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Understanding neutralising antibodies against SARS-CoV-2 and theirimplications in clinical practice

Military Medical Research 2022年第2期9卷 215-230页

作者： Natalie Yan-Lin pang Alexander shao-rong Pang Vincent T.Chow De-Yun Wang Yong Loo Lin School of Medicine National University of SingaporeSingapore 119228Singapore Department of Microbiology and Immunology National University of SingaporeScience Drive 2Singapore 117545Singapore Infectious Diseases Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore Department of Otolaryngology Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a newly identified member of the coronavirus family that has caused the coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2has disrupted the lives and livelihoods of millions worldwide. As of 23 August 2021, a total of 211,373,303 COVID-19cases have been confirmed globally with a death toll of 4,424,341. A strong understanding of the infection pathway of SARS-CoV-2, and how our immune system responds to the virus is highly pertinent for guiding the development and improvement of effective treatments. In this review, we discuss the current understanding of neutralising antibodies(NAbs) and their implications in clinical practice. The aspects include the pathophysiology of the immune response,particularly humoral adaptive immunity and the roles of NAbs from B cells in infection clearance. We summarise the onset and persistence of IgA, IgM and IgG antibodies, and we explore their roles in neutralising SARS-CoV-2, their persistence in convalescent individuals, and in reinfection. Furthermore, we also review the applications of neutralising antibodies in the clinical setting—from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion.

关键词： Severe acute respiratory syndrome coronavirus Coronavirus disease 2019 Neutralising antibodies Persistence Spike glycoprotein Receptor-binding domain B cells T cells Convalescent plasma

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Active oxygen center in oxidative coupling of methane on La_(2)O_(3) catalyst

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Journal of Energy Chemistry 2021年第9期30卷 649-659页

作者： Xiaohong Zhou Yaoqi pang Zebang Liu Evgeny I.Vovk alexander Pvan Bavel Shenggang Li Yong Yang School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shell Technology Centre Amsterdam P.O.Box 380001030 BN AmsterdamNetherlands CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

La_(2)O_(3) catalyzed oxidative coupling of methane(OCM) is a promising process that converts methane directly to valuable C_(2)(ethylene and ethane) products. Our online MS transient study results indicate that pristine surface without carbonate species demonstrates a higher selectivity to C_(2) products, and a lower light-off temperature as well. Further study is focused on carbonate-free La_(2)O_(3) catalyst surface for identification of active oxygen species associated with such products behavior. XPS reveals unique oxygen species with O 1 s binding energy of 531.5 e V correlated with OCM catalytic activity and carbonates removal. However, indicated thermal stability of this species is much higher than the surface peroxide or superoxide structures proposed by earlier computation models. Motivated by experimental results,DFT calculations reveal a new more stable peroxide structure, formed at the subsurface hexacoordinate lattice oxygen sites, with energy 2.18 e V lower than the previous models. The new model of subsurface peroxide provides a perspective for understanding of methyl radicals formation and C_(2) products selectivity in OCM over La_(2)O_(3) catalyst.

关键词： In-situ XPS Online MS DFT Oxidative coupling of methane High C_(2)selectivity Active oxygen center La_(2)O_(3)catalyst

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Synthesis and dissociation of soliton molecules in parallel optical-soliton reactors

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Light(Science & Applications) 2021年第7期10卷 1289-1303页

作者： Wenbin He Meng pang Dung-Han Yeh Jiapeng Huang Philip.St.J.Russell Max Planck Institute for the Science of Light Staudtstrasse 2 91058 ErlangenGermany Department of Physics Friedrich-Alexander-UniversitätStaudtstrasse 291058 ErlangenGermany State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China

Mode-locked lasers have been widely used to explore interactions between optical solitons,including bound-soliton states that may be regarded as“photonic molecules”.Conventional mode-locked lasers normally,however,host at most only a few solitons,which means that stochastic behaviours involving large numbers of solitons cannot easily be studied under controlled experimental conditions.Here we report the use of an optoacoustically mode-locked fibre laser to create hundreds of temporal traps or“reactors”in parallel,within each of which multiple solitons can be isolated and controlled both globally and individually using all-optical methods.We achieve on-demand synthesis and dissociation of soliton molecules within these reactors,in this way unfolding a novel panorama of diverse dynamics in which the statistics of multi-soliton interactions can be studied.The results are of crucial importance in understanding dynamical soliton interactions and may motivate potential applications for all-optical control of ultrafast light fields in optical resonators.

