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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

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Stroke & Vascular Neurology 2022年第3期7卷 182-189页

作者： Mengmeng Shi Xinyi Leng ying Li Zihan Chen ye Cao Tiffany Chung Bonaventure yM Ip Vincent HL Ip yannie Oy Soo Florence Sy Fan Sze Ho Ma Karen Ma Anne y y Chan Lisa WC Au Howan Leung alexander y lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Key Laboratory for Regenerative Medicine Ministry of Education(Shenzhen Base)Shenzhen Research InstituteThe Chinese University of Hong KongShenzhenChina Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics The Chinese University of Hong KongHong KongChina

Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely *** prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to *** Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke *** aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also ***,candidate genes were used for pathway and gene ontology enrichment *** Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of ***-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke *** of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke *** study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of ***,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic *** Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients.

关键词： patients metabolism intracranial

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Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis

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Stroke & Vascular Neurology 2022年第1期7卷 77-85页

作者： Linda LD Zhong ya Zheng alexander y lau Norman Wong Liang yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung yu Hong Kong Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong Kong Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Association for Integration of Chinese-Western Medicine Limited Hong Kong SARChina

Background Stroke is a major cause of death or long-term disability *** patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM *** The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were ***,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were *** included outcomes were dependency,motor function,depression and swallowing *** analysis was performed,and publication bias was assessed using funnel *** of review 58 studies and 6339 patients were included in the *** analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy *** superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also *** Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy ***,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn ***,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.

关键词： acupuncture routine alone

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Mindfulness Facets and Psychological Well-Being among Meditators:Serenity as a Mediating Process

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International Journal of Mental Health Promotion 2024年第3期26卷 177-187页

作者： Rebecca y.M.Cheung Iris yili Wang Elsa Ngar-Sze lau School of Psychology and Clinical Language Sciences University of ReadingReadingUK Department of Special Education and Counselling The Education University of Hong KongHong KongChina Department of Educational Administration and Policy The Chinese University of Hong KongHong KongChina

Guided by the theoretical processes of mindfulness and psychological well-being,this study examined serenity as a mediator between mindfulness facets and psychological well-being,as indexed by depressive symptoms and life *** were 133 mindfulness practitioners who took part in a 3-day transnational meditation event in Hong *** informed consent,participants completed a self-report *** findings from structural equation modeling showed that serenity mediated the relation between two facets of mindfulness,including describing and nonreacting to inner experience,and life *** also mediated the relation between the mindfulness facet of describing and depressive *** associations were indicated between two mindfulness facets,including observing and nonjudging of inner experience,and depressive *** together,the findings revealed mindfulness facets as major correlates of serenity and psychological outcomes among Chinese meditation *** foster psychological well-being,researchers,educators,and practitioners should pay attention to the role of serenity,describing,and nonreacting to inner experience in mental health.

关键词： Depressive symptoms mindfulness mindfulness practitioners satisfaction with life serenity

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Scanning transmission electron microscopy and atom probe tomography analysis of non-stoichiometry long-period-stacking-ordered structures in Mg-Ni-y/Sm alloys

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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： yimeng Chen Manuel Legrée Jean-Louis Bobet alexander Kvit CAMECA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg *** current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STEM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-y/Sm ternary alloys after extended isothermal *** on the alloying elements and their concentrations,Mg-Ni-y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg ***-STEM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(y/Sm)_(8) *** addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding *** results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STEM HAADF Hydrolysis properties.

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu yuet Chung Tsun Ming lau Manni Wang Wenyue Zhang yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing yan Li Amos M.T.Lee Jennifer H.y.Lam Sau Man Chan Wilfred H.S.Wong Issan y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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A new look at the first dinosaur discovered in Antarctica:reappraisal of Antarctopelta oliveroi(Ankylosauria:Parankylosauria)

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Advances in Polar Science 2024年第1期35卷 78-107页

作者： Sergio SOTO ACUÑA alexander OVARGAS Jonatan KALUZA Red Paleontológica U-Chile Departamento de BiologíaFacultad de CienciasUniversidad de ChileÑuñoa 7800003Chile Escuela de Geología Facultad de CienciasIngeniería y TecnologíaUniversidad MayorProvidenciaSantiago 7500994Chile Fundación de Historia Natural Félix de Azara Universidad MaimónidesBuenos Aires C1405Argentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina

The first dinosaur discovered in the Antarctic continent was the ankylosaur Antarctopelta oliveroi in the ***,since then several hypotheses of phylogenetical relationships have been proposed because these have been depended on how the skeletal remains have been *** main obstacle for clarifying its phylogenetic position is that many portions of the skeleton remain unknown,in addition to the presence of unknown characters in typical *** an ankylosaurid,nodosaurid,or even a chimaera,a recent proposal based on mostly complete material of a new ankylosaur from Chilean Patagonia provided support for a novel phylogenetic hypothesis:Antarctopelta and other southern ankylosaurs are an early branching clade,the Parankylosauria,whose origin probably dates to the Late *** the light of this new view,a redescription of the available skeletal remains is provided together with a new reconstruction of the first Antarctic dinosaur known to the science community.

