Regression Analysis and Defense in Depth to Protect Networks during the Global Corona Pandemic

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Journal of Information Security 2020年第4期11卷 261-291页

作者： Rodney alexander hutchinson Community College Hutchinson Kansas USA

The purpose of this research was to determine whether the Linear Regression Analysis can be effectively applied to the prioritization of defense-in-depth security tools and procedures to reduce cyber threats during the Global Corona Virus Pandemic. The way this was determined or methods used in this study consisted of scanning 20 peer reviewed Cybersecurity Articles from prominent Cybersecurity Journals for a list of defense in depth measures (tools and procedures) and the threats that those measures were designed to reduce. The methods further involved using the Likert Scale Model to create an ordinal ranking of the measures and threats. The defense in depth tools and procedures were then compared to see whether the Likert scale and Linear Regression Analysis could be effectively applied to prioritize and combine the measures to reduce pandemic related cyber threats. The results of this research reject the h0 null hypothesis that Linear Regression Analysis does not affect the relationship between the prioritization and combining of defense in depth tools and procedures (independent variables) and pandemic related cyber threats (dependent variables).

关键词： Information Assurance Defense in Depth Information Technology Network Security Cybersecurity Linear Regression Analysis Pandemic