关键词： optical soliton solitons

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格列宾希科夫和他的满语、民族志与萨满教研究

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吉林师范大学学报（人文社会科学版） 2018年第3期46卷 45-50页

作者：庞晓梅于洋俄罗斯科学院东方文献研究所俄罗斯圣彼得堡192281 吉林师范大学历史文化学院吉林四平136000

理解俄罗斯满学的历史,有必要认真研究亚历山大·维拉迪米洛维奇·格列宾希科夫(alexanderVladimirovich Grebenschikov)(1880—1941)的学术遗产。他的名字与《尼山萨满故事》手稿的发现密不可分。格列宾希科夫毕业于符拉迪沃斯托克东... 详细信息

理解俄罗斯满学的历史,有必要认真研究亚历山大·维拉迪米洛维奇·格列宾希科夫(alexanderVladimirovich Grebenschikov)(1880—1941)的学术遗产。他的名字与《尼山萨满故事》手稿的发现密不可分。格列宾希科夫毕业于符拉迪沃斯托克东方研究所,在研究所从事满语教学工作。1908年,他考察了东北瑷珲和齐齐哈尔附近村庄,搜集语言学和民族志方面资料,其考察报告于1909年发表在《亚洲公报》上。在报告中,格列宾希科夫标明并介绍了讲满语和达斡尔语的村庄,他计划在这些地方进行满族萨满教研究。1908年,他在瑷珲地区发现了《尼山萨满故事》手稿。1911年,格列宾希科夫被任命为符拉迪沃斯托克东方研究所满语教授,并建立满语语音学实验室。1932年,他到位于列宁格勒(今圣彼得堡)的俄罗斯科学院东方文献研究所工作。1941年12月,正值二战初期,格列宾希科夫在列宁格勒去世。格列宾希科夫的档案保存在俄罗斯科学院东方文献研究所,其中有珍贵的满族和达斡尔族萨满教资料,萨满神歌用俄语转写,反映了当时满语口语情况。1941年,格列宾希科夫完成了《钦定满洲祭神祭天典礼》的俄文翻译,但至今没有出版。东方文献研究所还保存了一组格列宾希科夫在满洲考察时所摄照片。

关键词：格列宾希科夫满族民俗符拉迪沃斯托克东方研究所东方文献研究所俄罗斯科学院满学《钦定满洲祭神祭天典礼》

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重新思考地理学对城市可持续发展的贡献——对话亚历山大·B·墨菲教授

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国际城市规划 2015年第4期30卷 127-128页

作者：庞璐滕雨薇刘伟同济大学建筑与城市规划学院规划系 <国际城市规划>杂志上海站

亚历山大·B·墨菲（alexander B.Murphy）,美国俄勒冈大学地理系教授,曾任美国地理学家学会（AAG：Association of American Geographers）主席（2003—2004年）,现任美国国家地理学会（NGS：National Geographic Society）资深副主席。他的主要研究领域是文化和政治地理学,主要研究区域为欧洲和中东。1997年他主编的《重新发现地理学》在世界地理学界产生了广泛的影响。墨菲教授发表过众多高质量的学术期刊文章,编写过数十部学术专著。采访时间：

关键词：地理学研究政治地理学俄勒冈大学学术期刊美国国家地理副主席地理系地理科学文化特征芒语

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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Genome Institute of Singapore Agency for Science Technology and Research Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

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一起贝类膝沟藻毒素中毒调查分析

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中国食品卫生杂志 2009年第3期21卷 265-267页

作者：林祥田庞中全张雨李继波张进柳运涛王大剀连云港市卫生监督所江苏连云港222006 赣榆县卫生监督所江苏连云港222100

目的了解膝沟藻毒素中毒流行病学特征,探讨预防和救治麻痹性贝毒中毒的措施;方法对中毒者进行调查,采集样品、观察藻种并计数密度,检测菲律宾蛤仔毒力,测定麻痹性贝毒毒素成分;结果养殖菲律宾蛤仔的海水中亚历山大藻密度为5×105细胞/L... 详细信息

目的了解膝沟藻毒素中毒流行病学特征,探讨预防和救治麻痹性贝毒中毒的措施;方法对中毒者进行调查,采集样品、观察藻种并计数密度,检测菲律宾蛤仔毒力,测定麻痹性贝毒毒素成分;结果养殖菲律宾蛤仔的海水中亚历山大藻密度为5×105细胞/L,病人食剩的生、熟菲律宾蛤仔毒力分别为16 603 MU/100 g和4 035 MU/100 g,样品中均检出GTX1,GTX2,GTX3,GTX4。结论菲律宾蛤仔引起的中毒事件是一起贝类膝沟藻毒素中毒。

关键词：毒素贝类食物中毒藻类综合预防治疗学卫生措施

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DETERMINATION OF THE REACTIVITIES OF 19 COMMON AMINO ACIDS IN BINDING RADIATION CHEMICALLY WITH ^(14)C-THYMINE

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Chinese Science Bulletin 1985年第6期30卷 829-832页

作者：沈恂庞素珍傅迎宪代军 Institute of Biophysics Academia Sinica Beijing Institute of Biophysics Academia Sinica Beijingince Alexander and Stacey (1959) found that a substantial fraction of DNA was unable to be separated from protein in the sperms of salmon fish after irradiation with electron beam and Smith (1962) found that the amount of "unextractable" (i.e. unable

Since alexander and Stacey (1959) found that a substantial fraction of DNA was unable to be separated from protein in the sperms of salmon fish after irradiation with electron beam and Smith (1962) found that the amou... 详细信息

关键词： irradiation unable salmon irradiated linking phenylalanine separated DNA bases enable

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced background.This paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS experiment.Two taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet pseudorapidity.Differences in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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