关键词： Antarctic Peninsula Biogeographic Weddellian Province Parankylosauria Antarctopelta

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Effect of autologous serum after amniotic membrane transplantation for persistent corneal ulcers

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1639-1644页

作者： Rozaliya Hristova Petya yankova Georgi Markov alexander Oscar yani Zdravkov Department of Ophthalmology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria Department of Clinical Immunology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria

AIM:To investigate the effect of adding autologous serum eye drops to the postoperative regime after amniotic membrane transplantation for severe persistent corneal ***:Forty eyes of 40 patients with persistent corneal ulcers were randomly assigned to artificial tears(sodium hyaluronate 0.2%,ATs group,n=20)or autologous serum eye drops(ASEDs,n=20)following treatment with amniotic membrane *** slit lamp images were acquired from all patients before and 30d post *** area with fibrovascular tissue was calculated using Image *** corneal sensitivity was assessed by Cochet-Bonnet aesthesiometry before and one month after *** tissue transparency was assessed with a novel optical ***:Mean age of patients was 61.65±16.47y and 57.3±19.11y in the ATs group and ASEDs group,***-two male and 18 female patients were included in the *** improvement in visual acuity was significantly greater in the ASEDs group(0.14±0.04)than the ATs(0.08±0.04;P=0.00046).Cochet-Bonnet aesthesiometry improved significantly after treatment with a similar rate between *** were no statistically significant differences in the area of postoperative fibrovascular tissue between the two groups(P=0.082).The success rate in the two groups was *** difference in densitometry between the ATs and ASEDs group was statistically significant(P=0.042)with greater reduction from baseline in the ASEDS ***:Autologous serum eye drops can lead to better visual acuity,more stable results and improved densitometry and should be considered in the postoperative care following amniotic membrane transplantation.

关键词： autologous serum amniotic membrane ocular surface persistent corneal ulcer

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A new look at the first dinosaur discovered in Antarctica: reappraisal of Antarctopelta oliveroi(Ankylosauria: Parankylosauria)

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Advances in Polar Science 2024年

作者： Sergio SOTO ACU?A alexander O.VARGAS Jonatan KALUZA Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Red Paleontológica U-Chile，Departamento de Biología， Facultad de Ciencias， Universidad de Chile Fundación de Historia Natural Félix de Azara， Universidad Maimónides Escuela de Geología，Facultad de Ciencias， Ingeniería y Tecnología， Universidad Mayor， Providencia

The first dinosaur discovered in the Antarctic continent was the ankylosaur Antarctopelta oliveroi in the 1980s. Nevertheless， since then several hypotheses of phylogenetical relationships have been proposed because these have been depended on how the skeletal remains have been interpreted. The main obstacle for clarifying its phylogenetic position is that many portions of the skeleton remain unknown， in addition to the presence of unknown characters in typical ankylosaurs. Considered an ankylosaurid， nodosaurid， or even a chimaera， a recent proposal based on mostly complete material of a new ankylosaur from Chilean Patagonia provided support for a novel phylogenetic hypothesis: Antarctopelta and other southern ankylosaurs are an early branching clade， the Parankylosauria， whose origin probably dates to the Late Jurassic. In the light of this new view， a redescription of the available skeletal remains is provided together with a new reconstruction of the first Antarctic dinosaur known to the science community.

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui yi Ho Feijun Hu yujeong Kim Hill Lam lau ying Lo Law Chi Seng Leung Chun yin Tong Kai Kap Wong Wing Lam yim Nikolay S.Karnaukhov Richard y.C.Kong Maria V.Babak yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Tailoring-compensated ferrimagnetic state and anomalous Hall effect in quaternary Mn–Ru–V–Ga Heusler compounds

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Chinese Physics B 2024年第7期33卷 595-603页

作者：梁瑾静郗学奎王文洪刘永昌 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Tiangong University Tianjin 300387China

Cubic Mn_(2)Ru_(x)Ga Heusler compound is a typical example of compensated ferrimagnet with attractive potential for high-density,ultrafast,and low-power spintronic *** the form of epitaxial thin films,Mn_(2)Ru_(x)Ga exhibits high spin polarization and high tunability of compensation temperature by freely changing the Ru content x in a broad range(0.3ycrystalline bulk buttons prepared by arc melting are systematically studied and it is found that in equilibrium bulk form,the cubic structure is unstable when xyed with a fourth element *** adjusting the content of V in the By adjusting the content of V in the Mn_(2)Ru_(0.75)V_(y)Ga and Mn_(2.25-y)Ru_(0.75)V_(y)Ga quaternary systems the magnetic compensation temperature is *** is achieved near 300 K which is confirmed by both the magnetic measurement and anomalous Hall effect *** analyses of the anomalous Hall effect scaling in quaternary Mn-Ru-V-Ga alloy reveal the dominant role of skew scattering,notably that contributed caused by the thermally excited phonons,in contrast to the dominant intrinsic mechanism found in many other 3d ferromagnets and Heusler *** is further shown that the Ga antisites and V content can simultaneously control the residual resistivity ratio(RRR)as well as the relative contribution of phonon and defect to the anomalous Hall effect a"/a0'in Mn-Ru-V-Ga,resulting in a scaling relation a"/a0'∝RRR^(1.8).

关键词： compensated ferrimagnet anomalous Hall effect residual resistivity ratio

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